Pharmacological and toxicological assessment of a potential GnRH vaccine in young-adult male pigs

Vaccine

Volumn 29, Issue 21, 2011, Pages 3791-3801

  Turkstra, J A ^a   Van Der Staay, F J ^b   Stockhofe Zurwieden, N ^b   Woelders, H ^b   Meloen, R H ^a   Schuurman, T ^a  

^a Pepscan Therapeutics   (Netherlands)

^b WAGENINGEN UNIVERSITY   (Netherlands)

Author keywords

Active immunization; Efficacy; GnRH; Safety; Testosterone

Indexed keywords

GONADOTROPHIN RELEASING HORMONE VACCINE; PEPTIDE VACCINE; TESTOSTERONE; UNCLASSIFIED DRUG;

ACCESSORY SEX ORGAN; ACTIVE IMMUNIZATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CASTRATED MALE; CONTROLLED STUDY; DRUG EFFICACY; DRUG SAFETY; FEVER; INJECTION SITE SWELLING; MALE; NONHUMAN; PRIORITY JOURNAL; SPERMATOZOON COUNT; SPERMATOZOON MOTILITY; SWINE; TESTIS SIZE; TESTOSTERONE BLOOD LEVEL;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; BODY TEMPERATURE; DRUG TOXICITY; GONADOTROPIN-RELEASING HORMONE; GONADOTROPINS; IMMUNIZATION; MALE; ORGAN SIZE; SEXUAL MATURATION; SPERM COUNT; SPERM MOTILITY; SUS SCROFA; TESTIS; TESTOSTERONE; UREA; VACCINES;

EID: 79955088381     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vaccine.2011.03.023     Document Type: Article

References (68)

