메뉴 건너뛰기




Volumn 63, Issue 5, 2011, Pages 432-438

Inhibition of T-cell activation and proliferation by mycophenolic acid in patients awaiting liver transplantation: PK/PD relationships

Author keywords

Lymphocyte functions; Mycophenolate mofetil; Mycophenolic acid concentrations

Indexed keywords

CD71 ANTIGEN; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR ALPHA; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; TUMOR NECROSIS FACTOR ALPHA;

EID: 79955476791     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2011.01.005     Document Type: Article
Times cited : (25)

References (30)
  • 1
    • 10844292763 scopus 로고    scopus 로고
    • Immunosuppressive drugs for kidney transplantation
    • DOI 10.1056/NEJMra033540
    • P.F. Halloran Immunosuppressive drugs for kidney transplantation N Engl J Med 351 2004 2715 2729 (Pubitemid 39665325)
    • (2004) New England Journal of Medicine , vol.351 , Issue.26 , pp. 2715-2729
    • Halloran, P.F.1
  • 2
    • 27644566143 scopus 로고    scopus 로고
    • Mechanisms of action of mycophenolate mofetil in preventing acute and chronic allograft rejection
    • A.C. Allison, and E.M. Eugui Mechanisms of action of mycophenolate mofetil in preventing acute and chronic allograft rejection Transplantation 80 2005 S181 S190
    • (2005) Transplantation , vol.80
    • Allison, A.C.1    Eugui, E.M.2
  • 3
    • 33846230492 scopus 로고    scopus 로고
    • Clinical pharmacokinetics and pharmacodynamics of mycophenolate in solid organ transplant recipients
    • DOI 10.2165/00003088-200746010-00002
    • C.E. Staatz, and S.E. Tett Clinical pharmacokinetics and pharmacodynamics of mycophenolate in solid organ transplant recipients Clin Pharmacokinet 46 2007 13 58 (Pubitemid 46091591)
    • (2007) Clinical Pharmacokinetics , vol.46 , Issue.1 , pp. 13-58
    • Staatz, C.E.1    Tett, S.E.2
  • 6
    • 41349118284 scopus 로고    scopus 로고
    • Pharmacodynamic monitoring of the conversion from mycophenolate mofetil to enteric-coated mycophenolate sodium in stable kidney-allograft recipients
    • T. Böhler, C. Canivet, S. Galvani, N. Therville, R. Salvayre, and A. Negre-Salvayre Pharmacodynamic monitoring of the conversion from mycophenolate mofetil to enteric-coated mycophenolate sodium in stable kidney-allograft recipients Int Immunopharmacol 8 2008 769 773
    • (2008) Int Immunopharmacol , vol.8 , pp. 769-773
    • Böhler, T.1    Canivet, C.2    Galvani, S.3    Therville, N.4    Salvayre, R.5    Negre-Salvayre, A.6
  • 7
    • 0026034886 scopus 로고
    • Lymphocyte-selective cytostatic and immunosuppressive effects of mycophenolic acid in vitro: Role of deoxyguanosine nucleotide depletion
    • E.M. Eugui, S.J. Almquist, C.D. Muller, and A.C. Allison Lymphocyte-selective cytostatic and immunosuppressive effects of mycophenolic acid in vitro: role of deoxyguanosine nucleotide depletion Scand J Immunol 33 1991 161 173
    • (1991) Scand J Immunol , vol.33 , pp. 161-173
    • Eugui, E.M.1    Almquist, S.J.2    Muller, C.D.3    Allison, A.C.4
  • 8
    • 0027831688 scopus 로고
    • Effects of combined administration of FK 506 and the purine biosynthesis inhibitors mizoribine or mycophenolic acid on lymphocyte DNA synthesis and T cell activation molecule expression in human mixed lymphocyte cultures
    • A.W. Thomson, J. Woo, G.Z. Yao, S. Todo, T.E. Starzl, and A. Zeevi Effects of combined administration of FK 506 and the purine biosynthesis inhibitors mizoribine or mycophenolic acid on lymphocyte DNA synthesis and T cell activation molecule expression in human mixed lymphocyte cultures Transpl Immunol 1 1993 146 150
    • (1993) Transpl Immunol , vol.1 , pp. 146-150
    • Thomson, A.W.1    Woo, J.2    Yao, G.Z.3    Todo, S.4    Starzl, T.E.5    Zeevi, A.6
  • 10
    • 67649398251 scopus 로고    scopus 로고
