Microarray-Based Prediction of Tumor Response to Neoadjuvant Radiochemotherapy of Patients With Locally Advanced Rectal Cancer

Clinical Gastroenterology and Hepatology

Volumn 6, Issue 1, 2008, Pages 53-61

  Rimkus, Caroline ^a   Friederichs, Jan ^a   Boulesteix, Anne laure ^b   Theisen, Jörg ^a   Mages, Jörg ^a   Becker, Karen ^c   Nekarda, Hjalmar ^a   Rosenberg, Robert ^a   Janssen, Klaus Peter ^a   Siewert, Jörg Rüdiger ^a  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^c TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; BIOPSY; CARCINOMA; FEMALE; GENE EXPRESSION PROFILING; HUMANS; MALE; MIDDLE AGED; NEOADJUVANT THERAPY; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PREDICTIVE VALUE OF TESTS; RECTAL NEOPLASMS; RECTUM; SENSITIVITY AND SPECIFICITY; TRANSCRIPTION FACTORS;

EID: 37349051638     PISSN: 15423565     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cgh.2007.10.022     Document Type: Article

References (44)

1. Sauer R., Becker H., Hohenberger W., et al. Preoperative versus postoperative chemoradiotherapy for rectal cancer. N Engl J Med 351 (2004) 1731-1740
2. Kapiteijn E., Marijnen C.A.M., Nagtegaal I.D., et al. Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer. N Engl J Med 345 (2001) 638-646
3. Rodel C., Martus P., Papadoupolos T., et al. Prognostic significance of tumor regression after preoperative chemoradiotherapy for rectal cancer. J Clin Oncol 23 (2005) 8688-8696
4. Rodel C., Grabenbauer G.G., Papadopoulos T., et al. Phase I/II trial of capecitabine, oxaliplatin, and radiation for rectal cancer. J Clin Oncol 21 (2003) 3098-3104
5. Rullier E., Goffre B., Bonnel C., et al. Preoperative radiochemotherapy and sphincter-saving resection for T3 carcinomas of the lower third of the rectum. Ann Surg 234 (2001) 633-640
6. Amthauer H., Denecke T., Rau B., et al. Response prediction by FDG-PET after neoadjuvant radiochemotherapy and combined regional hyperthermia of rectal cancer: correlation with endorectal ultrasound and histopathology. Eur J Nucl Med Mol Imaging 31 (2004) 811-819
7. Denecke T., Rau B., Hoffmann K.T., et al. Comparison of CT, MRI and FDG-PET in response prediction of patients with locally advanced rectal cancer after multimodal preoperative therapy: is there a benefit in using functional imaging?. Eur Radiol 15 (2005) 1658-1666
8. Gearhart S.L., Frassica D., Rosen R., et al. Improved staging with pretreatment positron emission tomography/computed tomography in low rectal cancer. Ann Surg Oncol 13 (2006) 397-404
9. Pasche B., Mulcahy M., and Benson A.B. Molecular markers in prognosis of colorectal cancer and prediction of response to treatment. Best Pract Res Clin Gastroenterol 16 (2002) 331-345
10. Popat S., Matakidou A., and Houlston R.S. Thymidiylate synthase expression and prognosis in colorectal cancer: a systematic review and meta-analysis. J Clin Oncol 22 (2004) 529-536
11. Ghadimi B.M., Grade M., Difilippantonio M.J., et al. Effectiveness of gene expression profiling for response prediction of rectal adenocarcinomas to preoperative chemoradiotherapy. J Clin Oncol 23 (2005) 1826-1838
12. Allegra C.J., Paik S., Colangelo L.H., et al. Prognostic value of thymidylate synthase, Ki-67, and p53 in patients with Dukes' B and C colon cancer: a National Cancer Institute-National Surgical Adjuvant Breast and Bowel Project collaborative study. J Clin Oncol 21 (2003) 241-250
13. Okonkwo A., Musunuri S., Talamonti M., et al. Molecular markers and prediction of response to chemoradiation in rectal cancer. Oncol Rep 8 (2001) 497-500
14. Saw R.P., Morgan M., Koorey D., et al. p53, deleted in colorectal cancer gene, and thymidylate synthase as predictors of histopathologic response and survival in low, locally advanced rectal cancer treated with preoperative adjuvant therapy. Dis Colon Rectum 46 (2003) 192-202
15. Spitz F.R., Giacco G.G., Hess K., et al. p53 immunohistochemical staining predicts residual disease after chemoradiation in patients with high-risk rectal cancer. Clin Cancer Res 3 (1997) 1685-1690
16. Friederichs J., Rosenberg R., Mages J., et al. Gene expression profiles of different stages of colorectal carcinoma: toward a molecular genetic understanding of tumor progression. Int J Colorectal Dis 20 (2005) 391-402
17. Notterman D.A., Alon U., Sierk A.J., et al. Transcriptional gene expression profiles of colorectal adenoma, adenocarcinoma and normal tissue examined by oligonucleotide arrays. Cancer Res 61 (2001) 3124-3130
18. Wang Y., Jatkoe T., Zhang Y., et al. Gene expression profiles and molecular markers to predict recurrence of Dukes' B colon cancer. J Clin Oncol 22 (2004) 1564-1571
