Effect of Mycophenolate Mofetil Monotherapy on T-Cell Functions and Inosine Monophosphate Dehydrogenase Activity in Patients Undergoing a Kidney Transplantation

Transplantation Proceedings

Volumn 38, Issue 7, 2006, Pages 2292-2294

  Kamar, N ^a,b   Glander, P ^b   Nolting, J ^a   Bohler T ^a   Hambach, P ^a   Liefeldt, L ^a   Neumayer, H H ^a   Klupp, J ^c   Budde, K ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b TOULOUSE UNIVERSITY HOSPITAL   (France)

^c NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CD71 ANTIGEN; IMMUNOSUPPRESSIVE AGENT; INOSINATE DEHYDROGENASE; INTERLEUKIN 2 RECEPTOR ALPHA; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER;

ARTICLE; CELL PROLIFERATION; CLINICAL ARTICLE; CYTOKINE PRODUCTION; DISEASE ASSOCIATION; DISEASE MARKER; GRAFT REJECTION; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; KIDNEY TRANSPLANTATION; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION;

ANTIGENS, CD; BIOLOGICAL MARKERS; HUMANS; IMMUNOSUPPRESSIVE AGENTS; IMP DEHYDROGENASE; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; KIDNEY TRANSPLANTATION; LIVING DONORS; MYCOPHENOLIC ACID; RECEPTORS, TRANSFERRIN; T-LYMPHOCYTES;

EID: 33846072003     PISSN: 00411345     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.transproceed.2006.06.121     Document Type: Article

References (8)

1. Dambrin C., Klupp J., and Morris R.E. Pharmacodynamics of immunosuppressive drugs. Curr Opin Immunol 12 (2000) 557
2. Glander P., Hambach P., Braun K.P., et al. Pre-transplant inosine monophosphate dehydrogenase activity is associated with clinical outcome after renal transplantation. Am J Transplant 4 (2004) 2045
3. Barten M.J., van Gelder T., Gummert J.F., et al. Novel assays of multiple lymphocyte functions in whole blood measure: new mechanisms of action of mycophenolate mofetil in vivo. Transpl Immunol 10 (2002) 1
4. Glander P., Braun K.P., Hambach P., et al. Non-radioactive determination of inosine 5′-monophosphate dehydro-genase (IMPDH) in peripheral mononuclear cells. Clin Biochem 34 (2001) 543
5. Budde K., Glander P., Braun K.P., et al. Pharmacodynamic monitoring of mycophenolate mofetil in renal allograft recipients. Transplant Proc 33 (2001) 3313
6. Laurent A.F., Dumont S., Poindron P., et al. Mycophenolic acid suppresses protein N-linked glycosylation in human monocytes and their adhesion to endothelial cells and to some substrates. Exp Hematol 24 (1996) 59
7. Catapano C.V., Dayton J.S., Mitchell B.S., et al. GTP depletion induced by IMP dehydrogenase inhibitors blocks RNA-primed DNA synthesis. Mol Pharmacol 47 (1995) 948
8. Mustelin T. GTP dependence of the transduction of mitogenic signals through the T3 complex in T lymphocytes indicates the involvement of a G-protein. FEBS Lett 213 (1987) 199