P-cadherin expression reduces melanoma growth, invasion, and responsiveness to growth factors in nude mice

European Journal of Cancer Prevention

Volumn 20, Issue 3, 2011, Pages 207-216

  Jacobs, Koen ^a   Feys, Lynn ^a   Vanhoecke, Barbara ^a   Van Marck, Veerle ^b   Bracke, Marc ^a  

^a GHENT UNIVERSITY HOSPITAL   (Belgium)

^b ANTWERP UNIVERSITY HOSPITAL   (Belgium)

Author keywords

cutaneous melanoma; growth factors; invasion; P cadherin; receptor tyrosine kinase; survival; tumor growth

Indexed keywords

P CADHERIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER GROWTH; CANCER INVASION; CANCER SURVIVAL; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; MELANOMA; MELANOMA CELL; MICROMETASTASIS; MOUSE; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; TUMOR XENOGRAFT;

ANIMALS; BLOTTING, WESTERN; CADHERINS; CELL ADHESION; CELL MOVEMENT; CELL PROLIFERATION; COLLAGEN; DRUG COMBINATIONS; FEMALE; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LAMININ; MELANOMA, EXPERIMENTAL; MICE; MICE, NUDE; MYOFIBROBLASTS; NEOPLASM INVASIVENESS; PROTEOGLYCANS; TUMOR CELLS, CULTURED;

EID: 79955074886     PISSN: 09598278     EISSN: None     Source Type: Journal    
DOI: 10.1097/CEJ.0b013e3283429e8b     Document Type: Article

References (36)