19. Eschrich S., Yang I., Bloom G., et al. Molecular staging for survival prediction of colorectal cancer patients. J Clin Oncol 23 (2005) 3526-3535
20. Lin Y.H., Friederichs J., Black M.A., et al. Multiple gene expression classifiers from different array platforms predict poor prognosis of colorectal cancer. Clin Cancer Res 13 (2007) 498-507
21. Chang J.C., Wooten E.C., Tsimelzon A., et al. Gene expression profiling for the prediction of therapeutic response to docetaxel in patients with breast cancer. Lancet 362 (2003) 362-369
22. Clarke P.A., George M.L., Easdale S., et al. Molecular pharmacology of cancer therapy in human colorectal cancer by gene expression profiling. Cancer Res 63 (2003) 6855-6863
23. Becker K., Mueller J.D., Schumacher C., et al. Histomorphology and grading of regression in gastric carcinoma treated with neoadjuvant chemotherapy. Cancer 98 (2003) 1521-1530
24. Mandard A.M., Dalibard F., Mandard J.C., et al. Pathologic assessment of tumor regression after preoperative chemoradiotherapy of esophageal carcinoma. Clinicopathological correlations. Cancer 73 (1994) 2680-2686
25. Ihaka R., and Gentleman R. R: a language for data analysis and graphics. J Comput Graph Stat 5 (1996) 299-314
26. Nguyen D.V., and Rocke D.M. Tumor classification by partial least squares using microarray gene expression data. Bioinformatics 18 (2002) 39-50
27. Boulesteix A.L. PLS dimension reduction for classification with microarray data. Stat Appl Genet Mol Biol 3 (2004) 33
28. Boulesteix A.L., and Strimmer K. Partial least squares: a versatile tool for the analysis of high-dimensional genomic data. Brief Bioinform 8 (2007) 32-44
29. Braga-Neto U.M., and Dougherty E.R. Is cross-validation valid for small-sample microarray classification?. Bioinformatics 20 (2004) 374-380
30. Storey J.D. A direct approach to false discovery rates. J Roy Stat Soc B 64 (2000) 479-490
31. Bossolasco M., Veillette F., Bertrand R., et al. Human TDE1, a TDE1/TMS family member, inhibits apoptosis in vitro and stimulates in vivo tumorigenesis. Oncogene 25 (2006) 4549-4558
32. Ishii N., Ishii T., and Hartman P.S. The role of the electron transport gene SDHC on lifespan and cancer. Exp Gerontol 41 (2006) 952-956
33. Thalappilly S., Sadasivam S., Radha V., et al. Involvement of caspase 1 and its activator Ipaf upstream of mitochondrial events in apoptosis. FEBS J 273 (2006) 2766-2778
34. Matsuyama R., Togo S., Shimizu D., et al. Predicting 5-fluorouracil chemosensitivity of liver metastases from colorectal cancer using primary tumor specimens: three-gene expression model predicts clinical response. Int J Cancer 119 (2006) 406-413
35. Smith F.M., Reynolds J.V., Miller N., et al. Pathological and molecular predictors of the response of rectal cancer to neoadjuvant radiochemotherapy. Eur J Surg Oncol 32 (2006) 55-64
36. Mori T., Anazawa Y., Matsui K., et al. Cyclin K as a direct transcriptional target of the p53 tumor suppressor. Neoplasia 4 (2002) 268-274
37. Ito Y., Takeda T., Okada M., et al. Expression of ets-1 and ets-2 in colonic neoplasms. Anticancer Res 22 (2002) 1581-1584
38. Horiuchi K., Umetani M., Minami T., et al. Wilms' tumor 1-associating protein regulates G2/M transition through stabilization of cyclin A2 mRNA. Proc Natl Acad Sci U S A 103 (2006) 17278-17283
39. Watanabe T., Komuro Y., Kiyomatsu T., et al. Prediction of sensitivity of rectal cancer cells in response to preoperative radiotherapy by DNA microarray analysis of gene expression profiles. Cancer Res 66 (2006) 3370-3374
40. Pusztai L., Ayers M., Stec J., et al. Gene expression profiles obtained from fine-needle aspirations of breast cancer reliably identify routine prognostic markers and reveal large-scale molecular differences between estrogen-negative and estrogen-positive tumors. Clin Cancer Res 9 (2003) 2406-2415
41. Cleator S.J., Powles T.J., Dexter T., et al. The effect of the stromal component of breast tumours on prediction of clinical outcome using gene expression microarray analysis. Breast Cancer Res 8 (2006) R32
42. Roman S., Cenni J.C., Roy P., et al. Value of rectal ultrasound in prediction staging and outcome in patients with rectal adenocarcinoma. Dis Colon Rectum 47 (2004) 1323-1330
43. Maretto I., Pomerri F., Pucciarelli S., et al. The potential of restaging in the prediction of pathologic response after preoperative chemoradiotherapy for rectal cancer. Ann Surg Oncol 14 (2007) 455-461
44. Ott K., Weber W.A., Lordick F., et al. Metabolic imaging predicts response, survival and recurrence in adenocarcinomas of the esophagogastric junction. J Clin Oncol 24 (2006) 4692-4698