Evaluation of variants in the selectin genes in age-related macular degeneration

BMC Medical Genetics

Volumn 12, Issue , 2011, Pages

  Mullins, Robert F ^a   Skeie, Jessica M ^a   Folk, James C ^a   Solivan Timpe, Frances M ^a   Oetting, Thomas A ^a   Huang, Jian ^b   Wang, Kai ^b   Stone, Edwin M ^a,c   Fingert, John H ^a  

^a UNIVERSITY OF IOWA   (United States)

^b UNIVERSITY OF IOWA   (United States)

^c HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; L SELECTIN; P SELECTIN GLYCOPROTEIN LIGAND 1; PADGEM PROTEIN;

ARTICLE; CHOROID; GENE FREQUENCY; GENETIC VARIABILITY; GENOTYPE; HUMAN; IMMUNOFLUORESCENCE; POLYMERASE CHAIN REACTION; PROTEIN EXPRESSION; RETINA; RETINA MACULA AGE RELATED DEGENERATION; SELE GENE; SELL GENE; SELP GENE; SINGLE NUCLEOTIDE POLYMORPHISM; ANIMAL; DISEASE MODEL; FLUORESCENCE MICROSCOPY; GENETICS; METABOLISM; METHODOLOGY; RETINA MACULA DEGENERATION; RISK;

ANIMALIA;

ANIMALS; CHOROID; DISEASE MODELS, ANIMAL; E-SELECTIN; GENETIC VARIATION; GENOTYPE; HUMANS; L-SELECTIN; MACULAR DEGENERATION; MICROSCOPY, FLUORESCENCE; P-SELECTIN; POLYMERASE CHAIN REACTION; POLYMORPHISM, SINGLE NUCLEOTIDE; RETINA; RISK;

EID: 79955117235     PISSN: None     EISSN: 14712350     Source Type: Journal    
DOI: 10.1186/1471-2350-12-58     Document Type: Article

References (35)

