A single loading dose of clopidogrel causes dose-dependent improvement of endothelial dysfunction in patients with stable coronary artery disease: Results of a double-blind, randomized study

Atherosclerosis

Volumn 196, Issue 2, 2008, Pages 689-695

  Warnholtz, Ascan ^a   Ostad, Mir Abolfazl ^a   Velich, Nathalie ^a   Trautmann, Christine ^a   Schinzel, Reinhard ^b   Walter, Ulrich ^c   Munzel, Thomas ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

^b Vasopharm BIOTECH GmbH   (Germany)

^c UNIVERSITY HOSPITAL WÜRZBURG   (Germany)

Author keywords

Clopidogrel; Endothelial dysfunction; Flow mediated dilation

Indexed keywords

ADENOSINE DIPHOSPHATE; CLOPIDOGREL; GLYCERYL TRINITRATE; ILOPROST; PLACEBO; PROSTAGLANDIN; PURINERGIC P2Y12 RECEPTOR; VASODILATOR STIMULATED PHOSPHOPROTEIN;

AGED; ARTICLE; BRACHIAL ARTERY; CARDIAC PATIENT; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORONARY ARTERY DISEASE; DOSE RESPONSE; DOSE TIME EFFECT RELATION; DOUBLE BLIND PROCEDURE; DRUG DOSE COMPARISON; DRUG MECHANISM; ENDOTHELIAL DYSFUNCTION; EX VIVO STUDY; FEMALE; FLOW MEDIATED DILATION; HUMAN; IN VIVO STUDY; LOADING DRUG DOSE; MAJOR CLINICAL STUDY; MALE; MEASUREMENT; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RANDOMIZED CONTROLLED TRIAL; THROMBOCYTE; VASODILATATION;

AGED; BLOOD PLATELETS; CELL ADHESION MOLECULES; CORONARY ARTERY DISEASE; DILATATION, PATHOLOGIC; DOUBLE-BLIND METHOD; ENDOTHELIUM, VASCULAR; FEMALE; HUMANS; MALE; MICROFILAMENT PROTEINS; MIDDLE AGED; PHOSPHOPROTEINS; RECEPTORS, PURINERGIC P2; SUPEROXIDES; TICLOPIDINE;

EID: 38349091974     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2006.12.009     Document Type: Article

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