Differences in binding modes of enantiomers of 1-acetamido boronic acid based protease inhibitors: Crystal structures of γ-chymotrypsin and subtilisin Carlsberg complexes

Biochemistry

Volumn 37, Issue 2, 1998, Pages 451-462

  Stoll, Vincent S ^a,b,c   Eger, Bryan T ^a   Hynes, Rosemary C ^a,c   Martichonok, Valeri ^c,d   Jones, J Bryan ^c   Pai, Emil F ^a,b,c  

^a UNIVERSITY OF TORONTO   (Canada)

^b PRINCESS MARGARET HOSPITAL   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

^d Arris Pharmaceuticals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BORONIC ACID DERIVATIVE; CHYMOTRYPSIN A; PROTEINASE; SUBTILISIN;

ARTICLE; BINDING AFFINITY; CRYSTAL STRUCTURE; ENZYME BINDING; ENZYME CONFORMATION; ENZYME SPECIFICITY; ENZYME SUBSTRATE COMPLEX; NONHUMAN; PRIORITY JOURNAL; STEREOCHEMISTRY;

BINDING SITES; BORONIC ACIDS; CHYMOTRYPSIN; CRYSTALLOGRAPHY, X-RAY; HISTIDINE; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION; SERINE; SERINE PROTEINASE INHIBITORS; STEREOISOMERISM; SUBTILISINS;

EID: 0032512422     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi971166o     Document Type: Article

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