Body fat distribution and organ weights of 14 common strains and a 22-strain consomic panel of rats

Physiology and Behavior

Volumn 103, Issue 5, 2011, Pages 523-529

  Reed, Danielle R ^a   Duke, Fujiko F ^a   Ellis, Hillary K ^a   Rosazza, Matthew R ^a   Lawler, Maureen P ^a   Alarcon, Laura K ^a   Tordoff, Michael G ^a  

^a MONELL CHEMICAL SENSES CENTER   (United States)

Author keywords

Adipose tissue; Body fat distribution; Consomics; Dissection; Genetics; Organ size; Organ weight; QTL

Indexed keywords

ADIPOSE TISSUE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY COMPOSITION; BODY FAT DISTRIBUTION; BODY HEIGHT; BODY SIZE; BODY WEIGHT; BRAIN; CHROMOSOME SUBSTITUTION STRAIN; CONTROLLED STUDY; ECTOPIC KIDNEY; GENETIC ANALYSIS; HEART; HERITABILITY; INTRAABDOMINAL FAT; LIPID STORAGE; LIVER; MALE; NONHUMAN; OBESITY; ORGAN WEIGHT; PRIORITY JOURNAL; QUANTITATIVE TRAIT LOCUS; RAT; SPLEEN; STRAIN DIFFERENCE;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; ANIMALS, OUTBRED STRAINS; BODY COMPOSITION; BODY FAT DISTRIBUTION; BODY WEIGHT; CROSSES, GENETIC; MALE; ORGAN SIZE; QUANTITATIVE TRAIT, HERITABLE; RATS; RATS, INBRED STRAINS; SPECIES SPECIFICITY;

EID: 79955499220     PISSN: 00319384     EISSN: 1873507X     Source Type: Journal    
DOI: 10.1016/j.physbeh.2011.04.006     Document Type: Article

References (45)

