Cardiopulmonary responses in spontaneously hypertensive and Wistar-Kyoto rats exposed to concentrated ambient particles from Detroit, Michigan

Inhalation Toxicology

Volumn 22, Issue 6, 2010, Pages 522-533

  Rohr, Annette C ^a   Wagner, James G ^b   Morishita, Masako ^c   Kamal, Ali ^c   Keeler, Gerald J ^c   Harkema, Jack R ^b  

^a ELECTRIC POWER RESEARCH INSTITUTE   (United States)

^b MICHIGAN STATE UNIVERSITY   (United States)

^c UNIVERSITY OF MICHIGAN   (United States)

Author keywords

CAPs; Heart rate variability; Particulate matter; Toxicology

Indexed keywords

ANTIMONY; C REACTIVE PROTEIN; CERIUM; LANTHANUM; OIL; TRACE METAL; VANADIUM;

AIRBORNE PARTICLE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD ANALYSIS; CARDIOVASCULAR RESPONSE; COMBUSTION; ELECTROCARDIOGRAPHY MONITORING; EXHAUST GAS; EXPOSURE; HEART RATE VARIABILITY; INCINERATION; LABORATORY APPARATUS, EQUIPMENT AND SUPPLIES; LUNG LAVAGE; LUNG PARENCHYMA; MALE; NONHUMAN; OIL INDUSTRY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RAT; SPONTANEOUSLY HYPERTENSIVE RAT; TELEMETRY; TISSUE LEVEL; UNITED STATES; WASTE; WIND; WISTAR KYOTO RAT;

AIR POLLUTANTS; ANIMALS; BRONCHOALVEOLAR LAVAGE FLUID; C-REACTIVE PROTEIN; ELECTROCARDIOGRAPHY; ENVIRONMENTAL MONITORING; HEART RATE; HYPERTENSION; LUNG; MALE; PARTICULATE MATTER; RATS; RATS, INBRED SHR; RATS, INBRED WKY; TRACE ELEMENTS; TROPONIN I;

ANIMALIA; RATTUS;

EID: 77951276365     PISSN: 08958378     EISSN: 10917691     Source Type: Journal    
DOI: 10.3109/08958370903524509     Document Type: Article

References (47)

