Differentiating C-Br and C-Cl bond activation by using solvent polarity: Applications to orthogonal alkyl-alkyl negishi reactions

Angewandte Chemie - International Edition

Volumn 50, Issue 17, 2011, Pages 3896-3899

  Hadei, Niloufar ^a   Achonduh, George T ^a   Valente, Cory ^a   O'Brien, Christopher J ^a   Organ, Michael G ^a  

^a YORK UNIVERSITY   (Canada)

Author keywords

alkyl alkyl coupling; cross coupling; Negishi reaction; orthogonal reactions; solvent polarity

Indexed keywords

ALKYL-ALKYL COUPLING; CROSS-COUPLINGS; NEGISHI REACTIONS; ORTHOGONAL REACTION; SOLVENT POLARITY;

ORGANIC SOLVENTS;

ALKYLATION;

EID: 79954605817     PISSN: 14337851     EISSN: 15213773     Source Type: Journal    
DOI: 10.1002/anie.201100705     Document Type: Article

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41. - to produce the corresponding alkyl bromide. This side reaction has the net effect of increasing the amount of 4, thus leading to a decrease in the observed or apparent selectivity. Although this side reaction has not been fully quantified, our observations indicate that it is minor in its contribution to 4.
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