1. Congdon N, O'Colmain B, Klaver C, Klein R, Munoz B, Friedman D, Kempen J, Taylor H, Mitchell P. Causes and prevalence of visual impairment among adults in the United States. Arch Ophthalmol 2004, 122:477-485.
2. de Jong PT. Age-related macular degeneration. N Engl J Med 2006, 355(14):1474-1485. 10.1056/NEJMra062326, 17021323.
3. Hageman G, Luthert P, Chong N, Johnson L, Anderson D, Mullins R. An integrated hypothesis that considers drusen as biomarkers of immune-mediated processes at the RPE-Bruch's membrane interface in aging and age-related macular degeneration. Prog Retin Eye Res 2001, 20:705-732. 10.1016/S1350-9462(01)00010-6, 11587915.
4. Anderson D, Mullins R, Hageman G, Johnson L. A role for local inflammation in the formation of drusen in the aging eye. Am J Ophthalmol 2002, 134:411-431. 10.1016/S0002-9394(02)01624-0, 12208254.
5. Penfold P, Killingsworth M, Sarks S. An ultrastructural study of the role of leucocytes and fibroblasts in the breakdown of Bruch's membrane. Australian Journal of Ophthalmology 1984, 12:23-31. 10.1111/j.1442-9071.1984.tb01120.x, 6732655.
6. Penfold P, Killingsworth M, Sarks S. Senile macular degeneration: the involvement of immunocompetent cells. Graefe's Archives for Clinical and Experimental Ophthalmology 1985, 223:69-76. 10.1007/BF02150948, 21497299.
7. Penfold P, Provis J, Billson F. Age-related macular degeneration: ultrastructural studies of the relationship of leukocytes to angiogenesis. Graefe's Arch Clin Exp Ophthalmol 1987, 225:70-76. 10.1007/BF02155808, 21497299.
8. Sarks S, Penfold P, Killingsworth M, van Driel D. Patterns in macular degeneration. Retinal diseases 1985, 87-93. Orlando: Grune and Stratton, Ryan S, Dawson A, Little H.
9. Espinosa-Heidman D, Suner I, Hernandez E, Monroy D, Csaky K, Cousins S. Macrophage depletion diminishes lesion size and severity in experimental choroidal neovascularization. Investigative Ophthalmology & Visual Science 2003, 44(8):3586-3592. 10.1167/iovs.03-0038, 21283161.
10. Sakurai E, Anand A, Ambati B, van Rooijen N, Ambati J. Macrophage depeletion inhibits experimental chorodial neovascularization. Invest Ophthalmol Vis Sci 2003, 44(8):3578-3585. 10.1167/iovs.03-0097, 12882810.
11. Zhou J, Pham L, Zhang N, He S, Gamulescu M, Spee C, Ryan S, Hinton D. Neutrophils promote experimental choroidal neovascularization. Mol Vis 2005, 11:414-424.
12. Apte RS, Richter J, Herndon J, Ferguson TA. Macrophages Inhibit Neovascularization in a Murine Model of Age-Related Macular Degeneration. PLoS Med 2006, 3(8).
13. Kelly J, Ali Khan A, Yin J, Ferguson TA, Apte RS. Senescence regulates macrophage activation and angiogenic fate at sites of tissue injury in mice. J Clin Invest 2007, 117(11):3421-3426. 10.1172/JCI32430, 2045608, 17975672.
14. Donnelly S, Haslett C, Dransfield I, Robertson C, Carter D, Ross J, Grant I, Tedder T. Role of selectins in development of adult respiratory distress syndrome. Lancet 1994, 344:215-219. 10.1016/S0140-6736(94)92995-5, 7518025.
15. Carden D, Xiao F, Moak C, Willis B, Robinson-Jackson S, Alexander S. Neutrophil elastase promotes lung microvascular injury and proteolysis of endothelial cadherins. Am J Physiol 1998, 275:H385-H392.
16. Ley K, Bullard D, Arbones M, Bosse R, Vestweber D, Tedder T, Beaudet A. Sequential contribution of L- and P-selectin to leukocyte rolling in vivo. Journal of Experimental Medicine 1995, 181:669-675. 10.1084/jem.181.2.669, 2191869, 7530761.
17. Rahman A, Kefer J, Bando M, Niles WD, Malik AB. E-selectin expression in human endothelial cells by TNF-alpha-induced oxidant generation and NF-kappaB activation. Am J Physiol 1998, 275(3 Pt 1):L533-544.
18. Patel KD, Zimmerman GA, Prescott SM, McEver RP, McIntyre TM. Oxygen radicals induce human endothelial cells to express GMP-140 and bind neutrophils. J Cell Biol 1991, 112(4):749-759. 10.1083/jcb.112.4.749, 2288852, 1704376.
19. Bless NM, Tojo SJ, Kawarai H, Natsume Y, Lentsch AB, Padgaonkar VA, Czermak BJ, Schmal H, Friedl HP, Ward PA. Differing patterns of P-selectin expression in lung injury. Am J Pathol 1998, 153(4):1113-1122. 10.1016/S0002-9440(10)65655-6, 1853061, 9777942.
20. Sperandio M, Gleissner CA, Ley K. Glycosylation in immune cell trafficking. Immunol Rev 2009, 230(1):97-113. 10.1111/j.1600-065X.2009.00795.x, 2745114, 19594631.
21. Mullins R, Kuehn M, Faidley E, Syed N, Stone E. Differential macular and peripheral expression of bestrophin in human eyes and its implication for Best disease. Invest Ophthalmol Vis Sci 2007, 48:3372-3380. 10.1167/iovs.06-0868, 17591911.
22. Mullins R, Grassi M, Skeie J. Glycoconjugates of choroidal neovascular membranes in age-related macular degeneration. Mol Vis 2005, 11:509-517.
23. A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss. Arch Ophthalmol 2001, 119:1417-1436. 1462955, 11594942.
24. Mullins R, Skeie J, Malone E, Kuehn M. Macular and peripheral distribution of ICAM-1 in the human choriocapillaris and retina. Mol Vis 2006, 12:224-235.
25. Mullins R, Hageman G. Human ocular drusen possess novel core domains with a distinct carbohydrate composition. Journal of Histochemistry and Cytochemistry 1999, 47:1533-1539. 10.1177/002215549904701205, 10567437.
26. McLeod D, Lefer D, Merges C, Lutty G. Enhanced expression of intracellular adhesion molecule-1 and P-selectin in the diabetic human retina and choroid. American Journal of Pathology 1995, 147(3):642-653. 1870979, 7545873.
27. Mullins R, Anderson D, Russell S, Hageman G. Ocular drusen contain proteins common to extracellular deposits associated with atherosclerosis, elastosis, amyloidosis, and dense deposit disease. FASEB Journal 2000, 14:835-846.
28. Grossniklaus HE, Ling JX, Wallace TM, Dithmar S, Lawson DH, Cohen C, Elner VM, Elner SG, Sternberg P. Macrophage and retinal pigment epithelium expression of angiogenic cytokines in choroidal neovascularization. Mol Vis 2002, 8:119-126.
29. Grossniklaus H, Cingle K, Yoon Y, Ketkar N, L'Hernault N, Brown S. Correlation of histologic 2-dimensional reconstruction and confocal scanning laser microscopic imaging of choroidal neovascularization in eyes with age-related maculopathy. Arch Ophthalmol 2000, 118:625-629.
30. Csaky K, Baffi J, Byrnes G, Wolfe J, Hilmer S, Flippin J, Cousins S. Recruitment of marrow-derived endothelial cells to experimental choroidal neovascularization by local expression of vascular endothelial growth facto. Exp Eye Res 2004, 78:1107-1116. 10.1016/j.exer.2004.01.010, 15109917.
31. Sakurai E, Taguchi H, Anand A, Ambati B, Gragoudas E, Miller J, Adamis A, Ambati J. Targeted disruption of the CD18 or ICAM-1 gene inhibits choroidal neovascularization. Invest Ophthalmol Vis Sci 2003, 44:2743-2749. 10.1167/iovs.02-1246, 12766082.
32. Yeh D, Bula D, Miller J, Gragoudas E, Arroyo J. Expression of leukocyte adhesion molecules in human subfoveal choroidal neovascular membranes treated with and without photodynamic therapy. Invest Ophthalmol Vis Sci 2004, 45:2368-2373. 10.1167/iovs.03-0981, 15223819.
33. Penfold PL, Liew SC, Madigan MC, Provis JM. Modulation of major histocompatibility complex class II expression in retinas with age-related macular degeneration. Investigative Ophthalmology & Visual Science 1997, 38(10):2125-2133.
34. Skeie J, Mullins R. Macrophages in neovascular age-related macular degeneration: friends or foes?. Eye 2008,
35. Bojanowski CM, Tuo J, Chew EY, Csaky KG, Chan CC. Analysis of Hemicentin-1, hOgg1, and E-selectin single nucleotide polymorphisms in age-related macular degeneration. Trans Am Ophthalmol Soc 2005, 103:37-44. discussion 44-35, 1447557, 17057786.