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Volumn 11, Issue 4, 2011, Pages 525-532

Telomerase-specific oncolytic virotherapy for human gastrointestinal cancer

Author keywords

adenovirus; colorectal cancer; lymph node; metastasis; telomerase

Indexed keywords

ADENOVIRUS VECTOR; CG 780; GREEN FLUORESCENT PROTEIN; OBP 301; ONCOLYTIC ADENOVIRUS; ONCOLYTIC VIRUS; TELOMELYSIN; TELOMERASE; TELOMERASE REVERSE TRANSCRIPTASE; TELOMESCAN; UNCLASSIFIED DRUG;

EID: 79955104230     PISSN: 14737140     EISSN: 17448328     Source Type: Journal    
DOI: 10.1586/era.10.200     Document Type: Article
Times cited : (13)

References (68)
  • 1
    • 29444445832 scopus 로고    scopus 로고
    • Adenovirus-based cancer gene therapy
    • DOI 10.2174/156652305774964677
    • Kaplan JM. Adenovirus-based cancer gene therapy. Curr. Gene Ther. 5(6), 595-605 (2005). (Pubitemid 43009504)
    • (2005) Current Gene Therapy , vol.5 , Issue.6 , pp. 595-605
    • Kaplan, J.M.1
  • 2
    • 41949096891 scopus 로고    scopus 로고
    • Oncolytic virotherapy: Molecular targets in tumor-selective replication and carrier cell-mediated delivery of oncolytic viruses
    • Guo ZS, Thorne SH, Bartlett DL. Oncolytic virotherapy: molecular targets in tumor-selective replication and carrier cell-mediated delivery of oncolytic viruses. Biochim. Biophys. Acta 1785(2), 217-231 (2008).
    • (2008) Biochim. Biophys. Acta , vol.1785 , Issue.2 , pp. 217-231
    • Guo, Z.S.1    Thorne, S.H.2    Bartlett, D.L.3
  • 3
    • 57749201655 scopus 로고    scopus 로고
    • Targeted and armed oncolytic poxviruses: A novel multi-mechanistic therapeutic class for cancer
    • Kirn DH, Thorne SH. Targeted and armed oncolytic poxviruses: a novel multi-mechanistic therapeutic class for cancer. Nat. Rev. Cancer 9(1), 64-71 (2009).
    • (2009) Nat. Rev. Cancer , vol.9 , Issue.1 , pp. 64-71
    • Kirn, D.H.1    Thorne, S.H.2
  • 4
    • 0032553652 scopus 로고    scopus 로고
    • Efficient construction of a recombinant adenovirus vector by an improved in vitro ligation method
    • DOI 10.1089/10430349850019418
    • Mizuguchi H, Kay MA. Efficient construction of a recombinant adenovirus vector by an improved in vitro ligation method. Hum. Gene Ther. 9(17), 2577-2583 (1998). (Pubitemid 29004630)
    • (1998) Human Gene Therapy , vol.9 , Issue.17 , pp. 2577-2583
    • Mizuguchi, H.1    Kay, M.A.2
  • 6
    • 0027933841 scopus 로고
    • Gene therapy of cystic fibrosis lung disease using E1 deleted adenoviruses: A phase I trial
    • Wilson JM, Engelhardt JF, Grossman M et al. Gene therapy of cystic fibrosis lung disease using E1 deleted adenoviruses: a Phase I trial. Hum. Gene Ther. 5(4), 501-519 (1994).
    • (1994) Hum. Gene Ther. , vol.5 , Issue.4 , pp. 501-519
    • Wilson, J.M.1    Engelhardt, J.F.2    Grossman, M.3
  • 7
    • 0028168641 scopus 로고
    • Administration of an adenovirus containing the human CFTR cDNA to the respiratory tract of individuals with cystic fibrosis
    • Crystal RG, McElvaney NG, Rosenfeld MA et al. Administration of an adenovirus containing the human CFTR cDNA to the respiratory tract of individuals with cystic fibrosis. Nat. Genet. 8(1), 42-51 (1994).
