New challenges in the diagnosis, management, and prevention of central venous catheter-related infections

Seminars in Respiratory and Critical Care Medicine

Volumn 32, Issue 2, 2011, Pages 139-150

  Timsit, Jean François ^a,b   Dubois, Yohann ^a   Minet, Clémence ^a   Bonadona, Agnès ^a   Lugosi, Maxime ^a   Ara Somohano, Claire ^a,b   Hamidfar Roy, Rebecca ^a   Schwebel, Carole ^a  

^a HÔPITAL MICHALLON   (France)

^b UNIV GRENOBLE ALPES   (France)

Author keywords

Catheter related infection; diagnosis; prevention; therapy

Indexed keywords

CHLORHEXIDINE; MINOCYCLINE; PROPOFOL; RIFAMPICIN; SULFADIAZINE; VANCOMYCIN;

ANTIBIOTIC THERAPY; ARTICLE; BLOOD CULTURE; BLOODSTREAM INFECTION; CENTRAL VENOUS CATHETER; ENDOCARDITIS; FEVER; HEALTH CARE POLICY; HEALTH PROGRAM; HUMAN; INFECTION; PRIORITY JOURNAL; THROMBOPHLEBITIS;

ANTI-INFECTIVE AGENTS; CATHETER-RELATED INFECTIONS; CATHETERIZATION, CENTRAL VENOUS; CRITICAL ILLNESS; DEVICE REMOVAL; HUMANS; INTENSIVE CARE UNITS; SEPSIS; SEVERITY OF ILLNESS INDEX; SHOCK, SEPTIC;

EID: 79955037994     PISSN: 10693424     EISSN: 10989048     Source Type: Journal    
DOI: 10.1055/s-0031-1275526     Document Type: Article

References (103)

