Structural basis for dual-inhibition mechanism of a non-classical kazal-type serine protease inhibitor from horseshoe crab in complex with subtilisin

PLoS ONE

Volumn 6, Issue 4, 2011, Pages

  Shenoy, Rajesh T ^a   Thangamani, Saravanan ^a,d   Velazquez Campoy, Adrian ^b,c   Ho, Bow ^a   Ding, Jeak Ling ^a   Sivaraman, J ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b UNIVERSITY OF ZARAGOZA   (Spain)

^c FUNDACIÓN ARAID   (Spain)

^d University of Texas Medical Branch School of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FURIN; PROTEIN CRSPI; SERINE PROTEINASE INHIBITOR; SUBTILISIN; UNCLASSIFIED DRUG; APROTININ; PEPTIDE;

ARTICLE; CARCINOSCORPIUS ROTUNDICAUDA; COMPLEX FORMATION; CRAB; CRYSTAL STRUCTURE; ENZYME BINDING; ENZYME INHIBITION; ENZYME SUBSTRATE; HOST PATHOGEN INTERACTION; INNATE IMMUNITY; NUCLEOTIDE SEQUENCE; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; STRUCTURE ACTIVITY RELATION; AMINO ACID SEQUENCE; ANIMAL; BACILLUS; CALORIMETRY; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; ENZYME ACTIVE SITE; ENZYMOLOGY; LIMULUS; METABOLISM; MOLECULAR GENETICS; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; SEQUENCE ALIGNMENT; X RAY CRYSTALLOGRAPHY;

BACTERIA (MICROORGANISMS); CARCINOSCORPIUS ROTUNDICAUDA; INVERTEBRATA; MEROSTOMATA;

AMINO ACID SEQUENCE; ANIMALS; BACILLUS; CALORIMETRY; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; HORSESHOE CRABS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PEPTIDES; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; SEQUENCE ALIGNMENT; STRUCTURE-ACTIVITY RELATIONSHIP; SUBTILISIN; TRYPSIN INHIBITOR, KAZAL PANCREATIC;

EID: 79955575381     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0018838     Document Type: Article

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