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Volumn 152, Issue 5, 2011, Pages 2076-2089

SMAD3 dosage determines androgen responsiveness and sets the pace of postnatal testis development

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN RECEPTOR; FOLLITROPIN; SMAD2 PROTEIN; SMAD3 PROTEIN;

EID: 79955422716     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2010-1453     Document Type: Article
Times cited : (30)

References (62)
  • 1
    • 0035004535 scopus 로고    scopus 로고
    • Testicular dysgenesis syndrome: An increasingly common developmental disorder with environmental aspects
    • Skakkebaek NE, Rajpert-De Meyts E, Main KM 2001 Testicular dysgenesis syndrome: an increasingly common developmental disorder with environmental aspect. Hum Reprod 16:972-978 (Pubitemid 32451837)
    • (2001) Human Reproduction , vol.16 , Issue.5 , pp. 972-978
    • Skakkebaek, N.E.1    Rajpert-De Meyts, E.2    Main, K.M.3
  • 2
    • 0023901568 scopus 로고
    • Evidence from Sertoli cell-depleted rats indicates that spermatid number in adults depends on numbers of Sertoli cells produced during perinatal development
    • Orth JM, Gunsalus GL, Lamperti AA 1988 Evidence from Sertoli cell-depleted rats indicates that spermatids number in adults depends on number of Sertoli cells produced during perinatal development. Endocrinology 122:787-794 (Pubitemid 18082030)
    • (1988) Endocrinology , vol.122 , Issue.3 , pp. 787-794
    • Orth, J.M.1    Gunsalus, G.L.2    Lamperti, A.A.3
  • 3
    • 65249154823 scopus 로고    scopus 로고
    • Androgen receptor roles in spermatogenesis and fertility: Lessons from testicular cell-specific androgen receptor knockout mice
    • Wang RS, Yeh S, Tzeng CR, Chang C 2009 Androgen receptor roles in spermatogenesis and fertility: lessons from testicular cell-specific androgen receptor knockout mice. Endocr Rev 30:119-132
    • (2009) Endocr Rev. , vol.30 , pp. 119-132
    • Wang, R.S.1    Yeh, S.2    Tzeng, C.R.3    Chang, C.4
  • 4
    • 33645918999 scopus 로고    scopus 로고
    • The Blood-Testis Barrier: Its Biology, Regulation, and Physiological Role in Spermatogenesis
    • DOI 10.1016/S0070-2153(05)71008-5, PII S0070215305710085
    • Wong CH, Cheng CY 2005 The blood-testis barrier: its biology, regulation and physiological role in spermatogenesis. Curr Topics Dev Biol 71:263-296 (Pubitemid 43588888)
    • (2005) Current Topics in Developmental Biology , vol.71 , pp. 263-296
    • Wong, C.1    Cheng, C.Y.2
  • 6
    • 0038346008 scopus 로고    scopus 로고
    • Proliferation and functional maturation of Sertoli cells, and their relevance to disorders of testis function in adulthood
    • Sharpe RM, McKinnell C, Kivlin C, Fisher JS 2003 Proliferation and functional maturation of Sertoli cells and their relevance to disorders of testis function in adulthood. Reproduction 125:769-784 (Pubitemid 36722545)
    • (2003) Reproduction , vol.125 , Issue.6 , pp. 769-784
    • Sharpe, R.M.1    McKinnell, C.2    Kivlin, C.3    Fisher, J.S.4
  • 7
    • 23944508939 scopus 로고    scopus 로고
    • Understanding the role of thyroid hormone in Sertoli cell development: A mechanistic hypothesis
    • DOI 10.1007/s00441-005-1082-z
    • Holsberger DR, Cooke PS 2005 Understanding the role of thyroid hormone in Sertoli cell development: a mechanistic hypothesis. Cell Tissue Res 322:133-140 (Pubitemid 41677664)
