Differential gene expressions in subcutaneous adipose tissue pointed to a delayed adipocytic differentiation in small pig fetuses compared to their heavier siblings

Differentiation

Volumn 81, Issue 4, 2011, Pages 253-260

  Gondret, F ^a,b   Perruchot, M H ^a,b   Tacher, S ^a,b   Berard J ^c   Bee, G ^c  

^a CEMAGREF   (France)

^b AGROCAMPUS OUEST   (France)

^c AGROSCOPE LIEBEFELD POSIEUX RESEARCH STATION ALP   (Switzerland)

Author keywords

Adipogenic genes; Adipose tissue; Arginine; Intra litter variation; Pig; Prenatal nutrition

Indexed keywords

ADIPOCYTE TYPE SPECIFIC PROTEIN FATTY ACID BINDING PROTEIN 4; ARGININE; DELTA LIKE HOMOLOG 1 PROTEIN; PREADIPOCYTE FACTOR 1; PROTEIN FZD7; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ADIPOCYTE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CEBPA GENE; CELL CYCLE PROGRESSION; CELL DIFFERENTIATION; CONTROLLED STUDY; DIET SUPPLEMENTATION; DLK1 GENE; DNA CONTENT; FABP4 GENE; FETUS; FETUS GROWTH; FETUS WEIGHT; FZD7 GENE; GENE; GENE EXPRESSION REGULATION; GENETIC VARIABILITY; GESTATIONAL AGE; LIPID STORAGE; LPL GENE; MATERNAL NUTRITION; ME1 GENE; NONHUMAN; NUCLEOTIDE SEQUENCE; PPARG GENE; PREF1 GENE; PREGNANCY; PRIORITY JOURNAL; SIBLING; SREBP1 GENE; SUBCUTANEOUS FAT; SWINE;

ADIPOCYTES; ADIPOGENESIS; ANIMALS; ARGININE; DIETARY SUPPLEMENTS; FEMALE; FETAL GROWTH RETARDATION; FETAL WEIGHT; FETUS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; PREGNANCY; SIBLINGS; SUBCUTANEOUS FAT; SWINE;

SUIDAE;

EID: 79954616706     PISSN: 03014681     EISSN: 14320436     Source Type: Journal    
DOI: 10.1016/j.diff.2011.02.002     Document Type: Article

References (42)

