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An alternative mechanism involving sequential C-H bond activation/carbopalladation of alkene/C-N bond formation is unlikely in our system because the bimolecular palladation of arenes is often assisted by protic acids. For example, see: ref 13d and Houlden, C. E.; Bailey, C. D.; Ford, J. G.; Gagné, M. R.; Lloyd-Jones, G. C.; Booker- Milburn, K. I. J. Am. Chem. Soc. 2008, 130, 10066.
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In additon, successful oxidative triple cyclization (Scheme 3) also rules out this mechanism. We thank the reviewer for pointing out this possibility
-
In additon, successful oxidative triple cyclization (Scheme 3) also rules out this mechanism. We thank the reviewer for pointing out this possibility.
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