    • Pharmacodynamic evaluation of the first dose of mycophenolate mofetil before kidney transplantation
    • N. Kamar, P. Glander, J. Nolting, T. Böhler, P. Hambach, and L. Liefeldt Pharmacodynamic evaluation of the first dose of mycophenolate mofetil before kidney transplantation Clin J Am Soc Nephrol 4 2009 936 942
    • (2009) Clin J Am Soc Nephrol , vol.4 , pp. 936-942
    • Kamar, N.1    Glander, P.2    Nolting, J.3    Böhler, T.4    Hambach, P.5    Liefeldt, L.6
  • 11
    • 33846072003 scopus 로고    scopus 로고
    • Effect of Mycophenolate Mofetil Monotherapy on T-Cell Functions and Inosine Monophosphate Dehydrogenase Activity in Patients Undergoing a Kidney Transplantation
    • DOI 10.1016/j.transproceed.2006.06.121, PII S0041134506007676
    • N. Kamar, P. Glander, J. Nolting, T. Böhler, P. Hambach, and L. Liefeldt Effect of mycophenolate mofetil monotherapy on T-cell functions and inosine monosphosphate dehydrogenase activity in patients undergoing a kidney transplantation Transplant Proc 38 2006 2292 2294 (Pubitemid 46068534)
    • (2006) Transplantation Proceedings , vol.38 , Issue.7 , pp. 2292-2294
    • Kamar, N.1    Glander, P.2    Nolting, J.3    Bohler, T.4    Hambach, P.5    Liefeldt, L.6    Neumayer, H.-H.7    Klupp, J.8    Budde, K.9
  • 12
    • 0036721788 scopus 로고    scopus 로고
    • Mycophenolic acid inhibits IL-2-dependent T cell proliferation, but not IL-2-dependent survival and sensitization to apoptosis
    • L. Quéméneur, M. Flacher, L.M. Gerland, M. Ffrench, J.P. Revillard, and N. Bonnefoy-Berard Mycophenolic acid inhibits IL-2-dependent T cell proliferation, but not IL-2-dependent survival and sensitization to apoptosis J Immunol 169 2002 2747 2755 (Pubitemid 34921024)
    • (2002) Journal of Immunology , vol.169 , Issue.5 , pp. 2747-2755
    • Quemeneur, L.1    Flacher, M.2    Gerland, L.-M.3    Ffrench, M.4    Revillard, J.-P.5    Bonnefoy-Berard, N.6
  • 13
    • 0036023133 scopus 로고    scopus 로고
    • Novel assays of multiple lymphocyte functions in whole blood measure: New mechanisms of action of mycophenolate mofetil in vivo
    • DOI 10.1016/S0966-3274(01)00041-7, PII S0966327401000417
    • M.J. Barten, T. van Gelder, J.F. Gummert, R. Shorthouse, and R.E. Morris Novel assays of multiple lymphocyte functions in whole blood measure: new mechanisms of action of mycophenolate mofetil in vivo Transpl Immunol 10 2002 1 14 (Pubitemid 34863319)
    • (2002) Transplant Immunology , vol.10 , Issue.1 , pp. 1-14
    • Barten, M.J.1    Van Gelder, T.2    Gummert, J.F.3    Shorthouse, R.4    Morris, R.E.5
  • 14
    • 0028941099 scopus 로고
    • The critical glycosylation site of human transferrin receptor contains a high-mannose oligosaccharide
    • G.R. Hayes, A. Williams, C.E. Costello, C.A. Enns, and J.J. Lucas The critical glycosylation site of human transferrin receptor contains a high-mannose oligosaccharide Glycobiology 5 1995 227 232
    • (1995) Glycobiology , vol.5 , pp. 227-232
    • Hayes, G.R.1    Williams, A.2    Costello, C.E.3    Enns, C.A.4    Lucas, J.J.5
  • 15
    • 0029918886 scopus 로고    scopus 로고
    • Purine metabolism and immunosuppressive effects of mycophenolate mofetil (MMF)
    • A.C. Allison, and E.M. Eugui Purine metabolism and immunosuppressive effects of mycophenolate mofetil [MMF] Clin Transplant 10 1996 77 84 (Pubitemid 26076435)
    • (1996) Clinical Transplantation , vol.10 , pp. 77-84
    • Allison, A.C.1    Eugui, E.M.2
  • 16
    • 0030071890 scopus 로고    scopus 로고
    • Mycophenolic acid suppresses protein N-linked glycosylation in human monocytes and their adhesion to endothelial cells and to some substrates
    • A.F. Laurent, S. Dumont, P. Poindron, and C.D. Muller Mycophenolic acid suppresses protein N-linked glycosylation in human monocytes and their adhesion to endothelial cells and to some substrates Exp Hematol 24 1996 59 67 (Pubitemid 26041775)
