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Volumn 21, Issue 12, 2007, Pages 1515-1523

Incident and prevalent herpes simplex virus type 2 infection increases risk of HIV acquisition among women in Uganda and Zimbabwe

(12)  Brown, Joelle M a   Wald, Anna d   Hubbard, Alan c   Rungruengthanakit, Kittipong g   Chipato, Tsungai h   Rugpao, Sungwal g   Mmiro, Francis f   Celentano, David D i   Salata, Robert S j   Morrison, Charles S k   Richardson, Barbra A e   Padian, Nancy S b  


Author keywords

Africa; Herpes simplex virus 2; HIV; Marginal structural models; Population attributable risk; Women

Indexed keywords

ADULT; ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; FOLLOW UP; HAZARD RATIO; HERPES SIMPLEX; HERPES SIMPLEX VIRUS 2; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMAN IMMUNODEFICIENCY VIRUS PREVALENCE; INCIDENCE; INFECTION RISK; MAJOR CLINICAL STUDY; PREVALENCE; PRIORITY JOURNAL; PROSPECTIVE STUDY; SEROPREVALENCE; SEXUAL BEHAVIOR; UGANDA; ZIMBABWE;

EID: 34447568145     PISSN: 02699370     EISSN: None     Source Type: Journal    
DOI: 10.1097/QAD.0b013e3282004929     Document Type: Article
Times cited : (81)

References (48)
  • 1
    • 0032961069 scopus 로고    scopus 로고
    • Genital ulcers: Etiology, clinical diagnosis, and associated human immunodeficiency virus infection in Kingston
    • Behets FM, Brathwaite AR, Hylton-Kong T, Chen CY, Hoffman I, Weiss JB, et al. Genital ulcers: etiology, clinical diagnosis, and associated human immunodeficiency virus infection in Kingston, Jamaica. Clin Infect Dis 1999; 28:1086-1090.
    • (1999) Jamaica. Clin Infect Dis , vol.28 , pp. 1086-1090
    • Behets, F.M.1    Brathwaite, A.R.2    Hylton-Kong, T.3    Chen, C.Y.4    Hoffman, I.5    Weiss, J.B.6
  • 2
    • 0031847862 scopus 로고    scopus 로고
    • Molecular methods for the diagnosis of genital ulcer disease in a sexually transmitted disease clinic population in northern Thailand: Predominance of herpes simplex virus infection
    • Beyrer C, Jitwatcharanan K, Natpratan C, Kaewvichit R, Nelson KE, Chen CY, et al. Molecular methods for the diagnosis of genital ulcer disease in a sexually transmitted disease clinic population in northern Thailand: predominance of herpes simplex virus infection. J Infect Dis 1998; 178:243-246.
    • (1998) J Infect Dis , vol.178 , pp. 243-246
    • Beyrer, C.1    Jitwatcharanan, K.2    Natpratan, C.3    Kaewvichit, R.4    Nelson, K.E.5    Chen, C.Y.6
  • 3
    • 0033977354 scopus 로고    scopus 로고
    • Human immunodeficiency virus infection and genital ulcer disease in South Africa: The herpetic connection
    • Chen CY, Ballard RC, Beck-Sague CM, Dangor Y, Radebe F, Schmid S, et al. Human immunodeficiency virus infection and genital ulcer disease in South Africa: the herpetic connection. Sex Transm Dis 2000; 27:21-29.
    • (2000) Sex Transm Dis , vol.27 , pp. 21-29
    • Chen, C.Y.1    Ballard, R.C.2    Beck-Sague, C.M.3    Dangor, Y.4    Radebe, F.5    Schmid, S.6
  • 6
    • 16944366643 scopus 로고    scopus 로고
    • Comparison of clinical diagnosis and standard laboratory and molecular methods for the diagnosis of genital ulcer disease in Lesotho: Association with human immunodeficiency virus infection
    • Morse SA, Trees DL, Htun Y, Radebe F, Orle KA, Dangor Y, et al. Comparison of clinical diagnosis and standard laboratory and molecular methods for the diagnosis of genital ulcer disease in Lesotho: association with human immunodeficiency virus infection. J Infect Dis 1997; 175:583-589.