    • (2005) Cell and Tissue Research , vol.322 , Issue.1 , pp. 133-140
    • Holsberger, D.R.1    Cooke, P.S.2
  • 9
    • 0028790956 scopus 로고
    • Activin stimulates Sertoli cell proliferation in a defined period of rat testis development
    • Boitani C, Stefanini M, Fragale A, Morena AR 1995 Activin stimulates Sertoli cell proliferation in a defined period of rat testis development. Endocrinology 136:5438-5444
    • (1995) Endocrinology , vol.136 , pp. 5438-5444
    • Boitani, C.1    Stefanini, M.2    Fragale, A.3    Morena, A.R.4
  • 10
    • 0037320544 scopus 로고    scopus 로고
    • Proliferative phase Sertoli cells display a developmentally regulated response to activin in vitro
    • DOI 10.1210/en.2002-220595
    • Buzzard JJ, Farnworth PG, DeKretser DM, O'Connor AE, Wreford NG, Morrison JR 2003 Proliferative phase Sertoli cells display a developmentally regulated response to activin in vitro. Endocrinology 144:474-483 (Pubitemid 36205218)
    • (2003) Endocrinology , vol.144 , Issue.2 , pp. 474-483
    • Buzzard, J.J.1    Farnworth, P.G.2    De Kretser, D.M.3    O'Connor, A.E.4    Wreford, N.G.5    Morrison, J.R.6
  • 11
    • 77954917321 scopus 로고    scopus 로고
    • Regulation of bloodtestis barrier dynamics by TGF-β3 is a Cdc42-dependent protein trafficking event
    • Wong EW, Mruk DD, Lee WM, Cheng C 2010 Regulation of bloodtestis barrier dynamics by TGF-β3 is a Cdc42-dependent protein trafficking event. Proc Natl Acad Sci USA 107:11399-11404
    • (2010) Proc. Natl. Acad. Sci. USA , vol.107 , pp. 11399-11404
    • Wong, E.W.1    Mruk, D.D.2    Lee, W.M.3    Cheng, C.4
  • 13
    • 78751681537 scopus 로고    scopus 로고
    • Activin A balances Sertoli and germ cell proliferation in the fetal mouse testis
    • Mendis S, Meachem S, Sarraj M, Loveland KL 2010 Activin A balances Sertoli and germ cell proliferation in the fetal mouse testis. Biol Reprod 84:379-391
    • (2010) Biol. Reprod. , vol.84 , pp. 379-391
    • Mendis, S.1    Meachem, S.2    Sarraj, M.3    Loveland, K.L.4
  • 14
    • 0026621796 scopus 로고
    • α-Inhibin is a tumour-suppressor gene with gonadal specificity in mice
    • DOI 10.1038/360313a0
    • Matzuk MM, Finegold MJ, Su JG, Hsueh AJ, Bradley A 1992 α-Inhibin is a tumour-suppressor gene with gonadal specificity in mice. Nature 360:313-319 (Pubitemid 23000668)
    • (1992) Nature , vol.360 , Issue.6402 , pp. 313-319
    • Matzuk, M.M.1    Finegold, M.J.2    Su, J.-G.J.3    Hsueh, A.J.W.4    Bradley, A.5
  • 15
    • 33747635422 scopus 로고    scopus 로고
    • Pituitary actions of ligands of the TGF-β family: Activins and inhibins
    • DOI 10.1530/rep.1.01073
    • Bilezikjian LM, Blount AL, Donaldson CJ, Vale WW 2006 Pituitary actions of ligands of the TGF-β family: activins and inhibins. Reproduction 132:207-215 (Pubitemid 44269703)
    • (2006) Reproduction , vol.132 , Issue.2 , pp. 207-215
    • Bilezikjian, L.M.1    Blount, A.L.2    Donaldson, C.J.3    Vale, W.W.4
  • 16
    • 0035218347 scopus 로고    scopus 로고
    • Age-dependent activin receptor expression pinpoints activin A as a physiological regulator of rat Sertoli cell proliferation
    • Fragale A, Puglisi R, Morena AR, Stefanini M, Boitani C 2001 Age-dependent activin receptor expression pinpoints activin A as a physiological regulator of rat Sertoli cell proliferation. Mol Hum Reprod 7:1107-1114 (Pubitemid 33150205)
