메뉴 건너뛰기




Volumn 103, Issue 3, 2008, Pages 857-864

The inhibition of the expression of the small Rho GTPase Rac1 induces differentiation with no effect on cell proliferation in growing human adult keratinocytes

Author keywords

c myc; Differentiation; MAPK; Normal human adult keratinocytes; Proliferation; Rac1

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE P38; MYC PROTEIN; RAC1 PROTEIN; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; SMALL INTERFERING RNA;

EID: 39049114765     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.21455     Document Type: Article
Times cited : (12)

References (24)
  • 1
    • 23244452354 scopus 로고    scopus 로고
    • Stem cell depletion through epidermal deletion of Rac1
    • Benitah SA, Frye M, Glogauer M, Watt MF. 2005. Stem cell depletion through epidermal deletion of Rac1. Science 309:933-935.
    • (2005) Science , vol.309 , pp. 933-935
    • Benitah, S.A.1    Frye, M.2    Glogauer, M.3    Watt, M.F.4
  • 2
    • 0030986411 scopus 로고    scopus 로고
    • Repression of c-Myc responsive genes in cycling cells caused G1 arrest trough reduction of cyclin E/CDK2 kinase activity
    • Berns K, Hijmans EM, Bernards R. 1997. Repression of c-Myc responsive genes in cycling cells caused G1 arrest trough reduction of cyclin E/CDK2 kinase activity. Oncogene 15:1347-1356.
    • (1997) Oncogene , vol.15 , pp. 1347-1356
    • Berns, K.1    Hijmans, E.M.2    Bernards, R.3
  • 3
    • 0030968177 scopus 로고    scopus 로고
    • The small GTP-ases Rho and Rac are required for the establishment of cadherin-dependent cell-cell contacts
    • Braga VM, Machesky LM, Hall A, Hotchin NA. 1997. The small GTP-ases Rho and Rac are required for the establishment of cadherin-dependent cell-cell contacts. J Cell Biol 137:1421-1431.
    • (1997) J Cell Biol , vol.137 , pp. 1421-1431
    • Braga, V.M.1    Machesky, L.M.2    Hall, A.3    Hotchin, N.A.4
  • 5
    • 0029055812 scopus 로고
    • The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signalling pathway
    • Coso OA, Chiariello M, Yu JC, Teramoto H, Crespo P, Xu N, Miki T, Gutkind JS. 1995. The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signalling pathway. Cell 81:1137-1146.
    • (1995) Cell , vol.81 , pp. 1137-1146
    • Coso, O.A.1    Chiariello, M.2    Yu, J.C.3    Teramoto, H.4    Crespo, P.5    Xu, N.6    Miki, T.7    Gutkind, J.S.8
  • 6
    • 0027948327 scopus 로고
    • Role of integrins in cell adhesion and polarity in normal keratinocytes and human skin pathologies
    • De Luca M, Pellegrini G, Zambruno G, Marchisio PC. 1994. Role of integrins in cell adhesion and polarity in normal keratinocytes and human skin pathologies. J Dermatol 21:821-828.
    • (1994) J Dermatol , vol.21 , pp. 821-828
    • De Luca, M.1    Pellegrini, G.2    Zambruno, G.3    Marchisio, P.C.4
  • 7
    • 0032491424 scopus 로고    scopus 로고
    • Citron rho-interacting kinase, a novel tissue-specific ser/thr kinase encompassing the Rho-Rac-binding protein Citron
    • Di Cunto F, Calautti E, Hsiao J, Ong L, Topley G, Turco E, Dotto GP. 1998. Citron rho-interacting kinase, a novel tissue-specific ser/thr kinase encompassing the Rho-Rac-binding protein Citron. J Biol Chem 273:29706-29711.
    • (1998) J Biol Chem , vol.273 , pp. 29706-29711
    • Di Cunto, F.1    Calautti, E.2    Hsiao, J.3    Ong, L.4    Topley, G.5    Turco, E.6    Dotto, G.P.7
  • 9
    • 0030830220 scopus 로고    scopus 로고
    • Cross-cascade activation of ERKs and ternary complex factors by Rho family proteins
