IκBα polymorphisms were associated with increased risk of gastric cancer in a southern Chinese population: A case-control study

Life Sciences

Volumn 88, Issue 17-18, 2011, Pages 792-797

  Wang, Shiyan ^a   Zhang, Mingdong ^a   Zeng, Zhirong ^b   Tian, Linwei ^a   Wu, Kaichun ^c   Chu, Jianhong ^a   Fan, Daiming ^c   Hu, Pinjin ^b   Sung, Joseph J Y ^a   Yu, Jun ^a,d  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^b SUN YAT SEN UNIVERSITY   (China)

^c FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^d CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Gastric cancer; Gene polymorphism; I B ; Risk factor

Indexed keywords

I KAPPA B ALPHA; LUCIFERASE;

ARTICLE; CANCER RISK; CHINESE; CONTROLLED STUDY; DNA POLYMORPHISM; ENZYME ACTIVITY; GENE SEQUENCE; HUMAN; MAJOR CLINICAL STUDY; NUCLEOTIDE SEQUENCE; STOMACH CANCER;

ALLELES; CASE-CONTROL STUDIES; CHINA; FEMALE; GENOTYPE; HOMOZYGOTE; HUMANS; I-KAPPA B PROTEINS; MALE; POLYMORPHISM, GENETIC; POLYMORPHISM, SINGLE NUCLEOTIDE; PROMOTER REGIONS, GENETIC; RISK FACTORS; STOMACH NEOPLASMS;

EID: 79954622970     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lfs.2011.02.016     Document Type: Article

References (35)

