Propofol depresses the cytotoxicity of X-ray irradiation through inhibition of gap junctions

Anesthesia and Analgesia

Volumn 112, Issue 5, 2011, Pages 1088-1095

  Zhao, Yuping ^a   Liu, Bing ^b   Wang, Qin ^b   Yuan, Dongdong ^b   Yang, Yan ^b   Hong, Xiaoting ^b   Wang, Xudong ^a   Tao, Liang ^b  

^a SUN YAT SEN UNIVERSITY   (China)

^b SUN YAT SEN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CONNEXIN 32; MESSENGER RNA; PROPOFOL;

ARTICLE; CYTOTOXICITY; DRUG EFFECT; DRUG MECHANISM; GAP JUNCTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING; X IRRADIATION;

EID: 79955480254     PISSN: 00032999     EISSN: None     Source Type: Journal    
DOI: 10.1213/ANE.0b013e31820f288e     Document Type: Article

References (43)

1. Showalter TN, Rao AS, Rani Anne P, Rosato FE, Rosato EL, Andrel J, Hyslop T, Xu X, Berger AC. Does intraoperative radiation therapy improve local tumor control in patients undergoing pancreaticoduodenectomy for pancreatic adenocarcinoma? A propensity score analysis. Ann Surg Oncol 2009;16:2116-22
2. Wojcieszek E, Rembielak A, Bialas B, Wojcieszek A. Anaesthesia for radiation therapy: Gliwice experience. Neoplasma 2010;57:155-60
3. Chalabi J, Patel S. Radiation therapy in children. Int Anesthesiol Clin 2009;47:45-53
4. Yeager M, Harris AL. Gap junction channel structure in the early 21st century: facts and fantasies. Curr Opin Cell Biol 2007;19:521-8 (Pubitemid 350016852)
5. Vinken M, Vanhaecke T, Papeleu P, Snykers S, Henkens T, Rogiers V. Connexins and their channels in cell growth and cell death. Cell Signal 2006;18:592-600 (Pubitemid 43113290)
6. Trosko JE, Chang CC. Mechanism of up-regulated gap junctional intercellular communication during chemoprevention and chemotherapy of cancer. Mutat Res 2001;480 -1:219-29 (Pubitemid 32744830)
7. Mesnil M, Crespin S, Avanzo JL, Zaidan-Dagli ML. Defective gap junctional intercellular communication in the carcinogenic process. Biochim Biophys Acta 2005;1719:125-45 (Pubitemid 41785641)
8. Krysko DV, Leybaert L, Vandenabeele P, D'Herde K. Gap junctions and the propagation of cell survival and cell death signals. Apoptosis 2005;10:459-69 (Pubitemid 40896652)
9. Nadarajah B, Jones AM, Evans WH, Parnavelas JG. Differential expression of connexins during neocortical development and neuronal circuit formation. J Neurosci 1997;17:3096-111 (Pubitemid 27175822)
10. Rash JE, Yasumura T, Davidson KG, Furman CS, Dudek FE, Nagy JI. Identification of cells expressing Cx43, Cx30, Cx26, Cx32 and Cx36 in gap junctions of rat brain and spinal cord. Cell Commun Adhes 2001;8:315-20
11. Sohl G, Maxeiner S, Willecke K. Expression and functions of neuronal gap junctions. Nat Rev Neurosci 2005;6:191-200 (Pubitemid 40342414)
12. Sai K, Kanno J, Hasegawa R, Trosko JE, Inoue T. Prevention of the down-regulation of gap junctional intercellular communication by green tea in the liver of mice fed pentachlorophenol. Carcinogenesis 2000;21:1671-6
13. Fujimoto E, Sato H, Shirai S, Nagashima Y, Fukumoto K, Hagiwara H, Negishi E, Ueno K, Omori Y, Yamasaki H, Hagiwara K, Yano T. Connexin32 as a tumor suppressor gene in a metastatic renal cell carcinoma cell line. Oncogene 2005;24:3684-90 (Pubitemid 40756238)
14. Kalvelyte A, Imbrasaite A, Bukauskiene A, Verselis VK, Bukauskas FF. Connexins and apoptotic transformation. Biochem Pharmacol 2003;66:1661-72 (Pubitemid 38373359)
15. Jensen R, Glazer PM. Cell-interdependent cisplatin killing by Ku/DNA-dependent protein kinase signaling transduced through gap junctions. Proc Natl Acad Sci USA 2004;101: 6134-9 (Pubitemid 38520540)
16. Azzam EI, de Toledo SM, Little JB. Direct evidence for the participation of gap junction-mediated intercellular communication in the transmission of damage signals from alphaparticle irradiated to nonirradiated cells. Proc Natl Acad Sci USA 2001;98:473-8 (Pubitemid 32105066)
17. Shao C, Furusawa Y, Aoki M, Ando K. Role of gap junctional intercellular communication in radiation-induced bystander effects in human fibroblasts. Radiat Res 2003;160:318-23 (Pubitemid 37052430)
18. Wentlandt K, Carlen PL, Kushnir M, Naus CC, El-Beheiry H. General anesthetics attenuate gap junction coupling in P19 cell line. J Neurosci Res 2005;81:746-52 (Pubitemid 41532170)
19. Mantz J, Cordier J, Giaume C. Effects of general anesthetics on intercellular communications mediated by gap junctions between astrocytes in primary culture. Anesthesiology 1993;78: 892-901 (Pubitemid 23141365)
20. Koreen IV, Elsayed WA, Liu YJ, Harris AL. Tetracyclineregulated expression enables purification and functional analysis of recombinant connexin channels from mammalian cells. Biochem J 2004;383:111-9 (Pubitemid 39389456)