1. Attig L., Djiane J., Gertler A., Rampin O., Larcher T., Boukthir S., Anton P.M., Madec J.Y., Gourdou I., Abdennebi-Najar L. Study of hypothalamic leptin receptor expression in low-birth-weight piglets and effects of leptin supplementation on neonatal growth and development. Am. J. Physiol. Endocrinol. Metab. 2008, 295:E1117-1125.
2. Berard J., Bee G. Effects of dietary l-arginine supplementation to gilts during early gestation on ftal survival, growth and myofiber formation. Animal 2010, 4:1680-1687.
3. Bergen W.G., Wu G. Intestinal nitrogen recycling and utilization in health and disease. J. Nutr. 2009, 139:821-825.
4. Chung K.Y., Choi C.B., Kawachi H., Yano H., Smith S.B. Trans-10, cis-12 conjugated linoleic acid antagonizes arginine-promoted differentiation of bovine preadipocytes. Adipocytes 2005, 2:93-100.
5. Deiuliis J.A., Li B., Lyvers-Peffer P.A., Moeller S.J., Lee K. Alternative splicing of delta-like 1 homolog (DLK1) in the pig and human. Comp. Biochem. Physiol. B Biochem. Mol. Biol. 2006, 145:50-59.
6. Du M., Yin J., Zhu M.J. Cellular signaling pathways regulating the initial stage of adipogenesis and marbling skeletal muscle. Meat Sci. 2010, 86:103-109.
7. Erkens T., Van Poucke M., Vandesompele J., Goossens K., Van Zeveren A., Peelman L.J. Development of a new set of reference genes for normalization of real-time RT-PCR data of porcine backfat and longissimus dorsi muscle, and evaluation with PPARGC1A. BMC Biotechnol. 2006, 6:41.
8. Flynn N.E., Meininger C.J., Haynes T.E., Wu G. The metabolic basis of arginine nutrition and pharmacotherapy. Biomed. Pharmacother. 2002, 56:427-438.
9. Garces C., Ruiz-Hidalgo M.J., Bonvini E., Goldstein J., Laborda J. Adipocyte differentiation is modulated by secreted delta-like (dlk) variants and requires the expression of membrane-associated dlk. Differentiation 1999, 64:103-114.
10. Gondret F., Lefaucheur L., Juin H., Louveau I., Lebret B. Low birth weight is associated with enlarged muscle fiber area and impaired meat tenderness of the longissimus muscle in pigs. J. Anim. Sci. 2006, 84:93-103.
11. Hazeleger W., Ramaekers R., Smits C., Kemp B. Effect of Progenos on placenta and fetal development in pigs. J. Anim. Sci. 2007, 85:98. [abstract No176].
12. Hausman G.J., Kauffman R.G. The histology of developing porcine adipose tissue. J. Anim. Sci. 1986, 63:642-658.
13. Herrera E., Amusquivar E. Lipid metabolism in the fetus and the newborn. Diabetes Metab. Res. Rev. 2000, 16:202-210.
14. Karunaratne J.P., Bayol S.A., Ashton C.J., Simbi B.H., Stickland N.C. Potential molecular mechanisms for the prenatal compartmentalisation of muscle and connective tissue in pigs. Differentiation 2009, 77:290-297.
15. Labarca C., Paigen K. A simple, rapid, and sensitive DNA assay procedure. Anal. Biochem. 1980, 102:344-352.
16. Lee K., Hausman G.J., Dean R.G. Expression of C/EBPα, Β and δ in fetal and postnatal subcutaneous adipose tissue. Mol. Cell. Biochem. 1998, 178:269-274.
17. Leenhouwers J.I., Knol E.F., de Groot P.N., Vos H., van der Lende T. Fetal development in the pig in relation to genetic merit for piglet survival. J. Anim. Sci. 2002, 80:1759-1770.
18. Mateo R.D., Wu G., Bazer F.W., Park J.C., Shinzato I., Kim S.W. Dietary l-arginine supplementation enhances the reproductive performance of gilts. J. Nutr. 2007, 137:652-656.
19. McNeel R.L., Ding S.T., Smith O.B., Mersmann H.J. Expression of porcine adipocyte transcripts during differentiation in vitro and in vivo. Comp. Biochem. Physiol. Part B 2000, 126:291-302.
20. McPherson R.L., Ji F., Wu G., Banton J.R., Kim S.W. Growth and compositional changes of fetal tissues in pigs. J. Anim. Sci. 2004, 82:2534-2540.
21. Morise A., Sève B., Macé K., Magliola C., Le Huërou-luron I., Louveau I. Impact of intrauterine growth retardation and early protein intake on growth, adipose tissue, and the insulin-like growth factor system in piglets. Pediatr. Res. 2009, 65:45-50.
