Relationship between osteoporosis and adipose tissue leptin and osteoprotegerin in patients with chronic obstructive pulmonary disease

Bone

Volumn 48, Issue 5, 2011, Pages 1008-1014

  Pobeha, Pavol ^a   Ukropec, Jozef ^b   Skyba, Peter ^a   Ukropcova, Barbara ^b   Joppa, Pavol ^a   Kurdiova, Timea ^b   Javorsky, Martin ^a   Klimes, Iwar ^b   Tkac, Ivan ^a   Gasperikova, Daniela ^b   Tkacova, Ruzena ^a  

^a P J AFÁRIK UNIVERSITY   (Slovakia)

^b INSTITUTE OF EXPERIMENTAL ENDOCRINOLOGY   (Slovakia)

Author keywords

Bone mineral density; Chronic obstructive pulmonary disease; Leptin; Osteoporosis; Osteoprotegerin

Indexed keywords

CARBON DIOXIDE; LEPTIN; OSTEOCALCIN; OSTEOPROTEGERIN; OXYGEN;

ADIPOSE TISSUE; ADULT; AGE; ARTICLE; BLOOD CARBON DIOXIDE TENSION; BLOOD OXYGEN TENSION; BODY COMPOSITION; BODY FAT; BODY MASS; BONE DENSITY; BONE TURNOVER; CHEMOLUMINESCENCE; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL ARTICLE; COMORBIDITY; CONTROLLED STUDY; DUAL ENERGY X RAY ABSORPTIOMETRY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FEMUR; FORCED EXPIRATORY VOLUME; FORCED VITAL CAPACITY; FUNCTIONAL RESIDUAL CAPACITY; HUMAN; HUMAN TISSUE; LUMBAR SPINE; LUNG FUNCTION; MALE; OSTEOPOROSIS; PREDICTION; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; SEX DIFFERENCE; SUBCUTANEOUS FAT; TOTAL LUNG CAPACITY;

EID: 79954597819     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2011.02.017     Document Type: Article

References (43)

