Stromal cells directly mediate the re-establishment of the lymph node compartments after transplantation by CXCR5 or CCL19/21 signalling

Immunology

Volumn 133, Issue 2, 2011, Pages 257-269

  Buettner, Manuela ^a   Bode, Ulrike ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

CCL19 CCL21; CXCR5; Fibroblastic reticular cells; Follicular dendritic cells; Lymph node; Regeneration

Indexed keywords

CHEMOKINE RECEPTOR CXCR5; ENHANCED GREEN FLUORESCENT PROTEIN; MACROPHAGE INFLAMMATORY PROTEIN 3BETA; SECONDARY LYMPHOID TISSUE CHEMOKINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; B LYMPHOCYTE; CD21 CD35 CELL; CELL PROLIFERATION; CELL REGENERATION; CELL STRUCTURE; CONTROLLED STUDY; FEMALE; FOLLICULAR DENDRITIC CELL; GP38 CELL; MESENTERY LYMPH NODE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; STROMA CELL; T LYMPHOCYTE; TRANSPLANTATION;

ANIMALS; B-LYMPHOCYTES; CELL PROLIFERATION; CHEMOKINE CCL19; CHEMOKINE CCL21; FEMALE; LYMPH NODES; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; RECEPTORS, COMPLEMENT 3B; RECEPTORS, CXCR5; SIGNAL TRANSDUCTION; STROMAL CELLS; T-LYMPHOCYTES;

EID: 79955032198     PISSN: 00192805     EISSN: 13652567     Source Type: Journal    
DOI: 10.1111/j.1365-2567.2011.03436.x     Document Type: Article

References (26)

1. Macpherson AJ, Smith K. Mesenteric lymph nodes at the center of immune anatomy. J Exp Med 2006; 203:497-500.
2. Crivellato E, Vacca A, Ribatti D. Setting the stage: an anatomist's view of the immune system. Trends Immunol 2004; 25:210-7.
3. Willard-Mack CL. Normal structure, function, and histology of lymph nodes. Toxicol Pathol 2006; 34:409-24.
4. Link A, Vogt TK, Favre S et al. Fibroblastic reticular cells in lymph nodes regulate the homeostasis of naive T cells. Nat Immunol 2007; 8:1255-65.
5. Luther SA, Tang HL, Hyman PL, Farr AG, Cyster JG. Coexpression of the chemokines ELC and SLC by T zone stromal cells and deletion of the ELC gene in the plt/plt mouse. Proc Natl Acad Sci USA 2000; 97:12694-9.
6. Bajenoff M, Egen JG, Koo LY et al. Stromal cell networks regulate lymphocyte entry, migration, and territoriality in lymph nodes. Immunity 2006; 25:989-1001.
7. Mueller SN, Germain RN. Stromal cell contributions to the homeostasis and functionality of the immune system. Nat Rev Immunol 2009; 9:618-29.
8. Forster R, valos-Misslitz AC, Rot A. CCR7 and its ligands: balancing immunity and tolerance. Nat Rev Immunol 2008; 8:362-71.
9. Allen CD, Cyster JG. Follicular dendritic cell networks of primary follicles and germinal centers: phenotype and function. Semin Immunol 2008; 20:14-25.
10. Ansel KM, Ngo VN, Hyman PL et al. A chemokine-driven positive feedback loop organizes lymphoid follicles. Nature 2000; 406:309-14.
11. Muller G, Hopken UE, Lipp M. The impact of CCR7 and CXCR5 on lymphoid organ development and systemic immunity. Immunol Rev 2003; 195:117-35.
12. Ngo VN, Korner H, Gunn MD et al. Lymphotoxin alpha/beta and tumor necrosis factor are required for stromal cell expression of homing chemokines in B and T cell areas of the spleen. J Exp Med 1999; 189:403-12.
13. Ahrendt M, Hammerschmidt SI, Pabst O, Pabst R, Bode U. Stromal cells confer lymph node-specific properties by shaping a unique microenvironment influencing local immune responses. J Immunol 2008; 181:1898-907.
14. Mori S, Nakano H, Aritomi K, Wang CR, Gunn MD, Kakiuchi T. Mice lacking expression of the chemokines CCL21-ser and CCL19 (plt mice) demonstrate delayed but enhanced T cell immune responses. J Exp Med 2001; 193:207-18.
15. Worbs T, Bode U, Yan S et al. Oral tolerance originates in the intestinal immune system and relies on antigen carriage by dendritic cells. J Exp Med 2006; 203:519-27.
16. + T cell progeny. Eur J Immunol 1999; 29:1487-95.
17. Buettner M, Pabst R, Bode U. Stromal cell heterogeneity in lymphoid organs. Trends Immunol 2010; 31:80-6.
18. Lammermann T, Sixt M. The microanatomy of T-cell responses. Immunol Rev 2008; 221:26-43.
19. Katakai T, Suto H, Sugai M et al. Organizer-like reticular stromal cell layer common to adult secondary lymphoid organs. J Immunol 2008; 181:6189-200.
20. Bajenoff M, Germain RN. B cell follicle development remodels the conduit system and allows soluble antigen delivery to follicular dendritic cells. Blood 2009; 114:4989-97.
21. Hammerschmidt SI, Ahrendt M, Bode U et al. Stromal mesenteric lymph node cells are essential for the generation of gut-homing T cells in vivo. J Exp Med 2008; 205:2483-90.
22. Scandella E, Bolinger B, Lattmann E et al. Restoration of lymphoid organ integrity through the interaction of lymphoid tissue-inducer cells with stroma of the T cell zone. Nat Immunol 2008; 9:667-75.
23. Luther SA, Bidgol A, Hargreaves DC et al. Differing activities of homeostatic chemokines CCL19, CCL21, and CXCL12 in lymphocyte and dendritic cell recruitment and lymphoid neogenesis. J Immunol 2002; 169:424-33.
24. Heinzel K, Benz C, Bleul CC. A silent chemokine receptor regulates steady-state leukocyte homing in vivo. Proc Natl Acad Sci USA 2007; 104:8421-6.
25. Yang BG, Tanaka T, Jang MH, Bai Z, Hayasaka H, Miyasaka M. Binding of lymphoid chemokines to collagen IV that accumulates in the basal lamina of high endothelial venules: its implications in lymphocyte trafficking. J Immunol 2007; 179:4376-82.
26. Velaga S, Herbrand H, Friedrichsen M et al. Chemokine receptor CXCR5 supports solitary intestinal lymphoid tissue formation, B cell homing, and induction of intestinal IgA responses. J Immunol 2009; 182:2610-9.