21. van den Ouweland JM, Church S. High total protein impairs appropriate gel barrier formation in BD Vacutainer blood collection tubes. Clin Chem 2007;53:364-5 (Pubitemid 46338290)
22. McCleane GJ, Fogarty DF, Watters CH. Factors that influence the induction dose of propofol. Anaesthesia 1991;46:59-61
23. White M, Kenny GN. Intravenous propofol anaesthesia using a computerised infusion system. Anaesthesia 1990;45:204-9 (Pubitemid 20091920)
24. Takei T, Saegusa H, Zong S, Murakoshi T, Makita K, Tanabe T. Anesthetic sensitivities to propofol and halothane in mice lacking the R-type (Cav2.3) Ca2- channel. Anesth Analg 2003;97:96-103 (Pubitemid 36736545)
25. Edwards GO, Botchway SW, Hirst G, Wharton CW, Chipman JK, Meldrum RA. Gap junction communication dynamics and bystander effects from ultrasoft X-rays. Br J Cancer 2004; 90:1450-6 (Pubitemid 38586275)
26. Wang Q, You T, Yuan D, Han X, Hong X, He B, Wang L, Tong X, Tao L, Harris AL. Cisplatin and oxaliplatin inhibit gap junctional communication by direct action and by reduction of connexin expression, thereby counteracting cytotoxic efficacy. J Pharmacol Exp Ther 2010;333:903-11
27. Ionta M, Ferreira RA, Pfister SC, Machado-Santelli GM. Exogenous Cx43 expression decrease cell proliferation rate in rat hepatocarcinoma cells independently of functional gap junction. Cancer Cell Int 2009;9:22
28. Yamada T, Ohyama H. Radiation-induced interphase death of rat thymocytes is internally programmed (apoptosis). Int J Radiat Biol Relat Stud Phys Chem Med 1988;53:65-75 (Pubitemid 18036554)
29. Iwamoto K, Shinomiya N, Mochizuki H. Different cell cycle mechanisms between UV-induced and X-ray-induced apoptosis in WiDr colorectal carcinoma cells. Apoptosis 1999;4:59-66 (Pubitemid 29378802)
30. Ferlini C, De Angelis C, Biselli R, Distefano M, Scambia G, Fattorossi A. Sequence of metabolic changes during X-rayinduced apoptosis. Exp Cell Res 1999;247:160-7 (Pubitemid 29393972)
31. Ferlini C, Di Cesare S, Rainaldi G, Malorni W, Samoggia P, Biselli R, Fattorossi A. Flow cytometric analysis of the early phases of apoptosis by cellular and nuclear techniques. Cytometry 1996;24:106-15 (Pubitemid 26193935)
32. Darzynkiewicz Z, Juan G, Li X, Gorczyca W, Murakami T, Traganos F. Cytometry in cell necrobiology: analysis of apoptosis and accidental cell death (necrosis). Cytometry 1997; 27:1-20 (Pubitemid 27059777)
33. Wilson MR, Close TW, Trosko JE. Cell population dynamics (apoptosis, mitosis, and cell-cell communication) during disruption of homeostasis. Exp Cell Res 2000;254:257-68 (Pubitemid 30080582)
34. Azzam EI, De Toledo SM, Spitz DR, Little JB. Oxidative metabolism modulates signal transduction and micronucleus formation in bystander cells from alpha-particle-irradiated normal human fibroblast cultures. Cancer Res 2002;62:5436-42
35. Lyng FM, Maguire P, McClean B, Seymour C, Mothersill C. The involvement of calcium and MAP kinase signaling pathways in the production of radiation-induced bystander effects. Radiat Res 2006;165:400-9
36. Milne SE, Troy A, Irwin MG, Kenny GN. Relationship between bispectral index, auditory evoked potential index and effectsite EC50 for propofol at two clinical end-points. Br J Anaesth 2003;90:127-31 (Pubitemid 36181954)
37. Shafer SL, Gregg KM. Algorithms to rapidly achieve and maintain stable drug concentrations at the site of drug effect with a computer-controlled infusion pump. J Pharmacokinet Biopharm 1992;20:147-69
38. Mantz J, Delumeau JC, Cordier J, Petitet F. Differential effects of propofol and ketamine on cytosolic calcium concentrations of astrocytes in primary culture. Br J Anaesth 1994;72:351-3 (Pubitemid 24089750)
39. Wentlandt K, Samoilova M, Carlen PL, El Beheiry H. General anesthetics inhibit gap junction communication in cultured organotypic hippocampal slices. Anesth Analg 2006;102: 1692-8 (Pubitemid 43799841)
40. Bennett MV, Barrio LC, Bargiello TA, Spray DC, Hertzberg E, Saez JC. Gap junctions: new tools, new answers, new questions. Neuron 1991;6:305-20
41. Rackauskas M, Neverauskas V, Skeberdis VA. Diversity and properties of connexin gap junction channels. Medicina (Kaunas) 2010;46:1-12
42. He B, Tong X, Wang L, Wang Q, Ye H, Liu B, Hong X, Tao L, Harris AL. Tramadol and flurbiprofen depress the cytotoxicity of cisplatin via their effects on gap junctions. Clin Cancer Res 2009;15:5803-10
43. Cruikshank SJ, Hopperstad M, Younger M, Connors BW, Spray DC, Srinivas M. Potent block of Cx36 and Cx50 gap junction channels by mefloquine. Proc Natl Acad Sci USA 2004;101:12364-9 (Pubitemid 39145449)