Virucidal activity of the dendrimer microbicide SPL7013 against HIV-1

Antiviral Research

Volumn 90, Issue 3, 2011, Pages 195-199

  Telwatte, Sushama ^a   Moore, Katie ^a   Johnson, Adam ^a   Tyssen, David ^a   Sterjovski, Jasminka ^a   Aldunate, Muriel ^a,b   Gorry, Paul R ^a,b,c   Ramsland, Paul A ^a,b,c   Lewis, Gareth R ^d   Paull, Jeremy R A ^d   Sonza, Secondo ^a,b   Tachedjian, Gilda ^a,b  

^a BURNET INSTITUTE   (Australia)

^b MONASH UNIVERSITY   (Australia)

^c UNIVERSITY OF MELBOURNE   (Australia)

^d Starpharma Holdings Limited   (Australia)

Author keywords

Dendrimer; HIV; Microbicide; SPL7013; Virucidal activity

Indexed keywords

CHEMOKINE RECEPTOR CXCR4; GAG PROTEIN; GLYCOPROTEIN GP 120; HLA DR ANTIGEN; HUMAN IMMUNODEFICIENCY VIRUS PROTEIN; MACROGOL; SUCROSE; VIVAGEL;

ANTIVIRAL ACTIVITY; ANTIVIRAL SUSCEPTIBILITY; ARTICLE; CLADISTICS; CONTROLLED STUDY; DRUG MECHANISM; DRUG POTENCY; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; PRECIPITATION; PRIORITY JOURNAL; STRAIN DIFFERENCE; ULTRACENTRIFUGATION; VIRION; VIRUS CAPSID; VIRUS INACTIVATION; VIRUS STRAIN; WESTERN BLOTTING;

ANTI-HIV AGENTS; CELL LINE; DENDRIMERS; GENE EXPRESSION REGULATION, VIRAL; HIV INFECTIONS; HIV-1; HUMANS; POLYLYSINE; RECEPTORS, CCR5; RECEPTORS, CXCR4;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN PAPILLOMAVIRUS; MIRIDAE; SIMPLEXVIRUS;

EID: 79955009095     PISSN: 01663542     EISSN: 18729096     Source Type: Journal    
DOI: 10.1016/j.antiviral.2011.03.186     Document Type: Article

References (31)