    • (1997) J Infect Dis , vol.175 , pp. 583-589
    • Morse, S.A.1    Trees, D.L.2    Htun, Y.3    Radebe, F.4    Orle, K.A.5    Dangor, Y.6
  • 7
    • 34447549681 scopus 로고    scopus 로고
    • WHO/UN AIDS. Herpes Simplex Virus Type 2: Programmatic and Research Priorities in Developing Countries. Geneva: World health Organization; 2001.
    • WHO/UN AIDS. Herpes Simplex Virus Type 2: Programmatic and Research Priorities in Developing Countries. Geneva: World health Organization; 2001.
  • 8
    • 0021955408 scopus 로고
    • Interferon gamma production by herpes simplex virus antigen-specific T cell clones from patients with recurrent herpes labialis
    • Cunningham AL, Nelson PA, Fathman CG, Merigan TC. Interferon gamma production by herpes simplex virus antigen-specific T cell clones from patients with recurrent herpes labialis. J Gen Virol 1985; 66 (Pt 2):249-258.
    • (1985) J Gen Virol , vol.66 , Issue.PART 2 , pp. 249-258
    • Cunningham, A.L.1    Nelson, P.A.2    Fathman, C.G.3    Merigan, T.C.4
  • 9
    • 0028301850 scopus 로고
    • Antigenic specificities of human CD4R T-cell clones recovered from recurrent genital herpes simplex virus type 2 lesions
    • Koelle DM, Corey L, Burke RL, Eisenberg RJ, Cohen GH, Pichyangkura R, et al. Antigenic specificities of human CD4R T-cell clones recovered from recurrent genital herpes simplex virus type 2 lesions. J Virol 1994; 68:2803-2810.
    • (1994) J Virol , vol.68 , pp. 2803-2810
    • Koelle, D.M.1    Corey, L.2    Burke, R.L.3    Eisenberg, R.J.4    Cohen, G.H.5    Pichyangkura, R.6
  • 11
    • 0036137322 scopus 로고    scopus 로고
    • Risk of human immunodeficiency virus infection in herpes simplex virus type 2-seropositive persons: A meta-analysis
    • Wald A, Link K. Risk of human immunodeficiency virus infection in herpes simplex virus type 2-seropositive persons: a meta-analysis. J Infect Dis 2002; 185:45-52.
    • (2002) J Infect Dis , vol.185 , pp. 45-52
    • Wald, A.1    Link, K.2
  • 12
    • 29144444035 scopus 로고    scopus 로고
    • Herpes simplex virus 2 infection increases HIV acquisition in men and women: Systematic review and meta-analysis of longitudinal studies
    • Freeman EE, Weiss HA, Glynn JR, Cross PL, Whitworth JA, Hayes RJ. Herpes simplex virus 2 infection increases HIV acquisition in men and women: systematic review and meta-analysis of longitudinal studies. AIDS 2006; 20:73-83.
    • (2006) AIDS , vol.20 , pp. 73-83
    • Freeman, E.E.1    Weiss, H.A.2    Glynn, J.R.3    Cross, P.L.4    Whitworth, J.A.5    Hayes, R.J.6
  • 13
    • 0028181255 scopus 로고
    • Risk factors for woman-to-man sexual transmission of the human immunodeficiency virus. Italian Study Group on HIV Heterosexual Transmission
    • Nicolosi A, Musicco M, Saracco A, Lazzarin A. Risk factors for woman-to-man sexual transmission of the human immunodeficiency virus. Italian Study Group on HIV Heterosexual Transmission. J Acquir Immune Defic Syndr 1994; 7:296-300.
    • (1994) J Acquir Immune Defic Syndr , vol.7 , pp. 296-300
    • Nicolosi, A.1    Musicco, M.2    Saracco, A.3    Lazzarin, A.4
  • 14
    • 0032778623 scopus 로고    scopus 로고
    • Rates of HIV-1 transmission within marriage in rural Uganda in relation to the HIV sero-status of the partners
    • Carpenter LM, Kamali A, Ruberantwari A, Malamba SS, Whitworth JA. Rates of HIV-1 transmission within marriage in rural Uganda in relation to the HIV sero-status of the partners. AIDS 1999; 13:1083-1089.
