Effect of valproate, lamotrigine and levetiracetam on excitability and firing properties of CA1 neurons in rat brain slices

Cellular and Molecular Neurobiology

Volumn 31, Issue 4, 2011, Pages 645-652

  Englund, Marita ^a   Hyllienmark, Lars ^a   Brismar, Tom ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Brain slice; CA1 cells; Epilepsy; Patch clamp; Sodium channel

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; BICUCULLINE; ETIRACETAM; LAMOTRIGINE; VALPROIC ACID;

ACTION POTENTIAL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FEMALE; HIPPOCAMPAL CA1 REGION; MALE; MEMBRANE STEADY POTENTIAL; NERVE CELL EXCITABILITY; NONHUMAN; PRIORITY JOURNAL; RAT;

ACTION POTENTIALS; ANIMALS; BICUCULLINE; CA1 REGION, HIPPOCAMPAL; FEMALE; MALE; NEURONS; PIRACETAM; RATS; RATS, SPRAGUE-DAWLEY; TRIAZINES; VALPROIC ACID;

RATTUS;

EID: 79955567495     PISSN: 02724340     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10571-011-9660-y     Document Type: Article

References (36)

1. H Albus R Williamson 1998 Electrophysiologic analysis of the actions of valproate on pyramidal neurons in the rat hippocampal slice Epilepsia 39 124 139 9577992 10.1111/j.1528-1157.1998.tb01350.x 1:CAS:528:DyaK1cXhtVGjsr8%3D (Pubitemid 28074348)
2. U Altrup G Gerlach H Reith MN Said EJ Speckmann 1992 Effects of valproate in a model nervous system (buccal ganglia of Helix pomatia): I. antiepileptic actions Epilepsia 33 743 752 1628593 10.1111/j.1528-1157.1992.tb02356.x 1:CAS:528:DyaK38XlsVegtro%3D
3. R Davis DH Peters D McTavish 1994 Valproic acid. A reappraisal of its pharmacological properties and clinical efficacy in epilepsy Drugs 47 332 372 7512905 10.2165/00003495-199447020-00008 1:STN:280:DyaK2c3hsFGitw%3D%3D
4. M Englund L Hyllienmark T Brismar 2001 Chemical hypoxia in hippocampal pyramidal cells affects membrane potential differentially depending on resting potential Neuroscience 106 89 94 11564419 10.1016/S0306-4522(01)00259-7 1:CAS:528:DC%2BD3MXms1Omsr4%3D (Pubitemid 32831076)
5. M Englund M Bjurling F Edin L Hyllienmark T Brismar 2004 Hypoxic excitability changes and sodium currents in hippocampus CA1 neurons Cell Mol Neurobiol 24 685 694 15485138 10.1023/B:CEMN.0000036405.53992.78 1:CAS:528:DC%2BD2cXmtFGjs7Y%3D (Pubitemid 39062430)
6. M Guven H Bozdemir I Gunay Y Sarica I Kahraman F Koc 2006 The actions of lamotrigine and levetiracetam on the conduction properties of isolated rat sciatic nerve Eur J Pharmacol 553 129 134 17067571 10.1016/j.ejphar.2006.09.045 1:CAS:528:DC%2BD28Xht1Ciu7nI (Pubitemid 44779604)
7. D Honack W Loscher 1992 Intravenous valproate: onset and duration of anticonvulsant activity against a series of electroconvulsions in comparison with diazepam and phenytoin Epilepsy Res 13 215 221 1493784 10.1016/0920- 1211(92)90055-X 1:STN:280:DyaK3s7lsVejtg%3D%3D (Pubitemid 23000924)
8. CW Huang JJ Tsai CC Huang SN Wu 2009 Experimental and simulation studies on the mechanisms of levetiracetam-mediated inhibition of delayed-rectifier potassium current (KV3.1): contribution to the firing of action potentials J Physiol Pharmacol 60 37 47 20065495 1:CAS:528:DC%2BC3cXht1Wisbo%3D