1. AJCC (2002). American Joint Committee cancer staging manual. 6th ed. New York, USA: Springer-Verlag.
2. Albergaria A, Ribeiro AS, Pinho S, Milanezi F, Carneiro V, Sousa B, et al. (2010). ICI 182, 780 induces P-cadherin overexpression in breast cancer cells through chromatin remodelling at the promoter level: a role for C/EBPβ in CDH3 gene activation. Hum Mol Genet 19:2554-2566.
3. Angst BD, Marcozzi C, Magee AI (2001). The cadherin superfamily: diversity in form and function. J Cell Sci 114:629-641. (Pubitemid 32237135)
4. Bachmann IM, Straume O, Puntervolle HE, Kalvenes MB, Akslen LA (2005). Importance of P-cadherin, β-catenin and Wnt5A/frizzled for progression of melanocytic tumors and prognosis in cutaneous melanoma. Clin Cancer Res 11:8606-8614. (Pubitemid 43005907)
5. Bauer R, Hein R, Bosserhoff AK (2005). A secreted form of P-cadherin is expressed in malignant melanoma. Exp Cell Res 305:418-426. (Pubitemid 40462552)
6. Bracke ME, Van Roy FM, Mareel MM (1996). The E-cadherin/catenin complex in invasion and metastasis. Curr Top Microbiol Immunol 213:123-161. (Pubitemid 26165088)
7. Brochez L, Nayaert JM (2000). Understanding the trends in melanoma incidence and mortality: where do we stand? Eur J Dermatol 10:1-76.
8. DeWever O, Mareel MM (2005). Pro-invasive molecular cross-signaling between cancer cells and myofibroblasts. In: Chapponier C, Desmoulieres A, Gabbiani G, editors. Tissue repair, contraction and the myofibroblast. New York, USA: Eurekah.com and Springer Science +Business Media.
9. De Wever O, Nguyen Q-D, Van Hoorde L, Bracke ME, Bruyneel E, Gespach C, et al. (2004). Tenascin-C and SF/HGF produced by myofibroblasts in vitro provide convergent proinvasive signals to human colon cancer cells through RhoA and Rac. FASEB J 18:1016-1018. (Pubitemid 39561510)
10. Dejana E, Lampugnani M, Martinez-estrada O, Bazzoni G (2000). The molecular organization of endothelial junctions and their functional role in vascular morphogenesis and permeability. Int J Dev Biol 44:743-748.
11. Foty RA, Steinberg MS (1997). Measurement of tumor cell cohesion and suppression of invasion by E- or P-cadherin. Cancer Res 57:5033-5036. (Pubitemid 27498115)
12. Gao CF, Vande Woude GF (2005). HGF/SF-met signaling in tumor progression. Cell Res 15:49-51. (Pubitemid 41653965)
13. Geller AC, Annas GD (2003). Epidemiology of melanoma and nonmelanoma skin cancer. Semin Oncol Nurs 19:2-11. (Pubitemid 40941059)
14. Geller AC, Swetter SM, Brooks S, Demierre MF, Yaroch AL (2007). Screening, early detection, and trends for melanoma: Current status (2000-2006) and future directions. J Am Acad Dermatol 57:555-572. (Pubitemid 47384936)
15. Gruss C, Herlyn M (2001). Role of cadherins and matrixins in melanoma. Curr Opin Oncol 13:117-123. (Pubitemid 32242859)
16. Hiscox S, Jiang WG (1999). Association of the HGF/SF receptor, c-met, with cell-surface adhesion molecule, E-cadherin, and catenins in human tumor cells. Biochem Biophys Res Commun 261:406-411. (Pubitemid 29392489)
17. Hsu M, Andl T, Li G, Meinkoth JL, Herlyn M (2000a). Cadherin repertoire determines partner-specific gap junctional communication during melanoma progression. J Cell Sci 113:1535-1542. (Pubitemid 30312502)
18. Hsu MY, Meier FE, Nesbit M, Hsu JY, Van Belle P, Elder DE, et al. (2000b). Ecadherin expression in melanoma cells restores keratinocyte-mediated growth control and down-regulates expression of invasion-related adhesion receptors. Am J Pathol 156:515-1525.
19. Jacobs K, Van Gele M, Forsyth R, Brochez L, Vanhoecke B, De Wever O, Bracke M (2010). P-cadherin counteracts myosin II-B function: implications in melanoma progression. Mol Cancer 9:255.
20. Karube H, Masuda H, Ishii Y, Takayama T (2002). E-cadherin expression is inversely proportional to tumor size in experimental liver metastases. J Surg Res 106:173-178.
21. Kremer M, Quintanilla-Martinez L, Fuchs M, Gamboa-Dominguez A, Haye S, Kalthoff H, et al. (2003). Influence of tumor-associated E-cadherin on tumorigenicity and metastasis. Carcinogenesis 24:1879-1886. (Pubitemid 38008528)
22. Küsters B.,Westphal JR, Smits D, Ruiter DJ,Wesseling P, Keilholz U, et al. (2001). The pattern of metastasis of human melanoma to the central nervous system is not influenced by integrin avb3 expression. Int J Cancer. 92: 176-180. (Pubitemid 32225366)
23. Orend G, Chiquet-Ehrismann R (2006). Tenascin-C signaling in cancer. Cancer Lett 244:143-163.
24. Orimo A, Gupta PB, Sgroi DC, Arenzana-Seisdedos F, Delauney T, Naeem R, et al. (2005). Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion. Cell 121:335-348. (Pubitemid 40692295)
25. Paredes J, Stove C, Stove V, Milanezi F, Van Marck V, Derycke L, et al. (2004). Pcadherin is up-regulated by the antiestrogen ICI 182, 780 and promotes invasion of human breast cancer cells. Cancer Res 64:8309-8317. (Pubitemid 39491769)
26. Qi J, Chen N, Wang J, Siu CH (2005). Transendothelial migration of melanoma cells involves N-cadherin-mediated adhesion and activation of the b-catenin signaling pathway. Mol Biol Cell 16:4386-4397. (Pubitemid 41262905)
27. Recio JA, Merlino G (2002). Hepatocyte growth factor/scatter factor activates proliferation in melanoma cells through p38 MAPK, ATF-2 and cyclin D1. Oncogene 21:1000-1008. (Pubitemid 34174512)
28. Sanders DSA, Blessing K, Hassan GAR, Bruton R, Marsden FR, Jankowski J (1999). Alterations in cadherin and catenin expression during the biological progression of melanocytic tumours. J Clin Pathol 52:151-157. (Pubitemid 29277155)
29. St. Croix B, Sheehan C, Rak JW, Florenes VA, Slingerland JM, Kerbel RS (1998). E-cadherin-dependent growth suppression is mediated by the cyclindependent kinase-inhibitor p27KIP1. J Cell Biol 142:557-571. (Pubitemid 28361560)
30. Takahashi K, Suzuki K (1996). Density-dependent inhibition of growth involves prevention of EGF receptor activation by E-cadherin-mediated cell-cell adhesion. Exp Cell Res 226:214-222. (Pubitemid 26238945)
31. Taniuchi K, Nakagawa H, Hosokawa M, Nakamura T, Eguchi H, Ohigashi H, et al. (2005). Overexpressed P-cadherin/CDH3 promotes motility of pancreatic cancer cells by interacting with p120ctn and activating rho-family GTPases. Cancer Res 65:3092-3099. (Pubitemid 40524589)
32. Tucker MA, Goldstein AM (2003). Melanoma etiology: where are we? Oncogene 22:3042-3052. (Pubitemid 36713754)
33. Valyi-Nagy IT, Hirka G, Jensen PJ, Shih IM, Juhasz I, Herlyn M (1993). Undifferentiated keratinocytes control growth, morphology, and antigen expression of normal melanocytes through cell-cell contact. Lab Invest 69:152-159. (Pubitemid 23262495)
34. Van Marck V, Stove C, Van Den Bossche K, Stove K, Paredes J, Vander Haeghen Y, et al. (2005). P-cadherin promotes cell-cell adhesion and counteracts invasion in human melanoma. Cancer Res 65:8774-8783. (Pubitemid 41379401)
35. Wheelock MJ, Johnson KR (2003). Cadherins as modulators of cellular phenotype. Annu Rev Cell Dev Biol 19:207-235. (Pubitemid 37487348)
36. Yu Y, Xin X (2007). Stromal-derived factor-1 regulates epithelial ovarian cancer cell invasion by activating matrix metalloproteinase-9 and matrix metalloproteinase-2. Eur J Cancer Prev 16:430-435.