Discovery of novel hepatoselective HMG-CoA reductase inhibitors for treating hypercholesterolemia: A bench-to-bedside case study on tissue selective drug distribution

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 9, 2011, Pages 2725-2731

  Pfefferkorn, Jeffrey A ^a   Litchfield, John ^a   Hutchings, Richard ^a   Cheng, Xue Min ^a   Larsen, Scott D ^a   Auerbach, Bruce ^a   Bush, Mark R ^a   Lee, Chitase ^a   Erasga, Noe ^a   Bowles, Daniel M ^a   Boyles, David C ^a   Lu, Gina ^a   Sekerke, Catherine ^a   Askew, Valerie ^a   Hanselman, Jeffrey C ^a   Dillon, Lisa ^a   Lin, Zhiwu ^a   Robertson, Andrew ^a   Olsen, Karl ^a   Boustany, Carine ^a   Atkinson, Karen ^a   Goosen, Theunis C ^a   Sahasrabudhe, Vaishali ^a   Chupka, Jonathan ^a   Duignan, David B ^a   Feng, Bo ^a   Scialis, Renato ^a   Kimoto, Emi ^a   Bi, Yi An ^a   Lai, Yurong ^a   El Kattan, Ayman ^a   Bakker Arkema, Rebecca ^a   Barclay, Paul ^a   Kindt, Erick ^a   Le, Vu ^a   Mandema, Jaap W ^a   Milad, Mark ^a   Tait, Bradley D ^a   Kennedy, Robert ^a   Trivedi, Bharat K ^a   Kowala, Mark ^a   more..

^a PFIZER INC   (United States)

Author keywords

Hepatoselective; HMG CoA reductase inhibitor; Hypercholesterolemia; Liver selective; Statin

Indexed keywords

7 [4 [(3 FLUOROBENZYL)CARBAMOYL] 5 CYCLOPROPYL 2 (4 FLUOROPHENYL) 1H IMIDAZOL 1 YL] 3,5 DIHYDROXYHEPTANOIC ACID; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; PF 03052334; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; CONFERENCE PAPER; CONTROLLED STUDY; DRUG DESIGN; DRUG DISTRIBUTION; DRUG HALF LIFE; HUMAN; HYPERCHOLESTEROLEMIA; LIVER CELL; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PROTEIN BINDING; RAT; TISSUE DISTRIBUTION;

ANIMALS; CELLS, CULTURED; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DISCOVERY; HEPATOCYTES; HEPTANOIC ACIDS; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; HYPERCHOLESTEROLEMIA; IMIDAZOLES; INHIBITORY CONCENTRATION 50; LIVER; MOLECULAR STRUCTURE; PYRAZOLES; RATS; TISSUE DISTRIBUTION;

EID: 79955475704     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.11.103     Document Type: Conference Paper

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