1. Padmenabhan V., Mc Neilly A.S. Is there a FSH releasing factor?. Reproduction 2001, 121:21-30.
2. Griswold M.D. The central role of Sertoli cells in spermatogenesis. Semin Cell Dev Biol 1998, 9:411-416.
3. Fraser H.M. Antifertility effects of GnRH. J Reprod Fertil 1982, 64:503-515.
4. Bonneau M., Enright W.J. Immunocastration in cattle and pigs. Livest Prod Sci 1995, 42:193-200.
5. Dowsett K.F., Knott L.M., Tshewang U., Jackson A.E., Bodero D.A.V., Trigg T.E. Suppression of testicular function using two dose rates of a reversible water soluble gonadotropin releasing hormone (GnRH) vaccine in colts. Aust Vet J 1996, 74:228-235.
6. Ladd A., Tsong Y.Y., Walfield A.M., Thau R. Development of an antifertility vaccine for pets based on active immunisation against luteinizing hormone-releasing hormone. Biol Reprod 1994, 51:1076-1083.
7. Miller L.A., Johns B.E., Killian G.J. Immunocontraception of white-tailed deer with GnRH vaccine. Am J Reprod Immunol 2000, 44:266-274.
8. Robbins S.C., Jelinski M.D., Stotish R.L. Assessment of the immunological and biological efficacy of two different doses of a recombinant GnRH vaccine in domestic male and female cats (Felis catus). J Reprod Immunol 2004, 64:107-119.
9. Dunshea F.R., Colantoni C., Howard K., McCauley I., Jackson P., Long K.A., et al. Vaccination of boars with a GnRH vaccine (Improvac) eliminates boar taint and increases growth performance. J Anim Sci 2001, 79:2524-2535.
10. Meloen R.H., Turkstra J.A., Lankhof H., Puijk W.C., Schaaper W.M., Dijkstra G., et al. Efficient immunocastration of male piglets by immunoneutralization of GnRH using a new GnRH-like peptide. Vaccine 1994, 12:741-746.
11. Zamaratskaia G., Andersson H.K., Chen G., Andersson K., Madej A., Lundström K. Effect of a gonadotropin-releasing hormone vaccine (Improvac™) on steroid hormones, boar taint compounds and performance in entire male pigs. Reprod Domest Anim 2008, 43(3):351-359.
12. Gual C., Garza-Flores J., Menjivar M., Gutierrez-Najar A., Pal R., Talwar G.P. Ability of an anti-luteinizing hormone-releasing hormone vaccine to inhibit gonadotropins in postmenopausal women. Fertil Steril 1997, 67:404-407.
13. Parkinson R.J., Simms M.S., Broome P., Humphreys J.E., Bishop M.C. A vaccination strategy for the long-term suppression of androgens in advanced prostate cancer. Eur Urol 2004, 45(2):171-175.
14. Simms M.S., Scholfield D.P., Jacobs E., Michaeli D., Broome P., Humphreys J.E., et al. Anti-GnRH antibodies can induce castrate levels of testosterone in patients with advanced prostate cancer. Br J Cancer 2000, 83:443-446.
15. Talwar G.P. Vaccines for control of fertility and hormone-dependent cancers. Immunol Cell Biol 1997, 75:184-189.
16. Talwar G.P., Diwan M., Dawar H., Frick J., Sharma S.K., Wadhwa S.N. Counter GnRH vaccine. Proceedings of the Symposium on 'Male Contraception: Present and Future' 1995, 309-318. M. Rajalakshmi, P.D. Griffin (Eds.).
17. Jemal A., Siegel R., Ward E., Hao Y., Xu J.T.M., et al. Cancer statistics, 2008. CA Cancer J Clin 2008, 58:71-96.
18. Korr L. Radiotherapy for the palliation of prostate cancer. Semin Surg Oncol 2000, 18:75-79.
19. Roscigno M., Sangalli M., Mazzoccoli B., Scattoni V., Da Pozzo L., Rigatti P. Medical therapy of prostate cancer. A review. Minerva Urol Nefrol 2005, 57(2):71-84.
20. Denmeade S.R., Isaacs J.T. A history of prostate cancer treatment. Nat Rev Cancer 2002, 2:289-296.
21. Oonk H.B., Turkstra J.A., Schaaper W.M.M., Erkens J.H.F., Schuitemaker-de Weerd M.H., van Nes A., et al. New GnRH-like peptide construct to optimize efficient immunocastration of male pigs by immunoneutralization of GnRH. Vaccine 1998, 16:1074-1082.
22. Turkstra J.A., van der Meer F.J.U.M., Knaap J., Rottier P.J.M., Teerds K.J., Colenbrander B., et al. Effects of GnRH immunization in sexually mature pony stallions. Anim Reprod Sci 2005, 86:247-259.
23. Holmberg L.A., Sandmaier B.M. Theratope vaccine (STn-KLH). Expert Opin Biol Ther 2001, 1:881-891.
24. Naylor P.H., Sztein M.B., Wada S., Maurer S., Holterman D., Kirkley J.E., et al. Preclinical and clinical studies on immunogenicity and safety of the HIV-1 p17-based synthetic peptide AIDS vaccine--HGP-30-KLH. Int J Immunopharmacol 1991, 13(Suppl. 1):117-127.
25. Blom A.G., Hilgers L.A. Sucrose fatty acid sulphate esters as novel vaccine adjuvants: effect of the chemical composition. Vaccine 2004, 23:743-754.
26. Bode G., Clausing P., Gervais F., Loegsted J., Luft J., Nogues V., et al. The utility of the minipig as an animal model in regulatory toxicology. J Pharmacol Toxicol Methods 2010, 62(3):196-220.
