Benign bone tumors-recent developments

Seminars in Diagnostic Pathology

Volumn 28, Issue 1, 2011, Pages 73-85

  Garcia, Roberto A ^a   Inwards, Carrie Y ^b   Unni, Krishnan K ^c  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b Mayo Clinic   (United States)

^c Elmbrook Memorial   (United States)

Author keywords

Benign bone tumors; Benign notochordal cell tumor; Chondroblastoma; Chondromyxoid fibroma; Enchondroma; Fibrous dysplasia; Giant cell tumor; Osteoblastoma; Osteochondroma; Osteoid osteoma

Indexed keywords

CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYTOKERATIN 18; CYTOKERATIN 19; CYTOKERATIN 8; GELATINASE A; GELATINASE B; NONSTEROID ANTIINFLAMMATORY AGENT; OSTEOCLAST DIFFERENTIATION FACTOR; PROSTAGLANDIN E2; PROTEIN S 100; PROTEOHEPARAN SULFATE; TUMOR NECROSIS FACTOR ALPHA;

ANEURYSMAL BONE CYST; ARTICLE; BENIGN NOTOCHORDAL CELL TUMOR; BONE DISEASE; BONE GRAFT; BONE RADIOGRAPHY; BONE REMODELING; BONE TUMOR; CALCIFICATION; CHONDROBLASTOMA; CHONDROMYXOID FIBROMA; CHROMOSOME ABERRATION; COMPUTER ASSISTED TOMOGRAPHY; CURETTAGE; DIAGNOSTIC ACCURACY; DIAPHYSIS; DIFFERENTIAL DIAGNOSIS; ENCHONDROMA; FIBROUS DYSPLASIA; GENE MUTATION; GIANT CELL TUMOR; HETEROZYGOSITY; HOMOZYGOSITY; HUMAN; MESENCHYME; METAPHYSIS; MINERALIZATION; NUCLEAR MAGNETIC RESONANCE IMAGING; OSTEOBLASTOMA; OSTEOCHONDROMA; OSTEOCLASTOMA; OSTEOID OSTEOMA; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; RADIOFREQUENCY ABLATION; SEX DIFFERENCE;

BONE AND BONES; BONE NEOPLASMS; CHONDROBLASTOMA; CHONDROMA; CHROMOSOME ABERRATIONS; FEMALE; FIBROUS DYSPLASIA OF BONE; GIANT CELL TUMOR OF BONE; HUMANS; MALE; NOTOCHORD; OSTEOBLASTOMA; OSTEOCHONDROMA; OSTEOMA, OSTEOID; PATHOLOGY, SURGICAL;

EID: 79955511323     PISSN: 07402570     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.semdp.2011.02.013     Document Type: Article

References (65)