    • Frost JA, Steen H, Shapiro P, Lewis T, Ahn N, Shaw PE, Cobb MH. 1997. Cross-cascade activation of ERKs and ternary complex factors by Rho family proteins. EMBO J 16:6426-6438.
    • (1997) EMBO J , vol.16 , pp. 6426-6438
    • Frost, J.A.1    Steen, H.2    Shapiro, P.3    Lewis, T.4    Ahn, N.5    Shaw, P.E.6    Cobb, M.H.7
  • 10
    • 23844514714 scopus 로고    scopus 로고
    • Negative control of keratinocyte differentiation by Rho/CRIK signalling coupled with up-regulation of KyoT1/2 (FHL1) expression
    • Grossi M, Hiou-Feige A, Tommasi Di Vignano A, Calautti E, Ostano P, Lee S, Chiorino G, Dotto GP. 2005. Negative control of keratinocyte differentiation by Rho/CRIK signalling coupled with up-regulation of KyoT1/2 (FHL1) expression. PNAS 102:11313-11318.
    • (2005) PNAS , vol.102 , pp. 11313-11318
    • Grossi, M.1    Hiou-Feige, A.2    Tommasi Di Vignano, A.3    Calautti, E.4    Ostano, P.5    Lee, S.6    Chiorino, G.7    Dotto, G.P.8
  • 11
    • 2342461732 scopus 로고    scopus 로고
    • Unique keratinization process in psoriasis: Late differentiation markers are abolished because of premature cell death
    • Iizuka H, Takahashi H, Honma M, Ishida-Yamamoto A. 2004. Unique keratinization process in psoriasis: Late differentiation markers are abolished because of premature cell death. J Dermatol 31:271-276.
    • (2004) J Dermatol , vol.31 , pp. 271-276
    • Iizuka, H.1    Takahashi, H.2    Honma, M.3    Ishida-Yamamoto, A.4
  • 12
    • 19944426510 scopus 로고    scopus 로고
    • Serine-threonine kinases and transcription factors active in signal transduction are detected at high levels of phosphorylation during mitosis in preimplantation embryos and trophoblast stem cells
    • Liu J, Puscheck EE, Wang F, Trostinskaia A, Barisic D, Maniere G, Wygle D, Zhong W, Rings EH, Rappolee DA. 2004. Serine-threonine kinases and transcription factors active in signal transduction are detected at high levels of phosphorylation during mitosis in preimplantation embryos and trophoblast stem cells. Reproduction 128:643-654.
    • (2004) Reproduction , vol.128 , pp. 643-654
    • Liu, J.1    Puscheck, E.E.2    Wang, F.3    Trostinskaia, A.4    Barisic, D.5    Maniere, G.6    Wygle, D.7    Zhong, W.8    Rings, E.H.9    Rappolee, D.A.10
  • 13
    • 0029070887 scopus 로고
    • Selective activation of the JNK signalling cascade and c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs
    • Minden A, Lin A, Claret FX, Abo A, Karin M. 1995. Selective activation of the JNK signalling cascade and c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs. Cell 81:1147-1157.
    • (1995) Cell , vol.81 , pp. 1147-1157
    • Minden, A.1    Lin, A.2    Claret, F.X.3    Abo, A.4    Karin, M.5
  • 14
    • 0345732643 scopus 로고    scopus 로고
    • A network of immediate early gene products propagates subtle differences in mitogen-activated protein kinase signal amplitude and duration
    • Murphy LO, MacKeigan JP, Blenis J. 2004. A network of immediate early gene products propagates subtle differences in mitogen-activated protein kinase signal amplitude and duration. Mol Cell Biol 24:144-153.
    • (2004) Mol Cell Biol , vol.24 , pp. 144-153
    • Murphy, L.O.1    MacKeigan, J.P.2    Blenis, J.3
  • 15
    • 14744305803 scopus 로고    scopus 로고
    • More than just proliferation: Myc function in stem cells
    • Murphy MJ, Wilson A, Trumpp A. 2005. More than just proliferation: Myc function in stem cells. Trends Cell Biol 15:128-137.
    • (2005) Trends Cell Biol , vol.15 , pp. 128-137
    • Murphy, M.J.1    Wilson, A.2    Trumpp, A.3
  • 16