1. Cinti S. The adipose organ 1999, Editrice Kurtis, Milano.
2. Vague J. Importance of the measurement of fat distribution in pathology. Bull Mem Soc Med Hop Paris 1950, 66:1572-1574.
3. Kirkland J.L., Hollenberg C.H., Gillon W.S. Effects of fat depot site on differentiation-dependent gene expression in rat preadipocytes. Int J Obes Relat Metab Disord 1996, 20(Suppl 3):S102-S107.
4. Yamamoto Y., Gesta S., Lee K.Y., Tran T.T., Saadatirad P., Kahn C.R. Adipose depots possess unique developmental gene signatures. Obesity (Silver Spring) 2010, 18:872-878.
5. Reed D.R., McDaniel A.H., Li X., Tordoff M.G., Bachmanov A.A. Quantitative trait loci for individual adipose depot weights in C57BL/6ByJ x 129P3/J F(2) mice. Mamm Genome 2006, 17:1065-1077.
6. Reed D.R. Animal models of gene-nutrient interactions. Obesity (Silver Spring) 2008, 16(Suppl 3):S23-S27.
7. National Bio Resource Project for the Rat (NBRP) National Bio Resource Project for the Rat (NBRP) 2007, http://www.anim.med.kyoto-u.ac.jp/NBR/home.htm.
8. Rat genome database Rat genome database 2007, http://rgd.mcw.edu/.
9. Levin B.E., Dunn-Meynell A.A., Balkan B., Keesey R.E. Selective breeding for diet-induced obesity and resistance in Sprague-Dawley rats. Am J Physiol 1997, 273:R725-R730.
10. Novelli E.L., Diniz Y.S., Galhardi C.M., Ebaid G.M., Rodrigues H.G., Mani F., et al. Anthropometrical parameters and markers of obesity in rats. Lab Anim 2007, 41:111-119.
11. West D.B., Diaz J., Roddy S., Woods S.C. Long-term effects on adiposity after preweaning nutritional manipulations in the gastrostomy-reared rat. J Nutr 1987, 117:1259-1264.
12. Schemmel R., Mickelsen O., Gill J.L. Dietary obesity in rats: body weight and body fat accretion in seven strains of rats. J Nutr 1970, 100:1041-1048.
13. Twigger S.N., Pruitt K.D., Fernandez-Suarez X.M., Karolchik D., Worley K.C., Maglott D.R., et al. What everybody should know about the rat genome and its online resources. Nat Genet 2008, 40:523-527.
14. Thomas M.A., Chen C.F., Jensen-Seaman M.I., Tonellato P.J., Twigger S.N. Phylogenetics of rat inbred strains. Mamm Genome 2003, 14:61-64.
15. Cowley A.W., Liang M., Roman R.J., Greene A.S., Jacob H.J. Consomic rat model systems for physiological genomics. Acta Physiol Scand 2004, 181:585-592.
16. Cowley A.W., Roman R.J., Jacob H.J. Application of chromosomal substitution techniques in gene-function discovery. J Physiol 2004, 554:46-55.
17. Mattson D.L., Dwinell M.R., Greene A.S., Kwitek A.E., Roman R.J., Cowley A.W., et al. Chromosomal mapping of the genetic basis of hypertension and renal disease in FHH rats. Am J Physiol Renal Physiol 2007, 293:F1905-F1914.
18. PhysGen PhysGen (Home Page) http://brc.mcw.edu/.
19. Reed D.R., Bachmanov A.A., Tordoff M.G. Forty mouse strain survey of body composition. Physiol Behav 2007, 91:593-600.
20. Tordoff M.G. Taste solution consumption by FHH-Chr nBN consomic rats. Chem Senses 2010, 35:473-489.
21. Tordoff M.G., Alarcon L.K., Lawler M.P. Preferences of 14 rat strains for 17 taste compounds. Physiol Behav 2008, 95:308-332.
22. Dyets Inc 100000 AIN-76A Purified rodent diet 2003, http://www.dyets.com/100000.htm.
23. Packard G.C., Boardman T.J. The use of percentages and size-specific indices to normalize physiological data for variation in body size: wasted time, wasted effort?. Comp Biochem Physiol A 1999, 122:37-44.
24. Reed D.R., Li X., McDaniel A.H., Lu K., Li S., Tordoff M.G., et al. Loci on chromosomes 2, 4, 9, and 16 for body weight, body length, and adiposity identified in a genome scan of an F2 intercross between the 129P3/J and C57BL/6ByJ mouse strains. Mamm Genome 2003, 14:302-313.
25. Reed D.R., McDaniel A.H., Avigdor M., Bachmanov A.A. QTL for body composition on chromosome 7 detected using a chromosome substitution mouse strain. Obesity (Silver Spring) 2008, 16:483-487.
26. Bachmanov A.A., Reed D.R., Tordoff M.G., Price R.A., Beauchamp G.K. Intake of ethanol, sodium chloride, sucrose, citric acid, and quinine hydrochloride solutions by mice: a genetic analysis. Behav Genet 1996, 26:563-573.
27. Lindsey J., Baker H. Historical foundations. The laboratory rat 2006, 1-36. Academic Press, New York. 2nd ed. M.A. Suckow, S. Weisbroth, F.L. Franklin (Eds.).
28. Svenson K.L., Von Smith R., Magnani P.A., Suetin H.R., Paigen B., Naggert J.K., et al. Multiple trait measurements in 43 inbred mouse strains capture the phenotypic diversity characteristic of human populations. J Appl Physiol 2007, 102:2369-2378.
29. Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., et al. Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Nature 2004, 428:493-521.
30. Zimdahl H., Nyakatura G., Brandt P., Schulz H., Hummel O., Fartmann B., et al. A SNP map of the rat genome generated from cDNA sequences. Science 2004, 303:807.
31. Brockmann G.A., Kratzsch J., Haley C.S., Renne U., Schwerin M., Karle S. Single QTL effects, epistasis, and pleiotropy account for two-thirds of the phenotypic F(2) variance of growth and obesity in DU6i x DBA/2 mice. Genome Res 2000, 10:1941-1957.
32. Shao H., Burrage L.C., Sinasac D.S., Hill A.E., Ernest S.R., O'Brien W., et al. Genetic architecture of complex traits: large phenotypic effects and pervasive epistasis. Proc Natl Acad Sci U S A 2008, 105:19910-19914.
33. Speliotes E.K., Willer C.J., Berndt S.I., Monda K.L., Thorleifsson G., Jackson A.U., et al. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet 2010, 42:937-948.
34. Reed D.R., Lawler M.P., Tordoff M.G. Reduced body weight is a common effect of gene knockout in mice. BMC Genet 2008, 9:4.
35. Iacobellis G., Corradi D., Sharma A.M. Epicardial adipose tissue: anatomic, biomolecular and clinical relationships with the heart. Nat Clin Pract Cardiovasc Med 2005, 2:536-543.
36. Shier P.D., Schemmel R. Effects of diet, age, strain and anatomical site on fat depot triglyceride and fatty acid content in rats. Proc Soc Exp Biol Med 1975, 149:864-870.
37. Schemmel R., Mickelsen O., Motawi K. Conversion of dietary to body energy in rats as affected by strain, sex and ration. J Nutr 1972, 102:1187-1197.
38. Perez de Heredia F., Garaulet M., Portillo M.P., Zamora S. Resistance to dietary obesity in rats given different high-energy diets. Int J Vitam Nutr Res 2006, 76:271-279.
39. Mickelsen O., Schemmel R., Gill J.L. Influence of diet, sex and age on skeletal size in seven strains of rats. Growth 1971, 35:11-22.
40. Poiley S.M. Growth tables for 66 strains and stocks of laboratory animals. Lab Anim Sci 1972, 22:758-779.
41. PhysGen http://pga.mcw.edu/?module=content&func=DataStatus.
42. Singer J.B., Hill A.E., Burrage L.C., Olszens K.R., Song J., Justice M., et al. Genetic dissection of complex traits with chromosome substitution strains of mice. Science 2004, 304:445-448.
43. Burrage L.C., Baskin-Hill A.E., Sinasac D.S., Singer J.B., Croniger C.M., Kirby A., et al. Genetic resistance to diet-induced obesity in chromosome substitution strains of mice. Mamm Genome 2010, 21:115-129.
44. Buchner D.A., Burrage L.C., Hill A.E., Yazbek S.N., O'Brien W.E., Croniger C.M., et al. Resistance to diet-induced obesity in mice with a single substituted chromosome. Physiol Genomics 2008, 35:116-122.
45. Ackroff K., Bonacchi K., Magee M., Yiin Y.M., Graves J.V., Sclafani A. Obesity by choice revisited: effects of food availability, flavor variety and nutrient composition on energy intake. Physiol Behav 2007, 92:468-478.