    • (1996) Experimental Hematology , vol.24 , Issue.1 , pp. 59-67
    • Laurent, A.F.1    Dumont, S.2    Poindron, P.3    Muller, C.D.4
  • 17
    • 0023153124 scopus 로고
    • GTP dependence of the transduction of mitogenic signals through the T3 complex in T lymphocytes indicates the involvement of a G-protein
    • DOI 10.1016/0014-5793(87)81491-6
    • T. Mustelin GTP dependence of the transduction of mitogenic signals through the T3 complex in T lymphocytes indicates theinvolvement of a G-protein FEBS Lett 213 1987 199 203 (Pubitemid 17036153)
    • (1987) FEBS Letters , vol.213 , Issue.1 , pp. 199-203
    • Mustelin, T.1
  • 18
    • 0027831688 scopus 로고
    • Effects of combined administration of FK 506 and the purine biosynthesis inhibitors mizoribine or mycophenolic acid on lymphocyte DNA synthesis and T-cell activation molecule expression in human mixed lymphocyte cultures
    • A.W. Thomson, J. Woo, G.Z. Yao, S. Todo, T.E. Starzl, and A. Zeevi Effects of combined administration of FK 506 and the purine biosynthesis inhibitors mizoribine or mycophenolic acid on lymphocyte DNA synthesis and T-cell activation molecule expression in human mixed lymphocyte cultures Transpl Immunol 1 1993 146 150
    • (1993) Transpl Immunol , vol.1 , pp. 146-150
    • Thomson, A.W.1    Woo, J.2    Yao, G.Z.3    Todo, S.4    Starzl, T.E.5    Zeevi, A.6
  • 19
    • 0027179319 scopus 로고
    • Effect of mycophenolate mofetil (RS-61443) on cytokine production: Inhibition of superantigen-induced cytokines
    • S.E. Nagy, J.P. Andersson, and U.G. Andersson Effect of mycophenolate mofetil ŽRS-61443 on cytokine production: inhibition of superantigen-induced cytokines Immunopharmacology 26 1993 11 20 (Pubitemid 23216870)
    • (1993) Immunopharmacology , vol.26 , Issue.1 , pp. 11-20
    • Nagy, S.E.1    Andersson, J.P.2    Andersson, U.G.3
  • 20
    • 0034045586 scopus 로고    scopus 로고
    • Mycophenolate mofetil and its mechanisms of action
    • DOI 10.1016/S0162-3109(00)00188-0, PII S0162310900001880
    • A.C. Allison, and E.M. Eugui Mycophenolate mofetil and its mechanisms of action Immunopharmacology 47 2000 85 118 (Pubitemid 30394534)
    • (2000) Immunopharmacology , vol.47 , Issue.2-3 , pp. 85-118
    • Allison, A.C.1    Eugui, E.M.2
  • 21
    • 79751533325 scopus 로고    scopus 로고
    • Population pharmacokinetics of mycophenolic acid in pediatric renal transplant patients using parametric and nonparametric approaches
    • A. Prémaud, L.T. Weber, B. Tönshoff, V.W. Armstrong, M. Oellerich, and S. Urien Population pharmacokinetics of mycophenolic acid in pediatric renal transplant patients using parametric and nonparametric approaches Pharmacol Res 2010 doi:10.1016/j.phrs.2010.10.017
    • (2010) Pharmacol Res
    • Prémaud, A.1    Weber, L.T.2    Tönshoff, B.3    Armstrong, V.W.4    Oellerich, M.5    Urien, S.6
  • 22
    • 70349976689 scopus 로고    scopus 로고
    • Limited sampling models and Bayesian estimation for mycophenolic acid area under the curve prediction in stable renal transplant patients co-medicated with ciclosporin or sirolimus
    • F.T. Musuamba, A. Rousseau, J.L. Bosmans, J.J. Senessael, J. Cumps, and P. Marquet Limited sampling models and Bayesian estimation for mycophenolic acid area under the curve prediction in stable renal transplant patients co-medicated with ciclosporin or sirolimus Clin Pharmacokinet 48 11 2009 745 758
    • (2009) Clin Pharmacokinet , vol.48 , Issue.11 , pp. 745-758
    • Musuamba, F.T.1    Rousseau, A.2    Bosmans, J.L.3    Senessael, J.J.4    Cumps, J.5    Marquet, P.6
  • 23
    • 23744457170 scopus 로고    scopus 로고
    • A double absorption-phase model adequately describes mycophenolic acid plasma profiles in De Novo renal transplant recipients given oral mycophenolate mofetil
    • DOI 10.2165/00003088-200544080-00005
