Adsorption of insulin with varying self-association profiles to a solid Teflon surface - Influence on protein structure, fibrillation tendency and thermal stability

European Journal of Pharmaceutical Sciences

Volumn 42, Issue 5, 2011, Pages 509-516

  Jorgensen, Lene ^a   Bennedsen, Pernille ^b   Hoffmann, Søren Vrønning ^c   Krogh, Rasmus Linnemann ^b   Pinholt, Charlotte ^a   Groenning, Minna ^a   Hostrup, Susanne ^b   Bukrinsky, Jens T ^b  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b NOVO NORDISK A S   (Denmark)

^c AARHUS UNIVERSITY   (Denmark)

Author keywords

Adsorption; Association profile; Circular dichroism; Fibrillation; Insulin; Protein adsorption; Solid surfaces

Indexed keywords

INSULIN; POLITEF; THIOFLAVINE;

ARTICLE; CONTROLLED STUDY; DRUG ADSORPTION; DRUG BINDING; DRUG STABILITY; GEL PERMEATION CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; PRIORITY JOURNAL; PROTEIN STRUCTURE; THERMOSTABILITY;

ADSORPTION; DRUG STABILITY; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; HYPOGLYCEMIC AGENTS; INSULIN; POLYTETRAFLUOROETHYLENE; PROTEIN DENATURATION; PROTEIN FOLDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; SURFACE PROPERTIES; TEMPERATURE;

EID: 79954634033     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejps.2011.02.007     Document Type: Article

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