    • (1999) AIDS , vol.13 , pp. 1083-1089
    • Carpenter, L.M.1    Kamali, A.2    Ruberantwari, A.3    Malamba, S.S.4    Whitworth, J.A.5
  • 15
    • 0037083809 scopus 로고    scopus 로고
    • del Mar Pujades Rodriguez M, Obasi A, Mosha F, Todd J, Brown D, Changalucha J, et al. Herpes simplex virus type 2 infection increases HIV incidence: a prospective study in rural Tanzania. AIDS 2002; 16:451-462.
    • del Mar Pujades Rodriguez M, Obasi A, Mosha F, Todd J, Brown D, Changalucha J, et al. Herpes simplex virus type 2 infection increases HIV incidence: a prospective study in rural Tanzania. AIDS 2002; 16:451-462.
  • 17
    • 0036790150 scopus 로고    scopus 로고
    • Detection of herpes simplex virus type 2-specific immunoglobulin G antibodies in African sera by using recombinant gG2, Western blotting, and gG2 inhibition
    • Hogrefe W, Su X, Song J, Ashley R, Kong L. Detection of herpes simplex virus type 2-specific immunoglobulin G antibodies in African sera by using recombinant gG2, Western blotting, and gG2 inhibition. J Clin Microbiol 2002; 40:3635-3640.
    • (2002) J Clin Microbiol , vol.40 , pp. 3635-3640
    • Hogrefe, W.1    Su, X.2    Song, J.3    Ashley, R.4    Kong, L.5
  • 18
    • 16544392279 scopus 로고    scopus 로고
    • Performance of a commercial, type-specific enzyme-linked immunosorbent assay for detection of herpes simplex virus type 2-specific antibodies in Ugandans
    • Laeyendecker O, Henson C, Gray RH, Nguyen RH, Horne BJ, Wawer MJ, et al. Performance of a commercial, type-specific enzyme-linked immunosorbent assay for detection of herpes simplex virus type 2-specific antibodies in Ugandans. J Clin Microbiol 2004; 42:1794-1796.
    • (2004) J Clin Microbiol , vol.42 , pp. 1794-1796
    • Laeyendecker, O.1    Henson, C.2    Gray, R.H.3    Nguyen, R.H.4    Horne, B.J.5    Wawer, M.J.6
  • 19
    • 0026603770 scopus 로고
    • Asymptomatic reactivation of herpes simplex virus in women after the first episode of genital herpes
    • Koelle DM, Benedetti J, Langenberg A, Corey L. Asymptomatic reactivation of herpes simplex virus in women after the first episode of genital herpes. Ann Intern Med 1992; 116:433-437.
    • (1992) Ann Intern Med , vol.116 , pp. 433-437
    • Koelle, D.M.1    Benedetti, J.2    Langenberg, A.3    Corey, L.4
  • 20
    • 0033529412 scopus 로고    scopus 로고
    • Clinical reactivation of genital herpes simplex virus infection decreases in frequency over time
    • Benedetti JK, Zeh J, Corey L. Clinical reactivation of genital herpes simplex virus infection decreases in frequency over time. Ann Intern Med 1999; 131:14-20.
    • (1999) Ann Intern Med , vol.131 , pp. 14-20
    • Benedetti, J.K.1    Zeh, J.2    Corey, L.3
  • 21
    • 77649173768 scopus 로고
    • Longitudinal data analysis using generalized linear models
    • Liang KY, Zeger SL. Longitudinal data analysis using generalized linear models. Biometrika 1986; 73:13-22.
    • (1986) Biometrika , vol.73 , pp. 13-22
    • Liang, K.Y.1    Zeger, S.L.2
  • 22
    • 0033847784 scopus 로고    scopus 로고
    • Marginal structural models and causal inference in epidemiology
    • Robins JM, Hernan MA, Brumback B. Marginal structural models and causal inference in epidemiology. Epidemiology 2000; 11:550-560.
    • (2000) Epidemiology , vol.11 , pp. 550-560
    • Robins, J.M.1    Hernan, M.A.2    Brumback, B.3
  • 24
    • 0001415308 scopus 로고    scopus 로고
    • Association, causation, and marginal structural models
    • Robins JM. Association, causation, and marginal structural models. Synthese 1999; 121:151-179.