1. Abdool Karim Q., Abdool Karim S.S., Frohlich J.A., Grobler A.C., Baxter C., Mansoor L.E., Kharsany A.B., Sibeko S., Mlisana K.P., Omar Z., Gengiah T.N., Maarschalk S., Arulappan N., Mlotshwa M., Morris L., Taylor D. Effectiveness and safety of tenofovir gel, an antiretroviral microbicide, for the prevention of HIV infection in women. Science 2010, 329:1168-1174.
2. Abner S.R., Guenthner P.C., Guarner J., Hancock K.A., Cummins J.E., Fink A., Gilmore G.T., Staley C., Ward A., Ali O., Binderow S., Cohen S., Grohskopf L.A., Paxton L., Hart C.E., Dezzutti C.S. A human colorectal explant culture to evaluate topical microbicides for the prevention of HIV infection. J. Infect. Dis. 2005, 192:1545-1556.
3. Balzarini J., Van Damme L. Microbicide drug candidates to prevent HIV infection. Lancet 2007, 369:787-797.
4. Bernstein D.I., Stanberry L.R., Sacks S., Ayisi N.K., Gong Y.H., Ireland J., Mumper R.J., Holan G., Matthews B., McCarthy T., Bourne N. Evaluations of unformulated and formulated dendrimer-based microbicide candidates in mouse and guinea pig models of genital herpes. Antimicrob. Agents Chemother. 2003, 47:3784-3788.
5. Brown J.M., Wald A., Hubbard A., Rungruengthanakit K., Chipato T., Rugpao S., Mmiro F., Celentano D.D., Salata R.S., Morrison C.S., Richardson B.A., Padian N.S. Incident and prevalent herpes simplex virus type 2 infection increases risk of HIV acquisition among women in Uganda and Zimbabwe. AIDS 2007, 21:1515-1523.
6. Chen M.Y., Millwood I.Y., Wand H., Poynten M., Law M., Kaldor J.M., Wesselingh S., Price C.F., Clark L.J., Paull J.R., Fairley C.K. A randomized controlled trial of the safety of candidate microbicide SPL7013 gel when applied to the penis. J. Acquir. Immune Defic. Syndr. 2009, 50:375-380.
7. Cummins J.E., Guarner J., Flowers L., Guenthner P.C., Bartlett J., Morken T., Grohskopf L.A., Paxton L., Dezzutti C.S. Preclinical testing of candidate topical microbicides for anti-human immunodeficiency virus type 1 activity and tissue toxicity in a human cervical explant culture. Antimicrob. Agents Chemother. 2007, 51:1770-1779.
8. Dezzutti C.S., James V.N., Ramos A., Sullivan S.T., Siddig A., Bush T.J., Grohskopf L.A., Paxton L., Subbarao S., Hart C.E. In vitro comparison of topical microbicides for prevention of human immunodeficiency virus type 1 transmission. Antimicrob. Agents Chemother. 2004, 48:3834-3844.
9. Figueiredo A., Moore K.L., Mak J., Sluis-Cremer N., de Bethune M.P., Tachedjian G. Potent nonnucleoside reverse transcriptase inhibitors target HIV-1 Gag-Pol. PLoS Pathog. 2006, 2:e119.
10. Fletcher P.S., Shattock R.J. PRO-2000, an antimicrobial gel for the potential prevention of HIV infection. Curr. Opin. Investig. Drugs 2008, 9:189-200.
11. Fletcher P.S., Wallace G.S., Mesquita P.M., Shattock R.J. Candidate polyanion microbicides inhibit HIV-1 infection and dissemination pathways in human cervical explants. Retrovirology 2006, 3:46.
12. Freeman E.E., Weiss H.A., Glynn J.R., Cross P.L., Whitworth J.A., Hayes R.J. Herpes simplex virus 2 infection increases HIV acquisition in men and women: systematic review and meta-analysis of longitudinal studies. AIDS 2006, 20:73-83.
13. Gong E., Matthews B., McCarthy T., Chu J., Holan G., Raff J., Sacks S. Evaluation of dendrimer SPL7013, a lead microbicide candidate against herpes simplex viruses. Antiviral Res. 2005, 68:139-146.
14. Gorry P.R., Bristol G., Zack J.A., Ritola K., Swanstrom R., Birch C.J., Bell J.E., Bannert N., Crawford K., Wang H., Schols D., De Clercq E., Kunstman K., Wolinsky S.M., Gabuzda D. Macrophage tropism of human immunodeficiency virus type 1 isolates from brain and lymphoid tissues predicts neurotropism independent of coreceptor specificity. J. Virol. 2001, 75:10073-10089.
15. Huskens D., Vermeire K., Profy A.T., Schols D. The candidate sulfonated microbicide, PRO 2000, has potential multiple mechanisms of action against HIV-1. Antiviral Res. 2009, 84:38-47.