    • A. Prémaud, J. Debord, A. Rousseau, Y. Le Meur, O. Toupance, and Y. Lebranchu A double absorption-phase model adequately describes mycophenolic acid plasma profiles in de novo renal transplant recipients given oral mycophenolate mofetil Clin Pharmacokinet 44 2005 837 847 (Pubitemid 41126931)
    • (2005) Clinical Pharmacokinetics , vol.44 , Issue.8 , pp. 837-847
    • Premaud, A.1    Debord, J.2    Rousseau, A.3    Le Meur, Y.4    Toupance, O.5    Lebranchu, Y.6    Hoizey, G.7    Le Guellec, C.8    Marquet, P.9
  • 24
    • 33750346955 scopus 로고    scopus 로고
    • Multidrug resistance protein 2 genetic polymorphisms influence mycophenolic acid exposure in renal allograft recipients
    • DOI 10.1097/01.tp.0000235533.29300.e7, PII 0000789020061027000012
    • M. Naesens, D.R.J. Kuypers, K. Verbeke, and Y. Vanrenterghem Multidrug Resistance protein 2 genetic polymorphisms influence mycophenolic acid exposure in renal allograft recipients Transplantation 2 8 2006 1074 1084 (Pubitemid 44632124)
    • (2006) Transplantation , vol.82 , Issue.8 , pp. 1074-1084
    • Naesens, M.1    Kuypers, D.R.J.2    Verbeke, K.3    Vanrenterghem, Y.4
  • 26
    • 73949148866 scopus 로고    scopus 로고
    • Feasibility of, and critical paths for mycophenolate mofetil Bayesian dose adjustment: Pharmacological re-appraisal of a concentration-controlled versus fixed-dose trial in renal transplant recipients
    • A. Prémaud, A. Rousseau, Y. Le Meur, N. Venisse, C. Loichot, and A. Turcant Feasibility of, and critical paths for mycophenolate mofetil Bayesian dose adjustment: pharmacological re-appraisal of a concentration-controlled versus fixed-dose trial in renal transplant recipients Pharmacol Res 61 2 2010 167 174
    • (2010) Pharmacol Res , vol.61 , Issue.2 , pp. 167-174
    • Prémaud, A.1    Rousseau, A.2    Le Meur, Y.3    Venisse, N.4    Loichot, C.5    Turcant, A.6
  • 27
    • 55949130835 scopus 로고    scopus 로고
    • Comparing mycophenolate mofetil regimens for de novo renal transplant recipients: The fixed-dose concentration-controlled trial
    • T. van Gelder, H.T. Silva, J.W. de Fijter, K. Budde, D. Kuypers, and G. Tyden Comparing mycophenolate mofetil regimens for de novo renal transplant recipients: the fixed-dose concentration-controlled trial Transplantation 86 8 2008 1043 1051
    • (2008) Transplantation , vol.86 , Issue.8 , pp. 1043-1051
    • Van Gelder, T.1    Silva, H.T.2    De Fijter, J.W.3    Budde, K.4    Kuypers, D.5    Tyden, G.6
  • 28
    • 0035116884 scopus 로고    scopus 로고
    • Pharmacokinetic, pharmacodynamic, and outcome investigations as the basis for mycophenolic acid therapeutic drug monitoring in renal and heart transplant patients
    • DOI 10.1016/S0009-9120(00)00184-3, PII S0009912000001843
    • L.M. Shaw, M. Korecka, D. DeNofrio, and K.L. Brayman Pharmacokinetic, pharmacodynamic, and outcome investigations as the basis for mycophenolic acid therapeutic drug monitoring in renal and heart transplant patients Clin Biochem 34 2001 17 22 (Pubitemid 32178501)
    • (2001) Clinical Biochemistry , vol.34 , Issue.1 , pp. 17-22
    • Shaw, L.M.1    Korecka, M.2    DeNofrio, D.3    Brayman, K.L.4
  • 29
    • 0034667746 scopus 로고    scopus 로고
    • Pharmacodynamics of mycophenolic acid in heart allograft recipients: Correlation of lymphocyte proliferation and activation with pharmacokinetics and graft histology
    • J.F. Gummert, M.J. Barten, T. Van Gelder, M.E. Billingham, and R.E. Morris Pharmacodynamics of mycophenolic acid in heart allograft recipients: correlation of lymphocyte proliferation and activation with pharmacokinetics and graft histology Transplantation 70 2000 1038 1049
    • (2000) Transplantation , vol.70 , pp. 1038-1049
    • Gummert, J.F.1    Barten, M.J.2    Van Gelder, T.3    Billingham, M.E.4    Morris, R.E.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.