    • (1994) Nat. Genet. , vol.8 , Issue.1 , pp. 42-51
    • Crystal, R.G.1    McElvaney, N.G.2    Rosenfeld, M.A.3
  • 10
    • 33846650370 scopus 로고    scopus 로고
    • Clinical trial results with oncolytic virotherapy: A century of promise, a decade of progress
    • DOI 10.1038/ncponc0736, PII NCPONC0736
    • Liu TC, Galanis E, Kirn D. Clinical trial results with oncolytic virotherapy: a century of promise, a decade of progress. Nat. Clin. Pract. Oncol. 4(2), 101-117 (2007). (Pubitemid 46189539)
    • (2007) Nature Clinical Practice Oncology , vol.4 , Issue.2 , pp. 101-117
    • Liu, T.-C.1    Galanis, E.2    Kirn, D.3
  • 11
    • 65549095995 scopus 로고    scopus 로고
    • Telomerase-specific virotherapy for human squamous cell carcinoma
    • Fujiwara T. Telomerase-specific virotherapy for human squamous cell carcinoma. Expert Opin. Biol. Ther. 9(3), 321-329 (2009).
    • (2009) Expert Opin. Biol. Ther. , vol.9 , Issue.3 , pp. 321-329
    • Fujiwara, T.1
  • 12
    • 0036161443 scopus 로고    scopus 로고
    • Oncolytic biotherapy: A novel therapeutic platform
    • DOI 10.1016/S1470-2045(01)00618-0
    • Hawkins LK, Lemoine NR, Kirn D. Oncolytic biotherapy: a novel therapeutic plafform. Lancet Oncol. 3(1), 17-26 (2002). (Pubitemid 34121142)
    • (2002) Lancet Oncology , vol.3 , Issue.1 , pp. 17-26
    • Hawkins, L.K.1    Lemoine, N.R.2    Kirn, D.3
  • 16
    • 0031798440 scopus 로고    scopus 로고
    • p53 Status does not determine outcome of E1B 55-kilodalton mutant adenovirus lytic infection
    • Goodrum FD, Ornelles DA. p53 status does not determine outcome of E1B 55-kilodalton mutant adenovirus lytic infection. J. Virol. 72(12), 9479-9490 (1998). (Pubitemid 28520811)
    • (1998) Journal of Virology , vol.72 , Issue.12 , pp. 9479-9490
    • Goodrum, F.D.1    Ornelles, D.A.2
  • 18
    • 0029963018 scopus 로고    scopus 로고
    • Clinical significance of occult micrometastasis in lymph nodes from patients with early gastric cancer who died of recurrence
    • DOI 10.1016/S0039-6060(96)80138-3
    • Maehara Y, Oshiro T, Endo K et al. Clinical significance of occult micrometastasis lymph nodes from patients with early gastric cancer who died of recurrence. Surgery 119(4), 397-402 (1996). (Pubitemid 26115831)
    • (1996) Surgery , vol.119 , Issue.4 , pp. 397-402
    • Maehara, Y.1    Oshiro, T.2    Endo, K.3    Baba, H.4    Oda, S.5    Ichiyoshi, Y.6    Kohnoe, S.7    Sugimachi, K.8
  • 19
    • 0033934185 scopus 로고    scopus 로고
    • Predictive factors associated with axillary lymph node metastases in T1a and T1b breast carcinomas: Analysis in more than 900 patients
    • Rivadeneira DE, Simmons RM, Christos PJ et al. Predictive factors associated with axillary lymph node metastases in T1a and T1b breast carcinomas: analysis in more than 900 patients. J. Am. Coll. Surg. 191(1), 1-6 (2000).
    • (2000) J. Am. Coll. Surg. , vol.191 , Issue.1 , pp. 1-6
    • Rivadeneira, D.E.1    Simmons, R.M.2    Christos, P.J.3
  • 20
  • 21
    • 0029078763 scopus 로고
    • The effect of extended lymphadenectomy on survival in patients with gastric adenocarcinoma
    • Volpe CM, Koo J, Miloro SM et al. The effect of extended lymphadenectomy on survival in patients with gastric adenocarcinoma. J. Am. Coll. Surg. 181(1), 56-64 (1995).
    • (1995) J. Am. Coll. Surg. , vol.181 , Issue.1 , pp. 56-64
    • Volpe, C.M.1    Koo, J.2    Miloro, S.M.3
  • 22
    • 0032010097 scopus 로고    scopus 로고
    • Extended Lymphadenectomy Is Associated with a Survival Benefit for Node-Negative Gastric Cancer
    • Harrison LE, Karpeh MS, Brennan MF. Extended lymphadenectomy is associated with a survival benefit for node-negative gastric cancer. J. Gastrointest. Surg. 2(2), 126-131 (1998). (Pubitemid 128432022)
    • (1998) Journal of Gastrointestinal Surgery , vol.2 , Issue.2 , pp. 126-131
    • Harrison, L.E.1    Karpeh, M.S.2    Brennan, M.F.3
  • 23
    • 48249141410 scopus 로고    scopus 로고
    • D2 lymphadenectomy alone or with para-aortic nodal dissection for gastric cancer
    • Sasako M, Sano T, Yamamoto S et al. D2 lymphadenectomy alone or with para-aortic nodal dissection for gastric cancer. N. Engl. J. Med. 359(5), 453-462 (2008).
