Clopidogrel improves endothelial function and NO bioavailability by sensitizing adenylyl cyclase in rats with congestive heart failure

Basic Research in Cardiology

Volumn 106, Issue 3, 2011, Pages 485-494

  Schäfer, Andreas ^a   Fraccarollo, Daniela ^a   Pförtsch, Stephanie ^b   Loch, Elena ^b   Neuser, Jonas ^b   Vogt, Christian ^b   Bauersachs, Johann ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b UNIVERSITY HOSPITAL WÜRZBURG   (Germany)

Author keywords

CHF; Clopidogrel; Endothelial dysfunction; Nitric oxide; Platelet activation

Indexed keywords

ACETYLCHOLINE; ADENOSINE; ADENYLATE CYCLASE; CLOPIDOGREL; ENDOTHELIAL NITRIC OXIDE SYNTHASE; NITRIC OXIDE; PHENYLEPHRINE; PLACEBO; PROSTAGLANDIN SYNTHASE; PROTEIN KINASE B; PURINERGIC P2Y12 RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY CONSTRICTION; ARTERY DILATATION; ARTICLE; CONGESTIVE HEART FAILURE; CONTROLLED STUDY; CORONARY ARTERY LIGATION; DRUG EFFECT; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; HEART INFARCTION; MALE; NONHUMAN; RAT; SIGNAL TRANSDUCTION; THORACIC AORTA; VASCULAR ENDOTHELIUM; VASCULAR RING;

ADENYLATE CYCLASE; ANIMALS; AORTA; BLOTTING, WESTERN; ENDOTHELIUM, VASCULAR; HEART FAILURE; MALE; NITRIC OXIDE; PURINERGIC P2Y RECEPTOR ANTAGONISTS; RATS; RATS, WISTAR; TICLOPIDINE; VASODILATION;

EID: 79955547957     PISSN: 03008428     EISSN: 14351803     Source Type: Journal    
DOI: 10.1007/s00395-011-0153-4     Document Type: Article

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