A Common NH53K Mutation in the Combining Site of Antibodies Raised against Chlamydial LPS Glycoconjugates Significantly Increases Avidity

Biochemistry

Volumn 50, Issue 16, 2011, Pages 3357-3368

  Blackler, Ryan J ^a   Müller Loennies, Sven ^b   Brooks, Cory L ^a   Evans, Dylan W ^a   Brade, Lore ^b   Kosma, Paul ^c   Brade, Helmut ^b   Evans, Stephen V ^a  

^a UNIVERSITY OF VICTORIA   (Canada)

^b RESEARCH CENTER BORSTEL   (Germany)

^c UNIVERSITY OF NATURAL RESOURCES AND LIFE SCIENCES   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY RESPONSE; ANTIBODY STRUCTURES; ANTIGEN BINDING; ANTIGEN-BINDING SITES; CARBOHYDRATE EPITOPES; COMPLEMENTARITY-DETERMINING REGIONS; GERMLINE; GLYCOCONJUGATES; INDUCED FIT; LIPOPOLYSACCHARIDES; MURINE MONOCLONAL ANTIBODY; MUTATION RESULTS; SINGLE MUTATION; SINGLE NUCLEOTIDES; ULOSONIC ACID;

AMINO ACIDS; CONFORMATIONS; HYDROGEN BONDS; MONOCLONAL ANTIBODIES; ORGANIC COMPOUNDS; SUGARS;

ANTIGENS;

3 DEOXY MANNO OCTULOSONIC ACID; ANTIBODY; ASPARAGINE; BACTERIUM LIPOPOLYSACCHARIDE; CARBOHYDRATE; EPITOPE; GLYCOCONJUGATE; LYSINE; MONOCLONAL ANTIBODY;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANTIBODY COMBINING SITE; ANTIBODY SPECIFICITY; ANTIBODY STRUCTURE; ANTIGEN BINDING; ARTICLE; CHLAMYDIA; COMPLEMENTARITY DETERMINING REGION; CRYSTAL STRUCTURE; GERM LINE; HYDROGEN BOND; MUTATION; PRIORITY JOURNAL; PROTEIN CONFORMATION; SINGLE NUCLEOTIDE POLYMORPHISM;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, BACTERIAL; BINDING SITES, ANTIBODY; CHLAMYDIA; COMPLEMENTARITY DETERMINING REGIONS; EPITOPES; IMMUNOGLOBULIN FAB FRAGMENTS; IMMUNOGLOBULIN HEAVY CHAINS; LIPOPOLYSACCHARIDES; MICE;

BACTERIA (MICROORGANISMS); MURINAE;

EID: 79955081531     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi101886v     Document Type: Article

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