Upregulation of the 5-lipoxygenase pathway in human aortic valves correlates with severity of stenosis and leads to leukotriene-induced effects on valvular myofibroblasts

Circulation

Volumn 123, Issue 12, 2011, Pages 1316-1325

  Nagy, Edit ^a   Andersson, Daniel C ^a   Caidahl, Kenneth ^a   Eriksson, Maria J ^a   Eriksson, Per ^a   Franco Cereceda, Anders ^a   Hansson, Göran K ^a   Bäck, Magnus ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

aortic valve stenosis; echocardiography; inflammation; leukotrienes; myofibroblasts

Indexed keywords

ARACHIDONATE 5 LIPOXYGENASE; CALCIUM; LEUKOTRIENE; LEUKOTRIENE A4 HYDROLASE; LEUKOTRIENE RECEPTOR; MESSENGER RNA; REACTIVE OXYGEN METABOLITE;

ADULT; AGED; AORTA VALVE STENOSIS; ARTICLE; CELL CULTURE; CONTROLLED STUDY; CORRELATIONAL STUDY; ECHOCARDIOGRAPHY; FEMALE; GENE EXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INFLAMMATION; MAJOR CLINICAL STUDY; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; MYOFIBROBLAST; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; SOFT TISSUE CALCIFICATION;

AGED; AORTIC VALVE; AORTIC VALVE STENOSIS; ARACHIDONATE 5-LIPOXYGENASE; CELLS, CULTURED; ECHOCARDIOGRAPHY; FEMALE; FIBROBLASTS; GENE EXPRESSION PROFILING; HUMANS; IMMUNOHISTOCHEMISTRY; LEUKOTRIENE C4; MALE; MIDDLE AGED; MITRAL VALVE; MYOCARDITIS; RECEPTORS, LEUKOTRIENE; SEVERITY OF ILLNESS INDEX; SIGNAL TRANSDUCTION; TRICUSPID VALVE; UP-REGULATION;

EID: 79954628327     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.110.966846     Document Type: Article

References (43)

