Gene expression profiling identifies p63 as a diagnostic marker for giant cell tumor of the bone

Modern Pathology

Volumn 21, Issue 5, 2008, Pages 531-539

  Lee, Cheng Han ^a,b   Espinosa, Inigo ^a   Jensen, Kristin C ^a   Subramanian, Subbaya ^a   Zhu, Shirley X ^a   Varma, Sushama ^a   Montgomery, Kelli D ^a   Nielsen, Torsten O ^b   Van De Rijn, Matt ^a   West, Robert B ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Gene expression profiling; Giant cell tumor of bone; p63; Tissue microarray; TP73L

Indexed keywords

COMPLEMENTARY DNA; PROTEIN P63; PROTEIN TP73L; TUMOR SUPPRESSOR PROTEIN;

ADULT; ANEURYSMAL BONE CYST; ARTICLE; CANCER CLASSIFICATION; CHONDROBLASTOMA; CLINICAL ARTICLE; CONTROLLED STUDY; DIFFERENTIAL DIAGNOSIS; DNA MICROARRAY; FEMALE; GENE CLUSTER; GENE EXPRESSION PROFILING; GENE IDENTIFICATION; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; OSTEOCLASTOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; TISSUE MICROARRAY;

ADULT; BONE CYSTS, ANEURYSMAL; BONE NEOPLASMS; DIAGNOSIS, DIFFERENTIAL; FEMALE; GENE EXPRESSION PROFILING; GIANT CELL TUMOR OF BONE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MEMBRANE PROTEINS; MIDDLE AGED; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; SARCOMA; TUMOR MARKERS, BIOLOGICAL;

EID: 41749100508     PISSN: 08933952     EISSN: 15300285     Source Type: Journal    
DOI: 10.1038/modpathol.3801023     Document Type: Article

References (23)

1. Reid R, Banerjee SS, Sciot R. Giant cell tumour. In: Fletcher CDM, Unni KK, Martens F (eds). World Health Organization Classification of Tumours, Pathology and Genetics of Tumours of Soft Tissue and Bone. IARC Press: Lyon, 2002, pp 310-312.
2. Wulling M, Engels C, Jesse N, et al. The nature of giant cell tumor of bone. J Cancer Res Clin Oncol 2001;127:467-474.
3. Zheng MH, Robbins P, Xu J, et al. The histogenesis of giant cell tumour of bone: a model of interaction between neoplastic cells and osteoclasts. Histol Histopathol 2001;16:297-307.
4. Wulling M, Delling G, Kaiser E. The origin of the neoplastic stromal cell in giant cell tumor of bone. Hum Pathol 2003;34:983-993.
5. West RB, Rubin BP, Miller MA, et al. A landscape effect in tenosynovial giant-cell tumor from activation of CSF1 expression by a translocation in a minority of tumor cells. Proc Natl Acad Sci USA 2006;103:690-695.
6. Nguyen TT, Schwartz EJ, West RB, et al. Expression of CD163 (hemoglobin scavenger receptor) in normal tissues, lymphomas, carcinomas, and sarcomas is largely restricted to the monocyte/macrophage lineage. Am J Surg Pathol 2005;29:617-624.
7. Perou CM, Jeffrey SS, van de Rijn M, et al. Distinctive gene expression patterns in human mammary epithelial cells and breast cancers. Proc Natl Acad Sci USA 1999;96:9212-9217.
8. Perou CM, Sorlie T, Eisen MB, et al. Molecular portraits of human breast tumours. Nature 2000;406:747-752.
9. Sherlock G, Hernandez-Boussard T, Kasarskis A, et al. The Stanford Microarray Database. Nucleic Acids Res 2001;29:152-155.
10. Tusher VG, Tibshirani R, Chu G. Significance analysis of microarrays applied to the ionizing radiation response. Proc Natl Acad Sci USA 2001;98:5116-5121.
11. Subramanian A, Tamayo P, Mootha VK, et al. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci USA 2005;102:15545-15550.
12. West RB, Corless CL, Chen X, et al. The novel marker, DOG1, is expressed ubiquitously in gastrointestinal stromal tumors irrespective of KIT or PDGFRA mutation status. Am J Pathol 2004;165:107-113.
13. Liu CL, Montgomery KD, Natkunam Y, et al. TMA-combiner, a simple software tool to permit analysis of replicate cores on tissue microarrays. Mod Pathol 2005;18:1641-1648.
14. Liu CL, Prapong W, Natkunam Y, et al. Software tools for high-throughput analysis and archiving of immunohistochemistry staining data obtained with tissue microarrays. Am J Pathol 2002;161:1557-1565.
15. Morgan T, Atkins GJ, Trivett MK, et al. Molecular profiling of giant cell tumor of bone and the osteoclastic localization of ligand for receptor activator of nuclear factor kappaB. Am J Pathol 2005;167:117-128.
16. Wuelling M, Delling G, Kaiser E. Differential gene expression in stromal cells of human giant cell tumor of bone. Virchows Arch 2004;445:621-630.
17. Huang L, Xu J, Wood DJ, Zheng MH. Gene expression of osteoprotegerin ligand, osteoprotegerin, and receptor activator of NF-kappaB in giant cell tumor of bone: possible involvement in tumor cell-induced osteoclast-like cell formation. Am J Pathol 2000;156:761-767.
18. Cohen Jr MM. The new bone biology: pathologic, molecular, and clinical correlates. Am J Med Genet 2006;140:2646-2706.
19. Guenther R, Krenn V, Morawietz L, et al. Giant cell tumors of the bone: molecular profiling and expression analysis of Ephrin A1 receptor, Claudin 7, CD52, FGFR3 and AMFR. Pathol Res Pract 2005;201:649-663.
20. Mills AA. p63: oncogene or tumor suppressor? Curr Opin Genet Dev 2006;16:38-44.
21. Moll UM, Slade N. p63 and p73: roles in development and tumor formation. Mol Cancer Res 2004;2:371-386.
22. Westfall MD, Pietenpol JA. p63: molecular complexity in development and cancer. Carcinogenesis 2004;25:857-864.
23. Hermanns P, Lee B. Transcriptional dysregulation in skeletal malformation syndromes. Am J Med Genet 2001;106:258-271.