Using gene expression profiling to predict response and prognosis in gastrointestinal cancers-the promise and the perils

Annals of Surgical Oncology

Volumn 18, Issue 5, 2011, Pages 1484-1491

  Brettingham Moore, Kate H ^a   Duong, Cuong P ^a,b   Heriot, Alexander G ^a,b   Thomas, Robert J S ^a,b   Phillips, Wayne A ^a,b  

^a PETER MACCALLUM CANCER CENTRE   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CAPECITABINE; CETUXIMAB; CISPLATIN; DOCETAXEL; FLUOROURACIL; FOLINIC ACID; GIMERACIL PLUS OTERACIL POTASSIUM PLUS TEGAFUR; IRINOTECAN; METHOTREXATE; MITOMYCIN C; OXALIPLATIN;

ANUS CANCER; ARTICLE; CANCER PATIENT; CANCER SURVIVAL; CANCER THERAPY; CLINICAL PRACTICE; COLON CANCER; COLORECTAL CANCER; DIGESTIVE SYSTEM CANCER; ESOPHAGUS CANCER; GENE EXPRESSION PROFILING; GENOMICS; GEOGRAPHIC INFORMATION SYSTEM; HUMAN; MEDICAL RESEARCH; MICROARRAY ANALYSIS; OUTCOME ASSESSMENT; OUTPATIENT DEPARTMENT; PROFESSIONAL PRACTICE; PROGNOSIS; RECTUM CANCER; STOMACH CANCER; TREATMENT RESPONSE; VALIDATION STUDY;

GASTROINTESTINAL NEOPLASMS; GENE EXPRESSION PROFILING; HUMANS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROGNOSIS; TUMOR MARKERS, BIOLOGICAL;

EID: 79955502488     PISSN: 10689265     EISSN: 15344681     Source Type: Journal    
DOI: 10.1245/s10434-010-1433-1     Document Type: Article

References (46)

