Apocynin prevents cyclooxygenase 2 expression in human monocytes through NADPH oxidase and glutathione redox-dependent mechanisms

Free Radical Biology and Medicine

Volumn 37, Issue 2, 2004, Pages 156-165

  Barbieri, Silvia S ^a   Cavalca, Viviana ^a   Eligini, Sonia ^a   Brambilla, Marta ^a   Caiani, Alessia ^a   Tremoli, Elena ^a   Colli, Susanna ^a,b  

^a UNIVERSITY OF MILAN   (Italy)

^b Dept of Pharmacological Sciences ^*  (Italy)

Author keywords

Apocynin; Cox 2; Cyclooxygenase 2; cyclooxygenase 2; diphenyleneiodonium; DPI; EMSA; Free radicals; Monocytes; NADPH oxidase; Nuclear Factor B; Prostaglandin E2; Reactive oxygen species; Reduced oxidized glutathione ratio

Indexed keywords

3 [3 TERT BUTYLTHIO 1 (4 CHLOROBENZYL) 5 ISOPROPYL 2 INDOLYL] 2,2 DIMETHYLPROPIONIC ACID; APOCYNIN; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; GLUTATHIONE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PHORBOL MYRISTATE; PICRORHIZA KURROA EXTRACT; PROTEIN P47; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; ROTENONE; ZYMOSAN;

ARTICLE; CELL ACTIVATION; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME SYNTHESIS; HUMAN; HUMAN CELL; MOLECULAR BIOLOGY; MONOCYTE; NORMAL HUMAN; OXIDATION REDUCTION REACTION; PICRORHIZA KURROA; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN EXPRESSION;

ACETOPHENONES; ANTIBODIES; ANTIOXIDANTS; BLOTTING, WESTERN; CELL NUCLEUS; CELLS, CULTURED; CYCLOOXYGENASE 2; DINOPROSTONE; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUTATHIONE; HUMANS; INFLAMMATION; ISOENZYMES; MEMBRANE PROTEINS; MONOCYTES; NADPH OXIDASE; NF-KAPPA B; OXIDATION-REDUCTION; OXYGEN; PEROXIDASE; PHOSPHOPROTEINS; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PROTEIN ISOFORMS; PROTEIN TRANSPORT; REACTIVE OXYGEN SPECIES; THROMBOXANE B2; TIME FACTORS;

ANIMALIA; PICRORHIZA KURROOA;

EID: 2942590474     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2004.04.020     Document Type: Article

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