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For examples of palladium-catalyzed oxidative cyclizations involving the formation of more than one bond, see: (a) Alexanian, E. J.; Lee, C.; Sorensen, E. J. J. Am. Chem. Soc. 2005, 127, 7690-7691.
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For screening of other reaction parameters, including the effects of solvent, temperature, and oxidant, see the Supporting Information
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For screening of other reaction parameters, including the effects of solvent, temperature, and oxidant, see the Supporting Information.
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17
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66149121793
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For details, see the Supporting Information
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For details, see the Supporting Information.
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For examples of 4-exo-trig cyclization, see: (a) Bräse, S. Synlett 1999, 1654-1656
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For examples of 4-exo-trig cyclization, see: (a) Bräse, S. Synlett 1999, 1654-1656.
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For the determination of relative stereochemistry of cyclization products, see the Supporting Information
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For the determination of relative stereochemistry of cyclization products, see the Supporting Information.
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For reviews of oxidative palladium catalysis, see: (a) Beccalli, E. M.; Broggini, G.; Martinelli, M.; Sottocornola, S. Chem. Rev. 2007, 107, 5318-5365.
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For recent examples using the Pd(II)/pyridine system, see: (a) Trend, R. M.; Ramtohul, Y. K.; Stoltz, B. M. J. Am. Chem. Soc. 2005, 127, 17778-17788.
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In the Heck-type cascade cyclization (see ref 2, olefin-isomerization reactions are a common problem. For examples, see: (a) Abelam, M. M, Overman, L. E. J. Am. Chem. Soc. 1987, 110, 2328-2329
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In the Heck-type cascade cyclization (see ref 2), olefin-isomerization reactions are a common problem. For examples, see: (a) Abelam, M. M.; Overman, L. E. J. Am. Chem. Soc. 1987, 110, 2328-2329.
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