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Volumn 152, Issue 5, 2011, Pages 1742-1744

The role played by the peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) activator, GW501516, in control of fatty acid metabolism: A new potential therapeutic target for treating metabolic syndrome

Author keywords

[No Author keywords available]

Indexed keywords

[2 METHYL 4 [4 METHYL 2 (4 TRIFLUOROMETHYLPHENYL) 5 THIAZOLYLMETHYLTHIO]PHENOXY]ACETIC ACID; GW 0472; GW 1514; GW 610742; HYDROCORTISONE; LIPOPROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA AGONIST; UNCLASSIFIED DRUG;

EID: 79955420151     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2011-0211     Document Type: Article
Times cited : (8)

References (22)
  • 1
    • 17144380822 scopus 로고    scopus 로고
    • The metabolic syndrome
    • DOI 10.1016/S0140-6736(05)66378-7
    • Eckel RH, Grundy SM, Zimmet PZ 2005 The metabolic syndrome. Lancet 365:1415-1428 (Pubitemid 40523737)
    • (2005) Lancet , vol.365 , Issue.9468 , pp. 1415-1428
    • Eckel, R.H.1    Grundy, S.M.2    Zimmet, P.Z.3
  • 2
    • 0037048669 scopus 로고    scopus 로고
    • Prevalence and trends in obesity among U. S. adults, 1999-2000
    • Flegal KM, Carroll MD, Ogden CL, Johnson CL 2002 Prevalence and trends in obesity among U. S. adults, 1999-2000. JAMA 288:1723-1727
    • (2002) JAMA , vol.288 , pp. 1723-1727
    • Flegal, K.M.1    Carroll, M.D.2    Ogden, C.L.3    Johnson, C.L.4
  • 3
    • 0037116641 scopus 로고    scopus 로고
    • Prevalence of the metabolic syndrome among US adults: Findings from the Third National Health and Nutrition Examination Survey
    • Ford ES, Giles WH, Dietz WH 2002 Prevalence of the metabolic syndrome among U. S. adults: findings from the third National Health and Nutrition Examination Survey. JAMA 287:356-359 (Pubitemid 34251969)
    • (2002) Journal of the American Medical Association , vol.287 , Issue.3 , pp. 356-359
    • Ford, E.S.1    Giles, W.H.2    Dietz, W.H.3
  • 4
    • 14544268116 scopus 로고    scopus 로고
    • Regulatory role of peroxisome proliferator-activated receptor delta (PPARδ) in muscle metabolism. A new target for metabolic syndrome treatment?
    • DOI 10.1016/j.biochi.2004.11.009
    • Grimaldi PA 2005 Regulatory role of peroxisome proliferator-activated receptor δ (PPARδ) in muscle metabolism. A new target for metabolic syndrome treatment? Biochimie (Paris) 87:5-8 (Pubitemid 40298758)
    • (2005) Biochimie , vol.87 , Issue.1 SPEC. ISSUE , pp. 5-8
    • Grimaldi, P.A.1
  • 6
    • 0027092522 scopus 로고
    • Abdominal obesity and the metabolic syndrome
    • Björntorp P 1992 Abdominal obesity and the metabolic syndrome. Ann Med 24:465-468 (Pubitemid 23014471)
    • (1992) Annals of Medicine , vol.24 , Issue.6 , pp. 465-468
    • Bjorntorp, P.1
  • 7
    • 10744233405 scopus 로고    scopus 로고
    • Effect of Abdominal Obesity on Insulin Resistance and the Components of the Metabolic Syndrome: Evidence Supporting Obesity as the Central Feature
    • DOI 10.1381/096089203322509255
    • Türkoglu C, Duman BS, Günay D, Cagatay P, Ozcan R, Büyükdevrim AS 2003 Effect of abdominal obesity on insulin resistance and the components of the metabolic syndrome: evidence supporting obesity as the central feature. Obes Surg 13:699-705 (Pubitemid 37352552)
    • (2003) Obesity Surgery , vol.13 , Issue.5 , pp. 699-705
    • Turkoglu, C.1    Duman, B.S.2    Gunay, D.3    Cagatay, P.4    Ozcan, R.5    Buyukdevrim, A.S.6
  • 8
    • 46249093117 scopus 로고    scopus 로고
    • Overproduction of very low-density lipoproteins is the hallmark of the dyslipidemia in the metabolic syndrome
    • Adiels M, Olofsson SO, Taskinen MR, Borén J 2008 Overproduction of very low-density lipoproteins is the hallmark of the dyslipidemia in the metabolic syndrome. Arterioscler Thromb Vasc Biol 28:1225-1236
    • (2008) Arterioscler Thromb. Vasc. Biol. , vol.28 , pp. 1225-1236
    • Adiels, M.1    Olofsson, S.O.2    Taskinen, M.R.3    Borén, J.4
  • 9
    • 49749121789 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor δ-agonist, GW501516, ameliorates insulin resistance, improves dyslipidaemia in monosodium L-glutamate metabolic syndrome mice
    • Chen W, Wang LL, Liu HY, Long L, Li S 2008 Peroxisome proliferator-activated receptor δ-agonist, GW501516, ameliorates insulin resistance, improves dyslipidaemia in monosodium L-glutamate metabolic syndrome mice. Basic Clin Pharmacol Toxicol 103:240-246
    • (2008) Basic Clin. Pharmacol. Toxicol. , vol.103 , pp. 240-246
    • Chen, W.1    Wang, L.L.2    Liu, H.Y.3    Long, L.4    Li, S.5
  • 10
  • 11
    • 34547136480 scopus 로고    scopus 로고
