N -(4-cyanotetrahydro-2 H -pyran-4-yl) and N -(1-cyanocyclohexyl) derivatives of 1,5-diarylpyrazole-3-carboxamides showing high affinity for 18 kDa translocator protein and/or cannabinoid receptors

Journal of Medicinal Chemistry

Volumn 54, Issue 8, 2011, Pages 2961-2970

  Donohue, Sean R ^a,b,c   Dannals, Robert F ^c   Halldin, Christer ^b   Pike, Victor W ^a  

^a NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^c JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 (2 BROMOPHENYL) 4 CYANO N (4 CYANOTETRAHYDRO 2H PYRAN 4 YL) 5 PHENYL 1H PYRAZOLE 3 CARBOXAMIDE; 1 (2 BROMOPHENYL) N (1 CYANOCYCLOHEXYL) 4 METHYL 5 PHENYL 1H PYRAZOLE 3 CARBOXAMIDE; 1 (2 BROMOPHENYL) N (1 CYANOCYCLOHEXYL) 5 (4 METHOXYPHENYL) 4 METHYL 1H PYRAZOLE 3 CARBOXAMIDE; 1 (2 BROMOPHENYL) N (4 CYANOTETRAHYDRO 2H PYRAN 4 YL) 4 METHYL 5 PHENYL 1H PYRAZOLE 3 CARBOXAMIDE; 1 (2 BROMOPHENYL) N (4 CYANOTETRAHYDRO 2H PYRAN 4 YL) 5 (3 FLUOROPHENYL) 4 METHYL 1H PYRAZOLE 3 CARBOXAMIDE; 1 (2 BROMOPHENYL) N (4 CYANOTETRAHYDRO 2H PYRAN 4 YL) 5 (4 FLUOROPHENYL) 4 METHYL 1H PYRAZOLE 3 CARBOXAMIDE; 1 (2 BROMOPHENYL) N (4 CYANOTETRAHYDRO 2H PYRAN 4 YL) 5 (4 METHOXYPHENYL) 4 METHYL 1H PYRAZOLE 3 CARBOXAMIDE; 1 (2 BROMOPHENYL) N (4 CYANOTETRAHYDRO 2H PYRAN 4 YL) 5 PHENYL 1H PYRAZOLE 3 CARBOXAMIDE; 1 (2 CHLOROPHENYL) N (4 CYANOTETRAHYDRO 2H PYRAN 4 YL) 4 METHYL 5 PHENYL 1H PYRAZOLE 3 CARBOXAMIDE; 1 (2 CHLOROPHENYL) N (4 CYANOTETRAHYDRO 2H PYRAN 4 YL) N,4 DIMETHYL 5 PHENYL 1H PYRAZOLE 3 CARBOXAMIDE; 1 (3 BROMOPHENYL) N (4 CYANOTETRAHYDRO 2H PYRAN 4 YL) 4 METHYL 5 PHENYL 1H PYRAZOLE 3 CARBOXAMIDE; 1 (3 BROMOPHENYL) N (4 CYANOTETRAHYDRO 2H PYRAN 4 YL) 5 (4 METHOXYPHENYL) 4 METHYL 1H PYRAZOLE 3 CARBOXAMIDE; 1 (4 BROMOPHENYL) N (4 CYANOTETRAHYDRO 2H PYRAN 4 YL) 4 METHYL 5 PHENYL 1H PYRAZOLE 3 CARBOXAMIDE; 1,5 DIARYLPYRAZOLE 3 CARBOXAMIDE DERIVATIVE; 4 BROMO 1 (3 BROMOPHENYL) N (4 CYANOTETRAHYDRO 2H PYRAN 4 YL) 5 (4 METHOXYPHENYL) 1H PYRAZOLE 3 CARBOXAMIDE; 4 CYANO N (4 CYANOTETRAHYDRO 2H PYRAN 4 YL) 1 (2 IODOPHENYL) 5 (4 METHOXYPHENYL) 1H PYRAZOLE 3 CARBOXAMIDE; CANNABINOID 1 RECEPTOR; CANNABINOID RECEPTOR; N (4 CYANOTETRAHYDRO 2H PYRAN 4 YL) 1 (2 FLUOROPHENYL) 4 METHYL 5 PHENYL 1H PYRAZOLE 3 CARBOXAMIDE; N (4 CYANOTETRAHYDRO 2H PYRAN 4 YL) 1 (2 FLUOROPHENYL) 5 (4 METHOXYPHENYL) 4 METHYL 1H PYRAZOLE 3 CARBOXAMIDE; N (4 CYANOTETRAHYDRO 2H PYRAN 4 YL) 1 (2 IODOPHENYL) 4 METHYL 5 PHENYL 1H PYRAZOLE 3 CARBOXAMIDE; N (4 CYANOTETRAHYDRO 2H PYRAN 4 YL) 1 (2 PHENYLPHENYL) 4 METHYL 5 PHENYL 1H PYRAZOLE 3 CARBOXAMIDE; RADIOLIGAND; RIMONABANT; UNCLASSIFIED DRUG;

ARTICLE; DRUG PROTEIN BINDING; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; LIPOPHILICITY; POSITRON EMISSION TOMOGRAPHY;

CARRIER PROTEINS; HUMANS; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; MODELS, CHEMICAL; PYRAZOLES; RADIOLIGAND ASSAY; RECEPTOR, CANNABINOID, CB1; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79955383737     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm2000536     Document Type: Article

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