An investigation into the immunogenicity of a GnRH analogue in male rats: A comparison of the toxicity of various adjuvants used in conjunction with GnRH-glycys

Vaccine

Volumn 14, Issue 5, 1996, Pages 451-457

  Ferro, V A ^a   O'Grady, J E ^a   Notman, J ^a   Stimson, W H ^a  

^a UNIVERSITY OF STRATHCLYDE   (United Kingdom)

Author keywords

Active immunization; Adjuvant; Antibody titres; GnRH analogue; Gonadal atrophy; Immunoneutralization; PPD; Testosterone

Indexed keywords

ALUMINUM HYDROXIDE; FREUND ADJUVANT; GONADORELIN DERIVATIVE; TESTOSTERONE;

ANIMAL EXPERIMENT; ANTIBODY RESPONSE; ARTICLE; CONTROLLED STUDY; DRUG TOXICITY; IMMUNIZATION; IMMUNOGENICITY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SPERMATOGENESIS;

ADJUVANTS, IMMUNOLOGIC; AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES; BODY WEIGHT; GONADOTROPIN-RELEASING HORMONE; IMMUNIZATION; MALE; MOLECULAR SEQUENCE DATA; RATS; RATS, INBRED F344; TESTOSTERONE; TUBERCULIN;

EID: 0029881990     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0264-410X(95)00164-V     Document Type: Article

References (40)