27. Ellegaard L., Cunningham A., Edwards S., Grand N., Nevalainen T., Prescott M., et al. Welfare of the minipig with special reference to use in regulatory toxicology studies. J Pharmacol Toxicol Methods 2010, 62(3):167-183.
28. Hilgers L.A., Blom A.G. Sucrose fatty acid sulphate esters as novel vaccine adjuvant. Vaccine 2006, 24(Suppl. 2). S2-81-2.
29. Turkstra J.A., Oonk H.B., Schaaper W.M.M., Meloen R.H. The role of the individual amino acids of a GnRH-tandem-dimer peptide used as an antigen for immunocastration of male piglets determined with systematic alanine replacements. Vaccine 2002, 20:406-412.
30. van de Wiel D.F.M., Erkens J., Koops W., Vos E., van Landeghem A.A.J. Periestrous and midluteal time courses of circulating LH FSH, prolactin, estradiol-17b and progesterone in the domestic pig. Biol Reprod 1981, 24:223-233.
31. Woelders H., Matthijs A., Engel B. Effects of trehalose and sucrose, osmolality of the freezing medium, and cooling rate on viability and intactness of bull sperm after freezing and thawing. Cryobiology 1997, 35:93-105.
32. Pursel V.G., Johnson L.A., Rampacek G.B. Acrosome morphology of boar spermatozoa incubated before cold shock. J Anim Sci 1972, 34:278-283.
33. Bailey T.L., Hudson R.S., Powe T.A., Riddell M.G., Wolfe D.F., Carson R.L. Caliper and ultrasonographic measurements of bovine testicles and a mathematical formula for determining testicular volume and weight in vivo. Theriogenology 1998, 49:581-594.
34. Awoniyi C.A., Chandrashekar V., Arthur R.D., Schanbacher B.D., Amador A.G., Falvo R.E. Pituitary and Leydig cell function in boars actively immunized against gonadotrophin-releasing hormone. J Reprod Fertil 1988, 84:295-302.
35. Wagner A., Claus R. Involvement of glucocorticoids in testicular involution after active immunization of boars against GnRH. Reproduction 2004, 127:275-283.
36. Caraty A., Bonneau M. Immunisation active du porc mâle contre la gonadolibérine: effets sur la secrétion d'hormones gonadotropes et sur la teneur en 5aandrost-16-ène-3-one du tissu adipeux. C R Seances Acad Sci D 1986, 303:673-676.
37. Esbenshade K.L., Britt J.H. Active immunization of gilts against gonadotropin-releasing hormone: effects on secretion of gonadotropins, reproductive function, and responses to agonists of gonadotropin-releasing hormone. Biol Reprod 1985, 33:569-577.
38. Dees W.L., Dearth R.K., Hooper R.N., Brinsko S.P., Romano J.E., Rahe H., et al. Lamprey gonadotropin-releasing hormone-III selectively releases follicle stimulating hormone in the bovine. Domest Anim Endocrinol 2001, 20:279-288.
39. Kauffold J., Schneider F., Zaremba W., Brüssow K.-P. Lamprey GnRH-III stimulates FSH secretion in barrows. Reprod Domest Anim 2005, 40(5):475-479.
40. McCann S.M., Karanth S., Mastronardi C.A., Dees W.L., Childs G., Miller B., et al. Control of gonadotropin secretion by follicle-stimulating hormone-releasing factor, luteinizing hormone-releasing hormone, and leptin. Arch Med Res 2001, 32:476-485.
41. Yu W.H., Karanth S., Walczewska A., Sower S.A., McCann S.M. A hypothalamic follicle-stimulating hormone-releasing decapeptide in the rat. Proc Natl Acad Sci U S A 1997, 94:9499-9503.
42. Amstalden M., Zieba D.A., Garcia M.R., Stanko R.L., Welsh T.H., Hansel W.H., et al. Evidence that lamprey GnRH-III does not release FSH selectively in cattle. Reproduction 2004, 127:35-43.
43. Barretero-Hernandez R., Vizcarra J.A., Bowen A., Galyean M. Lamprey GnRH-III releases luteinizing hormone but not follicle stimulating hormone in pigs. Reprod Domest Anim 2009, 45(6):983-987.
44. Turkstra J.A., Schaaper W.M.M., Oonk H.B., Meloen R.H. GnRH tandem peptides for inducing an immunogenic response to GnRH-I without cross-reactivity to other GnRH isoforms. Vaccine 2005, 23:4915-4920.
45. Bowen A., Berghman S.K., Kirby L., Wettemann J.D., Vizcarra R.P.J.A. Immunization of pigs against chicken gonadotropin-releasing hormone-II and lamprey gonadotropin-releasing hormone-III: effects on gonadotropin secretion and testicular function. J Anim Sci 2006, 84(11):2990-2999.
46. Janett F., Hussy D., Lischer C., Hassig M., Thun R. Semen characteristics after vasectomy in the ram. Theriogenology 2001, 56(3):485-491.
47. Neill J.D. GnRH and GnRH receptor genes in the human genome. Endocrinology 2002, 143:737-743.