1. Stewart BF, Siscovick D, Lind BK, Gardin JM, Gottdiener JS, Smith VE, Kitzman DW, Otto CM. Clinical factors associated with calcific aortic valve disease: Cardiovascular Health Study. J Am Coll Cardiol. 1997;29: 630-634. (Pubitemid 27116107)
2. Olsson M, Thyberg J, Nilsson J. Presence of oxidized low-density lipoprotein in nonrheumatic stenotic aortic valves. Arterioscler Thromb Vasc Biol. 1999;19:1218-1222. (Pubitemid 29227640)
3. Otto CM, Kuusisto J, Reichenbach DD, Gown AM, O'Brien KD. Characterization of the early lesion of 'degenerative' valvular aortic stenosis: histological and immunohistochemical studies. Circulation. 1994;90: 844-853. (Pubitemid 24242754)
4. Rajamannan NM, Gersh B, Bonow RO. Calcific aortic stenosis: from bench to the bedside: emerging clinical and cellular concepts. Heart. 2003;89:801-805. (Pubitemid 36760652)
5. Aikawa E, Nahrendorf M, Sosnovik D, Lok VM, Jaffer FA, Aikawa M, Weissleder R. Multimodality molecular imaging identifies proteolytic and osteogenic activities in early aortic valve disease. Circulation. 2007; 115:377-386. (Pubitemid 46148512)
6. Soini Y, Salo T, Satta J. Angiogenesis is involved in the pathogenesis of nonrheumatic aortic valve stenosis. Hum Pathol. 2003;34:756-763. (Pubitemid 37040610)
7. Chalajour F, Treede H, Ebrahimnejad A, Lauke H, Reichenspurner H, Ergun S. Angiogenic activation of valvular endothelial cells in aortic valve stenosis. Exp Cell Res. 2004;298:455-464. (Pubitemid 38950862)
8. Edep ME, Shirani J, Wolf P, Brown DL. Matrix metalloproteinase expression in nonrheumatic aortic stenosis. Cardiovasc Pathol. 2000;9: 281-286.
9. Kaden JJ, Dempfle CE, Grobholz R, Tran HT, Kilic R, Sarikoc A, Brueckmann M, Vahl C, Hagl S, Haase KK, Borggrefe M. Interleukin-1 beta promotes matrix metalloproteinase expression and cell proliferation in calcific aortic valve stenosis. Atherosclerosis. 2003;170:205-211. (Pubitemid 37377791)
10. Aikawa E, Aikawa M, Libby P, Figueiredo JL, Rusanescu G, Iwamoto Y, Fukuda D, Kohler RH, Shi GP, Jaffer FA, Weissleder R. Arterial and aortic valve calcification abolished by elastolytic cathepsin S deficiency in chronic renal disease. Circulation. 2009;119:1785-1794.
11. Mohler ER III, Gannon F, Reynolds C, Zimmerman R, Keane MG, Kaplan FS. Bone formation and inflammation in cardiac valves. Circulation. 2001;103:1522-1528. (Pubitemid 32226259)
12. Cowell SJ, Newby DE, Prescott RJ, Bloomfield P, Reid J, Northridge DB, Boon NA. A randomized trial of intensive lipid-lowering therapy in calcific aortic stenosis. N Engl J Med. 2005;352:2389-2397. (Pubitemid 40958435)
13. Rossebo AB, Pedersen TR, Boman K, Brudi P, Chambers JB, Egstrup K, Gerdts E, Gohlke-Barwolf C, Holme I, Kesaniemi YA, Malbecq W, Nienaber CA, Ray S, Skjaerpe T, Wachtell K, Willenheimer R. Intensive lipid lowering with simvastatin and ezetimibe in aortic stenosis. N Engl J Med. 2008;359:1343-1356.
14. Chan KL, Teo K, Dumesnil JG, Ni A, Tam J. Effect of lipid lowering with rosuvastatin on progression of aortic stenosis: results of the Aortic Stenosis Progression Observation: Measuring Effects of Rosuvastatin (ASTRONOMER) trial. Circulation. 2010;121:306-314.
15. Horstkotte D, Loogen F. The natural history of aortic valve stenosis. Eur Heart J. 1988;9(Suppl E):57-64.
16. Rajamannan NM, Subramaniam M, Rickard D, Stock SR, Donovan J, Springett M, Orszulak T, Fullerton DA, Tajik AJ, Bonow RO, Spelsberg T. Human aortic valve calcification is associated with an osteoblast phenotype. Circulation. 2003;107:2181-2184. (Pubitemid 36547209)
17. Helske S, Kupari M, Lindstedt KA, Kovanen PT. Aortic valve stenosis: an active atheroinflammatory process. Curr Opin Lipidol. 2007;18: 483-491. (Pubitemid 47462199)
18. Bäck M. Leukotriene receptors: crucial components in vascular inflammation. ScientificWorldJournal. 2007;7:1422-1439. (Pubitemid 47435431)
19. Dahlen SE. Treatment of asthma with antileukotrienes: first line or last resort therapy? Eur J Pharmacol. 2006;533:40-56.
20. Bäck M, Hansson GK. Leukotriene receptors in atherosclerosis. Ann Med. 2006;38:493-502. (Pubitemid 44764437)
21. Bäck M, Bu DX, Bränström R, Sheikine Y, Yan ZQ, Hansson GK. Leukotriene b4 signaling through nf-kappab-dependent blt1 receptors on vascular smooth muscle cells in atherosclerosis and intimal hyperplasia. Proc Natl Acad Sci USA. 2005;102:17501-17506. (Pubitemid 41740895)
22. Brezinski DA, Nesto RW, Serhan CN. Angioplasty triggers intracoronary leukotrienes and lipoxin A4: impact of aspirin therapy. Circulation. 1992;86:56-63.
23. Hlawaty H, Jacob MP, Louedec L, Letourneur D, Brink C, Michel JB, Feldman L, Bäck M. Leukotriene receptor antagonism and the prevention of extracellular matrix degradation during atherosclerosis and in-stent stenosis. Arterioscler Thromb Vasc Biol. 2009;29:518-524.