1. Lee E.H., Shafi M., Hui J.H.P. Osteoid osteoma: A current review. J Pediatr Orthop 2006, 26:695-700.
2. Dahlin's Bone Tumors: General Aspects and Data on 10,165 cases 2010, Lippincott Williams & Wilkins Publishers, Philadelphia. (ed 6). K.K. Unni, C.Y. Inwards (Eds.).
3. Hasegawa T., Hirose T., Sakamoto R., et al. Mechanism of pain in osteoid osteomas: An immunohistochemical study. Histopathology 1993, 22:487-491.
4. Mungo D.V., Zhang X., O'Keefe R.J., et al. COX-1 and COX-2 expression in osteoid osteomas. J Orthop Res 2002, 20:159-162.
5. Mylona S., Patsoura S., Galani P., et al. Osteoid osteomas in common and technically challenging locations treated with computed tomography-guided percutaneous radiofrequency ablation. Skeletal Radiol 2010, 39:443-449.
6. Akhlaghpoor S., Ahari A.A., Shabestari A.A., et al. Radiofrequency ablation of osteoid osteoma in atypical locations: A case series. Clin Orthop Relat Res 2010, 468:1963-1970.
7. Pathology and Genetics: Tumours of Soft Tissue and Bone 2002, IARC Press, Lyon. C.D.M. Fletcher, K.K. Unni, F. Mertens (Eds.).
8. Baruffi M.R., Volpon J.B., Neto J.B., et al. Osteoid osteomas with chromosome alterations involving 22q. Cancer Genet Cytogenet 2001, 124:127-131.
9. Cantwell C.P., Obyrne J., Eustace S. Current trends in treatment of osteoid osteoma with an emphasis on radiofrequency ablation. Eur Radiol 2004, 14:607-617.
10. Rosenthal D.I. Radiofrequency treatment. Orthop Clin North Am 2006, 37:475-484.
11. Akhlaghpoor S., Ahari A.A., Ahmadi S.A., et al. Histological evaluation of drill fragments obtained during osteoid osteoma radiofrequency ablation. Skeletal Radiol 2010, 39:451-455.
12. Dorfman H.D., Czerniak B. Bone Tumors 1998, Mosby, St. Louis.
13. Lucas D.R. Osteoblastoma. Arch Pathol Lab Med 2010, 134:1460-1466.
14. Berry M., Mankin H., Gebhardt M., et al. Osteoblastoma: A 30-year study of 99 cases. J Surg Oncol 2008, 98:179-183.
15. Lucas D.R., Unni K.K., McLeod R.A., et al. Osteoblastoma: Clinicopathologic study of 306 cases. Hum Pathol 1994, 25:117-134.
16. Giannico G., Holt G.E., Homlar K.C., et al. Osteoblastoma characterized by a three-way translocation: Report of a case and review of the literature. Cancer Genet Cytogenet 2009, 195:168-171.
17. Ruiz-Santiago F., Del Mar C., García M., et al. Percutaneous treatment of bone tumors by radiofrequency thermal ablation. Eur J Radiol 2011, 77:156-163.
18. Bertoni F., Bacchini P., Donati D., et al. Osteoblastoma-like osteosarcoma. The Rizzoli institute experience. Mod Pathol 1993, 6:707-716.
19. Dorfman H.D. New knowledge of fibro-osseous lesions of bone. Int J Surg Pathol 2010, 18(3 suppl):62S-65S.
20. DiCaprio M.R., Enneking W.F. Fibrous dysplasia. Pathophysiology, evaluation, and treatment. J Bone Joint Surg Am 2005, 87:1848-1864.
21. Chapurlat R.D., Orcel P. Fibrous dysplasia of bone and McCune-Albright syndrome. Best Pract Res Clin Rheumatol 2008, 22:55-69.
22. Ishida T., Dorfman H.D. Massive chondroid differentiation in fibrous dysplasia of bone (fibrocartilaginous dysplasia). Am J Surg Pathol 1993, 17:924-930.
23. Ruggieri P., Sim F.H., Bond J.R., et al. Malignancies in fibrous dysplasia. Cancer 1994, 73:1411-1424.
24. Dal Cin P., Sciot R., Brys P., et al. Recurrent chromosome aberrations in fibrous dysplasia of the bone: a report of the CHAMP study group. CHromosomes And MorPhology. Cancer Genet Cytogenet 2000, 122:30-32.
25. Bridge J.A., Swarts S.J., Buresh C., et al. Trisomies 8 and 20 characterize a subgroup of benign fibrous lesions arising in both soft tissue and bone. Am J Pathol 1999, 54:729-733.
