Gene expression profiling of human dermal fibroblasts exposed to bleomycin sulphate does not differentiate between radiation sensitive and control patients

Radiation Oncology

Volumn 6, Issue 1, 2011, Pages

  Westbury, Charlotte B ^a,b   Sahlberg, Kristine K ^c   Borresen Dale, Anne Lise ^c,d   Isacke, Clare M ^b   Yarnold, John R ^a  

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^b INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^c OSLO UNIVERSITY HOSPITAL   (Norway)

^d UNIVERSITY OF OSLO   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

BLEOMYCIN SULPHATE; DNA; RADIOSENSITIZING AGENT; UNCLASSIFIED DRUG; ANTINEOPLASTIC ANTIBIOTIC; BLEOMYCIN; RNA;

ADULT; ALLELE; APOPTOSIS; ARTICLE; BREAST CANCER; CELL CYCLE; CLINICAL ARTICLE; CONTROLLED STUDY; DNA DAMAGE; FEMALE; FRACTIONATION; GENE EXPRESSION PROFILING; HUMAN; IN VITRO STUDY; PHOTOGRAPHY; RADIOSENSITIVITY; RECEPTOR UPREGULATION; SKIN FIBROBLAST; TRANSCRIPTION REGULATION; BREAST; BREAST TUMOR; DNA MICROARRAY; FIBROBLAST; METABOLISM; MIDDLE AGED; PATHOLOGY; PHYSIOLOGY; RADIATION DOSE; SKIN;

ANTIBIOTICS, ANTINEOPLASTIC; BLEOMYCIN; BREAST; BREAST NEOPLASMS; DNA DAMAGE; FEMALE; FIBROBLASTS; GENE EXPRESSION PROFILING; HUMANS; MIDDLE AGED; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RADIATION TOLERANCE; RNA; SKIN;

EID: 79955118981     PISSN: None     EISSN: 1748717X     Source Type: Journal    
DOI: 10.1186/1748-717X-6-42     Document Type: Article

References (22)

