Commercial naphthenic acids and the organic fraction of oil sands process water downregulate pro-inflammatory gene expression and macrophage antimicrobial responses

Toxicology Letters

Volumn 203, Issue 1, 2011, Pages 62-73

  Garcia Garcia, Erick ^a   Pun, Jonathan ^a   Perez Estrada, Leonidas A ^a   Din, Mohamed Gamal El ^a   Smith, Daniel W ^a   Martin, Jonathan W ^a   Belosevic, Miodrag ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Cytokines; Ecotoxicology; Gene expression; Immunotoxicity; Inflammation; Macrophage; Mouse; Phagocytosis

Indexed keywords

COLONY STIMULATING FACTOR 1; GAMMA INTERFERON; IMMUNOTOXIN; INTERLEUKIN 1BETA; NAPHTHENIC ACID; NITRIC OXIDE; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIMICROBIAL ACTIVITY; ARTICLE; CELL PROLIFERATION; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOWN REGULATION; FEMALE; GENE EXPRESSION; IMMUNOTOXICITY; MACROPHAGE; MACROPHAGE ACTIVATION; MOUSE; NONHUMAN; OIL SANDS PROCESS WATER; PHAGOCYTOSIS; PRIORITY JOURNAL; RESPIRATORY BURST; SPLEEN;

ADMINISTRATION, ORAL; ANIMALS; CARBOXYLIC ACIDS; CELL PROLIFERATION; CELL SURVIVAL; CELLS, CULTURED; CYTOKINES; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; FEMALE; INDUSTRIAL WASTE; INFLAMMATION MEDIATORS; MACROPHAGE ACTIVATION; MACROPHAGES; MICE; MICE, INBRED C57BL; MINING; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; PHAGOCYTOSIS; REACTIVE OXYGEN SPECIES; RESPIRATORY BURST; TIME FACTORS; WATER POLLUTANTS, CHEMICAL;

MUS;

EID: 79954718200     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2011.03.005     Document Type: Article

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