    • (2008) N. Engl. J. Med. , vol.359 , Issue.5 , pp. 453-462
    • Sasako, M.1    Sano, T.2    Yamamoto, S.3
  • 24
    • 0035072933 scopus 로고    scopus 로고
    • Evaluation of the necessity for gastrectomy with lymph node dissection for patients with submucosal invasive gastric cancer
    • DOI 10.1046/j.1365-2168.2001.01725.x
    • Gotoda T, Sasako M, Ono H et al. Evaluation of the necessity for gastrectomy with lymph node dissection for patients with submucosal invasive gastric cancer. Br. J. Surg. 88(3), 444-449 (2001). (Pubitemid 32238711)
    • (2001) British Journal of Surgery , vol.88 , Issue.3 , pp. 444-449
    • Gotoda, T.1    Sasako, M.2    Ono, H.3    Katai, H.4    Sano, T.5    Shimoda, T.6
  • 25
    • 0031010342 scopus 로고    scopus 로고
    • A survey of telomerase activity in human cancer
    • Shay JW, Bacchetti S. A survey of telomerase activity in human cancer. Eur. J. Cancer 33(5), 787-791 (1997).
    • (1997) Eur. J. Cancer , vol.33 , Issue.5 , pp. 787-791
    • Shay, J.W.1    Bacchetti, S.2
  • 26
  • 27
    • 0029091386 scopus 로고
    • Activation of telomerase in human lymphocytes and hematopoietic progenitor cells
    • Hiyama K, Hirai Y, Kyoizumi S et al. Activation of telomerase in human lymphocytes and hematopoietic progenitor cells. J. Immunol. 155(8), 3711-3715 (1995).
    • (1995) J. Immunol. , vol.155 , Issue.8 , pp. 3711-3715
    • Hiyama, K.1    Hirai, Y.2    Kyoizumi, S.3
  • 29
    • 0036782884 scopus 로고    scopus 로고
    • Telomerase: A target for cancer therapeutics
    • DOI 10.1016/S1535-6108(02)00159-9
    • Shay JW, Wright WE. Telomerase: a target for cancer therapeutics. Cancer Cell 2(4), 257-265 (2002). (Pubitemid 41043959)
    • (2002) Cancer Cell , vol.2 , Issue.4 , pp. 257-265
    • Shay, J.W.1    Wright, W.E.2
  • 30
    • 0029096515 scopus 로고
    • The RNA component of human telomerase
    • Feng J, Funk WD, Wang SS et al. The RNA component of human telomerase. Science 269(5228), 1236-1241 (1995).
    • (1995) Science , vol.269 , Issue.5228 , pp. 1236-1241
    • Feng, J.1    Funk, W.D.2    Wang, S.S.3
  • 36
    • 79955112276 scopus 로고    scopus 로고
    • Analysis of telomerase RNA gene expression by in situ hybridization
    • Keith WN, Sarvesvaran J, Downey M. Analysis of telomerase RNA gene expression by in situ hybridization. Methods Mol. Biol. 19165-19181 (2002).
    • (2002) Methods Mol. Biol. , pp. 19165-19181
    • Keith, W.N.1    Sarvesvaran, J.2    Downey, M.3
  • 37
    • 33847074257 scopus 로고    scopus 로고
    • Modulation of telomerase promoter tumor selectivity in the context of oncolytic adenoviruses
    • Bilsland AE, Merron A, Vassaux G et al. Modulation of telomerase promoter tumor selectivity in the context of oncolytic adenoviruses. Cancer Res. 67(3), 1299-1307 (2007).