1. Rieger KE, Chu G. Portrait of transcriptional responses to ultraviolet and ionizing radiation in human cells. Nucleic Acids Res 2004, 32(16):4786-4803. 10.1093/nar/gkh783, 519099, 15356296.
2. Rodningen OK, Overgaard J, Alsner J, Hastie T, Borresen-Dale AL. Microarray analysis of the transcriptional response to single or multiple doses of ionizing radiation in human subcutaneous fibroblasts. Radiother Oncol 2005, 77(3):231-240. 10.1016/j.radonc.2005.09.020, 16297999.
3. Tachiiri S, Katagiri T, Tsunoda T, Oya N, Hiraoka M, Nakamura Y. Analysis of gene-expression profiles after gamma irradiation of normal human fibroblasts. Int J Radiat Oncol Biol Phys 2006, 64(1):272-279. 10.1016/j.ijrobp.2005.08.030, 16257130.
4. Zhou T, Chou JW, Simpson DA, Zhou Y, Mullen TE, Medeiros M, Bushel PR, Paules RS, Yang X, Hurban P, et al. Profiles of global gene expression in ionizing-radiation-damaged human diploid fibroblasts reveal synchronization behind the G1 checkpoint in a G0-like state of quiescence. Environ Health Perspect 2006, 114(4):553-559. 1440780, 16581545.
5. Quarmby S, West C, Magee B, Stewart A, Hunter R, Kumar S. Differential expression of cytokine genes in fibroblasts derived from skin biopsies of patients who developed minimal or severe normal tissue damage after radiotherapy. Radiat Res 2002, 157(3):243-248. 10.1667/0033-7587(2002)157[0243:DEOCGI]2.0.CO;2, 11839085.
6. Rodningen OK, Borresen-Dale AL, Alsner J, Hastie T, Overgaard J. Radiation-induced gene expression in human subcutaneous fibroblasts is predictive of radiation-induced fibrosis. Radiother Oncol 2008, 86(3):314-320. 10.1016/j.radonc.2007.09.013, 17963910.
7. Svensson JP, Stalpers LJ, Esveldt-van Lange RE, Franken NA, Haveman J, Klein B, Turesson I, Vrieling H, Giphart-Gassler M. Analysis of gene expression using gene sets discriminates cancer patients with and without late radiation toxicity. PLoS Med 2006, 3(10):e422. 10.1371/journal.pmed.0030422, 1626552, 17076557.
8. Povirk LF, Austin MJ. Genotoxicity of bleomycin. Mutat Res 1991, 257(2):127-143.
9. Koslowski R, Morgner J, Seidel D, Knoch KP, Kasper M. Postmitotic differentiation of rat lung fibroblasts: induction by bleomycin and effect on prolyl 4-hydroxylase. Exp Toxicol Pathol 2004, 55(6):481-487. 10.1078/0940-2993-00343, 15384253.
10. Robles SJ, Adami GR. Agents that cause DNA double strand breaks lead to p16INK4a enrichment and the premature senescence of normal fibroblasts. Oncogene 1998, 16(9):1113-1123. 10.1038/sj.onc.1201862, 9528853.
11. Rodemann HP, Binder A, Burger A, Guven N, Loffler H, Bamberg M. The underlying cellular mechanism of fibrosis. Kidney Int Suppl 1996, 54:S32-36.
12. Cutroneo KR. Evidence for TGF-beta1 and bleomycin intracellular signaling through autocrine regulation of Smad 3 binding to the proximal promoter of the Smad 7 gene. J Cell Biochem 2006, 97(5):933-939. 10.1002/jcb.20594, 16187293.
13. Rubin P, Johnston CJ, Williams JP, McDonald S, Finkelstein JN. A perpetual cascade of cytokines postirradiation leads to pulmonary fibrosis. Int J Radiat Oncol Biol Phys 1995, 33(1):99-109. 10.1016/0360-3016(95)00095-G, 7642437.
14. Yamamoto T, Takagawa S, Katayama I, Yamazaki K, Hamazaki Y, Shinkai H, Nishioka K. Animal model of sclerotic skin. I: Local injections of bleomycin induce sclerotic skin mimicking scleroderma. J Invest Dermatol 1999, 112(4):456-462. 10.1046/j.1523-1747.1999.00528.x, 10201529.
15. Yarnold J, Ashton A, Bliss J, Homewood J, Harper C, Hanson J, Haviland J, Bentzen S, Owen R. Fractionation sensitivity and dose response of late adverse effects in the breast after radiotherapy for early breast cancer: long-term results of a randomised trial. Radiother Oncol 2005, 75(1):9-17. 10.1016/j.radonc.2005.01.005, 15878095.
16. Peacock J, Ashton A, Bliss J, Bush C, Eady J, Jackson C, Owen R, Regan J, Yarnold J. Cellular radiosensitivity and complication risk after curative radiotherapy. Radiother Oncol 2000, 55(2):173-178. 10.1016/S0167-8140(00)00173-0, 10799729.
17. Tusher VG, Tibshirani R, Chu G. Significance analysis of microarrays applied to the ionizing radiation response. Proc Natl Acad Sci USA 2001, 98(9):5116-5121. 10.1073/pnas.091062498, 33173, 11309499.
18. Andreassen CN, Alsner J, Overgaard J, Herskind C, Haviland J, Owen R, Homewood J, Bliss J, Yarnold J. TGFB1 polymorphisms are associated with risk of late normal tissue complications in the breast after radiotherapy for early breast cancer. Radiother Oncol 2005, 75(1):18-21. 10.1016/j.radonc.2004.12.012, 15878096.
19. Alsner J, Rodningen OK, Overgaard J. Differential gene expression before and after ionizing radiation of subcutaneous fibroblasts identifies breast cancer patients resistant to radiation-induced fibrosis. Radiother Oncol 2007, 83(3):261-266. 10.1016/j.radonc.2007.05.001, 17512072.
20. Herskind C, Johansen J, Bentzen SM, Overgaard M, Overgaard J, Bamberg M, Rodemann HP. Fibroblast differentiation in subcutaneous fibrosis after postmastectomy radiotherapy. Acta Oncol 2000, 39(3):383-388. 10.1080/028418600750013159, 10987235.
21. Kaufmann WK, Kies PE. DNA signals for G2 checkpoint response in diploid human fibroblasts. Mutat Res 1998, 400(1-2):153-167.
22. Chen J, Stubbe J. Bleomycins: towards better therapeutics. Nat Rev Cancer 2005, 5(2):102-112. 10.1038/nrc1547, 15685195.