1. Boyle P, Levin BE. World Cancer Report 2008. Lyon, France: International Agency for Research on Cancer, 2008. p. 338, 344, 374.
2. V Gebski B Burmeister BM Smithers K Foo J Zalcberg J Simes 2007 Survival benefits from neoadjuvant chemoradiotherapy or chemotherapy in oesophageal carcinoma: a meta-analysis Lancet Oncol. 8 226 234 17329193 10.1016/S1470- 2045(07)70039-6 1:CAS:528:DC%2BD2sXisVCqs78%3D (Pubitemid 46291702)
3. R Sauer H Becker W Hohenberger C Rödel C Wittekind R Fietkau, et al. 2004 Preoperative versus postoperative chemoradiotherapy for rectal cancer N Engl J Med. 351 1731 1740 15496622 10.1056/NEJMoa040694 1:CAS:528: DC%2BD2cXovFSksbo%3D (Pubitemid 39383208)
4. D Cunningham WH Allum SP Stenning JN Thompson CJ Van de Velde M Nicolson, et al. 2006 Perioperative chemotherapy versus surgery alone for resectable gastroesophageal cancer N Engl J Med. 355 11 20 16822992 10.1056/NEJMoa055531 1:CAS:528:DC%2BD28Xms1Chsrw%3D
5. ZT Hammoud KA Kesler MK Ferguson RJ Battafarrano A Bhogaraju N Hanna, et al. 2006 Survival outcomes of resected patients who demonstrate a pathologic complete response after neoadjuvant chemoradiation therapy for locally advanced esophageal cancer Dis Esophagus. 19 69 72 16643172 10.1111/j.1442-2050.2006. 00542.x 1:STN:280:DC%2BD283js12gtA%3D%3D
6. AC Berger J Farma WJ Scott G Freedman L Weiner JD Cheng, et al. 2005 Complete response to neoadjuvant chemoradiotherapy in esophageal carcinoma is associated with significantly improved survival J Clin Oncol. 23 4330 4337 15781882 10.1200/JCO.2005.05.017 (Pubitemid 46207006)
7. SP Hiotis SM Weber AM Cohen BD Minsky PB Paty JG Guillem, et al. 2002 Assessing the predictive value of clinical complete response to neoadjuvant therapy for rectal cancer: an analysis of 488 patients J Am Coll Surg. 194 131 136 11848629 10.1016/S1072-7515(01)01159-0 (Pubitemid 34118868)
8. AY Lin WD Wong J Shia BD Minsky LK Temple JG Guillem, et al. 2008 Predictive clinicopathologic factors for limited response of T3 rectal cancer to combined modality therapy Int J Colorectal Dis. 23 243 249 18046561 10.1007/s00384-007-0406-8
9. RP Saw M Morgan D Koorey D Painter M Findlay G Stevens, et al. 2003 p53, deleted in colorectal cancer gene, and thymidylate synthase as predictors of histopathologic response and survival in low, locally advanced rectal cancer treated with preoperative adjuvant therapy Dis Colon Rectum. 46 192 202 12576893 10.1007/s10350-004-6524-2 (Pubitemid 36222619)
10. YA Park SK Sohn J Seong SH Baik KY Lee NK Kim, et al. 2006 Serum CEA as a predictor for the response to preoperative chemoradiation in rectal cancer J Surg Oncol. 93 145 150 16425302 10.1002/jso.20320 (Pubitemid 43235261)
11. SM Yoon DY Kim TH Kim KH Jung HJ Chang WS Koom, et al. 2007 Clinical parameters predicting pathologic tumor response after preoperative chemoradiotherapy for rectal cancer Int J Radiat Oncol Biol Phys. 69 1167 1172 17967307 10.1016/j.ijrobp.2007.04.047 (Pubitemid 47625840)
12. H Elsaleh B Powell P Soontrapornchai D Joseph F Goria N Spry, et al. 2000 p53 gene mutation, microsatellite instability and adjuvant chemotherapy: impact on survival of 388 patients with Dukes' C colon carcinoma Oncology. 58 52 59 10644941 10.1159/000012079 1:CAS:528:DC%2BD3cXht1aqsbw%3D (Pubitemid 30045310)
13. PE Blower JS Verducci S Lin J Zhou JH Chung Z Dai, et al. 2007 MicroRNA expression profiles for the NCI-60 cancer cell panel Mol Cancer Ther. 6 1483 1491 17483436 10.1158/1535-7163.MCT-07-0009 1:CAS:528:DC%2BD2sXotFalt7k%3D (Pubitemid 46954015)
14. K Kato S Iida H Uetake Y Takagi T Yamashita M Inokuchi, et al. 2008 Methylated TMS1 and DAPK genes predict prognosis and response to chemotherapy in gastric cancer Int J Cancer. 122 603 608 17943730 10.1002/ijc.23143 1:CAS:528:DC%2BD1cXhsVemsQ%3D%3D (Pubitemid 350308952)
15. LJ van't Veer H Dai MJ van de Vijver YD He AA Hart M Mao HL Peterse, et al. 2002 Gene expression profiling predicts clinical outcome of breast cancer Nature. 415 530 536 10.1038/415530a (Pubitemid 34130608)