    • (2007) CancerRes. , vol.67 , Issue.3 , pp. 1299-1307
    • Bilsland, A.E.1    Merron, A.2    Vassaux, G.3
  • 39
    • 0344844467 scopus 로고    scopus 로고
    • Replication of an Adenoviral Vector Controlled by the Human Telomerase Reverse Transcriptase Promoter Causes Tumor-Selective Tumor Lysis
    • Lanson NA Jr, Friedlander PL, Schwarzenberger P et al. Replication of an adenoviral vector controlled by the human telomerase reverse transcriptase promoter causes tumor-selective tumor lysis. Cancer Res. 63(22), 7936-7941 (2003). (Pubitemid 37466730)
    • (2003) Cancer Research , vol.63 , Issue.22 , pp. 7936-7941
    • Lanson Jr., N.A.1    Friedlander, P.L.2    Schwarzenberger, P.3    Kolls, J.K.4    Wang, G.5
  • 40
    • 1442348829 scopus 로고    scopus 로고
    • Conditionally replicative adenovirus driven by the human telomerase promoter provides broad-spectrum antitumor activity without liver toxicity
    • DOI 10.1038/sj.cgt.7700666
    • Irving J, Wang Z, Powell S et al. Conditionally replicative adenovirus driven by the human telomerase promoter provides broad-spectrum antitumor activity without liver toxicity. Cancer Gene Ther. 11(3), 174-185 (2004). (Pubitemid 38280520)
    • (2004) Cancer Gene Therapy , vol.11 , Issue.3 , pp. 174-185
    • Irving, J.1    Wang, Z.2    Powell, S.3    O'Sullivan, C.4    Mok, M.5    Murphy, B.6    Cardoza, L.7    Lebkowski, J.S.8    Majumdar, A.S.9
  • 41
    • 0142010649 scopus 로고    scopus 로고
    • Ad-mTERT-Δ19, a Conditional Replication-Competent Adenovirus Driven by the Human Telomerase Promoter, Selectively Replicates in and Elicits Cytopathic Effect in a Cancer Cell-Specific Manner
    • DOI 10.1089/104303403769211637
    • Kim E, Kim JH, Shin HY et al. Ad-mTERT-d19, a conditional replication-competent adenovirus driven by the human telomerase promoter, selectively replicates in and elicits cytopathic effect in a cancer cell-specific manner. Hum. Gene Ther. 14(15), 1415-1428 (2003). (Pubitemid 37268220)
    • (2003) Human Gene Therapy , vol.14 , Issue.15 , pp. 1415-1428
    • Kim, E.1    Kim, J.-H.2    Shin, H.-Y.3    Lee, H.4    Yang, J.M.5    Kim, J.6    Sohn, J.-H.7    Kim, H.8    Yun, C.-O.9
  • 42
    • 0042674013 scopus 로고    scopus 로고
    • Telomerase-dependent oncolytic adenovirus for cancer treatment
    • DOI 10.1038/sj.gt.3301987
    • Huang TG, Savontaus MJ, Shinozaki K et al. Telomerase-dependent oncolytic adenovirus for cancer treatment. Gene Ther. 10(15), 1241-1247 (2003). (Pubitemid 36934726)
    • (2003) Gene Therapy , vol.10 , Issue.15 , pp. 1241-1247
    • Huang, T.-G.1    Savontaus, M.J.2    Shinozaki, K.3    Sauter, B.V.4    Woo, S.L.C.5
  • 43
    • 0842329844 scopus 로고    scopus 로고
    • A novel oncolytic adenovirus targeting to telomerase activity in tumor cells with potent
    • DOI 10.1038/sj.onc.1207033
    • Zou W, Luo C, Zhang Z et al. A novel oncolytic adenovirus targeting to telomerase activity in tumor cells with potent. Oncogene 23(2), 457-464 (2004). (Pubitemid 38175000)
    • (2004) Oncogene , vol.23 , Issue.2 , pp. 457-464
    • Zou, W.1    Luo, C.2    Zhang, Z.3    Liu, J.4    Gu, J.5    Pei, Z.6    Qian, C.7    Liu, X.8
  • 44
    • 27944486111 scopus 로고    scopus 로고
    • Oncolytic adenovirus that overproduces ADP and replicates selectively in tumors due to hTERT promoter-regulated E4 gene expression
    • DOI 10.1038/sj.gt.3302581, PII 3302581
    • Kuppuswamy M, Spencer JF, Doronin K et al. Oncolytic adenovirus that overproduces ADP and replicates selectively in tumors due to hTERT promoter-regulated E4 gene expression. Gene Ther. 12(22), 1608-1617 (2005). (Pubitemid 41670351)
    • (2005) Gene Therapy , vol.12 , Issue.22 , pp. 1608-1617
    • Kuppuswamy, M.1    Spencer, J.F.2    Doronin, K.3    Tollefson, A.E.4    Wold, W.S.M.5    Toth, K.6