    • (2001) Molecular Human Reproduction , vol.7 , Issue.12 , pp. 1107-1114
    • Fragale, A.1    Puglisi, R.2    Morena, A.R.3    Stefanini, M.4    Boitani, C.5
  • 17
    • 0038682002 scopus 로고    scopus 로고
    • Mechanisms of TGF-β signaling from cell membrane to the nucleus
    • DOI 10.1016/S0092-8674(03)00432-X
    • Shi Y, Massague J 2003 Mechanisms of TGF-β signalling from cell membrane to the nucleus. Cell 113:685-700 (Pubitemid 36724933)
    • (2003) Cell , vol.113 , Issue.6 , pp. 685-700
    • Shi, Y.1    Massague, J.2
  • 19
    • 0032544448 scopus 로고    scopus 로고
    • Smad3 mutant mice develop metastatic colorectal cancer
    • DOI 10.1016/S0092-8674(00)81730-4
    • Zhu Y, Richardson JA, Parada LF, Graff JM 1998 Smad3 mutant mice develop metastatic colorectal cancer. Cell 94:703-714 (Pubitemid 28436003)
    • (1998) Cell , vol.94 , Issue.6 , pp. 703-714
    • Yuan, Z.1    Richardson, J.A.2    Parada, L.F.3    Graft, J.M.4
  • 21
    • 0034655352 scopus 로고    scopus 로고
    • Regulation of germ cell and sertoli cell development by activin, follistatin, and FSH
    • DOI 10.1006/dbio.2000.9625
    • Meehan T, Schlatt S, O'Bryan MK, de Kretser DM, Loveland KL 2000 Regulation of germ cell and Sertoli cell development by activin, follistatin and FSH. Dev Biol 220:225-237 (Pubitemid 30228149)
    • (2000) Developmental Biology , vol.220 , Issue.2 , pp. 225-237
    • Meehan, T.1    Schlatt, S.2    O'Bryan, M.K.3    De Kretser, D.M.4    Loveland, K.L.5
  • 23
    • 38149044891 scopus 로고    scopus 로고
    • SMAD expression in the testis: An insight into BMP regulation of spermatogenesis
    • Itman C, Loveland KL 2008 SMAD expression in the testis: an insight into BMP regulation of spermatogenesis. Dev Dyn 237:97-111
    • (2008) Dev. Dyn , vol.237 , pp. 97-111
    • Itman, C.1    Loveland, K.L.2
  • 24
    • 17344392308 scopus 로고    scopus 로고
    • A new mathematical model for relative quantification in real-time RT-PCR
    • Pfaffl MW 2001 A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 29: e45
    • (2001) Nucleic Acids Res. , vol.29
    • Pfaffl, M.W.1
  • 25
    • 74049087175 scopus 로고    scopus 로고
    • An RNA spiking method demonstrates that 18S rRNA is regulated by progesterone in the mouse uterus
    • Craythorn RG, Girling JE, Hedger MP, Rogers PA, Winnall WR 2009 An RNA spiking method demonstrates that 18S rRNA is regulated by progesterone in the mouse uterus. Mol Hum Reprod 15:757-761
    • (2009) Mol. Hum. Reprod. , vol.15 , pp. 757-761
    • Craythorn, R.G.1    Girling, J.E.2    Hedger, M.P.3    Rogers, P.A.4    Winnall, W.R.5
  • 26
    • 0018938263 scopus 로고
    • Establishment and characterization of two distinct mouse testicular epithelial cell lines
    • DOI 10.1095/biolreprod23.1.243
    • Mather JP 1980 Establishment and characterisation of two distinct mouse testicular epithelial cell lines. Biol Reprod 23:243-252 (Pubitemid 10015343)
    • (1980) Biology of Reproduction , vol.23 , Issue.1 , pp. 243-252
    • Mather, J.P.1
  • 27
    • 34547600509 scopus 로고    scopus 로고
    • Claudin-11 expression and localisation is regulated by androgens in rat Sertoli cells in vitro
    • DOI 10.1530/REP-06-0385
    • Kaitu'u-Lino T, Sluka P, Foo CFH, Stanton PG 2007 Claudin-11 expression and localization is regulated by androgens in rat Sertoli cells in vitro. Reproduction 133:1169-1179 (Pubitemid 47194246)
    • (2007) Reproduction , vol.133 , Issue.6 , pp. 1169-1179