16. MJ van de Vijver YD He LJ van't Veer H Dai AA Hart DW Voskuil, et al. 2002 A gene-expression signature as a predictor of survival in breast cancer N Engl J Med. 347 1999 2009 12490681 10.1056/NEJMoa021967 (Pubitemid 35461656)
17. M Buyse S Loi L van't Veer G Viale M Delorenzi AM Glas, et al. 2006 Validation and clinical utility of a 70-gene prognostic signature for women with node-negative breast cancer J Natl Cancer Inst. 98 1183 1192 16954471 10.1093/jnci/djj329 1:CAS:528:DC%2BD28Xps1yjtLw%3D (Pubitemid 44390989)
18. S Paik S Shak G Tang C Kim J Baker M Cronin, et al. 2004 A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer N Engl J Med. 351 2817 2826 15591335 10.1056/NEJMoa041588 1:CAS:528: DC%2BD2MXhslymsw%3D%3D (Pubitemid 40051905)
19. LA Habel S Shak MK Jacobs A Capra C Alexander M Pho, et al. 2006 A population-based study of tumor gene expression and risk of breast cancer death among lymph node-negative patients Breast Cancer Res. 8 R25 16737553 10.1186/bcr1412 (Pubitemid 43827376)
20. S Paik G Tang S Shak C Kim J Baker W Kim, et al. 2006 Gene expression and benefit of chemotherapy in women with node-negative, estrogen receptor-positive breast cancer J Clin Oncol. 24 3726 3734 16720680 10.1200/JCO.2005.04.7985 1:CAS:528:DC%2BD28XpsVaqsrs%3D (Pubitemid 46622311)
21. C Duong DM Greenawalt A Kowalczyk ML Ciavarella G Raskutti WK Murray, et al. 2007 Pretreatment gene expression profiles can be used to predict response to neoadjuvant chemoradiotherapy in esophageal cancer Ann Surg Oncol. 14 3602 3609 17896157 10.1245/s10434-007-9550-1 (Pubitemid 350160118)
22. M Schauer KP Janssen C Rimkus M Raggi M Feith H Friess, et al. 2010 Microarray-based response prediction in esophageal adenocarcinoma Clin Cancer Res. 16 330 337 20028767 10.1158/1078-0432.CCR-09-1673 1:CAS:528:DC%2BC3cXot1Sl
23. SG Maher CM Gillham SP Duggan PC Smyth N Miller C Muldoon, et al. 2009 Gene expression analysis of diagnostic biopsies predicts pathological response to neoadjuvant chemoradiotherapy of esophageal cancer Ann Surg. 250 729 737 19801928 10.1097/SLA.0b013e3181bce7e1
24. R Luthra TT Wu MG Luthra J Izzo E Lopez-Alvarez L Zhang, et al. 2006 Gene expression profiling of localized esophageal carcinomas: association with pathologic response to preoperative chemoradiation J Clin Oncol. 24 259 267 16344314 10.1200/JCO.2005.03.3688 1:CAS:528:DC%2BD28XhtVKqtrs%3D (Pubitemid 46628468)
25. CN Chen JJ Lin JJ Chen PH Lee CY Yang ML Kuo, et al. 2005 Gene expression profile predicts patient survival of gastric cancer after surgical resection J Clin Oncol. 23 7286 7295 16145069 10.1200/JCO.2004.00.2253 1:CAS:528: DC%2BD2MXhtF2nsL3E (Pubitemid 46202342)
26. Y Yamada T Arao T Gotoda H Taniguchi I Oda K Shirao, et al. 2008 Identification of prognostic biomarkers in gastric cancer using endoscopic biopsy samples Cancer Sci. 99 2193 2199 18957060 10.1111/j.1349-7006.2008.00935. x 1:CAS:528:DC%2BD1cXhsVKgtLvO
27. A Barrier F Roser PY Boelle B Franc C Tse D Brault, et al. 2007 Prognosis of stage II colon cancer by non-neoplastic mucosa gene expression profiling Oncogene. 26 2642 2648 17043639 10.1038/sj.onc.1210060 1:CAS:528: DC%2BD2sXktlOitbY%3D (Pubitemid 46632008)
28. S Eschrich I Yang G Bloom KY Kwong D Boulware A Cantor, et al. 2005 Molecular staging for survival prediction of colorectal cancer patients J Clin Oncol. 23 3526 3535 15908663 10.1200/JCO.2005.00.695 1:CAS:528: DC%2BD2MXlsVyhsrY%3D
29. YH Lin J Friederichs MA Black J Mages R Rosenberg PJ Guilford, et al. 2007 Multiple gene expression classifiers from different array platforms predict poor prognosis of colorectal cancer Clin Cancer Res. 13 498 507 17255271 10.1158/1078-0432.CCR-05-2734 1:CAS:528:DC%2BD2sXoslSltA%3D%3D (Pubitemid 46225355)
30. RN Jorissen P Gibbs M Christie S Prakash L Lipton J Desai, et al. 2009 Metastasis-Associated Gene Expression Changes Predict Poor Outcomes in Patients with Dukes Stage B and C Colorectal Cancer Clin Cancer Res. 15 7642 7651 19996206 10.1158/1078-0432.CCR-09-1431 1:CAS:528:DC%2BD1MXhsFGgurvL
