Characterization of occult hepatitis B virus infection from blood donors in China

Journal of Clinical Microbiology

Volumn 49, Issue 5, 2011, Pages 1730-1737

  Zheng, Xin ^a   Ye, Xianlin ^b   Zhang, Ling ^a   Wang, Wenjing ^a   Shuai, Lifang ^c   Wang, Anqi ^a   Zeng, Jinfeng ^b   Candotti, Daniel ^d   Allain, Jean Pierre ^a,e   Li, Chengyao ^a  

^a SOUTHERN MEDICAL UNIVERSITY   (China)

^b Shenzhen Blood Center   (China)

^c Hydrometeorological Centre of Guangzhou Military Region   (China)

^d NHS BLOOD AND TRANSPLANT   (United Kingdom)

^e UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; CORE PROTEIN; HEPATITIS B SURFACE ANTIGEN;

ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; AMINO ACID SUBSTITUTION; ARTICLE; BASIC CORE PROMOTER REGION; BLOOD DONOR; CHINA; CORE REGULATORY ELEMENT; DNA STRUCTURE; FEMALE; FOLLOW UP; GENOTYPE; HEPATITIS B; HUMAN; MALE; NUCLEOTIDE SEQUENCE; PRECORE PROMOTER REGION; PREVALENCE; PRIORITY JOURNAL; PROMOTER REGION; REGULATORY SEQUENCE; SEQUENCE ANALYSIS; STOP CODON; VIRUS GENOME; VIRUS LOAD; VIRUS REPLICATION; VIRUS STRAIN;

ADULT; BLOOD DONORS; CHINA; CLUSTER ANALYSIS; DNA, VIRAL; FEMALE; GENOTYPE; HEPATITIS B; HEPATITIS B ANTIBODIES; HEPATITIS B SURFACE ANTIGENS; HEPATITIS B VIRUS; HUMANS; INCIDENCE; MALE; MIDDLE AGED; PREVALENCE; SEQUENCE ANALYSIS, DNA;

HEPATITIS B VIRUS;

EID: 79955535103     PISSN: 00951137     EISSN: 1098660X     Source Type: Journal    
DOI: 10.1128/JCM.00145-11     Document Type: Article

References (21)

1. Allain, J. P., et al. 2009. Characterization of occult hepatitis B virus strains in South African blood donors. Hepatology 49:1868-1876.
2. Bertoletti, A., et al. 1994. Cytotoxic T lymphocyte response to a wild type hepatitis B virus epitope in patients chronically infected by variant viruses carrying substitutions within the epitope. J. Exp. Med. 180:933-943.
3. Bozkaya, H., B. Ayola, and A. S. Lok. 1996. High rate of mutations in the hepatitis B core gene during the immune clearance phase of chronic hepatitis B virus infection. Hepatology 24:32-37.
4. Candotti, D., et al. 2008. Characterization of occult hepatitis B virus from blood donors carrying genotype A2 or genotype D strains. J. Hepatol. 49: 537-547.
5. Candotti, D., O. Opare-Sem, H. Rezvan, F. Sarkodie, and J. P. Allain. 2006. Molecular and serological characterization of hepatitis B virus in deferred Ghanaian blood donors with and without elevated alanine amino transferase. J. Viral Hepat. 13:715-724.
6. Choi, W. C., et al. 2009. Window period and occult HBV infection among blood donor population in Hong Kong, p. 114. Abstr. 20th Reg. Cong. Int. Soc. Blood Transfusion, 14 to 18 November 2009, Nagoya, Japan. International Society of Blood Transfusion, Amsterdam, Netherlands.
7. Desmond, C. P., A. Bartholomeusz, S. Gaudieri, P. A. Revill, and S. R. Lewin. 2008. A systematic review of T-cell epitopes in hepatitis B virus: identification, genotypic variation and relevance to antiviral therapeutics. Antivir. Ther. 13:161-175.
8. Guarnieri, M., et al. 2006. Point mutations upstream of hepatitis B virus core gene affect DNA replication at the step of core protein expression. J. Virol. 80:587-595. (Pubitemid 43062871)
9. Khakoo, S. I., et al. 2000. Cytotoxic T lymphocyte responses and CTL epitope escape mutation in HBsAg, anti-HBe positive individuals. Gut 47: 137-143. (Pubitemid 30430423)
10. Kleinman, S. H., N. Lelie, and M. P. Busch. 2009. Infectivity of human immunodeficiency virus-1, hepatitis C virus, and hepatitis B virus and risk of transmission by transfusion. Transfusion 49:2454-2489.
11. Le Pogam, S., T. T. Yuan, G. K. Sahu, S. Chatterjee, and C. Shih. 2000. Low-level secretion of human hepatitis B virus virions caused by two independent, naturally occurring mutations (P5T and L60V) in the capsid protein. J. Virol. 74:9099-9105.
12. Liang, X., et al. 2009. Epidemiological serosurvey of hepatitis B in China: declining HBV prevalence due to hepatitis B vaccination. Vaccine 27:6550-6557.
13. Liu, C. J., et al. 2009. Hepatitis B virus basal core promoter mutation and DNA load correlate with expression of hepatitis B core antigen in patients with chronic hepatitis B. J. Infect. Dis. 199:742-749.
14. Mu, S. C., Y. M. Lin, G. M. Jow, and B. F. Chen. 2009. Occult hepatitis B virus infection in hepatitis B vaccinated children in Taiwan. J. Hepatol. 50:264-272.
15. Raimondo, G., et al. 2008. Statements from the Taormina expert meeting on occult hepatitis B virus infection. J. Hepatol. 49:652-657.
16. Sendi, H., et al. 2009. CTL escape mutations of core protein are more frequent in strains of HBeAg negative patients with low levels of HBV DNA. J. Clin. Virol. 46:259-264.
17. Tang, H., et al. 2005. The transcriptional transactivation function of HBx protein is important for its augmentation role in hepatitis B virus replication. J. Virol. 79:5548-5556. (Pubitemid 40548223)
18. Yuan, T. T., and C. Shih. 2000. A frequent, naturally occurring mutation (P130T) of human hepatitis B virus core antigen is compensatory for immature secretion phenotype of another frequent variant (I97L). J. Virol. 74: 4929-4932. (Pubitemid 30237926)
19. Yuan, T. T., P. C. Tai, and C. Shih. 1999. Subtype-independent immature secretion and subtype-dependent replication deficiency of a highly frequent, naturally occurring mutation of human hepatitis B virus core antigen. J. Virol. 73:10122-10128.
20. Yuan, Q., et al. 2010. Molecular characteristics of occult hepatitis B virus from blood donors in southeast China. J. Clin. Microbiol. 48:357-362.
21. Zahn, A., et al. 2008. Molecular characterization of occult hepatitis B virus in genotype E-infected subjects. J. Gen. Virol. 89:409-418.