1. A. Abdallah, H. Sato, J.C. Grutters, S. Veeraraghavan, P.A. Lympany, and H.J. Ruven Inhibitor kappa B-alpha (IkappaB-alpha) promoter polymorphisms in UK and Dutch sarcoidosis Genes Immun 4 2003 450 454 (Pubitemid 38967610)
2. T. Atsumi, K. Kato, K. Uno, K. Iijima, T. Koike, and A. Imatani Pathophysiological role of the activation of p38 mitogen-activated protein kinases in poorly differentiated gastric cancer Pathol Int 57 2007 635 644 (Pubitemid 47353039)
3. S.S. Barbieri, and B.B. Weksler Tobacco smoke cooperates with interleukin-1beta to alter beta-catenin trafficking in vascular endothelium resulting in increased permeability and induction of cyclooxygenase-2 expression in vitro and in vivo FASEB J 21 2007 1831 1843 (Pubitemid 46855629)
4. C.M. Cahill, and J.T. Rogers Interleukin (IL) 1beta induction of IL-6 is mediated by a novel phosphatidylinositol 3-kinase-dependent AKT/IkappaB kinase alpha pathway targeting activator protein-1 J Biol Chem 283 2008 25900 25912
5. P.K. Chakraborty, S.B. Mustafi, and S. Raha Pro-survival effects of repetitive low-grade oxidative stress are inhibited by simultaneous exposure to resveratrol Pharmacol Res 58 2008 281 289
6. P.R. Debruyne, M. Witek, L Gong, R Birbe, I. Chervoneva, and T. Jin Bile acids induce ectopic expression of intestinal guanylyl cyclase C through nuclear factor-kappaB and Cdx2 in human esophageal cells Gastroenterology 130 2006 1191 1206
7. M.P. Ebert, G. Fei, S. Kahmann, O. Müller, J. Yu, and J.J. Sung Increased beta-catenin mRNA levels and mutational alterations of the APC and beta-catenin gene are present in intestinal-type gastric cancer Carcinogenesis 23 2002 87 91 (Pubitemid 34213556)
8. M.P. Ebert, J. Yu, J. Hoffmann, A. Rocco, C. Röcken, and S. Kahmann Loss of beta-catenin expression in metastatic gastric cancer J Clin Oncol 21 2003 1708 1714 (Pubitemid 46638581)
9. S. Ghosh, M.J. May, and E.B. Kopp NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses Annu Rev Immunol 16 1998 225 260 2003 (Pubitemid 28183365)
10. F.R. Greten, L. Eckmann, T.F. Greten, J.M. Park, Z.W. Li, and L.J. Egan IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer Cell 118 2004 285 296 (Pubitemid 39061110)
11. R.J. Guo, E.R. Suh, and J.P. Lynch The role of Cdx proteins in intestinal development and cancer Cancer Biol Ther 3 2004 593 601 (Pubitemid 41351093)
12. S. Hansen, S.E. Vollset, M.H. Derakhshan, V. Fyfe, K.K. Melby, and S. Aase Two distinct aetiologies of cardia cancer; evidence from premorbid serological markers of gastric atrophy and Helicobacter pylori status Gut 56 2007 918 925 (Pubitemid 46999074)
13. Y.J. Jung, J.S. Isaacs, S. Lee, J Trepel, and L. Neckers IL-1beta-mediated up-regulation of HIF-1alpha via an NFkappaB/COX-2 pathway identifies HIF-1 as a critical link between inflammation and oncogenesis FASEB J 17 2003 2115 2117
14. F. Kamangar, Y.L. Qiao, M.J. Blaser, X.D. Sun, H. Katki, and J.H. Fan Helicobacter pylori and oesophageal and gastric cancers in a prospective study in China Br J Cancer 96 2007 172 176 (Pubitemid 46094658)
15. M. Karin, Y. Cao, F.R. Greten, and Z.W. Li NF-kappaB in cancer: from innocent bystander to major culprit Nat Rev Cancer 2 2002 301 310 (Pubitemid 37328783)
16. E. Kefaloyianni, C. Gaitanaki, and I. Beis ERK1/2 and p38-MAPK signalling pathways, through MSK1, are involved in NF-kappaB transactivation during oxidative stress in skeletal myoblasts Cell Signal 18 2006 2238 2251 (Pubitemid 44740489)
17. L.H. Kim, H.D. Shin, B.L. Park, J.H. Jung, J.Y. Kim, and Y.J. Kim Identification of variants in NFKBIA and association analysis with hepatocellular carcinoma risk among chronic HBV patients Hum Mutat 21 2003 652 653
18. W. Klein, A. Tromm, C. Folwaczny, M. Hagedorn, N. Duerig, and J.T. Epplen A polymorphism of the NFKBIA gene is associated with Crohn's disease patients lacking a predisposing allele of the CARD15 gene Int J Colorectal Dis 19 2004 153 156 (Pubitemid 38239837)
19. M. Kobayashi, S. Nagata, T. Iwasaki, K. Yanagihara, I. Saitoh, and Y. Karouji Dedifferentiation of adenocarcinomas by activation of phosphatidylinositol 3-kinase Proc Natl Acad Sci USA 96 1999 4874 4879 (Pubitemid 29214504)
20. J. Kountouras, C. Zavos, D. Chatzopoulos, and P. Katsinelos New aspects of Helicobacter pylori infection involvement in gastric oncogenesis J Surg Res 146 2008 149 158 (Pubitemid 351442939)
21. F. Kramer, J. Torzewski, J. Kamenz, K. Veit, V. Hombach, and J. Dedio Interleukin-1beta stimulates acute phase response and C-reactive protein synthesis by inducing an NFkappaB- and C/EBPbeta-dependent autocrine interleukin-6 loop Mol Immunol 45 2008 2678 2689
22. S. Kuphal, I. Poser, C Jobin, C. Hellerbrand, and A.K. Bosserhoff Loss of E-cadherin leads to upregulation of NFkappaB activity in malignant melanoma Oncogene 23 2004 8509 8519 (Pubitemid 39540801)
23. G. Kwon, J.A. Corbett, S. Hauser, J.R. Hill, J. Turk, and M.L. McDaniel Evidence for involvement of the proteasome complex (26S) and NFkappaB in IL-1beta-induced nitric oxide and prostaglandin production by rat islets and RINm5F cells Diabetes 47 1998 583 591 (Pubitemid 28160449)
24. J.L. Luo, S. Maeda, L.C. Hsu, H. Yagita, and M. Karin Inhibition of NF-kappaB in cancer cells converts inflammation-induced tumor growth mediated by TNFalpha to TRAIL-mediated tumor regression Cancer Cell 6 2004 297 305 (Pubitemid 39222042)
25. M.S. Maliner-Stratton, R.D. Klein, T.S. Udayakumar, R.B. Nagle, and G.T. Bowden Interleukin-1beta-induced promatrilysin expression is mediated by NFkappaB-regulated synthesis of interleukin-6 in the prostate carcinoma cell line, LNCaP Neoplasia 3 2001 509 520 (Pubitemid 33151017)
26. N. Mozzato-Chamay, E.L. Corbett, R.L. Bailey, D.C. Mabey, J. Raynes, and D.J. Conway Polymorphisms in the IkappaB-alpha promoter region and risk of diseases involving inflammation and fibrosis Genes Immun 2 2001 153 155 (Pubitemid 33674880)
27. H. Mutoh, S. Sakurai, K. Satoh, K. Tamada, H. Kita, and H. Osawa Development of gastric carcinoma from intestinal metaplasia in Cdx2-transgenic mice Cancer Res 64 2004 7740 7747 (Pubitemid 39446905)
28. J.M. O'Riordan, M.M. Abdel-latif, N. Ravi, D. McNamara, P.J. Byrne, and G.S. McDonald Proinflammatory cytokine and nuclear factor kappa-B expression along the inflammation-metaplasia-dysplasia-adenocarcinoma sequence in the esophagus Am J Gastroenterol 100 2005 1257 1264 (Pubitemid 40904346)
29. J. Osborne, A. Lake, F.E. Alexander, G.M. Taylor, and R.F. Jarrett Germline mutations and polymorphisms in the NFKBIA gene in Hodgkin lymphoma Int J Cancer 116 2005 646 651 (Pubitemid 41099203)
30. E. Pikarsky, R.M. Porat, I. Stein, R. Abramovitch, S. Amit, and S. Kasem NF-kappaB functions as a tumour promoter in inflammation-associated cancer Nature 431 2004 461 466 (Pubitemid 39329586)
31. D.G. Silberg, J. Sullivan, E. Kang, G.P. Swain, J. Moffett, and N.J. Sund Cdx2 ectopic expression induces gastric intestinal metaplasia in transgenic mice Gastroenterology 122 2002 689 696 (Pubitemid 34173821)
32. A.P. Sinke, A.R. Jayakumar, K.S. Panickar, M. Moriyama, P.V. Reddy, and M.D. Norenberg NFkappaB in the mechanism of ammonia-induced astrocyte swelling in culture J Neurochem 106 2008 2302 2311
33. Q. Xu, Y. Karouji, M. Kobayashi, S. Ihara, H. Konishi, and Y. Fukui The PI 3-kinase-Rac-p38 MAP kinase pathway is involved in the formation of signet-ring cell carcinoma Oncogene 22 2003 5537 5544 (Pubitemid 37102688)
34. N. Yamanaka, T. Morisaki, H. Nakashima, A. Tasaki, M. Kubo, and H. Kuga Interleukin 1beta enhances invasive ability of gastric carcinoma through nuclear factor-kappaB activation Clin Cancer Res 10 2004 1853 1859 (Pubitemid 38435577)
35. Y. Yuasa Control of gut differentiation and intestinal-type gastric carcinogenesis Nat Rev Cancer 3 2003 592 600 (Pubitemid 37328831)