  • 45
    • 0035417931 scopus 로고    scopus 로고
    • A hepatocellular carcinoma-specific adenovirus variant, CV890, eliminates distant human liver tumors in combination with doxorubicin
    • Li Y, Yu DC, Chen Y et al. A hepatocellular carcinoma-specific adenovirus variant, CV890, eliminates distant human liver tumors in combination with doxorubicin. Cancer Res. 61(17), 6428-6436 (2001). (Pubitemid 32783248)
    • (2001) Cancer Research , vol.61 , Issue.17 , pp. 6428-6436
    • Li, Y.1    Yu, D.-C.2    Chen, Y.3    Amin, P.4    Zhang, H.5    Nguyen, N.6    Henderson, D.R.7
  • 47
  • 49
    • 33847390325 scopus 로고    scopus 로고
    • Telomerase-specific oncolytic virotherapy for human cancer with the hTERT promoter
    • DOI 10.2174/156800907780058835
    • Fujiwara T, Urata Y, Tanaka N. Telomerase-specific oncolytic virotherapy for human cancer with the promoter. Curr. Cancer Drug Targets 7(2), 191-201 (2007). (Pubitemid 46348634)
    • (2007) Current Cancer Drug Targets , vol.7 , Issue.2 , pp. 191-201
    • Fujiwara, T.1    Urata, Y.2    Tanaka, N.3
  • 50
    • 33846686516 scopus 로고    scopus 로고
    • Systemic efficacy with oncolytic virus therapeutics: Clinical proof-of-concept and future directions
    • DOI 10.1158/0008-5472.CAN-06-2871
    • Liu TC, Kirn D. Systemic efficacy with oncolytic virus therapeutics: clinical proof-of-concept and future directions. Cancer Res. 67(2), 429-432 (2007). (Pubitemid 46192175)
    • (2007) Cancer Research , vol.67 , Issue.2 , pp. 429-432
    • Liu, T.-C.1    Kirn, D.2
  • 51
    • 49149086250 scopus 로고    scopus 로고
    • Adenovirus-mediated gene expression imaging to directly detect sentinel lymph node metastasis of prostate cancer
    • Burton JB, Johnson M, Sato M et al. Adenovirus-mediated gene expression imaging to directly detect sentinel lymph node metastasis of prostate cancer. Nat. Med. 14(8), 882-888 (2008).
    • (2008) Nat. Med. , vol.14 , Issue.8 , pp. 882-888
    • Burton, J.B.1    Johnson, M.2    Sato, M.3
  • 53
    • 65249144492 scopus 로고    scopus 로고
    • Telomerase-specific virotheranostics for human head and neck cancer
    • Kurihara Y, Watanabe Y, Onimatsu H et al. Telomerase-specific virotheranostics for human head and neck cancer. Clin. Cancer Res. 15(7), 2335-2343 (2009).
    • (2009) Clin. Cancer Res. , vol.15 , Issue.7 , pp. 2335-2343
    • Kurihara, Y.1    Watanabe, Y.2    Onimatsu, H.3
  • 54
    • 77953027875 scopus 로고    scopus 로고
    • In vivo biological purging for lymph node metastasis of human colorectal cancer by telomerase-specific oncolytic virotherapy
    • Kojima T, Watanabe Y, Hashimoto Y et al. In vivo biological purging for lymph node metastasis of human colorectal cancer by telomerase-specific oncolytic virotherapy. Ann. Surg. 251(6), 1079-1086 (2010).
    • (2010) Ann. Surg. , vol.251 , Issue.6 , pp. 1079-1086
    • Kojima, T.1    Watanabe, Y.2    Hashimoto, Y.3
  • 57
    • 0036984640 scopus 로고    scopus 로고
    • Role of angiogenesis in tumor growth and metastasis
    • Folkman J. Role of angiogenesis in tumor growth and metastasis. Semin. Oncol. 29(6 Suppl. 16), 15-18 (2002).
    • (2002) Semin. Oncol. , vol.29 , Issue.6-16 , pp. 15-18
    • Folkman, J.1
  • 58
    • 67549146091 scopus 로고    scopus 로고
    • Phase I trial of intratumoral administration of OBP-301 a novel telomerase-specific oncolytic virus in patients with advanced solid cancer: Evaluation of biodistribution and immune response
    • Fujiwara T, Tanaka N, Numunaitis JJ et al. Phase I trial of intratumoral administration of OBP-301, a novel telomerase-specific oncolytic virus, in patients with advanced solid cancer: evaluation of biodistribution and immune response. J. Clin. Oncol. 26(155), 3572 (2008).