26. Sakamoto A., Oda Y., Iwamoto Y., et al. A comparative study of fibrous dysplasia and osteofibrous dysplasia with regard to Gsalpha mutation at the Arg201 codon: Polymerase chain reaction-restriction fragment length polymorphism analysis of paraffin-embedded tissues. J Mol Diagn 2000, 2:67-72.
27. Yoshida A., Ushiku T., Motoi T., et al. Immunohistochemical analysis of MDM2 and CDK4 distinguishes low-grade osteosarcoma from benign mimics. Mod Pathol 2010, 23:1279-1288.
28. Andresen K.J., Sundaram M., Unni K.K., et al. Imaging features of low-grade central osteosarcoma of the long bones and pelvis. Skeletal Radiol 2004, 33:373-379.
29. Bovée J.V., Hogendoorn P.C., Wunder J.S., et al. Cartilage tumours and bone development: Molecular pathology and possible therapeutic targets. Nat Rev Cancer 2010, 10:481-488.
30. Hameetman L., Bovée J.V., Taminiau A.H., et al. Multiple osteochondromas: Clinicopathological and genetic spectrum and suggestions for clinical management. Hered Cancer Clin Pract 2004, 2:161-173.
31. Romeo S., Hogendoorn P.C.W., Dei Tos A.P. Benign cartilaginous tumor of bone. From morphology to somatic and germ-line genetics. Adv Anat Pathol 2009, 16:307-315.
32. Hameetman L., Szuhai K., Yavas A., et al. The role of EXT1 in nonhereditary osteochondroma: Identification of homozygous deletions. J Natl Cancer Inst 2007, 99:396-406.
33. Tallini G., Dorfman H., Brys P., et al. Correlation between clinicopathological features and karyotype in 100 cartilaginous and chordoid tumours. A report from the Chromosomes and Morphology (CHAMP) Collaborative Study Group. J Pathol 2002, 196:194-203.
34. Bell W.C., Klein M.J., Pitt M.J., et al. Molecular pathology of chondroid neoplasms: Part 1, Benign lesions. Skeletal Radiol 2006, 35:805-813.
35. Ahmed A.R., Tan T.S., Unni K.K., et al. Secondary chondrosarcoma in osteochondroma: Report of 107 patients. Clin Orthop Relat Res 2003, 411:193-206.
36. Bovée J.V., van den Broek L.J., Cleton-Jansen A.M., et al. Up-regulation of PTHrP and Bcl-2 expression characterizes the progression of osteochondroma towards peripheral chondrosarcoma and is a late event in central chondrosarcoma. Lab Invest 2000, 80:1925-1934.
37. Murphey M.D., Walker E.A., Wilson A.J., et al. From the archives of the AFIP: Imaging of primary chondrosarcoma: Radiologic-pathologic correlation. Radiographics 2003, 23:1245-1278.
38. Eefting D., Schrage Y.M., Geirnaerdt M.J., et al. EuroBoNeT consortium: Assessment of interobserver variability and histologic parameters to improve reliability in classification and grading of central cartilaginous tumors. Am J Surg Pathol 2009, 33:50-57.
39. Dancer J.Y., Henry S.P., Bondaruk J., et al. Expression of master regulatory genes controlling skeletal development in benign cartilage and bone forming tumors. Hum Pathol 2010, 41:1788-1793.
40. Swarts S.J., Neff J.R., Johansson S.L., et al. Significance of abnormalities of chromosomes 5 and 8 in chondroblastoma. Clin Orthop Relat Res 1998, 349:189-193.
41. Romeo S., Oosting J., Rozeman L.B., et al. The role of noncartilage-specific molecules in differentiation of cartilaginous tumors: lessons from chondroblastoma and chondromyxoid fibroma. Cancer 2007, 110:385-394.
42. Wülling M., Engels C., Jesse N., et al. The nature of giant cell tumor of bone. J Cancer Res Clin Oncol 2001, 127:467-474.
43. Wülling M., Delling G., Kaiser E. The origin of the neoplastic stromal cell in giant cell tumor of bone. Hum Pathol 2003, 34:983-993.
44. Lau Y.S., Sabokbar A., Gibbons C.L., et al. Phenotypic and molecular studies of giant-cell tumors of bone and soft tissue. Hum Pathol 2005, 36:945-954.
45. Murata A., Fujita T., Kawahara N., et al. Osteoblast lineage properties in giant cell tumors of bone. J Orthop Sci 2005, 10:581-588.