1. Suetens C, Morales I, Savey A et al. European surveillance of ICU-acquired infections (HELICS-ICU): methods and main results. J Hosp Infect 2007 65 Suppl 2 171-173 (Pubitemid 46805859)
2. Mermel L A. Prevention of intravascular catheter-related infections. Ann Intern Med 2000 132 5 391-402 (Pubitemid 30127778)
3. National Nosocomial Infections Surveillance System. National Nosocomial Infections Surveillance (NNIS) System Report, data summary from January 1992 through June 2004, issued October 2004. Am J Infect Control 2004 32 8 470-485
4. Siempos I I., Kopterides P, Tsangaris I, Dimopoulou I, Armaganidis A E. Impact of catheter-related bloodstream infections on the mortality of critically ill patients: a meta-analysis. Crit Care Med 2009 37 7 2283-2289
5. Soufir L, Timsit J F., Mahe C, Carlet J, Regnier B, Chevret S. Attributable morbidity and mortality of catheter-related septicemia in critically ill patients: a matched, risk-adjusted, cohort study. Infect Control Hosp Epidemiol 1999 20 6 396-401
6. Warren D K., Quadir W W., Hollenbeak C S., Elward A M., Cox M J., Fraser V J. Attributable cost of catheter-associated bloodstream infections among intensive care patients in a nonteaching hospital. Crit Care Med 2006 34 8 2084-2089 (Pubitemid 44305609)
7. Bouza E, Munoz P, Burillo A et al, Cardiovascular Infection Study Group. The challenge of anticipating catheter tip colonization in major heart surgery patients in the intensive care unit: are surface cultures useful? Crit Care Med 2005 33 9 1953-1960 (Pubitemid 41306515)
8. Linares J, Sitges-Serra A, Garau J, Pérez J L., Martin R. Pathogenesis of catheter sepsis: a prospective study with quantitative and semiquantitative cultures of catheter hub and segments. J Clin Microbiol 1985 21 3 357-360 (Pubitemid 15168645)
9. Lorente L, Jiménez A, Santana M et al. Microorganisms responsible for intravascular catheter-related bloodstream infection according to the catheter site. Crit Care Med 2007 35 10 2424-2427 (Pubitemid 47476245)
10. Sherertz R J., Raad I I., Belani A et al. Three-year experience with sonicated vascular catheter cultures in a clinical microbiology laboratory. J Clin Microbiol 1990 28 1 76-82 (Pubitemid 20016781)
11. Maki D G., Weise C E., Sarafin H W. A semiquantitative culture method for identifying intravenous-catheter-related infection. N Engl J Med 1977 296 23 1305-1309 (Pubitemid 8103695)
12. Safdar N, Fine J P., Maki D G. Meta-analysis: methods for diagnosing intravascular device-related bloodstream infection. Ann Intern Med 2005 142 6 451-466 (Pubitemid 40365432)
13. Mermel L A., Allon M, Bouza E et al. Clinical practice guidelines for the diagnosis and management of intravascular catheter-related infection: 2009 Update by the Infectious Diseases Society of America. Clin Infect Dis 2009 49 1 1-45
14. Souweine B, Heng A E., Aumeran C et al. Do antibiotics administered at the time of central venous catheter removal interfere with the evaluation of colonization? Intensive Care Med 2008 34 2 286-291 (Pubitemid 351207632)
15. Vandecasteele S J., Van Eldere J, Merckx R, Peetermans W E. The effect of systemic antibiotics on the microbiological diagnosis of experimental foreign body infections caused by Staphylococcus epidermidis. Diagn Microbiol Infect Dis 2004 48 2 89-95 (Pubitemid 38221502)
16. Armstrong C W., Mayhall C G., Miller K B. et al. Clinical predictors of infection of central venous catheters used for total parenteral nutrition. Infect Control Hosp Epidemiol 1990 11 2 71-78
17. Blot F, Nitenberg G, Chachaty E et al. Diagnosis of catheter-related bacteraemia: a prospective comparison of the time to positivity of hub-blood versus peripheral-blood cultures. Lancet 1999 354 9184 1071-1077 (Pubitemid 29452819)
