Differential gene expression before and after ionizing radiation of subcutaneous fibroblasts identifies breast cancer patients resistant to radiation-induced fibrosis

Radiotherapy and Oncology

Volumn 83, Issue 3, 2007, Pages 261-266

  Alsner, Jan ^a   Rødningen, Olaug K ^b   Overgaard, Jens ^a  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

^b UNIVERSITY OF OSLO   (Norway)

Author keywords

Differential gene expression; Fibroblasts; Ionizing radiation; Prediction; Radiation induced fibrosis

Indexed keywords

ARTICLE; BREAST CANCER; CONTROLLED STUDY; FIBROBLAST; FIBROSIS; GENE EXPRESSION; HIGH RISK PATIENT; HUMAN; HUMAN CELL; IONIZING RADIATION; MAJOR CLINICAL STUDY; MASTECTOMY; PRIORITY JOURNAL; RADIATION DOSE; REAL TIME POLYMERASE CHAIN REACTION; RISK FACTOR;

BREAST NEOPLASMS; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, RADIATION; FEMALE; FIBROBLASTS; FIBROSIS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; POLYMERASE CHAIN REACTION; RADIATION TOLERANCE; RADIATION, IONIZING; SUBCUTANEOUS TISSUE;

EID: 34250181748     PISSN: 01678140     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.radonc.2007.05.001     Document Type: Article

References (26)

1. O'Sullivan B., and Levin W. Late radiation-related fibrosis: pathogenesis, manifestations, and current management. Semin Radiat Oncol 13 (2003) 274-289
2. Gothard L., Cornes P., Brooker S., et al. Phase II study of vitamin E and pentoxifylline in patients with late side effects of pelvic radiotherapy. Radiother Oncol 75 (2005) 334-341
3. Haddad P., Kalaghchi B., and mouzegar-Hashemi F. Pentoxifylline and vitamin E combination for superficial radiation-induced fibrosis: a phase II clinical trial. Radiother Oncol 77 (2005) 324-326
4. Bentzen S.M., and Overgaard J. Patient-to-patient variability in the expression of radiation-induced normal tissue injury. Semin Radiat Oncol 4 (1994) 68-80
5. Bentzen S.M., Christensen J.J., Overgaard J., and Overgaard M. Some methodological problems in estimating radiobiological parameters from clinical data. Alpha/beta ratios and electron RBE for cutaneous reactions in patients treated with postmastectomy radiotherapy. Acta Oncol 27 (1988) 105-116
6. Kurtz J.M. The clinical radiobiology of breast cancer radiotherapy. Radiother Oncol 75 (2005) 6-8
7. Yarnold J., Ashton A., Bliss J., et al. Fractionation sensitivity and dose response of late adverse effects in the breast after radiotherapy for early breast cancer: long-term results of a randomised trial. Radiother Oncol 75 (2005) 9-17
8. Andreassen C.N., Alsner J., and Overgaard J. Does variability in normal tissue reactions after radiotherapy have a genetic basis - where and how to look for it?. Radiother Oncol 64 (2002) 131-140
9. Borgmann K., Roper B., El-Awady R., et al. Indicators of late normal tissue response after radiotherapy for head and neck cancer: fibroblasts, lymphocytes, genetics, DNA repair, and chromosome aberrations. Radiother Oncol 64 (2002) 141-152
10. Hoeller U., Borgmann K., Bonacker M., et al. Individual radiosensitivity measured with lymphocytes may be used to predict the risk of fibrosis after radiotherapy for breast cancer. Radiother Oncol 69 (2003) 137-144
11. Russell N.S., and Begg A.C. Predictive assays for normal tissue damage. Radiother Oncol 64 (2002) 125-129
12. Andreassen C.N. Can risk of radiotherapy-induced normal tissue complications be predicted from genetic profiles?. Acta Oncol 44 (2005) 801-815
13. Bentzen S.M. Preventing or reducing late side effects of radiation therapy: radiobiology meets molecular pathology. Nat Rev Cancer 6 (2006) 702-713
14. Ding L.H., Shingyoji M., Chen F., et al. Gene expression profiles of normal human fibroblasts after exposure to ionizing radiation: a comparative study of low and high doses. Radiat Res 164 (2005) 17-26
15. Tachiiri S., Katagiri T., Tsunoda T., Oya N., Hiraoka M., and Nakamura Y. Analysis of gene-expression profiles after gamma irradiation of normal human fibroblasts. Int J Radiat Oncol Biol Phys 64 (2006) 272-279
16. Ishikawa K., Koyama-Saegusa K., Otsuka Y., et al. Gene expression profile changes correlating with radioresistance in human cell lines. Int J Radiat Oncol Biol Phys 65 (2006) 234-245
17. Kis E., Szatmari T., Keszei M., et al. Microarray analysis of radiation response genes in primary human fibroblasts. Int J Radiat Oncol Biol Phys 66 (2006) 1506-1514
18. Heinloth A.N., Shackelford R.E., Innes C.L., et al. Identification of distinct and common gene expression changes after oxidative stress and gamma and ultraviolet radiation. Mol Carcinog 37 (2003) 65-82
19. Rødningen O.K., Overgaard J., Alsner J., Hastie T., and Børresen-Dale A.L. Microarray analysis of the transcriptional response to single or multiple doses of ionizing radiation in human subcutaneous fibroblasts. Radiother Oncol 77 (2005) 231-240
20. Sokolov M.V., Smirnova N.A., Camerini-Otero R.D., Neumann R.D., and Panyutin I.G. Microarray analysis of differentially expressed genes after exposure of normal human fibroblasts to ionizing radiation from an external source and from DNA-incorporated iodine-125 radionuclide. Gene 382 (2006) 47-56
21. Rødningen O.K., Alsner J., Hastie T., Overgaard J., and Børresen-Dale A.L. Application of microarray analyses to identify genes involved in radiation-induced fibrosis. Breast Cancer Res 7 Suppl 2 (2005) 542-543
22. Overgaard M., Bentzen S.M., Christensen J.J., and Madsen E.H. The value of the NSD formula in equation of acute and late radiation complications in normal tissue following 2 and 5 fractions per week in breast cancer patients treated with postmastectomy irradiation. Radiother Oncol 9 (1987) 1-11
23. Bentzen S.M., Overgaard M., Thames H.D., Christensen J.J., and Overgaard J. Early and late normal-tissue injury after postmastectomy radiotherapy alone or combined with chemotherapy. Int J Radiat Biol 56 (1989) 711-715
24. Andreassen C.N., Alsner J., Overgaard M., and Overgaard J. Prediction of normal tissue radiosensitivity from polymorphisms in candidate genes. Radiother Oncol 69 (2003) 127-135
25. Johansen J., Bentzen S.M., Overgaard J., and Overgaard M. Relationship between the in vitro radiosensitivity of skin fibroblasts and the expression of subcutaneous fibrosis, telangiectasia, and skin erythema after radiotherapy. Radiother Oncol 40 (1996) 101-109
26. Bentzen S.M., Overgaard M., and Overgaard J. Clinical correlations between late normal tissue endpoints after radiotherapy: implications for predictive assays of radiosensitivity. Eur J Cancer 29A (1993) 1373-1376