9. + channels in pyramidal cells of the hippocampal CA1 region in rat brain slices J Physiol 496 155 164 8910204 1:CAS:528:DyaK28Xmt1Wmu7g%3D (Pubitemid 26345584)
10. KM Kelly RA Gross RL Macdonald 1990 Valproic acid selectively reduces the low-threshold (T) calcium current in rat nodose neurons Neurosci Lett 116 233 238 2175404 10.1016/0304-3940(90)90416-7 1:CAS:528:DyaK3cXlvVCmu7w%3D (Pubitemid 20237166)
11. + channels in rat hippocampal neurones Br J Pharmacol 121 1231 1238 9249262 10.1038/sj.bjp.0701221 1:CAS:528:DyaK2sXkvFeqsb8%3D (Pubitemid 27303595)
12. W Loscher D Honack 1993 Profile of ucb L059, a novel anticonvulsant drug, in models of partial and generalized epilepsy in mice and rats Eur J Pharmacol 232 147 158 8467854 10.1016/0014-2999(93)90768-D 1:STN:280:DyaK3s3itlOmug%3D%3D (Pubitemid 23080189)
13. W Loscher M Vetter 1985 In vivo effects of aminooxyacetic acid and valproic acid on nerve terminal (synaptosomal) GABA levels in discrete brain areas of the rat. Correlation to pharmacological activities Biochem Pharmacol 34 1747 1756 3924047 10.1016/0006-2952(85)90645-8 1:STN:280:DyaL2M3isFKnsQ%3D%3D (Pubitemid 15096584)
14. W Loscher CP Fassbender B Nolting 1991 The role of technical, biological and pharmacological factors in the laboratory evaluation of anticonvulsant drugs. II. Maximal electroshock seizure models Epilepsy Res 8 79 94 2065646 10.1016/0920-1211(91)90075-Q 1:STN:280:DyaK3M3ptlSltg%3D%3D
15. BA Lynch N Lambeng K Nocka P Kensel-Hammes SM Bajjalieh A Matagne B Fuks 2004 The synaptic vesicle protein SV2A is the binding site for the antiepileptic drug levetiracetam Proc Natl Acad Sci USA 101 9861 9866 15210974 10.1073/pnas.0308208101 1:CAS:528:DC%2BD2cXlvVahtb8%3D (Pubitemid 38869327)
16. M Madeja DG Margineanu A Gorji E Siep P Boerrigter H Klitgaard EJ Speckmann 2003 Reduction of voltage-operated potassium currents by levetiracetam: a novel antiepileptic mechanism of action? Neuropharmacology 45 661 671 12941379 10.1016/S0028-3908(03)00248-X 1:CAS:528:DC%2BD3sXms1Ort7c%3D (Pubitemid 36980822)
17. DG Margineanu H Klitgaard 2000 Inhibition of neuronal hypersynchrony in vitro differentiates levetiracetam from classical antiepileptic drugs Pharmacol Res 42 281 285 10987984 10.1006/phrs.2000.0689 1:STN:280: DC%2BD3M%2FovF2rsg%3D%3D
18. ED Martin MA Pozo 2003 Valproate suppresses status epilepticus induced by 4-aminopyridine in CA1 hippocampus region Epilepsia 44 1375 1379 14636343 10.1046/j.1528-1157.2003.11603.x 1:CAS:528:DC%2BD3sXps12rs7Y%3D (Pubitemid 37385844)
19. +) current in pyramidal neurones of rat hippocampal slices Neurosci Lett 306 5 8 11403944 10.1016/S0304-3940(01)01884-5 1:CAS:528:DC%2BD3MXkt12htL8%3D (Pubitemid 32524284)
20. I Niespodziany H Klitgaard DG Margineanu 2004 Is the persistent sodium current a specific target of anti-absence drugs? Neuroreport 15 1049 1052 15076732 10.1097/00001756-200404290-00023 1:CAS:528:DC%2BD2cXkvFaju7s%3D (Pubitemid 38591260)
21. PN Patsalos 2004 Clinical pharmacokinetics of levetiracetam Clin Pharmacokinet 43 707 724 15301575 10.2165/00003088-200443110-00002 1:CAS:528:DC%2BD2cXnvVGms7c%3D (Pubitemid 39159001)