    • (2008) J. Clin. Oncol. , vol.26 , Issue.155 , pp. 3572
    • Fujiwara, T.1    Tanaka, N.2    Numunaitis, J.J.3
  • 59
    • 76349086193 scopus 로고    scopus 로고
    • A phase I study of telomerase-specific replication competent oncolytic adenovirus telomelysin for various solid tumors
    • Nemunaitis J, Tong AW, Nemunaitis M et al. A Phase I study of telomerase-specific replication competent oncolytic adenovirus (telomelysin), for various solid tumors. Mol. Ther. 18(2), 429-434 (2010).
    • (2010) Mol. Ther. , vol.18 , Issue.2 , pp. 429-434
    • Nemunaitis, J.1    Tong, A.W.2    Nemunaitis, M.3
  • 61
    • 33745161873 scopus 로고    scopus 로고
    • A Phase I Trial of Intravenous CG7870, a Replication-Selective, Prostate-Specific Antigen-Targeted Oncolytic Adenovirus, for the Treatment of Hormone-Refractory, Metastatic Prostate Cancer
    • DOI 10.1016/j.ymthe.2006.02.011, PII S152500160600075X
    • Small EJ, Carducci MA, Burke JM et al. A Phase I trial of intravenous CG7870, a replication-selective, prostate-specific antigen-targeted oncolytic adenovirus, for the treatment of hormone-refractory, metastatic prostate cancer. Mol. Ther. 14(1), 107-117 (2006). (Pubitemid 43899483)
    • (2006) Molecular Therapy , vol.14 , Issue.1 , pp. 107-117
    • Small, E.J.1    Carducci, M.A.2    Burke, J.M.3    Rodriguez, R.4    Fong, L.5    Van Ummersen, L.6    Yu, D.C.7    Aimi, J.8    Ando, D.9    Working, P.10    Kirn, D.11    Wilding, G.12
  • 62
    • 50049112424 scopus 로고    scopus 로고
    • Autophagy-inducing agents augment the antitumor effect of telerase-selve oncolytic adenovirus OBP-405 on glioblastoma cells
    • Yokoyama T, Iwado E, Kondo Y et al. Autophagy-inducing agents augment the antitumor effect of telerase-selve oncolytic adenovirus OBP-405 on glioblastoma cells. Gene Ther. 15(17), 1233-1239 (2008).
    • (2008) Gene Ther. , vol.15 , Issue.17 , pp. 1233-1239
    • Yokoyama, T.1    Iwado, E.2    Kondo, Y.3
  • 64
    • 33745190090 scopus 로고    scopus 로고
    • Enhanced antitumor efficacy of telomerase-selective oncolytic adenoviral agent OBP-401 with docetaxel: Preclinical evaluation of chemovirotherapy
    • Fujiwara T, Kagawa S, Kishimoto H et al. Enhanced antitumor efficacy of telomerase-selective oncolytic adenoviral agent OBP-401 with docetaxel: preclinical evaluation of chemovirotherapy. Int. J. Cancer 119(2), 432-440 (2006).
    • (2006) Int. J. Cancer , vol.119 , Issue.2 , pp. 432-440
    • Fujiwara, T.1    Kagawa, S.2    Kishimoto, H.3
  • 66
    • 66449119930 scopus 로고    scopus 로고
    • Preclinical evaluation of synergistic effect of telomerase-specific oncolytic virotherapy and gemcitabine for human lung cancer
    • Liu D, Kojima T, Ouchi M et al. Preclinical evaluation of synergistic effect of telomerase-specific oncolytic virotherapy and gemcitabine for human lung cancer. Mol. Cancer Ther. 8(4), 980-987 (2009).
    • (2009) Mol. Cancer Ther. , vol.8 , Issue.4 , pp. 980-987
    • Liu, D.1    Kojima, T.2    Ouchi, M.3
  • 68
    • 77953450592 scopus 로고    scopus 로고
    • Preclinical evaluation of differentially targeting dual virotherapy for human solid cancer
    • Sakai R, Kagawa S, Yamasaki Y et al. Preclinical evaluation of differentially targeting dual virotherapy for human solid cancer. Mol. Cancer Ther. 9(6), 1884-1893 (2010).
    • (2010) Mol. Cancer Ther. , vol.9 , Issue.6 , pp. 1884-1893
    • Sakai, R.1    Kagawa, S.2    Yamasaki, Y.3


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