    • (1999) Synthese , vol.121 , pp. 151-179
    • Robins, J.M.1
  • 25
    • 0033839024 scopus 로고    scopus 로고
    • Marginal structural models to estimate the causal effect of zidovudine on the survival of HIV-positive men
    • Hernan MA, Brumback B, Robins JM. Marginal structural models to estimate the causal effect of zidovudine on the survival of HIV-positive men. Epidemiology 2000; 11:561-570.
    • (2000) Epidemiology , vol.11 , pp. 561-570
    • Hernan, M.A.1    Brumback, B.2    Robins, J.M.3
  • 28
    • 0032745301 scopus 로고    scopus 로고
    • Prevalence and incidence of herpes simplex virus type 2 infection among male Zimbabwean factory workers
    • McFarland W, Gwanzura L, Bassett MT, Machekano R, Latif AS, Ley C, et al. Prevalence and incidence of herpes simplex virus type 2 infection among male Zimbabwean factory workers. J Infect Dis 1999; 180:1459-1465.
    • (1999) J Infect Dis , vol.180 , pp. 1459-1465
    • McFarland, W.1    Gwanzura, L.2    Bassett, M.T.3    Machekano, R.4    Latif, A.S.5    Ley, C.6
  • 29
    • 0028144841 scopus 로고
    • A longitudinal study of human immunodefi-ciency virus transmission by heterosexual partners. European Study Group on Heterosexual Transmission of HIV
    • de Vincenzi I. A longitudinal study of human immunodefi-ciency virus transmission by heterosexual partners. European Study Group on Heterosexual Transmission of HIV. N Engl J Med 1994; 331:341-346.
    • (1994) N Engl J Med , vol.331 , pp. 341-346
    • de Vincenzi, I.1
  • 30
    • 5344259658 scopus 로고    scopus 로고
    • Effectiveness of condoms in reducing heterosexual transmission of HIV
    • Cayley WE Jr. Effectiveness of condoms in reducing heterosexual transmission of HIV. Am Fam Physician 2004; 70:1268-1269.
    • (2004) Am Fam Physician , vol.70 , pp. 1268-1269
    • Cayley Jr., W.E.1
  • 32
    • 0035958293 scopus 로고    scopus 로고
    • Effect of condoms on reducing the transmission of herpes simplex virus type 2 from men to women
    • Wald A, Langenberg AG, Link K, Izu AE, Ashley R, Warren T, et al. Effect of condoms on reducing the transmission of herpes simplex virus type 2 from men to women. JAMA 2001; 285:3100-3106.
    • (2001) JAMA , vol.285 , pp. 3100-3106
    • Wald, A.1    Langenberg, A.G.2    Link, K.3    Izu, A.E.4    Ashley, R.5    Warren, T.6
  • 33
    • 4444220236 scopus 로고    scopus 로고
    • Incidence of herpes simplex virus type 2 infection in 5 sexually transmitted disease (STD) clinics and the effect of HIV/STD risk-reduction counseling
    • Gottlieb SL, Douglas JM Jr, Foster M, Schmid DS, Newman DR, Baron AE, et al. Incidence of herpes simplex virus type 2 infection in 5 sexually transmitted disease (STD) clinics and the effect of HIV/STD risk-reduction counseling. J Infect Dis 2004; 190:1059-1067.
    • (2004) J Infect Dis , vol.190 , pp. 1059-1067
    • Gottlieb, S.L.1    Douglas Jr, J.M.2    Foster, M.3    Schmid, D.S.4    Newman, D.R.5    Baron, A.E.6
  • 34
    • 4344592187 scopus 로고    scopus 로고
    • Prevention of herpes simplex virus type 2 transmission with antiviral therapy
    • Corey L, Ashley R. Prevention of herpes simplex virus type 2 transmission with antiviral therapy. Herpes 2004; 11:170A-174A.
    • (2004) Herpes , vol.11
    • Corey, L.1    Ashley, R.2
  • 35
    • 33745192537 scopus 로고    scopus 로고
    • Knowledge of partners' genital herpes protects against herpes simplex virus type 2 acquisition
    • Wald A, Krantz E, Selke S, Lairson E, Morrow RA, Zeh J. Knowledge of partners' genital herpes protects against herpes simplex virus type 2 acquisition. J Infect Dis 2006; 194:42-52.