1. Adams JE III, Bodor GS, Davila-Roman VG, Delmez JA, Apple FS, Ladenson JH, Jaffe AS. 1993. Cardiac troponin I: A marker with high specificity for cardiac injury. Circulation 88:101-106.
2. Batalha JR, Saldiva PH, Clarke RW, Coull BA, Stearns RC, Lawrence J, Murthy GG, Koutrakis P, Godleski JJ. 2002. Concentrated ambient air particles induce vasoconstriction of small pulmonary arteries in rats. Environ Health Perspect 110:1191-1197.
3. Bianchi G, Ferrari P, Cusi D, Salardi S, Guidi E, Niutta E, Tripodi G. 1986. Genetic and experimental hypertension in the animal model-Similarities and dissimilarities to the development of human hypertension. J. Cardiovasc. Pharmacol. 8:S64-S70.
4. Brook RD. 2008. Cardiovascular effects of air pollution: Review. Clin. Sci. 115:175-187.
5. Cavallari JM, Eisen EA, Fang SC, Schwartz J, Hauser R, Herrick RF, Christiani DC. 2008. PM2.5 metal exposures and nocturnal heart rate variability: A panel study of boilermaker construction workers. Environ Health. 7:36-43.
6. Chang CC, Hwang JS, Chan CC, Wang PY, Hu TH, Cheng TJ. 2004. Effects of concentrated ambient particles on heart rate, blood pressure, and cardiac contractility in spontaneously hypertensive rats. Inhal. Toxicol. 16:421-429.
7. Chang CC, Hwang JS, Chan CC, Cheng TJ. 2007. Interaction effects of ultrafine carbon black with iron and nickel on heart rate variability in spontaneously hypertensive rats. Environ. Health Perspect. 115:1012-1017.
8. Chen LC, Hwang J-S. 2005. Effects of subchronic exposures to concentrated ambient particles (CAPs) in mice: IV. Characterization of acute and chronic effects of ambient air fine particulate matter exposures on heartrate variability. Inhal. Toxicol. 17:209-216.
9. Cheng T-J, Hwang J-S, Wang P-Y, Tsai CF, Chen CY, Lin SH, Chan CC. 2003. Effects of concentrated ambient particles on heart rate and blood pressure in pulmonary hypertensive rats. Environ. Health Perspect. 111:147-150.
10. Chow JC, Watson JG, Kuhns H, Etyemezian V, Lowenthal DH, Crow D, Kohl SD, Engelbrecht JP, Green MC. 2004. Source profiles for industrial mobile, and area sources in the Big Bend Regional Aerosol Visibility and Observational study. Chemosphere 54:185-208.
11. Clarke RW, Coull B, Reinisch U, Catalano P, Killingsworth CR, Koutrakis P, Kavouras I, Murthy GG, Lawrence J, Lovett E, Wolfson JM, Verrier RL, Godleski JJ. 2000. Inhaled concentrated ambient particles are associated with hematologic and bronchoalveolar lavage changes in canines. Environ. Health Perspect. 108:1179-1187.
12. Devlin RB, Ghio AJ, Kehrl H, Sanders G, Cascio W. 2003. Elderly humans exposed to concentrated air pollution particles have decreased heart rate variability. Eur. Respir. J. 21(Suppl 40):76s-80s.
13. Elder A, Couderc JP, Gelein R, Eberly S, Cox C, Xia X, Zareba W, Hopke P, Watts W, Kittelson D, Frampton M, Utell M, Oberdorster G. 2007. Effects of on-road highway aerosol exposures on autonomic responses in aged spontaneously hypertensive rats. Inhal. Toxicol. 19:1-12.
14. Farraj AK, Haykal-Coates N, Winsett DW, Hazari MS, Carll AP, Rowan WH III, Ledbetter AD, Cascio WE, Costa DL. 2009. Increased conducted P-wave arrhythmias after a single oil fly ash inhalation exposure in hypertensive rats. Environ. Health Perspect. 117:709-715.
15. Gomez DR, Fernanda GM, Sanchez C, Bellato A, Smichowski P. 2005. Antimony: A traffic-related element in the atmosphere of Buenos Aires, Argentina. J. Environ. Monit. 7:1162-1168.
16. Gordon T, Nadziejko C, Schlesinger R, Chen LC. 1998. Pulmonary and cardiovascular effects of acute exposure to concentrated ambient particulate matter in rats. Toxicol. Lett. 96-97:285-288.
17. Gurgueira SA, Lawrence J, Coull B, Murthy GG, Gonzalez-Flecha B. 2002. Rapid increases in the steady-state concentration of reactive oxygen species in the lungs and heart after particulate air pollution inhalation. Environ. Health Perspect. 110:749-755.
18. Harkema JR, Keeler G, Wagner J, Morishita M, Timm E, Hotchkiss J, Marsik F, Dvonch T, Kaminski N, Barr E. 2002. Effects of concentrated ambient particles on normal and hypersecretory airways in rats. Research Report 120. Boston, MA: Health Effects Institute.
19. Holguin F, Tellez-Rojo MM, Hernandez M, Cortez M, Chow JC, Watson JG, Mannino D, Romieu I. 2003. Air pollution and heart rate variability among the elderly in Mexico City. Epidemiol 14:1-7.
20. Iijima A, Sato K, Fujitani Y, Fujimori E, Saito Y, Tanabe K, Ohara T, Kozawa K, Furuta N. 2009. Clarification of the predominant emission sources of antimony in airborne particulate matter and estimation of their effects on the atmosphere in Japan. Environ. Chem. 6:122.
21. Keeler GJ, Dvonch JT, Yip FY, Parker EA, Isreal BA, Marsik FJ, Morishita M, Barres JA, Robins TG, Brakefield-Caldwell W, Sam M. 2002. Assessment of personal and community-level exposures to particulate matter among children with asthma in Detroit, Michigan, as part of community action against asthma (CAAA). Environ. Health Perspect. 110 (Suppl 2):173-181.
22. Keeler GJ, Morishita M, Young L-H. 2005. Characterization of complex mixtures in urban atmospheres for inhalation exposure studies. Exp. Toxicol. Pathol. 57:19-29.
23. Kitto ME, Anderson DL, Gordon GE, Olmez I. 1992. Rare earth distributions in catalysts and airborne particles. Environ. Sci. Technol. 26: 1368-1375.