18. Abdelkefi A, Achour W, Ben Othman T et al. Difference in time to positivity is useful for the diagnosis of catheter-related bloodstream infection in hematopoietic stem cell transplant recipients. Bone Marrow Transplant 2005 35 4 397-401 (Pubitemid 40309486)
19. Raad I, Hanna H A., Alakech B, Chatzinikolaou I, Johnson M M., Tarrand J. Differential time to positivity: a useful method for diagnosing catheter-related bloodstream infections. Ann Intern Med 2004 140 1 18-25
20. Bouza E, Alvarado N, Alcalá L, Pérez M J., Rincon C, Munoz P. A randomized and prospective study of 3 procedures for the diagnosis of catheter-related bloodstream infection without catheter withdrawal. Clin Infect Dis 2007 44 6 820-826 (Pubitemid 46365307)
21. Catton J A., Dobbins B M., Kite P et al. In situ diagnosis of intravascular catheter-related bloodstream infection: a comparison of quantitative culture, differential time to positivity, and endoluminal brushing. Crit Care Med 2005 33 4 787-791
22. Guembe M, Rodriguez-Créixems M, Sánchez-Carrillo C, Pérez-Parra A, Martin-Rabadán P, Bouza E. How many lumens should be cultured in the conservative diagnosis of catheter-related bloodstream infections? Clin Infect Dis 2010 50 12 1575-1579
23. Rijnders B J., Peetermans W E., Verwaest C, Wilmer A, Van Wijngaerden E. Watchful waiting versus immediate catheter removal in ICU patients with suspected catheter-related infection: a randomized trial. Intensive Care Med 2004 30 6 1073-1080 (Pubitemid 38833358)
24. O'Grady N P., Alexander M, Dellinger E P. et al, Healthcare Infection Control Practices Advisory Committee. Guidelines for the prevention of intravascular catheter-related infections. Infect Control Hosp Epidemiol 2002 23 12 759-769 (Pubitemid 36020215)
25. Ishikawa Y, Kiyama T, Haga Y et al. Maximal sterile barrier precautions do not reduce catheter-related bloodstream infections in general surgery units: a multi-institutional randomized controlled trial. Ann Surg 2010 251 4 620-623
26. Raad I I., Hohn D C., Gilbreath B J. et al. Prevention of central venous catheter-related infections by using maximal sterile barrier precautions during insertion. Infect Control Hosp Epidemiol 1994 15 4 Pt 1 231-238
27. Parienti J J., Thibon P, Heller R et al, Antisepsie Chirurgicale des mains Study Group. Hand-rubbing with an aqueous alcoholic solution vs traditional surgical hand-scrubbing and 30-day surgical site infection rates: a randomized equivalence study. JAMA 2002 288 6 722-727 (Pubitemid 34848225)
28. Chaiyakunapruk N, Veenstra D L., Lipsky B A., Saint S. Chlorhexidine compared with povidone-iodine solution for vascular catheter-site care: a meta-analysis. Ann Intern Med 2002 136 11 792-801 (Pubitemid 34568649)
29. Vallés J, Fernández I, Alcaraz D et al. Prospective randomized trial of 3 antiseptic solutions for prevention of catheter colonization in an intensive care unit for adult patients. Infect Control Hosp Epidemiol 2008 29 9 847-853
30. McDonnell G, Russell A D. Antiseptics and disinfectants: activity, action, and resistance. Clin Microbiol Rev 1999 12 1 147-179 (Pubitemid 29055958)
31. Parienti J J., du Cheyron D, Ramakers M et al, Members of the NACRE Study Group. Alcoholic povidone-iodine to prevent central venous catheter colonization: a randomized unit-crossover study. Crit Care Med 2004 32 3 708-713 (Pubitemid 38340067)
32. Mimoz O, Villeminey S, Ragot S et al. Chlorhexidine-based antiseptic solution vs alcohol-based povidone-iodine for central venous catheter care. Arch Intern Med 2007 167 19 2066-2072 (Pubitemid 350036705)
33. Langgartner J, Linde H J., Lehn N, Reng M, Schölmerich J, Gluck T. Combined skin disinfection with chlorhexidine/propanol and aqueous povidone-iodine reduces bacterial colonisation of central venous catheters. Intensive Care Med 2004 30 6 1081-1088 (Pubitemid 38833359)
