HMGB-1 induces IL-6 production in human synovial fibroblasts through c-Src, Akt and NF-κB pathways

Journal of Cellular Physiology

Volumn 226, Issue 8, 2011, Pages 2006-2015

  Hou, Chun Han ^a,b   Fong, Yi Chin ^c,d   Tang, Chih Hsin ^c  

^a NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^c CHINA MEDICAL UNIVERSITY   (Taiwan)

^d CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ADVANCED GLYCATION END PRODUCT RECEPTOR; HIGH MOBILITY GROUP B1 PROTEIN; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; MONOCLONAL ANTIBODY; PROTEIN KINASE B; PROTEIN KINASE B INHIBITOR; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR; PYRROLIDINE DITHIOCARBAMATE; SMALL INTERFERING RNA; TOSYLPHENYLALANYL CHLOROMETHYL KETONE;

ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; FIBROBLAST; HUMAN; HUMAN CELL; INFLAMMATION; INTRACELLULAR SIGNALING; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

CELLS, CULTURED; FIBROBLASTS; HMGB1 PROTEIN; HUMANS; INTERLEUKIN-6; METABOLIC NETWORKS AND PATHWAYS; NF-KAPPA B; ONCOGENE PROTEIN V-AKT; PYRIMIDINES; PYRROLIDINES; SERINE PROTEINASE INHIBITORS; SIGNAL TRANSDUCTION; SRC-FAMILY KINASES; SYNOVIAL MEMBRANE; THIOCARBAMATES; TOSYLPHENYLALANYL CHLOROMETHYL KETONE;

EUKARYOTA;

EID: 79955103371     PISSN: 00219541     EISSN: 10974652     Source Type: Journal    
DOI: 10.1002/jcp.22541     Document Type: Article

References (36)