    • (2006) J Infect Dis , vol.194 , pp. 42-52
    • Wald, A.1    Krantz, E.2    Selke, S.3    Lairson, E.4    Morrow, R.A.5    Zeh, J.6
  • 36
    • 4344573865 scopus 로고    scopus 로고
    • Clinical trials of prophylactic and therapeutic herpes simplex virus vaccines
    • Stanberry LR. Clinical trials of prophylactic and therapeutic herpes simplex virus vaccines. Herpes 2004; 11 (Suppl 3):161A-169A.
    • (2004) Herpes , vol.11 , Issue.SUPPL. 3
    • Stanberry, L.R.1
  • 37
    • 1242292255 scopus 로고    scopus 로고
    • The potential epidemiological impact of a genital herpes vaccine for women
    • Garnett GP, Dubin G, Slaoui M, Darcis T. The potential epidemiological impact of a genital herpes vaccine for women. Sex Transm Infect 2004; 80:24-29.
    • (2004) Sex Transm Infect , vol.80 , pp. 24-29
    • Garnett, G.P.1    Dubin, G.2    Slaoui, M.3    Darcis, T.4
  • 38
    • 28444460441 scopus 로고    scopus 로고
    • Randomized, controlled intervention trial of male circumcision for reduction of HIV infection risk: The ANRS1265 Trial
    • Auvert B, Taljaard D, Lagarde E, Sobngwi-Tambekou J, Sitta R, Puren A. Randomized, controlled intervention trial of male circumcision for reduction of HIV infection risk: the ANRS1265 Trial. PLoS Med 2005; 2911:e298.
    • (2005) PLoS Med , vol.2911
    • Auvert, B.1    Taljaard, D.2    Lagarde, E.3    Sobngwi-Tambekou, J.4    Sitta, R.5    Puren, A.6
  • 39
    • 30144434185 scopus 로고    scopus 로고
    • An siRNA-based microbicide protects mice from lethal herpes simplex virus 2 infection
    • Palliser D, Chowdhury D, Wang QY, Lee SJ, Bronson RT, Knipe DM, et al. An siRNA-based microbicide protects mice from lethal herpes simplex virus 2 infection. Nature 2006; 439:89-94.
    • (2006) Nature , vol.439 , pp. 89-94
    • Palliser, D.1    Chowdhury, D.2    Wang, Q.Y.3    Lee, S.J.4    Bronson, R.T.5    Knipe, D.M.6
  • 40
    • 33644602042 scopus 로고    scopus 로고
    • Silencing herpes simplex virus with a vaginal microbicide
    • Johnson DC. Silencing herpes simplex virus with a vaginal microbicide. N Engl J Med 2006; 354:970-971.
    • (2006) N Engl J Med , vol.354 , pp. 970-971
    • Johnson, D.C.1
  • 41
    • 29744466672 scopus 로고    scopus 로고
    • gel inhibits HIV and herpes simplex virus infection following vaginal application: A double-blind placebo-controlled trial
    • Keller MJ, Zerhouni-Layachi B, Cheshenko N, John M, Hogarty K, Kasowitz A, et al. PRO 2000 gel inhibits HIV and herpes simplex virus infection following vaginal application: a double-blind placebo-controlled trial. J Infect Dis 2006; 193:27-35.
    • (2006) J Infect Dis , vol.193 , pp. 27-35
    • Keller, M.J.1    Zerhouni-Layachi, B.2    Cheshenko, N.3    John, M.4    Hogarty, K.5    Kasowitz, A.6
  • 42
    • 0036217080 scopus 로고    scopus 로고
    • Preclinical evaluation of sodium cellulose sulfate (Ushercell) as a contraceptive antimicrobial agent
    • Anderson RA, Feathergill KA, Diao XH, Cooper MD, Kirkpatrick R, Herold BC, et al. Preclinical evaluation of sodium cellulose sulfate (Ushercell) as a contraceptive antimicrobial agent. J Androl 2002; 23:426-438.