1. Rabe K.F., Hurd S., Anzueto A., Barnes P.J., Buist S.A., Calverley P., et al. Global initiative for chronic obstructive lung disease: global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD Executive Summary. Am. J. Respir. Crit. Care Med. 2007, 176:532-555.
2. Barnes P.J., Celli B.R. Systemic manifestations and comorbidities of COPD. Eur. Respir. J. 2009, 33:1165-1185.
3. Wouters E.F. Local and systemic inflammation in chronic obstructive pulmonary disease. Proc. Am. Thorac. Soc. 2005, 2:26-33.
4. Graat-Verboom L., Wouters E.F.M., Smeenk F.W.J.M., Van Den Borne B.E., Lunde R., Spruit M.A. Current status of research on osteoporosis in COPD: asystematic review. Eur. Respir. J. 2009, 34:209-218.
5. Graat-Verboom L., Spruit M.A., Van Den Borne B.E., Smeenk F.W., Martens E.J., Lunde R., Wouters E.F. Correlates of osteoporosis in chronic obstructive pulmonary disease: an underestimated systemic component. Respir. Med. 2009, 103:1143-1151.
6. Yawn B.P., Kaplan A. Co-morbidities in people with COPD: a result of multiple diseases, or multiple manifestations of smoking and reactive inflammation?. Prim. Care Respir. J. 2008, 17:199-205.
7. Roth M. Pathogenesis of COPD. Part III. Inflammation in COPD. Int. J. Tuberc. Lung. Dis. 2008, 12:375-380.
8. Magni P., Dozio E., Galliera E., Ruscica M., Corsi M.M. Molecular aspects of adipokine-bone interactions. Curr. Mol. Med. 2010, 10:522-532.
9. Cirmanova V., Bayer M., Starka L., Zajickova K. The effect of leptin on bone-an evolving concept of action. Physiol. Res. 2008, 57(Suppl 1):S143-S151.
10. Reid I.R. Relationships between fat and bone. Osteoporos. Int. 2008, 19:595-606.
11. Holloway W.R., Collier F.M., Aitken C.J., Myers D.E., Hodge J.M., Malakellis M., et al. Leptin inhibits osteoclast generation. J. Bone Miner. Res. 2002, 17:200-209.
12. Thomas T. The complex effects of leptin on bone metabolism through multiple pathways. Curr. Opin. Pharmacol. 2004, 4:295-300.
13. Boyce B.F., Xing L. Functions of RANKL/RANK/OPG in bone modeling and remodeling. Arch. Biochem. Biophys. 2008, 473:139-146.
14. Simonet W.S., Lacey D.L., Dunstan C.R., Kelley M., Chang M.S., Luthy R., et al. Osteoprotegerin: a novel secreted protein involved in the regulation of bone density. Cell 1997, 89:309-319.
15. Lorentzon M., Landin K., Mellstrom D., Ohlsson C. Leptin is a negative independent predictor of areal BMD and cortical bone size in young adult Swedish men. J. Bone Miner. Res. 2006, 21:1871-1878.
16. Iwamoto I., Douchi T., Kosha S., Murakami M., Fujino T., Nagata Y. Relationship between serum leptin level and regional bone mineral density, bone metabolic markers in healthy women. Acta Obstet. Gynecol. Scand. 2000, 79:1060-1064.
17. Blain H., Vuillemin A., Guillemin F., Durant R., Hanesse B., De Talance N., et al. Serum leptin level is a predictor of bone mineral density in postmenopausal women. J. Clin. Endocrinol. Metab. 2002, 87:1030-1035.
18. Yamauchi M., Sugimoto T., Yamauchi T., Nakaoka D., Kanazawa M., Yano S., et al. Plasma leptin concentrations are associated with bone mineral density and the presence of vertebral fractures in postmenopausal women. Clin. Endocrinol. (OXF) 2001, 55:341-347.
19. Misra M., Miller K.K., Cord J., Prabhakaran R., Herzog D.B., Goldstein M., et al. Relationships between serum adipokines, insulin levels, and bone density in girls with anorexia nervosa. J. Clin. Endocrinol. Metab. 2007, 92:2046-2052.
20. Coen G., Ballanti P., Fischer M.S., Balducci A., Calabria S., Colomarco L., et al. Serum leptin in dialysis renal osteodystrophy. Am. J. Kidney Dis. 2003, 42:1036-1042.
21. Eun I.S., Park W.W., Suh K.T., Kim J.I., Lee J.S. Association between osteoprotegerin gene polymorphism and bone mineral density in patients with adolescent idiopathic scoliosis. Eur. Spine J. 2009, 18:1936-1940.
22. Riches P.L., McRorie E., Fraser W.D., Determann C., Hof R., Ralston S.H. Osteoporosis associated with neutralizing autoantibodies against osteoprotegerin. N. Engl. J. Med. 2009, 361:1365-1459.