46. Roux S., Amazit L., Meduri G., Guiochon-Mantel A., Milgrom E., Mariette X. RANK (receptor activator of nuclear factor kappa B) and RANK ligand are expressed in giant cell tumors of bone. Am J Clin Pathol 2002, 117:210-216.
47. Thomas D.M., Skubitz K.M. Giant cell tumour of bone. Curr Opin Oncol 2009, 21:338-344.
48. Ghert M., Simunovic N., Cowan R.W., et al. Properties of the stromal cell in giant cell tumor of bone. Clin Orthop Relat Res 2007, 459:8-13.
49. Dickson B.C., Li S.Q., Wunder J.S., et al. Giant cell tumor of bone express p63. Mod Pathol 2008, 21:369-375.
50. Lee C.H., Espinosa I., Jensen K.C., et al. Gene expression profiling identifies p63 as a diagnostic marker for giant cell tumor of the bone. Mod Pathol 2008, 21:531-539.
51. Gebre-Medhin S., Broberg K., Jonson T., et al. Telomeric associations correlate with telomere length reduction and clonal chromosome aberrations in giant cell tumor of bone. Cytogenet Genome Res 2009, 124:121-127.
52. Balke M., Campanacci L., Gebert C., et al. Bisphosphonate treatment of aggressive primary, recurrent and metastatic giant cell tumour of bone. BMC Cancer 2010, 10:462.
53. Broadhead M.L., Clark J.C., Dass C.R., et al. Therapeutic targeting of osteoclast function and pathways. Expert Opin Ther Targets 2011, 15:169-181.
54. Thomas D., Henshaw R., Skubitz K., et al. Denosumab in patients with giant-cell tumour of bone: an open-label, phase 2 study. Lancet Oncol 2010, 11:275-280.
55. Yamaguchi T., Suzuki S., Ishiiwa H., et al. Benign notochordal cell tumors: A comparative histological study of benign notochordal cell tumors, classic chordomas, and notochordal vestiges of fetal intervertebral discs. Am J Surg Pathol 2004, 28:756-761.
56. Yamaguchi T., Suzuki S., Ishiiwa H., et al. Intraosseous benign notochordal cell tumours: Overlooked precursors of classic chordomas. Histopathology 2004, 44:597-602.
57. Darby A.J., Cassar-Pullicino V.N., McCall I.W., et al. Vertebral intra-osseous chordoma or giant notochordal rest. Skeletal Radiol 1999, 28:342-346.
58. Mirra J.M., Brien E.W. Giant notochordal hamartoma of intraosseous origin: A newly reported benign entity to be distinguished from chordoma. Report of two cases. Skeletal Radiol 2001, 30:698-709.
59. Kyriakos M., Totty W.G., Lenke L.G. Giant vertebral notochordal rest: A lesion distinct from chordoma: Discussion of an evolving concept. Am J Surg Pathol 2003, 27:396-406.
60. Yamaguchi T., Yamato M., Saotome K. First histologically confirmed case of a classic chordoma arising in a precursor benign notochordal lesion: differential diagnosis of benign and malignant notochordal lesions. Skeletal Radiol 2002, 31:413-418.
61. Yamaguchi T., Watanabe-Ishiiwa H., Suzuki S., et al. Incipient chordoma: A report of two cases of early-stage chordoma arising from benign notochordal cell tumors. Mod Pathol 2005, 18:1005-1010.
62. Deshpande V., Nielsen G.P., Rosenthal D.I., et al. Intraosseous benign notochord cell tumors (BNCT): Further evidence supporting a relationship to chordoma. Am J Surg Pathol 2007, 31:1573-1577.
63. Nishiguchi T., Mochizuki K., Tsujio T., et al. Lumbar vertebral chordoma arising from an intraosseous benign notochordal cell tumour: Radiological findings and histopathological description with a good clinical outcome. Br J Radiol 2010, 83:e49-e53.
64. Smith D.S., French G., Miller M. Multifocal benign notochordal cell tumours. Histopathology 2007, 51:412-414.
65. Yamaguchi T., Iwata J., Sugihara S., et al. Distinguishing benign notochordal cell tumors from vertebral chordoma. Skeletal Radiol 2008, 37:291-299.