48. Kumar N., Savage T., DeJesus W., Tsong Y.Y., Didolkar A., Sundaram K. Chronic toxicity and reversibility of antifertility effect of immunization against gonadotropin-releasing hormone in male rats and rabbits. Toxicol Sci 2000, 53:92-99.
49. Rovan E., Fiebiger E., Kalla N.R., Talwar G.P., Aulitzky W., Frick J. Effect of active immunization to luteinizing-hormone-releasing hormone on the fertility and histoarchitecture of the reproductive organs of male rat. Urol Res 1992, 20:323-334.
50. Ferro V.A., Khan M.A., McAdam D., Colston A., Aughey E., Mullen A.B., et al. Efficacy of an anti-fertility vaccine based on mammalian gonadotrophin releasing hormone (GnRH-I)-a histological comparison in male animals. Vet Immunol Immunopathol 2004, 101:73-86.
51. Apaja P.M., Aatsinki J.T., Rajaniemi H.J., Petaja-Repo U.E. Expression of the mature luteinizing hormone receptor in rodent urogenital and adrenal tissues is developmentally regulated at a post-translational level. Endocrinology 2005, 146:3224-3232.
52. Kakar S.S., Grantham K., Musgrove L.C., Devor D., Sellers J.C., Neill J.D. Rat gonadotropin-releasing hormone (GnRH) receptor: tissue expression and hormonal regulation of its mRNA. Mol Cell Endocrinol 1994, 101:151-157.
53. Awoniyi C.A., Kim W.K., Hurst B.S., Schlaff W.D. Immunoneutralization of gonadotropin-releasing hormone and subsequent treatment with testosterone silastic implants in rats: an approach toward developing a male contraceptive. Fertil Steril 1992, 58:403-408.
54. McLachlan R.I., Wreford N.G., Tsonis C., de Kretser D.M., Robertson D.M. Testosterone effects on spermatogenesis in the gonadotropin-releasing hormone-immunized rat. Biol Reprod 1994, 50:271-280.
55. Adams T.E., Adams B.M. Gonadotrope function in ovariectomized ewes actively immunized against gonadotropin-releasing hormone (GnRH). Biol Reprod 1986, 35:360-367.
56. Rabb M.H., Thompson D.L., Barry B.E., Colborn D.R., Hehnke K.E., Garza F. Effects of active immunization against GnRH on LH, FSH and prolactin storage, secretion and response to their secretagogues in pony geldings. J Anim Sci 1990, 68:3322-3329.
57. Ferro V.A., O'Grady J.E., Notman J., Stimson W.H. An investigation into the immunogenicity of a GnRH analogue in male rats: a comparison of the toxicity of various adjuvants used in conjunction with GnRH-glycys. Vaccine 1996, 14:451-457.
58. Vargas L., Sewell R., Marshall A., Galatioto J., Tsong Y.Y., Catterall J.F., et al. Immune complex deposition in adult male Sprague-Dawley rats chronically immunized with GnRH. Am J Reprod Immunol 2005, 54(5):292-310.
59. Claus R., Lacorn M., Danowski K., Pearce M.C., Bauer A. Short-term endocrine and metabolic reactions before and after second immunization against GnRH in boars. Vaccine 2007, 25(24):4689-4696.
60. Doornenbal H., Tong A.K., Newman J.A., Murray N.L., Mears G.J. Blood and serum components and organ weights in steers, bulls and zeranol-implanted bulls. J Anim Sci 1987, 64:489-496.
61. Morris J.M., Bubenik G.A. Seasonal levels of minerals, enzymes, nutrients and metabolic products in plasma of intact and castrated adult male white-tailed deer (Odocoileus virginianus). Comp Biochem Physiol A: Physiol 1983, 74:21-28.
62. Nishiyama T., Ishizaki F., Anraku T., Shimura H., Takahashi K. The influence of androgen deprivation therapy on metabolism in patients with prostate cancer. J Clin Endocrinol Metab 2005, 90:657-660.
63. Coma J., Zimmerman D.R., Carrion D. Relationship of rate of lean tissue growth and other factors to concentration of urea in plasma of pigs. J Anim Sci 1995, 73:3649-3656.
64. Metz C., Hohl K., Waidelich S., Drochner W., Claus R. Active immunization of boars against GnRH at an early age: consequences for testicular function, boar taint accumulation and N-retention. Livest Prod Sci 2002, 74:147-157.
65. Robertson I.S., Fraser H.M., Innes G.M., Jones A.S. Effect of immunological castration on sexual and production characteristics in male cattle. Vet Rec 1982, 111(23):529-531.
66. Tshewang U., Dowsett K.F., Knott L.M., Trigg T.E. Preliminary study of ovarian activity in fillies treated with a GnRH vaccine. Aust Vet J 1997, 75(9):663-667.
67. Clarke I.J., Brown B.W., Tran V.V., Scott C.J., Fry R., Milar R.P., et al. Neonatal immunization against gonadotropin-releasing hormone (GnRH) results in diminished GnRH secretion in adulthood. Endocrinology 1998, 139(4):2007-2014.
68. Molenaar G.J., Lugard-Kok C., Meloen R.H., Oonk R.B., de Koning J., Wensing C.J. Lesions in the hypothalamus after active immunisation against GnRH in the pig. J Neuroimmunol 1993, 48(1):1-11.