34. Merrer J, De Jonghe B, Golliot F et al, French Catheter Study Group in Intensive Care. Complications of femoral and subclavian venous catheterization in critically ill patients: a randomized controlled trial. JAMA 2001 286 6 700-707 (Pubitemid 33010363)
35. Ruesch S, Walder B, Tramèr M R. Complications of central venous catheters: internal jugular versus subclavian accessa systematic review. Crit Care Med 2002 30 2 454-460 (Pubitemid 34158135)
36. Timsit J F. Central venous access in intensive care unit patients: is the subclavian vein the royal route? Intensive Care Med 2002 28 8 1006-1008
37. Parienti J J., Thirion M, Mégarbane B et al, Members of the Cathedia Study Group. Femoral vs jugular venous catheterization and risk of nosocomial events in adults requiring acute renal replacement therapy: a randomized controlled trial. JAMA 2008 299 20 2413-2422 (Pubitemid 351749240)
38. Timsit J F., Bruneel F, Cheval C et al. Use of tunneled femoral catheters to prevent catheter-related infection: a randomized, controlled trial. Ann Intern Med 1999 130 9 729-735 (Pubitemid 29211510)
39. Timsit J F., Sebille V, Farkas J C. et al. Effect of subcutaneous tunneling on internal jugular catheter-related sepsis in critically ill patients: a prospective randomized multicenter study. JAMA 1996 276 17 1416-1420 (Pubitemid 26365848)
40. Hind D, Calvert N, McWilliams R et al. Ultrasonic locating devices for central venous cannulation: meta-analysis. BMJ 2003 327 7411 361
41. Karakitsos D, Labropoulos N, De Groot E et al. Real-time ultrasound-guided catheterisation of the internal jugular vein: a prospective comparison with the landmark technique in critical care patients. Crit Care 2006 10 6 R162
42. Raad I I., Luna M, Khalil S A., Costerton J W., Lam C, Bodey G P. The relationship between the thrombotic and infectious complications of central venous catheters. JAMA 1994 271 13 1014-1016 (Pubitemid 24099923)
43. Timsit J F., Farkas J C., Boyer J M. et al. Central vein catheter-related thrombosis in intensive care patients: incidence, risks factors, and relationship with catheter-related sepsis. Chest 1998 114 1 207-213
44. Mehall J R., Saltzman D A., Jackson R J., Smith S D. Fibrin sheath enhances central venous catheter infection. Crit Care Med 2002 30 4 908-912 (Pubitemid 34297817)
45. Keller J E., Hindman J W., Mehall J R., Smith S D. Enoxaparin inhibits fibrin sheath formation and decreases central venous catheter colonization following bacteremic challenge. Crit Care Med 2006 34 5 1450-1455
46. Pierce C M., Wade A, Mok Q. Heparin-bonded central venous lines reduce thrombotic and infective complications in critically ill children. Intensive Care Med 2000 26 7 967-972 (Pubitemid 30616052)
47. Abdelkefi A, Torjman L, Ladeb S et al. Randomized trial of prevention of catheter-related bloodstream infection by continuous infusion of low-dose unfractionated heparin in patients with hematologic and oncologic disease. J Clin Oncol 2005 23 31 7864-7870 (Pubitemid 46657384)
48. Timsit J F. Diagnosis and prevention of catheter-related infections. Curr Opin Crit Care 2007 13 5 563-571
49. Lucet J C., Bouadma L, Zahar J R. et al. Infectious risk associated with arterial catheters compared with central venous catheters. Crit Care Med 2010 38 4 1030-1035
50. Timsit J F., Schwebel C, Bouadma L et al, Dressing Study Group. Chlorhexidine-impregnated sponges and less frequent dressing changes for prevention of catheter-related infections in critically ill adults: a randomized controlled trial. JAMA 2009 301 12 1231-1241
51. Ho K M. Comment on: use of chlorhexidine-impregnated dressing to prevent vascular and epidural catheter colonization and infection: a meta-analysis. J Antimicrob Chemother 2010 65 4 811-814
52. Garland J S., Alex C P., Mueller C D. et al. A randomized trial comparing povidone-iodine to a chlorhexidine gluconate-impregnated dressing for prevention of central venous catheter infections in neonates. Pediatrics 2001 107 6 1431-1436