    • Kaitu'u-Lino, T.J.1    Sluka, P.2    Foo, C.F.H.3    Stanton, P.G.4
  • 28
    • 34948905649 scopus 로고    scopus 로고
    • Genetic removal of Smad3 from inhibin-null mice attenuates tumor progression by uncoupling extracellular mitogenic signals from the cell cycle machinery
    • DOI 10.1210/me.2006-0402
    • Looyenga BD, Hammer GD 2007 Genetic removal of Smad3 from inhibin-null mice attenuates tumor progression by uncoupling extracellular mitogenic signals from the cell cycle machinery. Mol Endocrinol 21:2440-2457 (Pubitemid 47529357)
    • (2007) Molecular Endocrinology , vol.21 , Issue.10 , pp. 2440-2457
    • Looyenga, B.D.1    Hammer, G.D.2
  • 29
    • 0025678485 scopus 로고
    • Proliferating cell nuclear antigen (PCNA) immunolocalization in paraffin sections: An index of cell proliferation with evidence of deregulated expression in some neoplasms
    • Hall PA, Levison DA, Woods AL, Yu CC, Kellock DB, Watkins JA, Barnes DM, Gillett CE, Camplejohn R, Dover R, et al. 1990 Proliferating cell nuclear antigen (PCNA) immunolocalization in paraffin sections: an index of cell proliferation with evidence of deregulated expression in some neoplasms. J Pathol 162:285-294
    • (1990) J. Pathol. , vol.162 , pp. 285-294
    • Hall, P.A.1    Levison, D.A.2    Woods, A.L.3    Yu, C.C.4    Kellock, D.B.5    Watkins, J.A.6    Barnes, D.M.7    Gillett, C.E.8    Camplejohn, R.9    Dover, R.10
  • 30
    • 0034827067 scopus 로고    scopus 로고
    • Vasa homolog genes in mammalian germ cell development
    • DOI 10.1247/csf.26.131
    • Noce T, Okamoto-Ito S, Tsunekawa N 2001 Vasa homolog genes in mammalian germ cell development. Cell Structure Funct 26:131-136 (Pubitemid 32894079)
    • (2001) Cell Structure and Function , vol.26 , Issue.3 , pp. 131-136
    • Noce, T.1    Okamoto-Ito, S.2    Tsunekawa, N.3
  • 33
    • 0036195674 scopus 로고    scopus 로고
    • Changes in Leydig cell gene expression during development in the mouse
    • O'Shaughnessy PJ, Willerton L, Baker PJ 2002 Changes in Leydig cell gene expression during development in the mouse. Biol Reprod 66:966-975 (Pubitemid 34263116)
    • (2002) Biology of Reproduction , vol.66 , Issue.4 , pp. 966-975
    • O'Shaughnessy, P.J.1    Willerton, L.2    Baker, P.J.3
  • 34
    • 0026094395 scopus 로고
    • Role of c-kit in mouse spermatogenesis: Identification of spermatogonia as a specific site of c-kit expression and function
    • Yoshinaga K, Nishikawa S, Ogawa M, Hayashi S, Kunisada T, Fujimoto T, Nishikawa S 1991 Role of c-kit in mouse spermatogenesis: identification of spermatogonia as a specific site of c-kit expression and function. Development 113:689-699
    • (1991) Development , vol.113 , pp. 689-699
    • Yoshinaga, K.1    Nishikawa, S.2    Ogawa, M.3    Hayashi, S.4    Kunisada, T.5    Fujimoto, T.6    Nishikawa, S.7
  • 35
    • 0344131384 scopus 로고    scopus 로고
    • Migration and ultrastructural localization of the c-kit receptor protein in spermatogenic cells and spermatozoa of the mouse
    • DOI 10.1016/S0022-5347(05)69003-9
    • Sandlow JI, Feng HL, Zheng LJ, Sandra A 1999 Migration and ultrastructural localization of the c-kit receptor proteininspermatogenic cells and spermatozoa of the mouse. J Urol 161:1676-1680 (Pubitemid 29420861)
    • (1999) Journal of Urology , vol.161 , Issue.5 , pp. 1676-1680
    • Sandlow, J.I.1    Feng, H.L.2    Zheng, L.J.3    Sandra, A.4