16. Jiang Y.H., Emau P., Cairns J.S., Flanary L., Morton W.R., McCarthy T.D., Tsai C.C. SPL7013 gel as a topical microbicide for prevention of vaginal transmission of SHIV89.6P in macaques. AIDS Res. Hum. Retroviruses 2005, 21:207-213.
17. Lackman-Smith C., Osterling C., Luckenbaugh K., Mankowski M., Snyder B., Lewis G., Paull J., Profy A., Ptak R.G., Buckheit R.W., Watson K.M., Cummins J.E., Sanders-Beer B.E. Development of a comprehensive human immunodeficiency virus type 1 screening algorithm for discovery and preclinical testing of topical microbicides. Antimicrob. Agents Chemother. 2008, 52:1768-1781.
18. Neurath A.R., Strick N., Jiang S., Li Y.Y., Debnath A.K. Anti-HIV-1 activity of cellulose acetate phthalate: synergy with soluble CD4 and induction of " dead-end" gp41 six-helix bundles. BMC Infect. Dis. 2002, 2:6.
19. Neurath A.R., Strick N., Li Y.Y. Anti-HIV-1 activity of anionic polymers: a comparative study of candidate microbicides. BMC Infect. Dis. 2002, 2:27.
20. O'Loughlin J., Millwood I.Y., McDonald H.M., Price C.F., Kaldor J.M., Paull J.R. Safety, tolerability, and pharmacokinetics of SPL7013 gel (VivaGel(R)): a dose ranging, phase I study. Sex. Transm. Dis. 2010, 37:100-104.
21. Oelrichs R.B., Lawson V.A., Coates K.M., Chatfield C., Deacon N.J., McPhee D.A. Rapid full-length genomic sequencing of two cytopathically heterogeneous Australian primary HIV-1 isolates. J. Biomed. Sci. 2000, 7:128-135.
22. Patton D.L., Cosgrove Sweeney Y.T., McCarthy T.D., Hillier S.L. Preclinical safety and efficacy assessments of dendrimer-based (SPL7013) microbicide gel formulations in a nonhuman primate model. Antimicrob. Agents Chemother. 2006, 50:1696-1700.
23. Pinter A. Roles of HIV-1 Env variable regions in viral neutralization and vaccine development. Curr. HIV Res. 2007, 5:542-553.
24. Rupp R., Rosenthal S.L., Stanberry L.R. VivaGel (SPL7013 Gel): a candidate dendrimer-microbicide for the prevention of HIV and HSV infection. Int. J. Nanomed. 2007, 2:561-566.
25. Rusconi S., Moonis M., Merrill D.P., Pallai P.V., Neidhardt E.A., Singh S.K., Willis K.J., Osburne M.S., Profy A.T., Jenson J.C., Hirsch M.S. Naphthalene sulfonate polymers with CD4-blocking and anti-human immunodeficiency virus type 1 activities. Antimicrob. Agents Chemother. 1996, 40:234-236.
26. Scordi-Bello I.A., Mosoian A., He C., Chen Y., Cheng Y., Jarvis G.A., Keller M.J., Hogarty K., Waller D.P., Profy A.T., Herold B.C., Klotman M.E. Candidate sulfonated and sulfated topical microbicides: comparison of anti-human immunodeficiency virus activities and mechanisms of action. Antimicrob. Agents Chemother. 2005, 49:3607-3615.
27. Shutt D.C., Jenkins L.M., Carolan E.J., Stapleton J., Daniels K.J., Kennedy R.C., Soll D.R. T cell syncytia induced by HIV release. T cell chemoattractants: demonstration with a newly developed single cell chemotaxis chamber. J. Cell. Sci. 1998, 111:99-109.
28. Sonza S., Johnson A., Tyssen D., Spelman T., Lewis G.R., Paull J.R., Tachedjian G. Enhancement of human immunodeficiency virus type 1 replication is not intrinsic to all polyanion-based microbicides. Antimicrob. Agents Chemother. 2009, 53:3565-3568.
29. Sterjovski J., Roche M., Churchill M.J., Ellett A., Farrugia W., Gray L.R., Cowley D., Poumbourios P., Lee B., Wesselingh S.L., Cunningham A.L., Ramsland P.A., Gorry P.R. An altered and more efficient mechanism of CCR5 engagement contributes to macrophage tropism of CCR5-using HIV-1 envelopes. Virology 2010, 404:269-278.
30. Tyssen D., Henderson S.A., Johnson A., Sterjovski J., Moore K., La J., Zanin M., Sonza S., Karellas P., Giannis M.P., Krippner G., Wesselingh S., McCarthy T., Gorry P.R., Ramsland P.A., Cone R., Paull J.R., Lewis G.R., Tachedjian G. Structure activity relationship of dendrimer microbicides with dual action antiviral activity. PLoS ONE 2010, 5:e12309.
31. UNAIDS, 2008. Joint United Nations Programme on HIV/AIDS (UNAIDS). Report on the global AIDS epidemic.