53. Gillies D, O'Riordan L, Wallen M, Rankin K, Morrison A, Nagy S. Timing of intravenous administration set changes: a systematic review. Infect Control Hosp Epidemiol 2004 25 3 240-250 (Pubitemid 38339631)
54. Bennett S N., McNeil M M., Bland L A. et al. Postoperative infections traced to contamination of an intravenous anesthetic, propofol. N Engl J Med 1995 333 3 147-154
55. Casey A L., Burnell S, Whinn H, Worthington T, Faroqui M H., Elliott T S. A prospective clinical trial to evaluate the microbial barrier of a needleless connector. J Hosp Infect 2007 65 3 212-218
56. Field K, McFarlane C, Cheng A C. et al. Incidence of catheter-related bloodstream infection among patients with a needleless, mechanical valve-based intravenous connector in an Australian hematology-oncology unit. Infect Control Hosp Epidemiol 2007 28 5 610-613 (Pubitemid 46814555)
57. Maragakis L L., Bradley K L., Song X et al. Increased catheter-related bloodstream infection rates after the introduction of a new mechanical valve intravenous access port. Infect Control Hosp Epidemiol 2006 27 1 67-70 (Pubitemid 46939753)
58. Rupp M E., Sholtz L A., Jourdan D R. et al. Outbreak of bloodstream infection temporally associated with the use of an intravascular needleless valve. Clin Infect Dis 2007 44 11 1408-1414 (Pubitemid 46801581)
59. Jarvis W R., Murphy C, Hall K K. et al. Health care-associated bloodstream infections associated with negative- or positive-pressure or displacement mechanical valve needleless connectors. Clin Infect Dis 2009 49 12 1821-1827
60. Veenstra D L., Saint S, Saha S, Lumley T, Sullivan S D. Efficacy of antiseptic-impregnated central venous catheters in preventing catheter-related bloodstream infection: a meta-analysis. JAMA 1999 281 3 261-267 (Pubitemid 29058116)
61. Walder B, Pittet D, Tramèr M R. Prevention of bloodstream infections with central venous catheters treated with anti-infective agents depends on catheter type and insertion time: evidence from a meta-analysis. Infect Control Hosp Epidemiol 2002 23 12 748-756 (Pubitemid 36020213)
62. Hockenhull J C., Dwan K M., Smith G W. et al. The clinical effectiveness of central venous catheters treated with anti-infective agents in preventing catheter-related bloodstream infections: a systematic review. Crit Care Med 2009 37 2 702-712
63. Tattawasart U, Maillard J Y., Furr J R., Russell A D. Development of resistance to chlorhexidine diacetate and cetylpyridinium chloride in Pseudomonas stutzeri and changes in antibiotic susceptibility. J Hosp Infect 1999 42 3 219-229 (Pubitemid 29353738)
64. Falagas M E., Fragoulis K, Bliziotis I A., Chatzinikolaou I. Rifampicin-impregnated central venous catheters: a meta-analysis of randomized controlled trials. J Antimicrob Chemother 2007 59 3 359-369 (Pubitemid 47073442)
65. Darouiche R O., Berger D H., Khardori N et al. Comparison of antimicrobial impregnation with tunneling of long-term central venous catheters: a randomized controlled trial. Ann Surg 2005 242 2 193-200 (Pubitemid 41033435)
66. Leon C, Ruiz-Santana S, Rello J et al, Cabala Study Group. Benefits of minocycline and rifampin-impregnated central venous catheters: a prospective, randomized, double-blind, controlled, multicenter trial. Intensive Care Med 2004 30 10 1891-1899 (Pubitemid 39468410)
67. Ramos E R., Reitzel R, Jiang Y et al. Clinical effectiveness and risk of emerging resistance associated with prolonged use of antibiotic-impregnated catheters: more than 0.5 million catheter days and 7 years of clinical experience. Crit Care Med 2011 39 2 245-251
68. Noimark S, Dunnill C W., Wilson M, Parkin I P. The role of surfaces in catheter-associated infections. Chem Soc Rev 2009 38 12 3435-3448