1. Schally, A.V., Arimura, A. and Kastin, A.J. Hypothalamic regulatory hormones. Science 1973, 179, 341-350
2. Braden, T.D., Hawes, B.E. and Conn, P.M. Synthesis of GnRH receptors by gonadotrope cell cultures. Endocrinology 1989, 125, 1623-1629
3. Conn, P.M., Huckle, W.R., Andrews, W.V. and McArdle, C.A. The molecular mechanism of action of GnRH in the pituitary. In: Recent Progress in Hormone Research (Ed. Clarke, J.H). Academic Press, New York, 1987, Chap. 43, pp. 29-68
4. Besser, G.M. and Mortimer, C.H. Clinical endocrinology. In: Frontiers in Neuroendocrinology (Eds Martin, L. and Ganong, W.). Raven Press, New York, 1976, pp. 227-240
5. Kastin, A.J., Zarate, A., Midgley, A.R. and Canales, E.S. Ovulation confirmed by pregnancy after infusion of porcine LHRH. J. Clin. Endocrinol. Metab. 1971, 33, 980-982
6. Tcholakian, R.K., De La Cruz, A. and Chowdhury, M. Unusual anti-reproductive properties of an analogue of LHRH in male rats. Fertility Sterility 1978, 30, 600-603
7. 10) LHRH Ethylamide. Endocrinology 1978, 103, 641-643
8. Schriock, E., Monroe, S.E., Henzel, M. and Jaffe, R.B. Treatment of endometriosis with a potent agonist of gonadotropin-releasing hormone (nafarelin). Fertility Sterility 1985, 44, 583-588
9. Adashi, E.Y. Potential utility of gonadotropin releasing hormone agonists in the management of ovarian hyperandrogenism. Fertility Sterility 1990, 53, 765-779
10. Schally, A.V., Kastin, A.J. and Coy, D.H. LHRH and its analogues: recent basic and clinical investigation. Int. J. Fertil. 1976, 21, 1-30
11. Petri, W., Seidel, R. and Sandow, J. A pharmaceutical approach to long-term therapy with peptides. In: LHRH and its Analogues (Eds Labrie, F., Belanger, A. and Dupont, A.). Elsevier, Amsterdam, 1984
12. Fraser, H.M. and Baird, D.T. Clinical applications of LHRH analogues. Balliere's Clinical Endocrinology and Metabolism (Ed. Burger, H.G.). Balliere, Tindall, 1987, Vol. 1, pp. 43-70
13. MacLeod, T.L., Eisen, A. and Sussman, G.L. Anaphylactic reaction to synthetic luteinising hormone releasing hormone. Fertility Sterility 1987, 48, 500-502
14. Linde, R., Doelle, G.C. and Alexander, N. Reversible inhibition of testicular steroidogenesis and spermatogenesis by a potent gonadotrophin-releasing hormone agonist in normal men. N. Engl. J. Med. 1981, 305, 663-667
15. Jeffcoate, I.A. and Keeling, B.J. In: Immunological Aspects of Reproduction in Mammals (Ed. Crichton, D.B.). 1984, pp. 363-377
16. Giri, D.K., Jayaraman, S., Neelaram, G.S., Jayashankar, R. and Talwar, G.P. Prostatic hypoplasia in bonnet monkeys following active immunisation with semi-synthetic anti-LHRH vaccine. Exp. Mol. Pathol. 1991, 54, 255-264
17. Adams, TE. and Adams, B.M. Reproductive function and feed-lot performance of beef heifers actively immunised against GnRH. J. Animal Sci. 1990, 68, 2793-2802
18. Furr, B.J.A. and Nicholson, R.I. Use of analogues of luteinizing hormone-releasing hormone for the treatment of cancer. J. Reprod. Fert. 1982, 64, 529-539
19. Nicholson, R.I. and Golder, M.P. The effect of synthetic antioestrogens on the growth and biochemistry of rat mammary tumours. Eur. J. Cancer. 1975, 11, 571-579
20. Tiong, G.K.L., Gill, H.S., Lofthouse, S. and Puri, N.K. Comparison of conventional adjuvants and "adjuvant-free" monoclonal antibody targeting for stimulating antibody responses against a conjugate of luteinizing hormone releasing hormone and avidin. Vaccine 1993, 11, 425-430
21. Jayashankar, R., Chaudhary, M.K., Singh, O., Alam, A. and Talwar, G.P. Semisynthetic anti-LHRH vaccine causing atrophy of the prostate. Prostate 1989, 14, 3-11
22. Ferro, V.A., O'Grady, J.E., Notman J. and Stimson, W.H. Immunological castration in male rats using a GnRH analogue conjugated. Food Agricultural Immun. 1995, in press
23. Freund, J. The mode fraction of immunologic adjuvants. Adv. Tuberc. Res. 1956, 7, 130-147
24. Bennett, B., Check, I.J., Olsen, M.R. and Hunter, R.L. A comparison of commercially available adjuvants for use in research. J. Immunol. Meth. 1992, 153, 31-40
25. Glenny, A.T., Pope, C.G., Waddington, H. and Wallace, U. The antigenic value of the toxin-antitoxin precipitates of Ramon. J. Pathol. Bacteriol. 1926, 29, 38-39
26. Turk, J.L. and Parker, D. Granuloma formation in normal guinea pigs injected intradermally with aluminium and zirconium compounds. J. Invest. Dermatol. 1977, 68, 336-340
27. Bomford, R. The comparative selectivity of adjuvants for humoral and cell mediated immunity. Clin. Exp. Immunol. 1980, 39, 435-441
28. Brewer, J.M., Roberts, C.W., O'Grady, J.E. and Alexander, J. Non-ionic surfactant vesicles as vaccine delivery systems. Second Conference on Industrial Immunology 1994, pp. 34-36
29. Azmin, M.N., Florence, A.T., Handjani-Vila, R.M., Stuart, J.F.R., Vanlerberghe, G.G. and Whittaker, J.S. The effect of non-ionic surfactant vesicles (niosome) entrapment on the absorption and distribution of methotrexate in mice. J. Pharm. Pharmac. 1985, 37, 237-242
30. Brewer, J.M. and Alexander, J. The adjuvant activity of non-ionic surfactant vesicles (niosomes) on the BALB/c humoral response to bovine serum albumin. Immunology 1992, 75, 570-575
31. Aithal, H.N., Knigge, K.M., Kartha, S., Czyzewski, E.A. and Toback, F.G. An alternative method utilizing small quantities of ligand for affinity purification of monospecific antibodies. J. Immunol. Meth. 1988, 112, 63-69
32. Deakin, H., Ord, M.G. and Stockes, L.A. Glucose-6-phosphate-dehydrogenase activity and thiol content of thymus nuclei from control and x-irradiated rats. Biochem. J. 1963, 89, 296-304
33. Morrison, C.A., Fishleigh, R.V., Ward, D.J. and Robson, B. Computer aided design and physiological testing of a LHRH analogue for "adjuvant-free" immunocastration. Febs. Lett. 1987, 214, 65-70
34. Amyx, H.L. Control of animal pain and distress in antibody production and infectious disease studies. J. Am. Vet. Med. Assoc. 1987, 191, 1287-1289
35. Broderson, J.R. A retrospective review of lesions associated with the use of Freund's adjuvant. Lab. Animal Sci. 1989, 39, 400-405
36. Sad, S., Chauhan, V.S., Arunan, K. and Raghupathy, R. Synthetic gonadotrophin-releasing hormone (GnRH) vaccines incorporating GnRH and synthetic T-helper epitopes. Vaccine 1993, 11, 1145-1150
37. Awoniyi, C.A., Santulli, R., Chandrashekar, V., Schanbacher, B. D and Zirkin, B.R. Quantitative restoration of advance spermatogenic cells in adult male rats made azospermic by active immunisation against LH or GnRH. Endocrinology 1989, 125, 1303-1309
38. Giri, D.K., Chaudhury, M.K., Jayashankar, R. et al. Histopathological changes in reproductive organs of male Wistar rats following active immunisation against LHRH. Exp. Mol. Pathol. 1990, 52, 54-56
39. Kreuter, J. Nanoparticles as potent adjuvants for vaccines. In: New Generation Vaccines (Eds Gregoriadis, G., Allison, A. and Poste, G.). Plenum Press, New York, 1993, pp. 73-82
40. Handjani-Vila, R.M., Ribier, A., Rondot, B. and Vanlerberghe, G. Dispersions of lamellar phases of non ionic lipids in cosmetic products. Int. J. Cosmetic Sci. 1979, 1, 303-307