22. NP Poolos M Migliore D Johnston 2002 Pharmacological upregulation of h-channels reduces the excitability of pyramidal neuron dendrites Nat Neurosci 5 767 774 12118259 1:CAS:528:DC%2BD38XlsFejsr0%3D (Pubitemid 34827595)
23. MA Rogawski W Loscher 2004 The neurobiology of antiepileptic drugs Nat Rev Neurosci 5 553 564 15208697 10.1038/nrn1430 1:CAS:528:DC%2BD2cXkvF2kt7o%3D (Pubitemid 38868551)
24. + currents in cortical neurons: functional implications Eur J Pharmacol 307 113 116 8831112 10.1016/0014-2999(96)00265-8 1:CAS:528: DyaK28XjvFGisrg%3D (Pubitemid 26226292)
25. JF Storm 1987 Action potential repolarization and a fast after-hyperpolarization in rat hippocampal pyramidal cells J Physiol 385 733 759 2443676 1:STN:280:DyaL1c%2FhtVOmtQ%3D%3D (Pubitemid 17048959)
26. + current in neocortical neurons Epilepsy Res 32 304 308 9761329 10.1016/S0920-1211(98)00060- 6 1:CAS:528:DyaK1cXkvFOrt7w%3D (Pubitemid 28419498)
27. RJ Van den Berg P Kok RA Voskuyl 1993 Valproate and sodium currents in cultured hippocampal neurons Exp Brain Res 93 279 287 8387930 (Pubitemid 23159064)
28. AM Van Dongen MG Van Erp RA Voskuyl 1986 Valproate reduces excitability by blockage of sodium and potassium conductance Epilepsia 27 177 182 10.1111/j.1528-1157.1986.tb03525.x (Pubitemid 16065356)
29. M Vreugdenhil WJ Wadman 1999 Modulation of sodium currents in rat CA1 neurons by carbamazepine and valproate after kindling epileptogenesis Epilepsia 40 1512 1522 10565577 10.1111/j.1528-1157.1999.tb02034.x 1:CAS:528: DyaK1MXnslGiurY%3D (Pubitemid 29518079)
30. AW Wamil W Loscher MJ McLean 1997 Trans-2-en-valproic acid limits action potential firing frequency in mouse central neurons in cell culture J Pharmacol Exp Ther 280 1349 1356 9067323 1:CAS:528:DyaK2sXhvF2mtbk%3D (Pubitemid 27166733)
31. + channels in rat hippocampal neurones Pflugers Arch 430 437 446 7491269 10.1007/BF00373920 1:CAS:528:DyaK2MXmvFamtr0%3D
32. ML Zeise S Kasparow W Zieglgansberger 1991 Valproate suppresses N-methyl-d-aspartate- evoked, transient depolarizations in the rat neocortex in vitro Brain Res 544 345 348 2039949 10.1016/0006-8993(91)90078-A 1:CAS:528:DyaK3MXit1Wgsrc%3D
33. C Zona M Avoli 1990 Effects induced by the antiepileptic drug valproic acid upon the ionic currents recorded in rat neocortical neurons in cell culture Exp Brain Res 81 313 317 2168843 10.1007/BF00228121 1:CAS:528: DyaK3cXmtVCks7c%3D (Pubitemid 20216607)
34. C Zona M Avoli 1997 Lamotrigine reduces voltage-gated sodium currents in rat central neurons in culture Epilepsia 38 522 525 9184596 10.1111/j.1528-1157. 1997.tb01135.x 1:CAS:528:DyaK2sXjsVGqu7k%3D (Pubitemid 27199905)
35. + currents Seizure 10 279 286 11466024 10.1053/seiz.2000. 0504 1:STN:280:DC%2BD3MvhslCitQ%3D%3D (Pubitemid 32705452)
36. C Zona V Tancredi P Longone G D'Arcangelo M D'Antuono M Manfredi M Avoli 2002 Neocortical potassium currents are enhanced by the antiepileptic drug lamotrigine Epilepsia 43 685 690 12102669 10.1046/j.1528-1157.2002.51401.x 1:CAS:528:DC%2BD38Xmt1Oiu7c%3D (Pubitemid 34774248)