    • New therapeutic target for metabolic syndrome: PPARδ
    • DOI 10.1507/endocrj.KR-99
    • Takahashi S, Tanaka T, Sakai J 2007 New therapeutic target for metabolic syndrome: PPARδ. Endocr J 54:347-357 (Pubitemid 47105421)
    • (2007) Endocrine Journal , vol.54 , Issue.3 , pp. 347-357
    • Takahashi, S.1    Tanaka, T.2    Sakai, J.3
  • 12
    • 26844431513 scopus 로고    scopus 로고
    • Dual and pan-peroxisome proliferator-activated receptors (PPAR) co-agonism: The bezafibrate lessons
    • Tenenbaum A, Motro M, Fisman EZ 2005 Dual and pan-peroxisome proliferator-activated receptors (PPAR) co-agonism: the bezafibrate lessons. Cardiovasc Diabetol 16:14
    • (2005) Cardiovasc. Diabetol , vol.16 , pp. 14
    • Tenenbaum, A.1    Motro, M.2    Fisman, E.Z.3
  • 13
    • 34548182594 scopus 로고    scopus 로고
    • PPAR dual agonists: Are they opening Pandora's Box?
    • DOI 10.1016/j.phrs.2007.03.002, PII S1043661807000503
    • Balakumar P, Rose M, Ganti SS, Krishan P, Singh M 2007 PPAR dual agonists: are they opening Pandora's box? Pharmacol Res 56:91-98 (Pubitemid 47304493)
    • (2007) Pharmacological Research , vol.56 , Issue.2 , pp. 91-98
    • Balakumar, P.1    Rose, M.2    Ganti, S.S.3    Krishan, P.4    Singh, M.5
  • 14
    • 77950202392 scopus 로고    scopus 로고
    • Activation of peroxisome proliferator-activated receptor-δ by GW501516 prevents fatty acidinduced nuclear factor κB activation and insulin resistance in skeletal muscle cells
    • Coll T, Alvarez-Guardia D, Barroso E, Gómez-Foix AM, Palomer X, Laguna JC, Vázquez-Carrera M 2010 Activation of peroxisome proliferator-activated receptor-δ by GW501516 prevents fatty acidinduced nuclear factor κB activation and insulin resistance in skeletal muscle cells. Endocrinology 151:1560-1569
    • (2010) Endocrinology , vol.151 , pp. 1560-1569
    • Coll, T.1    Alvarez-Guardia, D.2    Barroso, E.3    Gómez-Foix, A.M.4    Palomer, X.5    Laguna, J.C.6    Vázquez-Carrera, M.7
  • 15
    • 79955368052 scopus 로고    scopus 로고
    • The PPARβ/δ activator GW501516 prevents the downregulation of AMPK caused by a high-fat diet in liver and amplifies the PGC-1α-lipin 1-PPARα pathway leading to increased fatty acid oxidation
    • Barroso E, Rodriguez-Calvo R, Serrano-Marco L, Astudillo AM, Balsinde J, Palomer X, Vazquez-Carrera M The PPARβ/δ activator GW501516 prevents the downregulation of AMPK caused by a high-fat diet in liver and amplifies the PGC-1α-lipin 1-PPARα pathway leading to increased fatty acid oxidation. Endocrinology 152:1848-1859
    • Endocrinology , vol.152 , pp. 1848-1859
    • Barroso, E.1    Rodriguez-Calvo, R.2    Serrano-Marco, L.3    Astudillo, A.M.4    Balsinde, J.5    Palomer, X.6    Vazquez-Carrera, M.7
  • 17
    • 2442692690 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor β/δ regulates very low density lipoprotein production and catabolism in mice on a Western diet
    • DOI 10.1074/jbc.M312802200
    • Akiyama TE, Lambert G, Nicol CJ, Matsusue K, Peters JM, Brewer Jr HB, Gonzalez FJ 2004 Peroxisome proliferator-activated receptor β/δ regulates very low density lipoprotein production and catabolism in mice on a Western diet. J Biol Chem 279:20874-20881 (Pubitemid 38656484)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.20 , pp. 20874-20881
    • Akiyama, T.E.1    Lambert, G.2    Nicol, C.J.3    Matsusue, K.4    Peters, J.M.5    Brewer Jr., H.B.6    Gonzalez, F.J.7
  • 18
    • 34547112065 scopus 로고    scopus 로고
    • Role of AMP kinase and PPARδ in the regulation of lipid and glucose metabolism in human skeletal muscle
    • DOI 10.1074/jbc.M702329200
    • Krämer DK, Al-Khalili L, Guigas B, Leng Y, Garcia-Roves PM, Krook A 2007 Role of AMP kinase and PPAR δ in the regulation of lipid and glucose metabolism in human skeletal muscle. J Biol Chem 282:19313-19320 (Pubitemid 47100082)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.27 , pp. 19313-19320
    • Kramer, D.K.1    Al-Khalili, L.2    Guigas, B.3    Leng, Y.4    Garcia-Roves, P.M.5    Krook, A.6
  • 19
    • 71949096402 scopus 로고    scopus 로고
    • Improved insulin sensitivity by calorie restriction is associated with reduction of ERK and p70S6K activities in the liver of obese Zucker rats
    • Zheng Y, Zhang W, Pendleton E, Leng S, Wu J, Chen R, Sun XJ 2009 Improved insulin sensitivity by calorie restriction is associated with reduction of ERK and p70S6K activities in the liver of obese Zucker rats. J Endocrinol 203:337-347
    • (2009) J. Endocrinol. , vol.203 , pp. 337-347
    • Zheng, Y.1    Zhang, W.2    Pendleton, E.3    Leng, S.4    Wu, J.5    Chen, R.6    Sun, X.J.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.