Predictive clinicopathologic factors for limited response of T3 rectal cancer to combined modality therapy

International Journal of Colorectal Disease

Volumn 23, Issue 3, 2008, Pages 243-249

  Lin, Anne Y ^a   Wong, W Douglas ^a   Shia, Jinru ^a   Minsky, Bruce D ^a   Temple, Larissa K ^a   Guillem, José G ^a   Paty, Philip B ^a   Weiser, Martin R ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

Combined modality therapy; Rectal cancer; Tumor downstaging

Indexed keywords

ANTINEOPLASTIC AGENT; FLUOROURACIL; IRINOTECAN; OXALIPLATIN;

ADJUVANT THERAPY; ADULT; AGED; ARTICLE; CANCER ADJUVANT THERAPY; CANCER RADIOTHERAPY; CANCER RECURRENCE; CANCER STAGING; CANCER SURVIVAL; CHI SQUARE TEST; CLINICAL FEATURE; COHORT ANALYSIS; CONTINUOUS INFUSION; DIGITAL RECTAL EXAMINATION; DISEASE FREE SURVIVAL; ECHOGRAPHY; FEMALE; HUMAN; KAPLAN MEIER METHOD; MAJOR CLINICAL STUDY; MALE; METASTASIS; MOLECULAR DYNAMICS; MULTIMODALITY CANCER THERAPY; MULTIVARIATE LOGISTIC REGRESSION ANALYSIS; PREOPERATIVE EVALUATION; PRIORITY JOURNAL; RECTOSCOPY; RECTUM BIOPSY; RECTUM CANCER; TREATMENT RESPONSE; TUMOR CLASSIFICATION; TUMOR VOLUME;

ADULT; AGED; AGED, 80 AND OVER; COLONOSCOPY; COMBINED MODALITY THERAPY; DISEASE-FREE SURVIVAL; ENDOSONOGRAPHY; FEMALE; FOLLOW-UP STUDIES; HUMANS; MALE; MIDDLE AGED; NEOPLASM STAGING; PALPATION; PROGNOSIS; PROSPECTIVE STUDIES; RECTAL NEOPLASMS;

EID: 38649124038     PISSN: 01791958     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00384-007-0406-8     Document Type: Article

References (21)

1. NIH Consensus Conference (1990) Adjuvant therapy for patients with colon and rectal cancer. JAMA 264:1444-1450
2. Moertel CG, Fleming TR, Macdonald JS et al (1990) Levamisole and fluorouracil for adjuvant therapy of resected colon carcinoma. N Engl J Med 322:352-358
3. Moertel CG, Fleming TR, Macdonald JS et al (1995) Fluorouracil plus levamisole as effective adjuvant therapy after resection of stage III colon carcinoma: A final report. Ann Intern Med 122:321-326
4. Sauer R, Becker H, Hohenberger W et al (2004) Preoperative versus postoperative chemoradiotherapy for rectal cancer. N Engl J Med 351:1731-1740
5. Guillem JG, Chessin DB, Cohen AM et al (2005) Long-term oncologic outcome following preoperative combined modality therapy and total mesorectal excision of locally advanced rectal cancer. Ann Surg 241:829-836
6. Theodoropoulos G, Wise WE, Padmanabhan A et al (2002) T-level downstaging and complete pathologic response after preoperative chemoradiation for advanced rectal cancer result in decreased recurrence and improved disease-free survival. Dis Colon Rectum 45:895-903
7. Hildebrandt U, Feifel G (1985) Preoperative staging of rectal cancer by intrarectal ultrasound. Dis Colon Rectum 28:42-46
8. Stipa F, Zernecke A, Moore HG et al (2004) Residual mesorectal lymph node involvement following neoadjuvant combined-modality therapy: rationale for radical resection. Ann Surg Oncol 11:187-191
9. Read TE, McNevin MS, Gross EK et al (2001) Neoadjuvant therapy for adenocarcinoma of the rectum: Tumor response and acute toxicity. Dis Colon Rectum 44:513-522
10. Stipa F, Chessin DB, Shia J et al (2006) A pathologic complete response of rectal cancer to preoperative combined-modality therapy results in improved oncological outcome compared with those who achieve no downstaging on the basis of preoperative endorectal ultrasonography. Ann Surg Oncol 13:1047-1053
11. Willett CG, Badizadegan K, Ancukiewicz M, Shellito PC (1999) Prognostic factors in stage T3N0 rectal cancer: Do all patients require postoperative pelvic irradiation and chemotherapy? Dis Colon Rectum 42:167-173
12. Das P, Skibber JM, Rodriguez-Bigas MA et al (2007) Predictors of tumor response and downstaging in patients who receive preoperative chemoradiation for rectal cancer. Cancer 109:1750-1755
13. Kwok H, Bissett IP, Hill GL (2000) Preoperative staging of rectal cancer. Int J Colorectal Dis 15:9-20
14. Ueno H, Mochizuki H, Tamakuma S (1998) Prognostic significance of extranodal microscopic foci discontinuous with primary lesion in rectal cancer. Dis Colon Rectum 41:55-61
15. Valentini V, Coco C, Cellini N et al (1998) Preoperative chemoradiation for extraperitoneal T3 rectal cancer: Acute toxicity, tumor response, and sphincter preservation. Int J Radiat Oncol Biol Phys 40:1067-1075
16. Vuong T, Belliveau PJ, Michel RP et al (2002) Conformal preoperative endorectal brachytherapy treatment for locally advanced rectal cancer: early results of a phase I/II study. Dis Colon Rectum 45:1486-1493
17. Jakobsen A, Mortensen JP, Bisgaard C et al (2006) Preoperative chemoradiation of locally advanced T3 rectal cancer combined with an endorectal boost. Int J Radiat Oncol Biol Phys 64:461-465
18. Chau I, Cunningham D (2006) Adjuvant therapy in colon cancer - what, when and how? Ann Oncol 17:1347-1359
19. Minsky B O'Reilly E, Wong WD et al (1999) Daily low-dose irinotecan (CPT-11) plus pelvic irradiation as preoperative treatment of locally advanced rectal cancer. Proc Am Soc Clin Oncol 18:266a[Meeting Abstract]
20. Mehta VK, Cho C, Ford JM et al (2003) Phase II trial of preoperative 3D conformal radiotherapy, protracted venous infusion 5-fluorouracil, and weekly CPT-11, followed by surgery for ultrasound-staged T3 rectal cancer. Int J Radiat Oncol Biol Phys 55:132-137
21. Zhu AX, Willett CG (2005) Combined modality treatment for rectal cancer. Semin Oncol 32:103-112