Functionality and specificity of gene markers for skin sensitization in dendritic cells

Toxicology Letters

Volumn 203, Issue 2, 2011, Pages 106-110

  Lambrechts, Nathalie ^a   Nelissen, Inge ^a   Van Tendeloo, Viggo ^b   Witters, Hilda ^a   Van Den Heuvel, Rosette ^a   Hooyberghs, Jef ^a,c   Schoeters, Greet ^a,b  

^a FLEMISH INSTITUTE FOR TECHNOLOGICAL RESEARCH VITO   (Belgium)

^b UNIVERSITY OF ANTWERP   (Belgium)

^c HASSELT UNIVERSITY   (Belgium)

Author keywords

Allergen specific signal; Danger; Dendritic cell; Gene markers; Skin sensitization; VITOSENS

Indexed keywords

1 FLUORO 2,4 DINITROBENZENE; AQUAPORIN 3; BINDING PROTEIN; BIOLOGICAL MARKER; CD34 ANTIBODY; CD83 ANTIGEN; CD86 ANTIGEN; CELL SURFACE MARKER; CHEMOKINE RECEPTOR CCR2; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; HLA DR ANTIGEN; LIPOPOLYSACCHARIDE; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE; PLECKSTRIN HOMOLOGY SEC7 AND COILED COIL DOMAIN BINDING PROTEIN; PRE B CELL COLONY ENHANCING FACTOR 1; SOLUTE CARRIER FAMILY 2 MEMBER 3; UNCLASSIFIED DRUG;

ARTICLE; CELL ACTIVATION; CELL ACTIVITY; CELL ASSAY; CELL MATURATION; CONTROLLED STUDY; DENDRITIC CELL; ENZYME ACTIVATION; FLOW CYTOMETRY; GENE EXPRESSION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN FUNCTION; RECEPTOR DOWN REGULATION; SIGNAL TRANSDUCTION; SKIN SENSITIZATION; TRANSCRIPTOMICS;

ANIMAL TESTING ALTERNATIVES; ANTIGENS, CD34; CYCLOOXYGENASE 2; DENDRITIC CELLS; DERMATITIS, ALLERGIC CONTACT; DINITROFLUOROBENZENE; FLOW CYTOMETRY; GENE EXPRESSION PROFILING; HUMANS; RECEPTORS, CCR2; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA;

EID: 79955481875     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2011.02.015     Document Type: Article

References (26)