24. Kodavanti UP, Schladweiler MC, Ledbetter AD, McGee JK, Walsh L, Gilmour PS, Highfill JW, Davies D, Pinkerton KE, Richards JH, Crissman K, Andrews D, Costa DL. 2005. Consistent pulmonary and systemic responses from inhalation of fine concentrated ambient particles: Roles of rat strains used and physicochemical properties. Environ. Health Perspect. 113:1561-1568.
25. Kooter IM, Boere AJ, Fokkens PH, Leseman DL, Dormans JA, Cassee FR. 2006. Response of spontaneously hypertensive rats to inhalation of fine and ultrafine particles from traffic: Experimental controlled study. Part Fibre Toxicol. 15:3-7.
26. Lanki T, De Hartog JJ, Heinrich J, Hoek G, Janssen NA, Peters A, Stolzel M, Timonen KL, Vallius M, Vanninen E, Pekkanen J. 2006. Can we identify sources of fine particles responsible for exercise-induced ischemia on days with elevated air pollution? The ULTRA Study. Environ. Health Perspect. 114:655-660.
27. Lewis TC, Robins TG, Dvonch JT, Keeler GJ, Yip FY, Mentz GB, Lin X, Parker EA, Israel BA, Gonzalez L, Hill Y. 2005. Air pollution-associated changes in lung function among asthmatic children in Detroit. Environ. Health Perspect. 113:1068-1075.
28. Lippmann M, Hwang J-S, Maciejczyk P, Chen L-C. 2005. PM source apportionment for short-term cardiac function changes in ApoE ?/?; mice. Environ. Health Perspect. 113:1575-1579.
29. Magari SR, Schwartz J, Williams PL, Hauser R, Smith TJ, Christiani DC. 2002. The association of particulate air metal concentrations with heart rate variability. Environ. Health Perspect. 110:875-880.
30. Morishita M, Keeler GJ, Wagner JG, Marsik F, Timm E, Dvonch J, Harkema J. 2004. Pulmonary retention of particulate matter is associated with airway inflammation in allergic rats exposed to air pollution in urban Detroit. Inhal. Toxicol. 16:663-674.
31. Morishita M, Keeler GJ, Wagner JG, Harkema JR. 2006. Source identification of ambient PM2.5 during summer inhalation exposure studies in Detroit, MI. Atmos. Environ. 40:3823-3834.
32. Morishita M, Keeler GJ, McDonald JD, Wagner JG, Young LH, Utsunomiya S, Ewing RC, Harkema JR. 2009. Investigation of source-to-receptor pathway of anthropogenic PM2.5 in Detroit, Michigan: Comparison of two inhalation exposure studies. Atmos. Environ. 43:1805-1813.
33. Niwa Y, Hiura Y, Sawamura H, Iwai N. 2008. Inhalation exposure to carbon black induces inflammatory response in rats. Circ. J. 72:144-149.
34. Olmez I, Gordon GE. 1985. Rare earths: Atmospheric signatures for oil-fired power plants and refineries. Science 229:966-968.
35. Peters A, Perz S, Doring A, Stieber J, Koenig W, Wichmann H-E. 1999. Increases in heart rate during an air pollution episode. Am. J. Epidemiol. 150:1094-1098.
36. Pham H, Bonham AC, Pinkerton KE, Chen CY. 2009. Central neuroplasticity and decreased heart rate variability after particulate matter exposure in mice. Environ. Health Perspect. 117:1448-1453.
37. Saldiva PH, Clarke RW, Coull BA, Stearns RC, Lawrence J, Murthy GG, Diaz E, Koutrakis P, Suh H, Tsuda A, Godleski JJ. 2002. Lung inflammation induced by concentrated ambient air particles is related to particle composition. Am. J. Respir. Crit. Care Med. 165: 1610-1617.
38. Schauer JJ, Lough GC, Shafer MM, Christensen WF, Arndt MF, DeMinter JT, Park J-S. 2006. Characterization of Metals Emitted from Motor Vehicles. Research Report 133. Boston MA: Health Effects Institute.
39. Schwartz J, Morris R. 1995. Air pollution and hospital admissions for cardiovascular disease in Detroit Michigan. Am. J. Epidemiol. 142: 23-35.
40. Shi Q, Ling M, Zhang X, Zhang M, Kadijevic L, Liu S, Laurino JP. 1999. Degradation of cardiac troponin I in serum complicates comparisons of cardiac troponin I assays. Clin. Chem. 45:1018-1025.
41. Simkhovich BZ, Kleinman MT, Kloner RA. 2008. Air pollution and cardiovascular injury: Epidemiology, toxicology, and mechanisms. J. Am. Coll. Cardiol. 52:719-726.
42. Sioutas C, Koutrakis P, Ferguson ST, Burton RM. 1997. Development and evaluation of a prototype ambient particle concentrator for inhalation exposure studies. Inhal. Toxicol. 7:633-644.
43. Smith KR, Kim S, Recendez JJ, Teague SV, Menache MG, Grubbs DE, Sioutas C, Pinkerton KE. 2003. Airborne particles of the California Central Valley alter the lungs of healthy adult rats. Environ. Health Perspect. 111:902-908.
44. Urch B, Brook JR, Wasserstein D, Brook RD, Rajagopolan S, Corey P, Silverman F. 2004. Relative contributions of PM2.5 chemical constituents to acute arterial vasoconstriction in humans. Inhal. Toxicol. 16: 345-352.
45. Watkinson WP, Campen MJ, Nolan JP, Costa DL. 2001. Cardiovascular and systemic responses to inhaled pollutants in rodents: Effects of ozone and particulate matter. Environ. Health Perspect. 109(S4): 539-546.
46. Wellenius GA, Batalha JR, Diaz EA, Lawrence J, Coull BA, Katz T, Verrier RL, Godleski JJ. 2004. Cardiac effects of carbon monoxide and ambient particles in a rat model of myocardial infarction. Toxicol. Sci. 80: 367-376.
47. Wichers LB, Nolan JP, Winsett DW, Ledbetter AD, Kodavanti UP, Schladweiler MC, Costa DL, Watkinson WP. 2004. Effects of instilled combustion-derived particles in spontaneously hypertensive rats. Part I: Cardiovascular responses. Inhal. Toxicol. 16:391-405.