  • 37
    • 0026067317 scopus 로고
    • Expression of the c-kit proto-oncogene in the murine male germ cells
    • Sorrentino V, Giorgi M, Geremia R, Besmer P, Rossi P 1991 Expression of the c-kit proto-oncogene in the murine male germ cells. Oncogene 6:149-151 (Pubitemid 21923995)
    • (1991) Oncogene , vol.6 , Issue.1 , pp. 149-151
    • Sorrentino, V.1    Giorgi, M.2    Geremia, R.3    Besmer, P.4    Rossi, P.5
  • 38
    • 0027958447 scopus 로고
    • The gene encoding a major component of the lateral elements of synaptonemal complexes of the rat is related to X-linked lymphocyte-regulated genes
    • Lammers JH, Offenberg HH, van Aalderen M, Vink AC, Dietrich AJ, Heyting C 1994 The gene encoding a major component of the lateral elements of synaptonemal complexes of the rat is related to X-linked lymphocyte-regulated genes. Mol Cell Biol 14:1137-1146 (Pubitemid 24036564)
    • (1994) Molecular and Cellular Biology , vol.14 , Issue.2 , pp. 1137-1146
    • Lammers, J.H.M.1    Offenberg, H.H.2    Van Aalderen, M.3    Vink, A.C.G.4    Dietrich, A.J.J.5    Heyting, C.6
  • 39
    • 0026538427 scopus 로고
    • Expression of a glyceraldehyde 3-phosphate dehydrogenase gene specific to mouse spermatogenic cells
    • Welch JE, Schatte EC, O'Brien DA, Eddy EM 1992 Expression of a glyceraldehyde 3-phosphate dehydrogenase gene specific to mouse spermatogenic cells. Biol Reprod 46:869-878
    • (1992) Biol. Reprod. , vol.46 , pp. 869-878
    • Welch, J.E.1    Schatte, E.C.2    O'Brien, D.A.3    Eddy, E.M.4
  • 42
    • 18844407557 scopus 로고    scopus 로고
    • The role of androgens in sertoli cell proliferation and functional maturation: Studies in mice with total or sertoli cell-selective ablation of the androgen receptor
    • DOI 10.1210/en.2004-1630
    • Tan KA, De Gendt K, Atanassova N, Walker M, Sharpe RM, Saunders PT, Denolet E, Verhoeven G 2005 The role of androgens in Sertoli cell proliferation and functional maturation: studies in mice with total or Sertoli cell-selective ablation of the androgen receptor. Endocrinology 146:2674-2683 (Pubitemid 40695570)
    • (2005) Endocrinology , vol.146 , Issue.6 , pp. 2674-2683
    • Tan, K.A.L.1    De Gendt, K.2    Atanassova, N.3    Walker, M.4    Sharpe, R.M.5    Saunders, P.T.K.6    Denolet, E.7    Verhoeven, G.8
  • 43
    • 0042529299 scopus 로고    scopus 로고
    • Thyroid hormone, retinoic acid, and testosterone suppress proliferation and induce markers of differentiation in cultured rat Sertoli cells
    • DOI 10.1210/en.2003-0379
    • Buzzard JJ, Wreford NG, Morrison JR 2003 Thyroid hormone, retinoic acid and testosterone suppress proliferation and induce markers of differentiation in cultured rat Sertoli cells. Endocrinology 144:3722-3731 (Pubitemid 37088722)
    • (2003) Endocrinology , vol.144 , Issue.9 , pp. 3722-3731
    • Buzzard, J.J.1    Wreford, N.G.2    Morrison, J.R.3
  • 47
    • 70349086989 scopus 로고    scopus 로고
    • Activin A enhances prostate cancer cell migration through activation of androgen receptor and is overexpressedin metastatic prostate cancer
    • Kang HY, Huang HY, Hsieh CY, Li CF, Shyr CR, Tsai MY, Chang C, Chuang YC, Huang KE 2009 Activin A enhances prostate cancer cell migration through activation of androgen receptor and is overexpressedin metastatic prostate cancer. J Bone Miner Res 24:1180-1193