1. Brodmerkel C.M., Huber R., Covington M., Diamond S., Hall L., Collins R., Leffet L., Gallagher K., Feldman P., Collier P., Stow M., Gu X., Baribaud F., Shin N., Thomas B., Burn T., Hollis G., Yeleswaram S., Solomon K., Friedman S., Wang A., Xue C.B., Newton R.C., Scherle P., Vaddi K. Discovery and pharmacological characterization of a novel rodent-active CCR2 antagonist INCB3344. J. Immunol. 2005, 175:5370-5378.
2. CEC, C. o. t. E. C., 2001. White Paper: Strategy for a future Chemicals Policy. COM (2001) 88 final, 27 February 2001.
3. de Baey A., Lanzavecchia A. The role of aquaporins in dendritic cell macropinocytosis. J. Exp. Med. 2000, 191:743-748.
4. Harizi H., Juzan M., Pitard V., Moreau J.F., Gualde N. Cyclooxygenase-2-issued prostaglandin e(2) enhances the production of endogenous IL-10, which down-regulates dendritic cell functions. J. Immunol. 2002, 168:2255-2263.
5. Hartung T., Bremer S., Casati S., Coecke S., Corvi R., Fortaner S., Gribaldo L., Halder M., Hoffmann S., Roi A.J., Prieto P., Sabbioni E., Scott L., Worth A., Zuang V. A modular approach to the ECVAM principles on test validity. Altern. Lab. Anim. 2004, 32:467-472.
6. Hellemans J., Mortier G., De Paepe A., Speleman F., Vandesompele J. qBase relative quantification framework and software for management and automated analysis of real-time quantitative PCR data. Genome Biol. 2007, 8:R19.
7. Hooyberghs J., Schoeters E., Lambrechts N., Nelissen I., Witters H., Schoeters G., Van Den Heuvel R. A cell-based in vitro alternative to identify skin sensitizers by gene expression. Toxicol. Appl. Pharmacol. 2008, 231:103-111.
8. Hulette B.C., Ryan C.A., Gildea L.A., Gerberick G.F. Relationship of CD86 surface marker expression and cytotoxicity on dendritic cells exposed to chemical allergen. Toxicol. Appl. Pharmacol. 2005, 209:159-166.
9. Jimenez F., Quinones M.P., Martinez H.G., Estrada C.A., Clark K., Garavito E., Ibarra J., Melby P.C., Ahuja S.S. CCR2 plays a critical role in dendritic cell maturation: possible role of CCL2 and NF-kappaB. J. Immunol. 2010, 184:5571-5581.
10. Krewski D., Andersen M.E., Mantus E., Zeise L. Toxicity testing in the 21st century: implications for human health risk assessment. Risk Anal. 2009, 29:474-479.
11. Lambrechts N., Vanheel H., Hooyberghs J., De Boever P., Witters H., Van Den Heuvel R., Van Tendeloo V., Nelissen I., Schoeters G. Gene markers in dendritic cells unravel pieces of the skin sensitization puzzle. Toxicol. Lett. 2010, 196:95-103.
12. Lambrechts N., Vanheel H., Nelissen I., Witters H., Van Den Heuvel R., Van Tendeloo V., Schoeters G., Hooyberghs J. Assessment of chemical skin sensitizing potency by an in vitro assay based on human dendritic cells. Toxicol. Sci. 2010, 116:122-129.
13. Lardon F., Snoeck H.W., Berneman Z.N., Van Tendeloo V.F., Nijs G., Lenjou M., et al. Generation of dendritic cells from bone marrow progenitors using GM-CSF, TNF-alpha, and additional cytokines: antagonistic effects of IL-4 and IFN-gamma and selective involvement of TNF-alpha receptor-1. Immunology 1997, 91:553-559.
14. Liu A.H. Endotoxin exposure in allergy and asthma: reconciling a paradox. J. Allergy Clin. Immunol. 2002, 109:379-392.
15. Matzinger P. An innate sense of danger. Semin. Immunol. 1998, 10:399-415.
16. Matzinger P. The danger model: a renewed sense of self. Science 2002, 296:301-305.
17. Moreno C.S., Beresford G.W., Louis-Plence P., Morris A.C., Boss J.M. CREB regulates MHC class II expression in a CIITA-dependent manner. Immunity 1999, 10:143-151.
18. Pauwels M., Rogiers V. Human health safety evaluation of cosmetics in the EU: a legally imposed challenge to science. Toxicol. Appl. Pharmacol. 2010, 243(2):260-274.
19. Pouplana R., Lozano J.J., Ruiz J. Molecular modelling of the differential interaction between several non-steroidal anti-inflammatory drugs and human prostaglandin endoperoxide H synthase-2 (h-PGHS-2). J. Mol. Graph. Model. 2002, 20:329-343.
20. Romani N., Clausen B.E., Stoitzner P. Langerhans cells and more: langerin-expressing dendritic cell subsets in the skin. Immunol. Rev. 2010, 234:120-141.
21. Schoeters E., Verheyen G.R., Nelissen I., Van Rompay A.R., Hooyberghs J., Van Den Heuvel R.L., Witters H., Schoeters G.E., Van Tendeloo V.F., Berneman Z.N. Microarray analyses in dendritic cells reveal potential biomarkers for chemical-induced skin sensitization. Mol. Immunol. 2007, 44:3222-3233.
22. Vandesompele J., De Preter K., Pattyn F., Poppe B., Van Roy N., De Paepe A., Speleman F. Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol. 2002, 3. RESEARCH0034.
23. Vocanson M., Hennino A., Rozieres A., Poyet G., Nicolas J.F. Effector and regulatory mechanisms in allergic contact dermatitis. Allergy 2009, 64:1699-1714.
24. Whittaker D.S., Bahjat K.S., Moldawer L.L., Clare-Salzler M.J. Autoregulation of human monocyte-derived dendritic cell maturation and IL-12 production by cyclooxygenase-2-mediated prostanoid production. J. Immunol. 2000, 165:4298-4304.
25. Willart M.A., Lambrecht B.N. The danger within: endogenous danger signals, atopy and asthma. Clin. Exp. Allergy 2009, 39:12-19.
26. Zlotnik A., Yoshie O. Chemokines: a new classification system and their role in immunity. Immunity 2000, 12:121-127.