69. Garland J S., Alex C P., Henrickson K J., McAuliffe T L., Maki D G. A vancomycin-heparin lock solution for prevention of nosocomial bloodstream infection in critically ill neonates with peripherally inserted central venous catheters: a prospective, randomized trial. Pediatrics 2005 116 2 e198-e205 (Pubitemid 44161440)
70. Yahav D, Rozen-Zvi B, Gafter-Gvili A, Leibovici L, Gafter U, Paul M. Antimicrobial lock solutions for the prevention of infections associated with intravascular catheters in patients undergoing hemodialysis: systematic review and meta-analysis of randomized, controlled trials. Clin Infect Dis 2008 47 1 83-93 (Pubitemid 351920592)
71. Raad I I., Fang X, Keutgen X M., Jiang Y, Sherertz R, Hachem R. The role of chelators in preventing biofilm formation and catheter-related bloodstream infections. Curr Opin Infect Dis 2008 21 4 385-392
72. Jurewitsch B, Jeejeebhoy K N. Taurolidine lock: the key to prevention of recurrent catheter-related bloodstream infections. Clin Nutr 2005 24 3 462-465 (Pubitemid 40668434)
73. Sherertz R J., Boger M S., Collins C A., Mason L, Raad I I. Comparative in vitro efficacies of various catheter lock solutions. Antimicrob Agents Chemother 2006 50 5 1865-1868
74. Solomon L R., Cheesbrough J S., Ebah L et al. A randomized double-blind controlled trial of taurolidine-citrate catheter locks for the prevention of bacteremia in patients treated with hemodialysis. Am J Kidney Dis 2010 55 6 1060-1068
75. Raad I, Hanna H, Dvorak T, Chaiban G, Hachem R. Optimal antimicrobial catheter lock solution, using different combinations of minocycline, EDTA, and 25-percent ethanol, rapidly eradicates organisms embedded in biofilm. Antimicrob Agents Chemother 2007 51 1 78-83 (Pubitemid 46047690)
76. Onland W, Shin C E., Fustar S, Rushing T, Wong W Y. Ethanol-lock technique for persistent bacteremia of long-term intravascular devices in pediatric patients. Arch Pediatr Adolesc Med 2006 160 10 1049-1053 (Pubitemid 44520635)
77. Balestrino D, Souweine B, Charbonnel N et al. Eradication of microorganisms embedded in biofilm by an ethanol-based catheter lock solution. Nephrol Dial Transplant 2009 24 10 3204-3209
78. Sanders J, Pithie A, Ganly P et al. A prospective double-blind randomized trial comparing intraluminal ethanol with heparinized saline for the prevention of catheter-associated bloodstream infection in immunosuppressed haematology patients. J Antimicrob Chemother 2008 62 4 809-815
79. Slobbe L, Doorduijn J K., Lugtenburg P J. et al. Prevention of catheter-related bacteremia with a daily ethanol lock in patients with tunnelled catheters: a randomized, placebo-controlled trial. PLoS ONE 2010 5 5 e10840
80. Gastmeier P, Geffers C, Brandt C et al. Effectiveness of a nationwide nosocomial infection surveillance system for reducing nosocomial infections. J Hosp Infect 2006 64 1 16-22 (Pubitemid 44161382)
81. Shapey I M., Foster M A., Whitehouse T, Jumaa P, Bion J F. Central venous catheter-related bloodstream infections: improving post-insertion catheter care. J Hosp Infect 2009 71 2 117-122
82. Trick W E., Vernon M O., Welbel S F., Wisniewski M F., Jernigan J A., Weinstein R A. Unnecessary use of central venous catheters: the need to look outside the intensive care unit. Infect Control Hosp Epidemiol 2004 25 3 266-268 (Pubitemid 38339636)
83. Eggimann P, Hugonnet S, Sax H, Harbarth S, Chevrolet J C., Pittet D. Long-term reduction of vascular access-associated bloodstream infection. Ann Intern Med 2005 142 10 875-876 (Pubitemid 40664055)
84. Khouli H, Jahnes K, Shapiro J et al. Performance of medical residents in sterile techniques during central vein catheterization: randomized trial of efficacy of simulation-based training. Chest 2011 139 1 80-87
85. Barsuk J H., Cohen E R., Feinglass J, McGaghie W C., Wayne D B. Use of simulation-based education to reduce catheter-related bloodstream infections. Arch Intern Med 2009 169 15 1420-1423
