Discovery of potent nucleotide-mimicking competitive inhibitors of hepatitis C virus NS3 helicase

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 9, 2011, Pages 2776-2779

  Gemma, Sandra ^a   Butini, Stefania ^a   Campiani, Giuseppe ^a   Brindisi, Margherita ^a   Zanoli, Samantha ^a,b   Romano, Maria Pia ^a   Tripaldi, Pierangela ^a   Savini, Luisa ^a   Fiorini, Isabella ^a   Borrelli, Giuseppe ^a   Novellino, Ettore ^a,c   Maga, Giovanni ^a,b  

^a UNIVERSITY OF SIENA   (Italy)

^b CNR   (Italy)

^c UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

HCV; Helicase; Hydrazides

Indexed keywords

ANTIVIRUS AGENT; ENZYME INHIBITOR; HELICASE; HYDRAZIDE DERIVATIVE; NONSTRUCTURAL PROTEIN 3;

COMPETITIVE INHIBITION; CONFERENCE PAPER; DRUG POTENCY; DRUG STRUCTURE; ENZYME INHIBITION; HEPATITIS C VIRUS;

BINDING, COMPETITIVE; DRUG DISCOVERY; HEPACIVIRUS; HYDRAZINES; PROTEIN BINDING; PYRAZINES; QUINOLINES; VIRAL NONSTRUCTURAL PROTEINS;

HEPATITIS C VIRUS;

EID: 79955467262     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.09.002     Document Type: Conference Paper

References (22)

1. Q.L. Choo , G. Kuo , A.J. Weiner , L.R. Overby , D.W. Bradley , and M. Houghton Science 244 1989 359
2. A. Ascione , T. Tartaglione , and G.G. Di Costanzo Dig. Liver Dis. 39 2007 S4
3. M.K. Jain , and C. Zoellner Expert. Opin. Pharmacother. 11 2010 673
4. D.P. Webster , P. Klenerman , J. Collier , and K.J. Jeffery Lancet Infect. Dis. 9 2009 108
5. A. Opar Nat. Rev. Drug Discov. 9 2010 501
6. A.A. Kolykhalov , K. Mihalik , S.M. Feinstone , and C.M. Rice J. Virol. 74 2000 2046
7. P. Borowski , S. Schalinski , and H. Schmitz Antiviral Res. 55 2002 397
8. C.L. Tai , W.K. Chi , D.S. Chen , and L.H. Hwang J. Virol. 70 1996 8477
9. Y. Gwack , D.W. Kim , J.H. Han , and J. Choe Eur. J. Biochem. 250 1997 47
10. A. Sampath , and R. Padmanabhan Antiviral Res. 81 2009 6
11. C.P. Gordon , and P.A. Keller J. Med. Chem. 48 2005 1
12. C.S. Chen , C.T. Chiou , G.S. Chen , S.C. Chen , C.Y. Hu , W.K. Chi , Y.D. Chu , L.H. Hwang , P.J. Chen , D.S. Chen , S.H. Liaw , and J.W. Chern J. Med. Chem. 52 2009 2716
13. P. Borowski , J. Deinert , S. Schalinski , M. Bretner , K. Ginalski , T. Kulikowski , and D. Shugar Eur. J. Biochem. 270 2003 1645
14. M. Krawczyk , M. Wasowska-Lukawska , I. Oszczapowicz , and A.M. Boguszewska-Chachulska Biol. Chem. 390 2009 351
15. Diana, G. D.; Bailey, T. R. U.S. 5633,388, 1997.
16. Janetka, J. W. L.; Mullican, M. D. WO 00/24725, 2000.
17. C.W. Phoon , P.Y. Ng , A.E. Ting , S.L. Yeo , and M.M. Sim Bioorg. Med. Chem. Lett. 11 2001 1647
18. S. Kandil , S. Biondaro , D. Vlachakis , A.C. Cummins , A. Coluccia , C. Berry , P. Leyssen , J. Neyts , and A. Brancale Bioorg. Med. Chem. Lett. 19 2009 2935
19. G. Maga , S. Gemma , C. Fattorusso , G.A. Locatelli , S. Butini , M. Persico , G. Kukreja , M.P. Romano , L. Chiasserini , L. Savini , E. Novellino , V. Nacci , S. Spadari , and G. Campiani Biochemistry 44 2005 9637
20. G. Campiani , F. Aiello , M. Fabbrini , E. Morelli , A. Ramunno , S. Armaroli , V. Nacci , A. Garofalo , G. Greco , E. Novellino , G. Maga , S. Spadari , A. Bergamini , L. Ventura , B. Bongiovanni , M. Capozzi , F. Bolacchi , S. Marini , M. Coletta , G. Guiso , and G. Caccia J. Med. Chem. 44 2001 305
21. S. Gemma , G. Kukreja , P. Tripaldi , M. Altarelli , M. Bernetti , S. Franceschini , L. Savini , G. Campiani , C. Fattorusso , and S. Butini Tetrahedron Lett. 49 2008 2074
22. G. Campiani , C. Fattorusso , S. Butini , A. Gaeta , M. Agnusdei , S. Gemma , M. Persico , B. Catalanotti , L. Savini , V. Nacci , E. Novellino , H.W. Holloway , N.H. Greig , T. Belinskaya , J.M. Fedorko , and A. Saxena J. Med. Chem. 48 2005 1919