1. Abeyama K, Eng W, Jester JV, Vink AA, Edelbaum D, Cockerell CJ, Bergstresser PR, Takashima A. 2000. A role for NF-kappaB-dependent gene transactivation in sunburn. J Clin Invest 105: 1751-1759.
2. Bustin M. 1999. Regulation of DNA-dependent activities by the functional motifs of the high-mobility-group chromosomal proteins. Mol Cell Biol 19: 5237-5246.
3. Bustin M, Lehn DA, Landsman D. 1990. Structural features of the HMG chromosomal proteins and their genes. Biochim Biophys Acta 1049: 231-243.
4. Chen Q, Dong L, Wang L, Kang L, Xu B. 2009. Advanced glycation end products impair function of late endothelial progenitor cells through effects on protein kinase Akt and cyclooxygenase-2. Biochem Biophys Res Commun 381: 192-197.
5. Chen Z, Hagler J, Palombella VJ, Melandri F, Scherer D, Ballard D, Maniatis T. 1995. Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway. Genes Dev 9: 1586-1597.
6. Chiu YC, Fong YC, Lai CH, Hung CH, Hsu HC, Lee TS, Yang RS, Fu WM, Tang CH. 2008. Thrombin-induced IL-6 production in human synovial fibroblasts is mediated by PAR1, phospholipase C, protein kinase C alpha, c-Src, NF-kappa B and p300 pathway. Mol Immunol 45: 1587-1599.
7. Chiu YC, Lin CY, Chen CP, Huang KC, Tong KM, Tzeng CY, Lee TS, Hsu HC, Tang CH. 2009. Peptidoglycan enhances IL-6 production in human synovial fibroblasts via TLR2 receptor, focal adhesion kinase, Akt, and AP-1-dependent pathway. J Immunol 183: 2785-2792.
8. Clouet J, Vinatier C, Merceron C, Pot-vaucel M, Maugars Y, Weiss P, Grimandi G, Guicheux J. 2009. From osteoarthritis treatments to future regenerative therapies for cartilage. Drug Discov Today 14: 913-925.
9. Franke S, Sommer M, Ruster C, Bondeva T, Marticke J, Hofmann G, Hein G, Wolf G. 2009. Advanced glycation end products induce cell cycle arrest and proinflammatory changes in osteoarthritic fibroblast-like synovial cells. Arthritis Res Ther 11: R136.
10. Gallucci S, Lolkema M, Matzinger P. 1999. Natural adjuvants: Endogenous activators of dendritic cells. Nat Med 5: 1249-1255.
11. Graeve L, Baumann M, Heinrich PC. 1993. Interleukin-6 in autoimmune disease. Role of IL-6 in physiology and pathology of the immune defense. Clin Investig 71: 664-671.
12. Grassl C, Luckow B, Schlondorff D, Dendorfer U. 1999. Transcriptional regulation of the interleukin-6 gene in mesangial cells. J Am Soc Nephrol 10: 1466-1477.
13. Grimble RF. 1998. Nutritional modulation of cytokine biology. Nutrition 14: 634-640.
14. Hou FF, Jiang JP, Guo JQ, Wang GB, Zhang X, Stern DM, Schmidt AM, Owen WF, Jr. 2002. Receptor for advanced glycation end products on human synovial fibroblasts: Role in the pathogenesis of dialysis-related amyloidosis. J Am Soc Nephrol 13: 1296-1306.
15. Hsu HC, Fong YC, Chang CS, Hsu CJ, Hsu SF, Lin JG, Fu WM, Yang RS, Tang CH. 2007. Ultrasound induces cyclooxygenase-2 expression through integrin, integrin-linked kinase, Akt, NF-kappaB and p300 pathway in human chondrocytes. Cell Signal 19: 2317-2328.
16. Jones SA. 2005. Directing transition from innate to acquired immunity: Defining a role for IL-6. J Immunol 175: 3463-3468.
17. Liu Y, Liang C, Liu X, Liao B, Pan X, Ren Y, Fan M, Li M, He Z, Wu J, Wu Z. 2010. AGEs increased migration and inflammatory responses of adventitial fibroblasts via RAGE, MAPK and NF-kappaB pathways. Atherosclerosis 208: 34-42.
18. Maniatis T. 1997. Catalysis by a multiprotein IkappaB kinase complex. Science 278: 818-819.
19. Matsusaka T, Fujikawa K, Nishio Y, Mukaida N, Matsushima K, Kishimoto T, Akira S. 1993. Transcription factors NF-IL6 and NF-kappa B synergistically activate transcription of the inflammatory cytokines, interleukin 6 and interleukin 8. Proc Natl Acad Sci USA 90: 10193-10197.
20. Mor A, Abramson SB, Pillinger MH. 2005. The fibroblast-like synovial cell in rheumatoid arthritis: A key player in inflammation and joint destruction. Clin Immunol 115: 118-128.
21. Mosevitsky MI, Novitskaya VA, Iogannsen MG, Zabezhinsky MA. 1989. Tissue specificity of nucleo-cytoplasmic distribution of HMG1 and HMG2 proteins and their probable functions. Eur J Biochem 185: 303-310.
22. Okamoto H, Katagiri Y, Kiire A, Momohara S, Kamatani N. 2008. Serum amyloid A activates nuclear factor-kappaB in rheumatoid synovial fibroblasts through binding to receptor of advanced glycation end-products. J Rheumatol 35: 752-756.
23. Pelletier JP, Martel-Pelletier J, Abramson SB. 2001. Osteoarthritis, an inflammatory disease: Potential implication for the selection of new therapeutic targets. Arthritis Rheum 44: 1237-1247.
24. Persson E, Voznesensky OS, Huang YF, Lerner UH. 2005. Increased expression of interleukin-6 by vasoactive intestinal peptide is associated with regulation of CREB, AP-1 and C/EBP, but not NF-kappaB, in mouse calvarial osteoblasts. Bone 37: 513-529.
25. Pullerits R, Jonsson IM, Verdrengh M, Bokarewa M, Andersson U, Erlandsson-Harris H, Tarkowski A. 2003. High mobility group box chromosomal protein 1, a DNA binding cytokine, induces arthritis. Arthritis Rheum 48: 1693-1700.
26. Roskoski R, Jr. 2005. Src kinase regulation by phosphorylation and dephosphorylation. Biochem Biophys Res Commun 331: 1-14.
27. Schmidt AM, Yan SD, Yan SF, Stern DM. 2001. The multiligand receptor RAGE as a progression factor amplifying immune and inflammatory responses. J Clin Invest 108: 949-955.
28. Steenvoorden MM, Toes RE, Ronday HK, Huizinga TW, Degroot J. 2007. RAGE activation induces invasiveness of RA fibroblast-like synoviocytes in vitro. Clin Exp Rheumatol 25: 740-742.
29. Sunahori K, Yamamura M, Yamana J, Takasugi K, Kawashima M, Makino H. 2006. Increased expression of receptor for advanced glycation end products by synovial tissue macrophages in rheumatoid arthritis. Arthritis Rheum 54: 97-104.
30. Tang CH, Chiu YC, Tan TW, Yang RS, Fu WM. 2007. Adiponectin enhances IL-6 production in human synovial fibroblast via an AdipoR1 receptor, AMPK, p38, and NF-kappa B pathway. J Immunol 179: 5483-5492.
31. Tang CH, Hsu CJ, Yang WH, Fong YC. 2010a. Lipoteichoic acid enhances IL-6 production in human synovial fibroblasts via TLR2 receptor, PKCdelta and c-Src dependent pathways. Biochem Pharmacol 79: 1648-1657.
32. Tang CH, Yamamoto A, Lin YT, Fong YC, Tan TW. 2010b. Involvement of matrix metalloproteinase-3 in CCL5/CCR5 pathway of chondrosarcomas metastasis. Biochem Pharmacol 79: 209-217.
33. Taniguchi N, Kawahara K, Yone K, Hashiguchi T, Yamakuchi M, Goto M, Inoue K, Yamada S, Ijiri K, Matsunaga S, Nakajima T, Komiya S, Maruyama I. 2003. High mobility group box chromosomal protein 1 plays a role in the pathogenesis of rheumatoid arthritis as a novel cytokine. Arthritis Rheum 48: 971-981.
34. Wright AA, Cook C, Abbott JH. 2009. Variables associated with the progression of hip osteoarthritis: A systematic review. Arthritis Rheum 61: 925-936.
35. Yeh M, Gharavi NM, Choi J, Hsieh X, Reed E, Mouillesseaux KP, Cole AL, Reddy ST, Berliner JA. 2004. Oxidized phospholipids increase interleukin 8 (IL-8) synthesis by activation of the c-src/signal transducers and activators of transcription (STAT)3 pathway. J Biol Chem 279: 30175-30181.
36. Yokota K, Miyazaki T, Hirano M, Akiyama Y, Mimura T. 2006. Simvastatin inhibits production of interleukin 6 (IL-6) and IL-8 and cell proliferation induced by tumor necrosis factor-alpha in fibroblast-like synoviocytes from patients with rheumatoid arthritis. J Rheumatol 33: 463-471.