Synthesis and in vitro autoradiographic evaluation of a novel high-affinity radioiodinated ligand for imaging brain cannabinoid subtype-1 receptors

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 21, 2009, Pages 6209-6212

  Donohue, Sean R ^a,b   Varnäs, Katarina ^b   Jia, Zhisheng ^b   Gulyás, Balázs ^b   Pike, Victor W ^a   Halldin, Christer ^b  

^a NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

CB1 receptors; PET; Radioiodination; Radioligand; SPECT

Indexed keywords

1 1 (2 IODOPHENYL) 4 CYANO 5 (4 METHOXYPHENYL) N (PIPERIDIN 1 YL) 1H PYRAZOLE 3 CARBOXYLATE I 125; CANNABINOID 1 RECEPTOR; SD 7015; UNCLASSIFIED DRUG;

ARTICLE; AUTOPSY; AUTORADIOGRAPHY; CLINICAL EVALUATION; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; IN VITRO STUDY; PRIMATE; RADIOIODINATION;

BRAIN; HUMANS; IODINE RADIOISOTOPES; LIGANDS; PIPERIDINES; PYRAZOLES; RADIOPHARMACEUTICALS; RECEPTOR, CANNABINOID, CB1; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON;

PRIMATES;

EID: 71749107571     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.08.092     Document Type: Article

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