23. Vondracek S.F., Voelkel N.F., McDermott M.T., Valdez C. The relationship between adipokines, body composition, and bone density in men with chronic obstructive pulmonary disease. Int. J. COPD 2009, 4:267-277.
24. Eagan T.M., Ueland T., Wagner P.D., Hardie J.A., Mollnes T.E., Damas J.K., et al. Systemic inflammatory markers in chronic obstructive pulmonary disease: results from the Bergen COPD Cohort Study. Eur. Respir. J. 2010, 35:540-548.
25. Mahler D., Wells C. Evaluation of clinical methods for rating dyspnea. Chest 1988, 93:580-586.
26. Jones P.W., Quirk F.H., Baveystock C.M., Littlejohns P. A self-complete measure of health status for chronic airflow limitation. The St. George's Respiratory Questionnaire. Am. Rev. Respir. Dis. 1992, 145:1321-1327.
27. Baecke J., Burema J., Frijters J. A short questionaire for the measurement of habitual physical activity in epidemiological studies. Am. J. Clin. Nutr. 1982, 11:936-942.
28. Miller M., Hankinson J., Brusasco V., Burgos F., Casaburi R., Coates A., et al. Standardisation spirometry. Eur. Respir. J. 2005, 26:319-338.
29. NHLBI/WHO Global Initiative for Chronic Obstructive Lung Disease (GOLD) Workshop: Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. 2009 update. Available from: Date last accessed: 08. September 2010. http://www.goldcopd.com.
30. WHO Scientific Group on the Prevention and management of Osteoporosis. Prevention an Management of Osteoporosis: report of a WHO scientific group. Geneva 2003; Date last accessed: June 10, 2010. http://whqlibdoc.who.int/trs/WHO_TRS_921.pdf.
31. Klein D. Quantification using real-time PCR technology: applications and limitations. Trends Mol. Med. 2002, 8:257-260.
32. Lappalainen T., Kolehmainen M., Schwab U., Pulkkinen L., Laaksonen D.E., Rauramaa R., et al. Serum concentrations and expressions of serum amyloid A and leptin in adipose tissue are interrelated: the Genobin study. Eur. J. Endocrinol. 2008, 158:333-341.
33. Kulak C.A., Kimmel D.B., Kulak J., Rabelo L.M., Zhou H., Guo X.E., et al. Skeletal microstructural abnormalities in postmenopausal women with chronic obstructive pulmonary disease. J. Bone Miner. Res. 2010, 25:1931-1940.
34. Sabit R., Bolton C.E., Edwards P.H., Pettit R.J., Evans W.D., Mceniery C.M., et al. Arterial stiffness and osteoporosis in chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 2007, 175:1259-1265.
35. Shepherd A.J., Casss A.R., Carlson C.A., Ray L. Development and internal validation of the male osteoporosis risk estimation score. Ann. Fam. Med. 2007, 5:540-546.
36. Bolton C.E., Ionescu A.A., Shiels K.M., Pettit R.J., Edwards P.H., Stone M.D., et al. Associated loss of fat-free mass and bone mineral density in chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 2004, 170:1286-1293.
37. Vrieze A., De Greef M.H., Wijkstra P.J., Wempe J.B. Low bone mineral density in COPD patients related to worse lung function, low weight and decreased fat-free mass. Osteoporosis Int. 2007, 18:1197-1202.
38. Kjensli A., Mowinckel P., Ryg M.S., Falch J.A. Low bone mineral density is related to severity of chronic obstructive pulmonary disease. Bone 2007, 40:493-497.
39. Bolton C.E., Cannings-John R., Edwards P.H., Ionescu A.A., Evans W.D., Pettit R.J., et al. What community measurements can be used to predict bone disease in patients with COPD?. Respir. Med. 2008, 102:651-657.
40. Nuti R., Siviero P., Maggi S., Gugliemi G., Caffarelli C., Crepaldi G., Connelli S. Vertebral fractures in patients with chronic obstructive pulmonary disease: the EOLO Study. Osteoporosis Int. 2009, 20:989-998.
41. Burguera B., Hofbauer L.C., Thomas T., Gori F., Evans G.L., Khosla S., et al. Leptin reduces ovariectomy-induced bone loss in rats. Endocrinology 2001, 142:3546-3553.
42. An J.J., Han D.H., Kim D.M., Kim S.H., Rhee Y., Lee E.J., Lim S.K. Expression and regulation of osteoprotegerin in adipose tissue. Yonsei Med. J. 2007, 48:765-772.
43. Golledge J., Jayalath R., Oliver L., Parr A., Schurgers L., Clancy P. Relationship between CT anthropometric measurements, adipokines and abdominal aortic calcification. Atherosclerosis 2008, 197:428-434.