24. Lang RM, Bierig M, Devereux RB, Flachskampf FA, Foster E, Pellikka PA, Picard MH, Roman MJ, Seward J, Shanewise JS, Solomon SD, Spencer KT, Sutton MS, Stewart WJ. Recommendations for chamber quantification. J Am Soc Echocardiogr. 2005;18:1440-1463.
25. Vahanian A, Baumgartner H, Bax J, Butchart E, Dion R, Filippatos G, Flachskampf F, Hall R, Iung B, Kasprzak J, Nataf P, Tornos P, Torracca L, Wenink A. Guidelines on the management of valvular heart disease. Eur Heart J. 2007;28:230-268.
26. Baumgartner H, Hung J, Bermejo J, Chambers JB, Evangelista A, Griffin BP, Iung B, Otto CM, Pellikka PA, Quinones M. Echocardiographic assessment of valve stenosis: EAE/ASE recommendations for clinical practice. Eur J Echocardiogr. 2009;10:1-25.
27. Schroeder A, Mueller O, Stocker S, Salowsky R, Leiber M, Gassmann M, Lightfoot S, Menzel W, Granzow M, Ragg T. The RIN: an RNA integrity number for assigning integrity values to RNA measurements. BMC Mol Biol. 2006;7:3.
28. Kochtebane N, Choqueux C, Passefort S, Nataf P, Messika-Zeitoun D, Bartagi A, Michel JB, Angles-Cano E, Jacob MP. Plasmin induces apoptosis of aortic valvular myofibroblasts. J Pathol. 2010;221:37-48.
29. Bäck M, Airila-Månsson S, Jogestrand T, Söder B, Söder PO. Increased leukotriene concentrations in gingival crevicular fluid from subjects with periodontal disease and atherosclerosis. Atherosclerosis. 2007;193: 389-394.
30. Olsson M, Rosenqvist M, Nilsson J. Expression of HLA-DR antigen and smooth muscle cell differentiation markers by valvular fibroblasts in degenerative aortic stenosis. J Am Coll Cardiol. 1994;24: 1664-1671. (Pubitemid 24369191)
31. Beppu S, Suzuki S, Matsuda H, Ohmori F, Nagata S, Miyatake K. Rapidity of progression of aortic stenosis in patients with congenital bicuspid aortic valves. Am J Cardiol. 1993;71:322-327. (Pubitemid 23053442)
32. Fondard O, Detaint D, Iung B, Choqueux C, Adle-Biassette H, Jarraya M, Hvass U, Couetil JP, Henin D, Michel JB, Vahanian A, Jacob MP. Extracellular matrix remodelling in human aortic valve disease: the role of matrix metalloproteinases and their tissue inhibitors. Eur Heart J. 2005;26:1333-1341. (Pubitemid 41435466)
33. Soini Y, Satta J, Maatta M, Autio-Harmainen H. Expression of MMP2, MMP9, MT1-MMP, TIMP1, and TIMP2 mRNA in valvular lesions of the heart. J Pathol. 2001;194:225-231.
34. Jian B, Jones PL, Li Q, Mohler ER III, Schoen FJ, Levy RJ. Matrix metalloproteinase-2 is associated with tenascin-C in calcific aortic stenosis. Am J Pathol. 2001;159:321-327. (Pubitemid 33704217)
35. Houard X, Ollivier V, Louedec L, Michel JB, Bäck M. Differential inflammatory activity across human abdominal aortic aneurysms reveals neutrophil-derived leukotriene B4 as a major chemotactic factor released from the intraluminal thrombus. FASEB J. 2009;23:1376-1383.
36. Kim EY, Seo JM, Cho KJ, Kim JH. Ras-induced invasion and metastasis are regulated by a leukotriene B4 receptor BLT2-linked pathway. Oncogene. 2010;29:1167-1178.
37. Allen S, Dashwood M, Morrison K, Yacoub M. Differential leukotriene constrictor responses in human atherosclerotic coronary arteries. Circulation. 1998;97:2406-2413. (Pubitemid 28278184)
38. Snetkov VA, Hapgood KJ, McVicker CG, Lee TH, Ward JP. Mechanisms of leukotriene D4-induced constriction in human small bronchioles. Br J Pharmacol. 2001;133:243-252. (Pubitemid 32507043)
39. Hafizi S, Taylor PM, Chester AH, Allen SP, Yacoub MH. Mitogenic and secretory responses of human valve interstitial cells to vasoactive agents. J Heart Valve Dis. 2000;9:454-458. (Pubitemid 30395140)
40. Brookes PS, Yoon Y, Robotham JL, Anders MW, Sheu SS. Calcium, ATP, and ROS: a mitochondrial love-hate triangle. Am J Physiol Cell Physiol. 2004;287:C817-C833. (Pubitemid 39238305)
41. Jian B, Narula N, Li QY, Mohler ER III, Levy RJ. Progression of aortic valve stenosis: TGF-1 is present in calcified aortic valve cusps and promotes aortic valve interstitial cell calcification via apoptosis. Ann. Thorac Surg. 2003;75:457-465; discussion 465-456. (Pubitemid 36184488)
42. Liberman M, Bassi E, Martinatti MK, Lario FC, Wosniak J Jr, Pomerantzeff PM, Laurindo FR. Oxidant generation predominates around calcifying foci and enhances progression of aortic valve calcification. Arterioscler Thromb Vasc Biol. 2008;28:463-470.
43. Mandal CC, Ganapathy S, Gorin Y, Mahadev K, Block K, Abboud H, Harris SE, Ghosh-Choudhury G, Ghosh-Choudhury N. Reactive oxygen species derived from Nox-4 mediate BMP-2 gene transcription and osteoblast differentiation. Biochem J. 2010;433:393-402.