Relationship between bispectral index, auditory evoked potential index and effect-site EC50 for propofol at two clinical end-points

British Journal of Anaesthesia

Volumn 90, Issue 2, 2003, Pages 127-131

  Milne, S E ^a   Troy, A ^a   Irwin, M G ^b   Kenny, G N C ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Anaesthesia, depth; Anaesthetics i.v., propofol; Monitoring, bispectral index; Monitoring, electroencephalography; Monitoring, evoked potentials; Pharmacokinetics, propofol

Indexed keywords

INTRAVENOUS ANESTHETIC AGENT; PROPOFOL;

ADULT; ANESTHESIST; ARTICLE; CAUCASIAN; CLINICAL ARTICLE; CONCENTRATION (PARAMETERS); CONSCIOUSNESS; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG BLOOD LEVEL; DRUG DELIVERY SYSTEM; DRUG INFUSION; DRUG TARGETING; ELECTROPHYSIOLOGY; EVOKED AUDITORY RESPONSE; FEMALE; HUMAN; INFUSION PUMP; LOGISTIC REGRESSION ANALYSIS; MALE; OUTCOMES RESEARCH; PAIN ASSESSMENT; PREDICTION; PRIORITY JOURNAL; STIMULUS RESPONSE; SURGICAL PATIENT; TETANY;

EID: 0037311796     PISSN: 00070912     EISSN: None     Source Type: Journal    
DOI: 10.1093/bja/aeg035     Document Type: Article

References (16)

1. Zbinden AM, Maggiorini M, Petersen F, et al. Anesthetic depth defined using multiple noxious stimuli during isoflurane/oxygen anesthesia. I. Motor reactions. Anesthesiology 1994; 80: 253-60
2. Smith C, McEwan AI, Jhaveri R, et al. The interaction of fentanyl on the Cp50 of propofol for loss of consciousness and skin incision. Anesthesiology 1994; 81: 820-8
3. White M, Kenny GNC. Intravenous propofol anaesthesia using a computerised infusion system. Anaesthesia 1990; 45: 204-9
4. Shafer SL, Gregg KM. Algorithms to rapidly achieve and maintain stable drug concentrations at the site of drug effect with a computer-controlled infusion pump. J Pharmacokinet Biopharm 1992; 20: 147-69
5. Glen JB. The development of 'Diprifusor': a TCI system for propofol. Anaesthesia 1998; 53 (suppl 1): 13-21
6. 50, BIS and AEPI at onset of anaesthesia. Eur J Anaesthesiol 2000; 17 (suppl 19): A378
7. Mantzaridis H, Kenny GNC. Auditory evoked potential index: a quantitative measure of changes in auditory evoked potentials during general anaesthesia. Anaesthesia 1997; 52: 1030-6
8. Davies FW, Mantzaridis H, Kenny GNC, Fisher AC. Middle latency auditory evoked potentials during repeated transitions from consciousness to unconsciousness. Anaesthesia 1996; 51: 107-13
9. Gajraj RJ, Doi M, Mantzaridis H, Kenny GNC. Analysis of the EEG bispectrum, auditory evoked potentials and the EEG power spectrum during repeated transitions from consciousness to unconsciousness. Br J Anaesth 1997; 80: 46-52
10. Gajraj RJ, Doi M, Mantzaridis H, Kenny GNC. Comparison of bispectral EEG analysis and auditory evoked potentials for monitoring depth of anaesthesia during propofol anaesthesia. Br J Anaesth 1999; 82: 672-8
11. Marsh B, White M, Morton N, Kenny GNC. Pharmacokinetic model driven infusion of propofol in children. Br J Anaesth 1991; 67: 41-8
12. White M, Schenkels MJ, Engbers; FH, et al. Effect-site modelling of propofol using auditory evoked potentials. Br J Anaesth 1999; 82: 333-9
13. Taylor I, White M, Kenny, GN. Assessment of the value and pattern of use of a target controlled propofol infusion system. Int J Clin Monit Comput 1993; 10: 175-80
14. Wakeling HG, Zimmerman JB, Howell S, Glass PS. Targeting effect compartment or central compartment concentration of propofol: what predicts loss of consciousness? Anesthesiology 1999; 90: 92-7
15. Kazama T, Ikeda K, Morita K. Reduction by fentanyl of the Cp50 values of propofol and hemodynamic responses to various noxious stimuli. Anesthesiology 1997; 87: 213-27
16. Irwin MG, Hui TWC, Milne SE, Kenny GNC. Propofol effective concentration 50 and its relationship to bispectral index. Anaesthesia 2002; 57: 242-8