Thrombin-induced IL-6 production in human synovial fibroblasts is mediated by PAR1, phospholipase C, protein kinase Cα, c-Src, NF-kappaB and p300 pathway

Molecular Immunology

Volumn 45, Issue 6, 2008, Pages 1587-1599

  Chiu, Yung Cheng ^a,b   Fong, Yi Chin ^c   Lai, Chih Ho ^b   Hung, Chien Hui ^b   Hsu, Horng Chaung ^c   Lee, Tu Sheng ^a   Yang, Rong Sen ^d   Fu, Wen Mei ^d   Tang, Chih Hsin ^b  

^a TAICHUNG VETERANS GENERAL HOSPITAL   (Taiwan)

^b CHINA MEDICAL UNIVERSITY   (Taiwan)

^c CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^d NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

c Src; IL 6; NF B; RA; Thrombin

Indexed keywords

I KAPPA B; I KAPPA B KINASE ALPHA; I KAPPA B KINASE BETA; I KAPPA B KINASE INHIBITOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; LUCIFERASE; PHOSPHOLIPASE C; PHOSPHOLIPASE C INHIBITOR; PROTEIN KINASE C ALPHA; PROTEIN KINASE C ALPHA INHIBITOR; PROTEINASE ACTIVATED RECEPTOR 1; PROTEINASE ACTIVATED RECEPTOR 2; SMALL INTERFERING RNA; THROMBIN;

ACETYLATION; ARTICLE; CYTOSOL; FIBROBLAST; HUMAN; IMMUNE RESPONSE; MEMBRANE BINDING; NUCLEOTIDE SEQUENCE; ONCOGENE SRC; PRIORITY JOURNAL; PROTEIN BINDING; UPREGULATION;

CELLS, CULTURED; ENZYME ACTIVATION; FIBROBLASTS; HUMANS; INTERLEUKIN-6; NF-KAPPA B; P300-CBP TRANSCRIPTION FACTORS; PHOSPHORYLATION; PROTEIN KINASE C-ALPHA; PROTO-ONCOGENE PROTEINS PP60(C-SRC); RECEPTOR, PAR-1; SIGNAL TRANSDUCTION; SYNOVIAL MEMBRANE; THROMBIN; TYPE C PHOSPHOLIPASES; UP-REGULATION;

EID: 38949094588     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molimm.2007.10.004     Document Type: Article

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