    • 0033170561 scopus 로고    scopus 로고
    • High cell density, phorbol ester and retinoic acid upregulate involucrin and downregulate suprabasal keratin 10 in autocrine cultures of human epidermal keratinocytes
    • Poumay Y, Herphelin F, Smits P, De Potter TY, Pittelkow MR. 1999. High cell density, phorbol ester and retinoic acid upregulate involucrin and downregulate suprabasal keratin 10 in autocrine cultures of human epidermal keratinocytes. Mol Cell Biol Res Commun 2:138-144.
    • (1999) Mol Cell Biol Res Commun , vol.2 , pp. 138-144
    • Poumay, Y.1    Herphelin, F.2    Smits, P.3    De Potter, T.Y.4    Pittelkow, M.R.5
  • 17
    • 0036019586 scopus 로고    scopus 로고
    • Ca(2+)/calmodulin-dependent protein kinase (CaM-kinase) inhibitor KN-62 suppresses the activity of mitogen-activated protein kinase (MAPK), c-myc activation and human keratinocyte proliferation
    • Praskova M, Kalenderova S, Miteva L, Poumay Y, Mitev V. 2002. Ca(2+)/calmodulin-dependent protein kinase (CaM-kinase) inhibitor KN-62 suppresses the activity of mitogen-activated protein kinase (MAPK), c-myc activation and human keratinocyte proliferation. Arch Dermatol Res 294:198-202.
    • (2002) Arch Dermatol Res , vol.294 , pp. 198-202
    • Praskova, M.1    Kalenderova, S.2    Miteva, L.3    Poumay, Y.4    Mitev, V.5
  • 19
    • 0034306997 scopus 로고    scopus 로고
    • Multiple Ras-dependent phosphorylation pathways regulate Myc protein stability
    • Sears R, Nuckolls F, Haura E, Taya Y, Tamai K, Nevins JR. 2000. Multiple Ras-dependent phosphorylation pathways regulate Myc protein stability. Genes Dev 14:2501-2514.
    • (2000) Genes Dev , vol.14 , pp. 2501-2514
    • Sears, R.1    Nuckolls, F.2    Haura, E.3    Taya, Y.4    Tamai, K.5    Nevins, J.R.6
  • 20
    • 0032472938 scopus 로고    scopus 로고
    • A strain-independent postnatal neurodegeneration in mice lacking the EGF receptor
    • Sibilia M, Steinbach JP, Stingl L, Aguzzi A, Wagner EF. 1998. A strain-independent postnatal neurodegeneration in mice lacking the EGF receptor. EMBO J 17:719-731.
    • (1998) EMBO J , vol.17 , pp. 719-731
    • Sibilia, M.1    Steinbach, J.P.2    Stingl, L.3    Aguzzi, A.4    Wagner, E.F.5
  • 22
    • 33845919326 scopus 로고    scopus 로고
    • The ins and outs of myc regulation by posttranslational mechanisms
    • Vervoorts J, Lüscher-Firzlaff J, Lüscher B. 2006. The ins and outs of myc regulation by posttranslational mechanisms. J Biol Chem 281:34725-34729.
    • (2006) J Biol Chem , vol.281 , pp. 34725-34729
    • Vervoorts, J.1    Lüscher-Firzlaff, J.2    Lüscher, B.3
  • 23
    • 33846662015 scopus 로고    scopus 로고
    • Cell type-specific functions of Rho GTPases revealed by gene targeting in mice
    • Wang L, Zheng Y. 2007. Cell type-specific functions of Rho GTPases revealed by gene targeting in mice. Trends Cell Biol 17:58-64.
    • (2007) Trends Cell Biol , vol.17 , pp. 58-64
    • Wang, L.1    Zheng, Y.2
  • 24
    • 18844436010 scopus 로고    scopus 로고
    • Endogenous Myc controls mammalian epidermal cell size, hyperproliferation, endoreplication and stem cell amplification
    • Zanet JP, Pibre S, Jacquet C, Ramirez A, de Alboran IM, Gandarillas A. 2005. Endogenous Myc controls mammalian epidermal cell size, hyperproliferation, endoreplication and stem cell amplification. J Cell Sci 118:1693-1704.
    • (2005) J Cell Sci , vol.118 , pp. 1693-1704
    • Zanet, J.P.1    Pibre, S.2    Jacquet, C.3    Ramirez, A.4    de Alboran, I.M.5    Gandarillas, A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.