    • (2002) J Androl , vol.23 , pp. 426-438
    • Anderson, R.A.1    Feathergill, K.A.2    Diao, X.H.3    Cooper, M.D.4    Kirkpatrick, R.5    Herold, B.C.6
  • 43
    • 7444259596 scopus 로고    scopus 로고
    • Protective effect of a natural carrageenan on genital herpes simplex virus infection in mice
    • Carlucci MJ, Scolaro LA, Noseda MD, Cerezo AS, Damonte EB. Protective effect of a natural carrageenan on genital herpes simplex virus infection in mice. Antiviral Res 2004; 64:137-141.
    • (2004) Antiviral Res , vol.64 , pp. 137-141
    • Carlucci, M.J.1    Scolaro, L.A.2    Noseda, M.D.3    Cerezo, A.S.4    Damonte, E.B.5
  • 44
    • 10744228936 scopus 로고    scopus 로고
    • Evaluations of unformulated and formulated dendrimer-based microbicide candidates inmouse and guinea pigmodels of genital herpes
    • Bernstein DI, Stanberry LR, Sacks S, AyisiNK, GongYH, Ireland J, et al. Evaluations of unformulated and formulated dendrimer-based microbicide candidates inmouse and guinea pigmodels of genital herpes. Antimicrob Agents Chemother 2003; 47:3784-3788.
    • (2003) Antimicrob Agents Chemother , vol.47 , pp. 3784-3788
    • Bernstein, D.I.1    Stanberry, L.R.2    Sacks, S.3    Ayisi, N.K.4    Gong, Y.H.5    Ireland, J.6
  • 45
    • 0034968797 scopus 로고    scopus 로고
    • Tests of Buffergel for contraception and prevention of sexually transmitted diseases in animal models
    • Zeitlin L, Hoen TE, Achilles SL, Hegarty TA, Jerse AE, Kreider JW, et al. Tests of Buffergel for contraception and prevention of sexually transmitted diseases in animal models. Sex Transm Dis 2001; 28:417-423.
    • (2001) Sex Transm Dis , vol.28 , pp. 417-423
    • Zeitlin, L.1    Hoen, T.E.2    Achilles, S.L.3    Hegarty, T.A.4    Jerse, A.E.5    Kreider, J.W.6
  • 46
    • 0035039512 scopus 로고    scopus 로고
    • Comparison of microbicides for efficacy in protecting mice against vaginal challenge with herpes simplex virus type 2, cytotoxicity, antibacterial properties, and sperm immobilization
    • Maguire RA, Bergman N, Phillips DM. Comparison of microbicides for efficacy in protecting mice against vaginal challenge with herpes simplex virus type 2, cytotoxicity, antibacterial properties, and sperm immobilization. Sex Transm Dis 2001; 28:259-265.
    • (2001) Sex Transm Dis , vol.28 , pp. 259-265
    • Maguire, R.A.1    Bergman, N.2    Phillips, D.M.3
  • 47
    • 0033988128 scopus 로고    scopus 로고
    • In vitro and in vivo evaluations of sodium lauryl sulfate and dextran sulfate as microbicides against herpes simplex and human immunodeficiency viruses
    • Piret J, Lamontagne J, Bestman-Smith J, Roy S, Gourde P, Desormeaux A, et al. In vitro and in vivo evaluations of sodium lauryl sulfate and dextran sulfate as microbicides against herpes simplex and human immunodeficiency viruses. J Clin Microbiol 2000; 38:110-119.
    • (2000) J Clin Microbiol , vol.38 , pp. 110-119
    • Piret, J.1    Lamontagne, J.2    Bestman-Smith, J.3    Roy, S.4    Gourde, P.5    Desormeaux, A.6
  • 48
    • 0036193979 scopus 로고    scopus 로고
    • Efficacy and safety of a new vaginal contraceptive antimicrobial formulation containing high molecular weight poly(sodium 4-styrenesulfonate)
    • Zaneveld LJ, Waller DP, Anderson RA, Chany C 2nd, Rencher WF, Feathergill K, et al. Efficacy and safety of a new vaginal contraceptive antimicrobial formulation containing high molecular weight poly(sodium 4-styrenesulfonate). Biol Reprod 2002; 66:886-894.
    • (2002) Biol Reprod , vol.66 , pp. 886-894
    • Zaneveld, L.J.1    Waller, D.P.2    Anderson, R.A.3    Chany 2nd, C.4    Rencher, W.F.5    Feathergill, K.6


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