    • (2009) J. Bone Miner. Res. , vol.24 , pp. 1180-1193
    • Kang, H.Y.1    Huang, H.Y.2    Hsieh, C.Y.3    Li, C.F.4    Shyr, C.R.5    Tsai, M.Y.6    Chang, C.7    Chuang, Y.C.8    Huang, K.E.9
  • 48
    • 15544382569 scopus 로고    scopus 로고
    • Androgen-regulated transcripts in the neonatal mouse testis as determined through microarray analysis
    • DOI 10.1095/biolreprod.104.035915
    • Zhou Q, Shima JE, Nie R, Friel PJ, Griswold MD 2005 Androgenregulated transcripts in the neonatal mouse testis as determined through microarray analysis. Biol Reprod 72:1010-1019 (Pubitemid 40404280)
    • (2005) Biology of Reproduction , vol.72 , Issue.4 , pp. 1010-1019
    • Zhou, Q.1    Shima, J.E.2    Nie, R.3    Friel, P.J.4    Griswold, M.D.5
  • 51
    • 0016767238 scopus 로고
    • Normal spermatozoa from androgen-resistant germ cells of chimeric mice and the role of androgen in spermatogenesis
    • Lyon MF, Glenister PH, Lamoreux ML 1975 Normal spermatozoa from androgen-resistant germ cells of chimeric mice and the role of androgen in spermatogenesis. Nature 258:620-622
    • (1975) Nature , vol.258 , pp. 620-622
    • Lyon, M.F.1    Glenister, P.H.2    Lamoreux, M.L.3
  • 53
    • 29644445928 scopus 로고    scopus 로고
    • Atypical development of Sertoli cells and impairment of spermatogenesis in the hypogonadal (hpg) mouse
    • DOI 10.1111/j.1469-7580.2005.00493.x
    • Myers M, Ebling FJ, Nwagwu M, Boulton R, Wadhwa K, Stewart J, Kerr JB 2005 Atypical development of Sertoli cells and impairment of spermatogenesis in the hypogonadal (hpg) mouse. J Anat 207:797-811 (Pubitemid 43019738)
    • (2005) Journal of Anatomy , vol.207 , Issue.6 , pp. 797-811
    • Myers, M.1    Ebling, F.J.P.2    Nwagwu, M.3    Boulton, R.4    Wadhwa, K.5    Stewart, J.6    Kerr, J.B.7
  • 54
    • 0033304579 scopus 로고    scopus 로고
    • Spermatogenesis without gonadotropins: Maintenance has a lower testosterone threshold than initiation
    • Handelsman DJ, Spaliviero JA, Simpson JM, Allan CM, Singh J 1999 Spermatogenesis without gonadotropins: maintenance has a lower testosterone threshold than initiation. Endocrinology 140:3938-3946 (Pubitemid 30647087)
    • (1999) Endocrinology , vol.140 , Issue.9 , pp. 3938-3946
    • Handelsman, D.J.1    Spaliviero, J.A.2    Simpson, J.M.3    Allan, C.M.4    Singh, J.5
  • 58
    • 33645215270 scopus 로고    scopus 로고
    • Endocrine disrupters and human puberty
    • discussion 286-290
    • Den Hond E, Schoeters G 2006 Endocrine disrupters and human puberty. Int J Androl 29:264-271; discussion 286-290
    • (2006) Int. J. Androl. , vol.29 , pp. 264-271
    • Hond, E.D.1    Schoeters, G.2
  • 62
    • 33846213525 scopus 로고    scopus 로고
    • Calmodulin-androgen receptor (AR) interaction: Calcium-dependent, calpain-mediated breakdown of AR in LNCaP prostate cancer cells
    • DOI 10.1158/0008-5472.CAN-06-2918
    • Pelley RP, Chinnakannu K, Murthy S, Strickland FM, Menon M, Dou QP, Barrack ER, Reddy GP 2006 Calmodulin-androgen receptor (AR) interaction: calcium-dependent, calpain-mediated breakdown of AR in LNCaP prostate cancer cells. Cancer Res 66:11754-11762 (Pubitemid 46094187)
    • (2006) Cancer Research , vol.66 , Issue.24 , pp. 11754-11762
    • Pelley, R.P.1    Chinnakannu, K.2    Murthy, S.3    Strickland, F.M.4    Menon, M.5    Dou, Q.P.6    Barrack, E.R.7    Reddy, G.P.-V.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.