22. Mueller E., Drori S., Aiyer A., Yie J., Sarraf P., Chen H., Hauser S., Rosen E.D., Ge K., Roeder R.G., Spiegelman B.M. Genetic analysis of adipogenesis through peroxisome proliferator-activated receptor gamma isoforms. J. Biol. Chem. 2002, 277:41925-41930.
23. Muhlhausler B.S., Duffield J.A., McMillen IC. Increased maternal nutrition stimulates peroxisome activated receptor-gamma, adiponectin, and leptin messenger ribonucleic acid expression in adipose tissue before birth. Endocrinol. 2007, 148:878-885.
24. Nygard A.B., Jørgensen C.B., Cirera S., Fredholm M. Selection of reference genes for gene expression studies in pig tissues using SYBR green qPCR. BMC Mol. Biol. 2007, 8:67.
25. Park J.R., Jung J.W., Lee Y.S., Kang K.S. The roles of Wnt antagonists Dkk1 and SFRP4 during adipogenesis of human adipose tissue-derived mesenchymal stem cells. Cell. Prolif. 2008, 41:859-874.
26. Perry J.S., Rowell J.O. Variations in fetal weight and vascular supply along the uterine horn of the pig. J. Reprod. Fertil. 1969, 19:527-534.
27. Poore K.R., Fowden A.L. The effects of birth weight and postnatal growth patterns on fat depth and plasma leptin concentrations in juvenile and adult pigs. J. Physiol. 2004, 558:295-304.
28. Quiniou N., Dagorn J., Gaudre D. Variation of piglets birth weight and consequences on subsequent performance. Livest. Prod. Sci. 2002, 78:63-70.
29. Ramaekers P., Kemp B., van der Lende T. Progenos in sows increases number of piglets born. J. Anim. Sci. 2006, 84:394. [abstract N°462].
30. Rehfeldt C., Kuhn G. Consequences of birth weight for postnatal growth performance, and carcass quality in pigs as related to myogenesis. J. Anim. Sci. 2006, 84:E113-E123.
31. Rosen E.D., Spiegelman B.M. Molecular regulation of adipogenesis. Annu. Rev. Cell Dev. Biol. 2000, 2(16):145-171.
32. Samulin J., Berg P.R., Sundvold H., Grindflek E., Lien S. Expression of DLK1 splice variants during porcine adipocyte development in vitro and in vivo. Anim. Genet. 2009, 40:239-241.
33. Suzuki S., Sembon S., Iwamoto M., Fuchimoto D., Onishi A. Identification of genes downregulated during differentiation of porcine mesenteric adipocytes. J. Anim. Sci. 2008, 86:3367-3376.
34. Tan J.T., McLennan S.V., Song W.W., Lo L.W., Bonner J.G., Williams P.F., Twigg S.M. Connective tissue growth factor inhibitis adipocyte differentiation. Am. J. Physiol. Cell Physiol. 2008, 295:C740-C751.
35. Town S.C., Putman C.T., Turchinsky N.J., Dizon W.T., Foxcroft G.R. Number of conceptuses in utero affects porcine fetal muscle development. Reproduction 2004, 128:443-454.
36. Trayhurn P., Temple N.J., Van Aerde J. Evidence from immunoblotting studies on uncoupling protein that brown adipose tissue is not present in the domestic pig. Can. J. Physiol. Pharmacol. 1989, 67:1480-1485.
37. Vandesompele J., De Preter K., Pattyn F., Poppe B., Van Roy N., De Paepe A., Speleman F. Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol. 2002, 3. RESEARCH0034.
38. Wigmore P.M., Stickland N.C. Muscle development in large and small pig fetuses. J. Anat. 1983, 137:235-245.
39. Williams P.J., Marten N., Wilson V., Litten-Brown J.C., Corson A.M., Clarke L., Symonds M.E., Mostyn A. Influence of birth weight on gene regulators of lipid metabolism and utilization in subcutaneous adipose tissue and skeletal muscle of neonatal pigs. Reproduction 2009, 138:609-617.
40. Wu G., Bazer F.W., Burghardt R.C., Johnson G.A., Kim S.W., Li X.L., Satterfield M.C., Spencer T.E. Impacts of amino acid nutrition on pregnancy outcome in pigs: Mechanisms and implications for swine production. J. Anim. Sci. 2010, 88:E195-204.
41. Wu G., Bazer F.W., Cudd T.A., Jobgen W.S., Kim S.W., Lassala A., Li P., Matis J.H., Meininger C.J., Spencer T.E. Pharmacokinetics and safety of arginine supplementation in animals. J. Nutr. 2007, 137:1673S-1680S.
42. Yan H., Aziz E., Shillabeer G., Wong A., Shangavi D., Kermouni A., Abdel-Hafez M., Lau D.C.W. Nitric oxide promotes differentiation of rat white preadipocytes in culture. J. Lipid Res. 2002, 43:2123-2129.