86. Gastmeier P, Geffers C. Prevention of catheter-related bloodstream infections: analysis of studies published between 2002 and 2005. J Hosp Infect 2006 64 4 326-335 (Pubitemid 44661037)
87. Pronovost P, Needham D, Berenholtz S et al. An intervention to decrease catheter-related bloodstream infections in the ICU. N Engl J Med 2006 355 26 2725-2732 (Pubitemid 46021509)
88. Pérez Parra A, Cruz Menárguez M, Pérez Granda M J., Tomey M J., Padilla B, Bouza E. A simple educational intervention to decrease incidence of central line-associated bloodstream infection (CLABSI) in intensive care units with low baseline incidence of CLABSI. Infect Control Hosp Epidemiol 2010 31 9 964-967
89. Sawyer M, Weeks K, Goeschel C A. et al. Using evidence, rigorous measurement, and collaboration to eliminate central catheter-associated bloodstream infections. Crit Care Med 2010 38 8, Suppl S292-S298
90. Shuman E K., Washer L L., Arndt J L. et al. Analysis of central line-associated bloodstream infections in the intensive care unit after implementation of central line bundles. Infect Control Hosp Epidemiol 2010 31 5 551-553
91. Pronovost P J., Goeschel C A., Colantuoni E et al. Sustaining reductions in catheter related bloodstream infections in Michigan intensive care units: observational study. BMJ 2010 340 c309
92. Lin M Y., Hota B, Khan Y M. et al, CDC Prevention Epicenter Program. Quality of traditional surveillance for public reporting of nosocomial bloodstream infection rates. JAMA 2010 304 18 2035-2041
93. Niedner M F., 2008 National Association of Children's Hospitals and Related Institutions Pediatric Intensive Care Unit Patient Care FOCUS Group. The harder you look, the more you find: catheter-associated bloodstream infection surveillance variability. Am J Infect Control 2010 38 8 585-595
94. Carlet J, Fabry J, Amalberti R, Degos L. The zero risk concept for hospital-acquired infections: a risky business! Clin Infect Dis 2009 49 5 747-749
95. Raad I, Hanna H, Maki D. Intravascular catheter-related infections: advances in diagnosis, prevention, and management. Lancet Infect Dis 2007 7 10 645-657 (Pubitemid 47444563)
96. Nucci M, Anaissie E, Betts R F. et al. Early removal of central venous catheter in patients with candidemia does not improve outcome: analysis of 842 patients from 2 randomized clinical trials. Clin Infect Dis 2010 51 3 295-303
97. Ekkelenkamp M B., van der Bruggen T, van de Vijver D A., Wolfs T F., Bonten M J. Bacteremic complications of intravascular catheters colonized with Staphylococcus aureus. Clin Infect Dis 2008 46 1 114-118 (Pubitemid 351263571)
98. Pérez-Parra A, Munoz P, Guinea J, Martin-Rabadán P, Guembe M, Bouza E. Is Candida colonization of central vascular catheters in non-candidemic, non-neutropenic patients an indication for antifungals? Intensive Care Med 2009 35 4 707-712
99. Roberts J A., Lipman J. Pharmacokinetic issues for antibiotics in the critically ill patient. Crit Care Med 2009 37 3 840-851 quiz 859
100. Frank D A., Meuse J, Hirsch D, Ibrahim J G., van den Abbeele A D. The treatment and outcome of cancer patients with thromboses on central venous catheters. J Thromb Thrombolysis 2000 10 3 271-275 (Pubitemid 32041136)
101. Rehm S J., Boucher H, Levine D et al. Daptomycin versus vancomycin plus gentamicin for treatment of bacteraemia and endocarditis due to Staphylococcus aureus: subset analysis of patients infected with methicillin-resistant isolates. J Antimicrob Chemother 2008 62 6 1413-1421
102. Lodise T P., Miller C D., Graves J et al. Predictors of high vancomycin MIC values among patients with methicillin-resistant Staphylococcus aureus bacteraemia. J Antimicrob Chemother 2008 62 5 1138-1141
103. Falagas M E., Vardakas K Z., Athanasiou S. Intravenous heparin in combination with antibiotics for the treatment of deep vein septic thrombophlebitis: a systematic review. Eur J Pharmacol 2007 557 2-3 93-98 (Pubitemid 46186298)