31. T Watanabe Y Komuro T Kiyomatsu T Kanazawa Y Kazama J Tanaka, et al. 2006 Prediction of sensitivity of rectal cancer cells in response to preoperative radiotherapy by DNA microarray analysis of gene expression profiles Cancer Res. 66 3370 3374 16585155 10.1158/0008-5472.CAN-05-3834 1:CAS:528: DC%2BD28XjtVOktrk%3D
32. IJ Kim SB Lim HC Kang HJ Chang SA Ahn HW Park, et al. 2007 Microarray gene expression profiling for predicting complete response to preoperative chemoradiotherapy in patients with advanced rectal cancer Dis Colon Rectum. 50 1342 1353 17665260 10.1007/s10350-007-277-7 (Pubitemid 47472394)
33. Daemen A, Gevaert O, De Bie T, Debucquoy A, Machiels JP, De Moor B, et al. Integrating microarray and proteomics data to predict the response on cetuximab in patients with rectal cancer. Pac Symp Biocomput. 2008;166-77.
34. C Rimkus J Friederichs AL Boulesteix J Theisen J Mages K Becker, et al. 2008 Microarray-based prediction of tumor response to neoadjuvant radiochemotherapy of patients with locally advanced rectal cancer Clin Gastroenterol Hepatol. 6 53 61 18166477 10.1016/j.cgh.2007.10.022 1:CAS:528:DC%2BD1cXhslOktL8%3D (Pubitemid 350309530)
35. A Debucquoy K Haustermans A Daemen S Aydin L Libbrecht O Gevaert, et al. 2009 Molecular response to cetuximab and efficacy of preoperative cetuximab-based chemoradiation in rectal cancer J Clin Oncol. 27 2751 2757 19332731 10.1200/JCO.2008.18.5033 1:CAS:528:DC%2BD1MXosVehsrw%3D
36. BM Ghadimi M Grade MJ Difilippantonio S Varma R Simon C Montagna, et al. 2005 Effectiveness of gene expression profiling for response prediction of rectal adenocarcinomas to preoperative chemoradiotherapy J Clin Oncol. 23 1826 1838 15774776 10.1200/JCO.2005.00.406 1:CAS:528:DC%2BD2MXjt1Ckurk%3D (Pubitemid 46217459)
37. O Bruland O Fluge H Immervoll L Balteskard M Myklebust A Skarstein, et al. 2008 Gene expression reveals two distinct groups of anal carcinomas with clinical implications Br J Cancer. 98 1264 1273 18349847 10.1038/sj.bjc.6604285 1:CAS:528:DC%2BD1cXktVKhsro%3D (Pubitemid 351481671)
38. P Farmer H Bonnefoi P Anderle D Cameron P Wirapati V Becette, et al. 2009 A stroma-related gene signature predicts resistance to neoadjuvant chemotherapy in breast cancer Nat Med. 15 68 74 19122658 10.1038/nm.1908 1:CAS:528:DC%2BD1MXhtVyjsQ%3D%3D
39. A Barrier PY Boelle A Lemoine A Flahault S Dudoit M Huguier 2005 Gene expression profiling of nonneoplastic mucosa may predict clinical outcome of colon cancer patients Dis Colon Rectum. 48 2238 2248 16228831 10.1007/s10350-005-0175-9 (Pubitemid 43074444)
40. S Michiels S Koscielny C Hill 2005 Prediction of cancer outcome with microarrays: a multiple random validation strategy Lancet. 365 488 492 15705458 10.1016/S0140-6736(05)17866-0 1:CAS:528:DC%2BD2MXhtlSgt7s%3D (Pubitemid 40215731)
41. AO Berg K Armstrong J Botkin N Calonge J Haddow M Hayes, et al. 2009 Recommendations from the EGAPP Working Group: can tumor gene expression profiling improve outcomes in patients with breast cancer? Genet Med. 11 66 73 10.1097/GIM.0b013e3181928f56
42. MF Kalady LF de Campos-Lobato L Stocchi DP Geisler D Dietz IC Lavery, et al. 2009 Predictive factors of pathologic complete response after neoadjuvant chemoradiation for rectal cancer Ann Surg. 250 582 589
43. P Therasse SG Arbuck EA Eisenhauer J Wanders RS Kaplan L Rubinstein, et al. 2000 New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada J Natl Cancer Inst. 92 205 216 10655437 10.1093/jnci/92.3.205 1:STN:280: DC%2BD3c7it1Gitg%3D%3D
44. AB Miller B Hoogstraten M Staquet A Winkler 1981 Reporting results of cancer treatment Cancer. 47 207 214 7459811 10.1002/1097-0142(19810101)47: 1<207::AID-CNCR2820470134>3.0.CO;2-6 1:STN:280:DyaL3M7htFOltw%3D%3D (Pubitemid 11167383)
45. A Habr-Gama RO Perez W Nadalin J Sabbaga U Ribeiro Jr AH Silva e Sousa Jr, et al. 2004 Operative versus nonoperative treatment for stage 0 distal rectal cancer following chemoradiation therapy: long-term results Ann Surg. 240 711 718 15383798 (Pubitemid 39281293)
46. CH Ooi T Ivanova J Wu M Lee IB Tan J Tao, et al. 2009 Oncogenic pathway combinations predict clinical prognosis in gastric cancer PLoS Genet. 5 e1000676 19798449 10.1371/journal.pgen.1000676