Synthesis and antitumor screening of new 1,7-diphenyl-3-(1,3-disubstituted- 1H-pyrazole-4-carbonyl)-[1,2,4]triazolo[4,3-a]pyrimidin-5(1H)-ones

Archives of Pharmacal Research

Volumn 33, Issue 1, 2010, Pages 55-60

  Shawali, Ahmad S ^a   Sherif, Sherif M ^a   Darwish, Manal A A ^a   El Merzabani, Mahmoud M ^b  

^a CAIRO UNIVERSITY   (Egypt)

^b CAIRO UNIVERSITY   (Egypt)

Author keywords

1,2,4 Triazolo 4,3 a pyrimidine; Enaminone; Hydrazonoyl halides; Pyrazole

Indexed keywords

1,7 DIPHENYL 3 (1,3 DISUBSTITUTED 1H PYRAZOLE 4 CARBONYL) [1,2,4]TRIAZOLO[4,3 ALPHA]PYRIMIDIN 5(1H) ONE DERIVATIVE; 1,7 DIPHENYL 3 [1,3 DIPHENYLPYRAZOLE 4 CARBONYL] [1,2,4]TRIAZOLO [4,3 ALPHA]PYRIMIDIN 5(1H) ONE; 1,7 DIPHENYL 3 [3 (2 NAPHTHOYL) 1 (4 METHYLPHENYL)PYRAZOLE 4 CARBONYL] [1,2,4]TRIAZOLO [4,3 ALPHA]PYRIMIDIN 5(1H) ONE; 1,7 DIPHENYL 3 [3 (2 NAPHTHOYL) 1 PHENYLPYRAZOLE 4 CARBONYL] [1,2,4]TRIAZOLO [4,3 ALPHA]PYRIMIDIN 5(1H) ONE; 1,7 DIPHENYL 3 [3 (2 THIOPHENYL) 1 (4 NITROPHENYL)PYRAZOLE 4 CARBONYL] [1,2,4]TRIAZOLO [4,3 ALPHA]PYRIMIDIN 5(1H) ONE; 1,7 DIPHENYL 3 [3 (N PHENYLAMINOCARBONYL) 1 (4 CHLOROPHENYL)PYRAZOLE 4 CARBONYL] [1,2,4]TRIAZOLO [4,3 ALPHA]PYRIMIDIN 5(1H) ONE; 1,7 DIPHENYL 3 [3 (N PHENYLAMINOCARBONYL) 1 (4 METHYLPHENYL)PYRAZOLE 4 CARBONYL] [1,2,4]TRIAZOLO [4,3 ALPHA]PYRIMIDIN 5(1H) ONE; 1,7 DIPHENYL 3 [3 ETHOXYCARBONYL 1 (4 CHLOROPHENYL)PYRAZOLE 4 CARBONYL] [1,2,4]TRIAZOLO [4,3 ALPHA]PYRIMIDIN 5(1H) ONE; 1,7 DIPHENYL 3 [3 ETHOXYCARBONYL 1 (4 METHYLPHENYL)PYRAZOLE 4 CARBONYL] [1,2,4]TRIAZOLO [4,3 ALPHA]PYRIMIDIN 5(1H) ONE; 1,7 DIPHENYL 3 [3 ETHOXYCARBONYL 1 (4 NITROPHENYL)PYRAZOLE 4 CARBONYL] [1,2,4]TRIAZOLO [4,3 ALPHA]PYRIMIDIN 5(1H) ONE; 1,7 DIPHENYL 3 [3 ETHOXYCARBONYL 1 PHENYLPYRAZOLE 4 CARBONYL] [1,2,4]TRIAZOLO [4,3 ALPHA]PYRIMIDIN 5(1H) ONE; 3[3 (DIMETHYLAMINO)ACRYLOYL] 1,7 DIPHENYL[1,2,4]TRIAZOLO [4,3 ALPHA]PYRIMIDIN 5(1H) ONE; 3[3 ACETYL 1 (4 CHLOROPHENYL)PYRAZOLE 4 CARBONYL] 1,7 DIPHENYL[1,2,4]TRIAZOLO [4,3 ALPHA]PYRIMIDIN 5(1H) ONE; 3[3 ACETYL 1 (4 METHYLPHENYL)PYRAZOLE 4 CARBONYL] 1,7 DIPHENYL[1,2,4]TRIAZOLO [4,3 ALPHA]PYRIMIDIN 5(1H) ONE; 3[3 ACETYL 1 PHENYLPYRAZOLE 4 CARBONYL] 1,7 DIPHENYL[1,2,4]TRIAZOLO [4,3 ALPHA]PYRIMIDIN 5(1H) ONE; 3[3 BENZOYL 1 (4 CHLOROPHENYL)PYRAZOLE 4 CARBONYL] 1,7 DIPHENYL[1,2,4]TRIAZOLO [4,3 ALPHA]PYRIMIDIN 5(1H) ONE; 3[3 BENZOYL 1 PHENYLPYRAZOLE 4 CARBONYL] 1,7 DIPHENYL[1,2,4]TRIAZOLO [4,3 ALPHA]PYRIMIDIN 5(1H) ONE; ANTINEOPLASTIC AGENT; DOXORUBICIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; IN VITRO STUDY; MELTING POINT; MOUSE; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; ANTINEOPLASTIC AGENTS; CARCINOMA, EHRLICH TUMOR; CELL LINE, TUMOR; DOXORUBICIN; DRUG SCREENING ASSAYS, ANTITUMOR; INDICATORS AND REAGENTS; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; MICE; PYRIMIDINONES; SPECTROPHOTOMETRY, INFRARED; TRIAZOLES;

EID: 77949906684     PISSN: 02536269     EISSN: 19763786     Source Type: Journal    
DOI: 10.1007/s12272-010-2224-8     Document Type: Article

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